N S Goldstein

Summary

Affiliation: William Beaumont Hospital
Country: USA

Publications

  1. ncbi request reprint Recent pathology related advances in colorectal adenocarcinomas
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI, USA
    Eur J Surg Oncol 27:446-50. 2001
  2. ncbi request reprint Estrogen receptor antibody incubation time and extent of immunoreactivity in invasive carcinoma of the breast: the importance of optimizing antibody avidity
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Appl Immunohistochem Mol Morphol 15:203-7. 2007
  3. ncbi request reprint Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, U S A
    Am J Surg Pathol 26:179-89. 2002
  4. ncbi request reprint Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 92:1331-46. 2001
  5. ncbi request reprint Recommendations for improved standardization of immunohistochemistry
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Appl Immunohistochem Mol Morphol 15:124-33. 2007
  6. ncbi request reprint Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Cancer 92:738-47. 2001
  7. ncbi request reprint Molecular classification system identifies invasive breast carcinoma patients who are most likely and those who are least likely to achieve a complete pathologic response after neoadjuvant chemotherapy
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 110:1687-96. 2007
  8. ncbi request reprint Proximal small-bowel mucosal villous intraepithelial lymphocytes
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Histopathology 44:199-205. 2004
  9. ncbi request reprint Intraductal carcinoma of the breast: pathologic features associated with local recurrence in patients treated with breast-conserving therapy
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Surg Pathol 24:1058-67. 2000
  10. ncbi request reprint Gastric cardia inflammation and intestinal metaplasia: associations with reflux esophagitis and Helicobacter pylori
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073 6769, USA
    Mod Pathol 12:1017-24. 1999

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Recent pathology related advances in colorectal adenocarcinomas
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI, USA
    Eur J Surg Oncol 27:446-50. 2001
    ..Formats for standardized reporting of colorectal resection specimens are presented as a means to improve quality and consistency of pathological data recording and collection...
  2. ncbi request reprint Estrogen receptor antibody incubation time and extent of immunoreactivity in invasive carcinoma of the breast: the importance of optimizing antibody avidity
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Appl Immunohistochem Mol Morphol 15:203-7. 2007
    ..Optimization of IHC staining protocols should include evaluating the Ab incubation time and chromogen detection system. These factors can substantially alter the extent and intensity of ER IHC staining...
  3. ncbi request reprint Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, U S A
    Am J Surg Pathol 26:179-89. 2002
    ..Thus, all palpable lymph nodes should be recovered, including those that are 1 or 2 mm...
  4. ncbi request reprint Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 92:1331-46. 2001
    ..An epidermal growth factor receptor (EGFR) immunohistochemical detection system currently is being developed. The current study attempts to address background EGFR reactivity issues before determining the optimum EGFR scoring system...
  5. ncbi request reprint Recommendations for improved standardization of immunohistochemistry
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Appl Immunohistochem Mol Morphol 15:124-33. 2007
    ..Definitions and detailed guidelines pertaining to these areas are provided...
  6. ncbi request reprint Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Cancer 92:738-47. 2001
    ..First, does the risk of a subsequent carcinoma decrease over time after an LCIS biopsy and second, what is the clinical significance of E-cadherin-reactive LCIS?..
  7. ncbi request reprint Molecular classification system identifies invasive breast carcinoma patients who are most likely and those who are least likely to achieve a complete pathologic response after neoadjuvant chemotherapy
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 110:1687-96. 2007
    ..In the current study, the authors evaluated whether response to neoadjuvant chemotherapy was correlated with the molecular classification groups...
  8. ncbi request reprint Proximal small-bowel mucosal villous intraepithelial lymphocytes
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Histopathology 44:199-205. 2004
    ..These patients are usually incorrectly diagnosed with GS. However, they do not respond to a gluten-free diet and slowly improve over months...
  9. ncbi request reprint Intraductal carcinoma of the breast: pathologic features associated with local recurrence in patients treated with breast-conserving therapy
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Surg Pathol 24:1058-67. 2000
    ..These results suggest that the volume of DCIS in the specimen, and the volume of DCIS near the margin are associated with local recurrence. These features can be used to identify those patients with a higher chance of local recurrence...
  10. ncbi request reprint Gastric cardia inflammation and intestinal metaplasia: associations with reflux esophagitis and Helicobacter pylori
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073 6769, USA
    Mod Pathol 12:1017-24. 1999
    ..Pathologists should refrain from applying the term Barrett's esophagus for biopsies procured from the cardia that show intestinal metaplasia in patients with a normal squamocolumnar junction...
  11. ncbi request reprint Metastatic minimally invasive (encapsulated) follicular and Hurthle cell thyroid carcinoma: a study of 34 patients
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Mod Pathol 13:123-30. 2000
    ..The number of complete capsular penetration or vascular invasion foci was not associated with the initial site of metastasis or the interval between the surgery and the metastasis...
  12. ncbi request reprint Gastric cardia intestinal metaplasia: biopsy follow-up of 85 patients
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Mod Pathol 13:1072-9. 2000
    ..Gastric cardia intestinal metaplasia (CIM), denoted by goblet cells is common. The frequency of persistent CIM is unknown...
  13. ncbi request reprint Colon signet ring cell adenocarcinoma: immunohistochemical characterization and comparison with gastric and typical colon adenocarcinomas
    N S Goldstein
    Department of Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073 6769, USA
    Appl Immunohistochem Mol Morphol 8:183-8. 2000
    ..