Larry Kestin

Summary

Affiliation: William Beaumont Hospital
Country: USA

Publications

  1. ncbi request reprint Practical application of biochemical failure definitions: what to do and when to do it
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:304-15. 2002
  2. ncbi request reprint Defining a radiotherapy target with positron emission tomography
    Quinten C Black
    21st Century Oncology, Inc, Asheville, NC, USA
    Int J Radiat Oncol Biol Phys 60:1272-82. 2004
  3. ncbi request reprint Intensity modulation to improve dose uniformity with tangential breast radiotherapy: initial clinical experience
    L L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 48:1559-68. 2000
  4. ncbi request reprint Potential survival advantage with early androgen deprivation for biochemical failure after external beam radiotherapy: the importance of accurately defining biochemical disease status
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 60:453-62. 2004
  5. ncbi request reprint Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 57:875-90. 2003
  6. ncbi request reprint Treatment of prostate cancer with radiotherapy: should the entire seminal vesicles be included in the clinical target volume?
    Larry Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:686-97. 2002
  7. ncbi request reprint Pathologic evidence of dose-response and dose-volume relationships for prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:107-18. 2002
  8. doi request reprint Long-term patterns of in-breast failure in patients with early stage breast cancer treated with breast-conserving therapy: a molecular based clonality evaluation
    Samuel McGrath
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Am J Clin Oncol 33:17-22. 2010
  9. doi request reprint Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: a matched-pair analysis with 10-year follow-up
    J Vito Antonucci
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 74:447-52. 2009
  10. ncbi request reprint Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1124-30. 2007

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Practical application of biochemical failure definitions: what to do and when to do it
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:304-15. 2002
    ..We performed an extensive analysis of post-radiotherapy PSA measurements to determine the clinical significance of biochemical failure (BF) and the correlation of BF with clinical failure (CF) and cause-specific death (CSD)...
  2. ncbi request reprint Defining a radiotherapy target with positron emission tomography
    Quinten C Black
    21st Century Oncology, Inc, Asheville, NC, USA
    Int J Radiat Oncol Biol Phys 60:1272-82. 2004
    ..We performed a series of phantom studies to determine an accurate and uniformly applicable method for defining a GTV with FDG-PET...
  3. ncbi request reprint Intensity modulation to improve dose uniformity with tangential breast radiotherapy: initial clinical experience
    L L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 48:1559-68. 2000
    ..The technique of multiple static multileaf collimator (sMLC) segments was used to facilitate IMRT...
  4. ncbi request reprint Potential survival advantage with early androgen deprivation for biochemical failure after external beam radiotherapy: the importance of accurately defining biochemical disease status
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 60:453-62. 2004
    ..after clinical failure (clinical failure), and the associated impact of various BF definitions...
  5. ncbi request reprint Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 57:875-90. 2003
    ....
  6. ncbi request reprint Treatment of prostate cancer with radiotherapy: should the entire seminal vesicles be included in the clinical target volume?
    Larry Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:686-97. 2002
    ....
  7. ncbi request reprint Pathologic evidence of dose-response and dose-volume relationships for prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:107-18. 2002
    ..We performed a detailed pathologic review of posttreatment biopsy specimens in an attempt to clarify their relationship with clinical outcome and radiation dose...
  8. doi request reprint Long-term patterns of in-breast failure in patients with early stage breast cancer treated with breast-conserving therapy: a molecular based clonality evaluation
    Samuel McGrath
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Am J Clin Oncol 33:17-22. 2010
    ....
  9. doi request reprint Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: a matched-pair analysis with 10-year follow-up
    J Vito Antonucci
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 74:447-52. 2009
    ..e., accelerated partial breast irradiation, [APBI]) in selected patients treated with breast-conserving therapy (BCT) and compare them with results of matched BCT patients who underwent whole-breast irradiation (WBI)...
  10. ncbi request reprint Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1124-30. 2007
    ....
  11. doi request reprint Comparison of acute and late toxicities for three modern high-dose radiation treatment techniques for localized prostate cancer
    Nasiruddin Mohammed
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 82:204-12. 2012
    ..We compared acute and late genitourinary (GU) and gastrointestinal (GI) toxicities in prostate cancer patients treated with three different high-dose radiation techniques...
  12. doi request reprint Lack of benefit for the addition of androgen deprivation therapy to dose-escalated radiotherapy in the treatment of intermediate- and high-risk prostate cancer
    Daniel Krauss
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 80:1064-71. 2011
    ..Assessment of androgen deprivation therapy (ADT) benefits for prostate cancer treated with dose-escalated radiotherapy (RT)...
  13. doi request reprint Identifying differences between biochemical failure and cure: incidence rates and predictors
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 81:e369-75. 2011
    ..Patients treated with radiation therapy (RT) for prostate cancer were evaluated to estimate the length of time required to document biochemical cure (BC) after treatment and the variables associated with long-term treatment efficacy...
  14. ncbi request reprint Long-term efficacy and patterns of failure after accelerated partial breast irradiation: a molecular assay-based clonality evaluation
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 68:341-6. 2007
    ..To determine the long-term efficacy and cosmetic results of accelerated partial breast irradiation (APBI) by reviewing our institution's experience...
  15. ncbi request reprint Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Int J Radiat Oncol Biol Phys 57:1247-53. 2003
    ..We present our ongoing clinical experience utilizing 3D conformal radiation therapy (3D-CRT) to deliver partial-breast irradiation (PBI) in patients with early-stage breast cancer treated with breast-conserving therapy...
  16. ncbi request reprint The use of molecular assays to establish definitively the clonality of ipsilateral breast tumor recurrences and patterns of in-breast failure in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 109:1264-72. 2007
    ....
  17. doi request reprint Four-year efficacy, cosmesis, and toxicity using three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation
    Peter Y Chen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 76:991-7. 2010
    ..This prospective study examines the use of three-dimensional conformal external beam radiation therapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Four-year data on efficacy, cosmesis, and toxicity are presented...
  18. ncbi request reprint Limited-field radiation therapy in the management of early-stage breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    J Natl Cancer Inst 95:1205-10. 2003
    ..e., limited-field radiation therapy) in selected patients treated with breast-conserving therapy and compared them with results of matched breast-conserving therapy patients who underwent whole-breast radiation therapy...
  19. pmc Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
    Ching Yee O Wong
    Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA
    Radiat Oncol 2:18. 2007
    ..To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy...
  20. ncbi request reprint Factors associated with local recurrence and cause-specific survival in patients with ductal carcinoma in situ of the breast treated with breast-conserving therapy or mastectomy
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Beaumont Cancer Institute, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 63:1514-21. 2005
    ....
  21. doi request reprint Limitations of the American Society of Therapeutic Radiology and Oncology Consensus Panel guidelines on the use of accelerated partial breast irradiation
    Frank Vicini
    Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 79:977-84. 2011
    ....
  22. doi request reprint Dose escalation improves cancer-related events at 10 years for intermediate- and high-risk prostate cancer patients treated with hypofractionated high-dose-rate boost and external beam radiotherapy
    Alvaro A Martinez
    Radiation Oncology Department, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Int J Radiat Oncol Biol Phys 79:363-70. 2011
    ....
  23. ncbi request reprint Partial breast irradiation in breast conserving therapy by way of intersitial brachytherapy
    Pamela R Benitez
    Department of Surgery, William Beaumont Hospital, 3577 W 13 Mile Rd, Suite No 201, Royal Oak, MI 48073, USA
    Am J Surg 188:355-64. 2004
    ....
  24. ncbi request reprint Conformal high dose rate brachytherapy improves biochemical control and cause specific survival in patients with prostate cancer and poor prognostic factors
    Alvaro Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    J Urol 169:974-9; discussion 979-80. 2003
    ..To achieve this outcome a brachytherapy boost was given. We report the results of the first high dose rate dose-escalation brachytherapy trial...
  25. ncbi request reprint Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 68:1375-80. 2007
    ..In the present analysis, we reviewed the acute and chronic toxicity of this IMRT approach compared with conventional wedge-based treatment...
  26. ncbi request reprint The role of high-dose rate brachytherapy in locally advanced prostate cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Semin Radiat Oncol 13:98-108. 2003
    ....
  27. ncbi request reprint Computed tomography guided management of interfractional patient variation
    Di Yan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Semin Radiat Oncol 15:168-79. 2005
    ....
  28. ncbi request reprint Factors associated with ipsilateral breast failure and distant metastases in patients with invasive breast carcinoma treated with breast-conserving therapy. A clinicopathologic study of 607 neoplasms from 583 patients
    Neal S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 120:500-27. 2003
    ..The amount of carcinoma near the margin and volume of excised parenchyma related directly to the amount of residual carcinoma in the adjacent breast parenchyma...
  29. doi request reprint Differences in disease presentation, management techniques, treatment outcome, and toxicities in African-American women with early stage breast cancer treated with breast-conserving therapy
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 116:3485-92. 2010
    ..Data on patients who received breast-conserving therapy (BCT) for early stage breast cancer were examined to detect differences in disease presentation, management techniques, long-term treatment outcomes, and toxicities based on race...
  30. doi request reprint Comparison of IGRT registration strategies for optimal coverage of primary lung tumors and involved nodes based on multiple four-dimensional CT scans obtained throughout the radiotherapy course
    Nasiruddin Mohammed
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 82:1541-8. 2012
    ....
  31. ncbi request reprint Changes in the respiratory pattern during radiotherapy for cancer in the lung
    Geoffrey Hugo
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Radiother Oncol 78:326-31. 2006
    ..To quantify changes in patients' diaphragm motion pattern over the course of radiotherapy and to evaluate the implications of these changes for 4D radiotherapy...
  32. ncbi request reprint An interinstitutional and interspecialty comparison of treatment outcome data for patients with prostate carcinoma based on predefined prognostic categories and minimum follow-up
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 95:2126-35. 2002
    ..The current study was conducted to compare and contrast outcomes with different forms of therapy for patients with prostate carcinoma who were treated at several institutions using predefined prognostic categories...
  33. ncbi request reprint Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:1336-44. 2002
    ..To present our clinical experience using intensity-modulated radiation therapy (IMRT) to improve dose uniformity and treatment efficacy in patients with early-stage breast cancer treated with breast-conserving therapy...
  34. ncbi request reprint Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy?
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 97:910-9. 2003
    ....
  35. ncbi request reprint Limitations in the use of serum prostate specific antigen levels to monitor patients after treatment for prostate cancer
    Frank A Vicini
    Departments of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 173:1456-62. 2005
    ..We reviewed the literature to help clarify the benefits and/or hazards associated with monitoring serum prostate specific antigen (PSA) after treatment with surgery or radiation therapy (RT) for nonmetastatic prostate cancer...
  36. doi request reprint Molecular evidence demonstrating local treatment failure is the source of distant metastases in some patients treated for breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 71:689-94. 2008
    ..To examine the clonality relationships among initial invasive breast carcinoma (IBC), ipsilateral breast failure (IBF), and distant metastasis (DM) to determine the effect of local tumor recurrence on the development of DMs...
  37. ncbi request reprint The emerging role of brachytherapy in the management of patients with breast cancer
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Semin Radiat Oncol 12:31-9. 2002
    ..Although preliminary results with brachytherapy alone are encouraging, proper patient selection and optimal dosimetric guidelines must be employed in order to achieve success when used in this setting...
  38. ncbi request reprint Estrogen replacement therapy in breast cancer survivors: a matched-controlled series
    David A Decker
    Department of Medicine, William Beaumont Hospital, Royal Oak Troy, MI 48073, USA
    Menopause 10:277-85. 2003
    ..We report the consequences of ERT compared with a historical matched-control group...
  39. ncbi request reprint Wedge resection margin distances and residual adenocarcinoma in lobectomy specimens
    Neal S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 120:720-4. 2003
    ....
  40. ncbi request reprint Addressing glucose sensitivity measured by F-18 FDG PET in lung cancers for radiation treatment planning and monitoring
    Ching Yee Oliver Wong
    Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Int J Radiat Oncol Biol Phys 65:132-7. 2006
    ..To address glucose sensitivity in lung cancers before and after radiation treatment (Tx)...
  41. doi request reprint A cost comparison analysis of adjuvant radiation therapy techniques after breast-conserving surgery
    Thomas Lanni
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Breast J 19:162-7. 2013
    ..APBI using brachytherapy techniques was less costly than conventional WBRT with a standard boost...
  42. ncbi request reprint Clinicopathologic analysis of microscopic extension in lung adenocarcinoma: defining clinical target volume for radiotherapy
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:334-41. 2007
    ..To determine the gross tumor volume (GTV) to clinical target volume margin for non-small-cell lung cancer treatment planning...
  43. ncbi request reprint Predictors for chronic urinary toxicity after the treatment of prostate cancer with adaptive three-dimensional conformal radiotherapy: dose-volume analysis of a phase II dose-escalation study
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1100-9. 2007
    ..To identify factors predictive for chronic urinary toxicity secondary to high-dose adaptive three-dimensional conformal radiation...
  44. ncbi request reprint The influence of percentage of preradiation needle biopsies with adenocarcinoma and total radiation dose on the pathologic response of unfavorable prostate adenocarcinoma
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 117:927-34. 2002
    ..Gleason score and gland volume did not contribute significantly to this relationship...
  45. ncbi request reprint Percentage of positive biopsy cores as predictor of clinical outcome in prostate cancer treated with radiotherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 168:1994-9. 2002
    ..We performed a complete pathology analysis of pretreatment biopsy specimens in an attempt to clarify their impact on clinical outcome following radiotherapy...
  46. ncbi request reprint Image-guided radiotherapy via daily online cone-beam CT substantially reduces margin requirements for stereotactic lung radiotherapy
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 70:1045-56. 2008
    ..To determine treatment accuracy and margins for stereotactic lung radiotherapy with and without cone-beam CT (CBCT) image guidance...
  47. pmc Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy
    Andrew J Stephenson
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195 0001, USA
    J Clin Oncol 25:2035-41. 2007
    ..We developed a nomogram to predict the probability of cancer control at 6 years after SRT for PSA-defined recurrence...
  48. ncbi request reprint Predictive factors for late genitourinary and gastrointestinal toxicity in patients with prostate cancer treated with adjuvant or salvage radiotherapy
    Mary Feng
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 68:1417-23. 2007
    ..To determine the rate and magnitude of late genitourinary (GU) and gastrointestinal (GI) toxicities after salvage or adjuvant radiotherapy (RT) for prostate cancer, and to determine predictive factors for these toxicities...
  49. ncbi request reprint Unification of a common biochemical failure definition for prostate cancer treated with brachytherapy or external beam radiotherapy with or without androgen deprivation
    Dwight L Fitch
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 66:1430-9. 2006
    ..We retrospectively analyzed our institution's experience treating localized prostate cancer in an attempt to determine a BF definition that could be applied for these various treatment modalities...
  50. doi request reprint Dosimetric advantages of four-dimensional adaptive image-guided radiotherapy for lung tumors using online cone-beam computed tomography
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 70:582-9. 2008
    ....
  51. ncbi request reprint Clinical implications of defining the gross tumor volume with combination of CT and 18FDG-positron emission tomography in non-small-cell lung cancer
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 67:709-19. 2007
    ..To compare the planning target volume (PTV) definitions for computed tomography (CT) vs. positron emission tomography (PET) in non-small-cell lung cancer (NSCLC)...
  52. ncbi request reprint Improved biochemical outcome with adjuvant radiotherapy after radical prostatectomy for prostate cancer with poor pathologic features
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 61:714-24. 2005
    ..We performed a retrospective comparison of our institution's experience treating prostate cancer with RP vs. RP followed by adjuvant EBRT...
  53. ncbi request reprint Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 122:728-39. 2004
    ..Tubular carcinoma as a distinct morphologic entity should be restricted to neoplasms with 70% or more tubularity, pure grade 1 nuclei, and rare mitoses. Other definitions of tubular carcinoma do not guarantee the excellent prognosis...
  54. ncbi request reprint Changes in temporal patterns of local failure after breast-conserving therapy and their prognostic implications
    Daniel J Krauss
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 60:731-40. 2004
    ..elsewhere [E]) and to compare these to rates of contralateral failure in women with Stages I/II breast cancer treated with conservative surgery (CS) and radiation therapy (RT)...
  55. ncbi request reprint Defining the clinical target volume for patients with early-stage breast cancer treated with lumpectomy and accelerated partial breast irradiation: a pathologic analysis
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 60:722-30. 2004
    ..This pathologic analysis was conducted to help define the clinical target volume (CTV) for partial breast irradiation (PBI) by analyzing the amount and distance of residual disease found at reexcision after an initial lumpectomy...
  56. ncbi request reprint Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 56:704-15. 2003
    ....
  57. ncbi request reprint Use of pathologic factors to assist in establishing adequacy of excision before radiotherapy in patients treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 60:86-94. 2004
    ..We reviewed our experience in patients with early-stage breast carcinoma treated with breast-conserving therapy (BCT) to identify pathologic factors useful in defining the adequacy of excision before radiotherapy (RT)...
  58. ncbi request reprint Impact of breathing motion on whole breast radiotherapy: a dosimetric analysis using active breathing control
    Robert C Frazier
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 58:1041-7. 2004
    ..The active breathing control (ABC) apparatus was used to quantify the effect of breathing motion on whole breast radiotherapy (RT) with standard wedges and intensity-modulated RT (IMRT)...
  59. ncbi request reprint Three-dimensional evaluation of intra- and interfraction immobilization of lung and chest wall using active breathing control: a reproducibility study with breast cancer patients
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 57:968-78. 2003
    ....
  60. ncbi request reprint MRI-based volumetric assessment of cardiac anatomy and dose reduction via active breathing control during irradiation for left-sided breast cancer
    Daniel J Krauss
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 61:1243-50. 2005
    ....
  61. ncbi request reprint Molecular clonality relationships in initial carcinomas, ipsilateral breast failures, and distant metastases in patients treated with breast-conserving therapy: evidence suggesting that some distant metastases are derived from ipsilateral breast failures
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 124:49-57. 2005
    ..The relationships of initial carcinomas, IBFs, and DMs are complex. DMs seem to be the direct result of IBFs in some cases. Some carcinomas seem to be composed of subclones with different and unrelated IBF and DM potential...
  62. ncbi request reprint The impact of lobular carcinoma in situ in association with invasive breast cancer on the rate of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy
    Shruti Jolly
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 66:365-71. 2006
    ..We examined the impact of the presence and extent of LCIS associated with invasive breast cancer on clinical outcome in BCT patients...
  63. ncbi request reprint Changes in management techniques and patterns of disease recurrence over time in patients with breast carcinoma treated with breast-conserving therapy at a single institution
    Helen Pass
    Department of Surgery, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 101:713-20. 2004
    ..The goals of the current study were to determine the frequency and use of optimal local and systemic therapy techniques and to evaluate the impact of these changes on treatment efficacy...
  64. ncbi request reprint Long-term cosmetic results and toxicity after accelerated partial-breast irradiation: a method of radiation delivery by interstitial brachytherapy for the treatment of early-stage breast carcinoma
    Peter Y Chen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 106:991-9. 2006
    ..The objective of this study was to assess the cosmesis and toxicities in patients with early-stage breast carcinoma who received treatment with accelerated partial breast irradiation (APBI) using interstitial brachytherapy...
  65. ncbi request reprint Phase II dose escalation study of image-guided adaptive radiotherapy for prostate cancer: use of dose-volume constraints to achieve rectal isotoxicity
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 63:141-9. 2005
    ..We analyzed rectal toxicity rates in different dose levels and treatment groups to determine whether equivalent toxicity rates were achieved as hypothesized when the protocol was started...
  66. ncbi request reprint Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48703, USA
    Int J Radiat Oncol Biol Phys 62:1297-308. 2005
    ..We analyzed our experience treating localized prostate cancer with image-guided off-line correction with adaptive high-dose radiotherapy (ART) in our Phase II dose escalation study to identify factors predictive of chronic rectal toxicity...
  67. ncbi request reprint Risk factors for regional nodal failure after breast-conserving therapy: regional nodal irradiation reduces rate of axillary failure in patients with four or more positive lymph nodes
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 56:658-70. 2003
    ....
  68. ncbi request reprint Accelerated partial breast irradiation using 3D conformal radiation therapy (3D-CRT)
    Kathy L Baglan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 55:302-11. 2003
    ..We present a novel three-dimensional conformal radiation therapy (3D-CRT) technique to treat the lumpectomy cavity, plus a 1.5-cm margin, in patients with early-stage breast cancer and study its clinical feasibility...
  69. ncbi request reprint Molecular clonality determination of ipsilateral recurrence of invasive breast carcinomas after breast-conserving therapy: comparison with clinical and biologic factors
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 123:679-89. 2005
    ..Molecular clonality assays may provide a reliable means of identifying patients who might benefit from systemic chemotherapy at the time of IBF...
  70. ncbi request reprint Clinicopathologic analysis of extracapsular extension in prostate cancer: should the clinical target volume be expanded posterolaterally to account for microscopic extension?
    K Kenneth Chao
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, and Department of Radiaiton Oncology, University of Florida, Jacksonville, USA
    Int J Radiat Oncol Biol Phys 65:999-1007. 2006
    ....
  71. ncbi request reprint Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 55:392-406. 2003
    ..To compare the DT-mDIBH technique to other standard techniques and to evaluate the dosimetric effect of intensity-modulated radiation therapy (IMRT)...
  72. ncbi request reprint Use of individual fraction size data from 3756 patients to directly determine the alpha/beta ratio of prostate cancer
    Scott G Williams
    Division of Radiation Oncology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia
    Int J Radiat Oncol Biol Phys 68:24-33. 2007
    ..To examine the effect of fraction size and total dose of radiation on recurrence of localized prostate cancer...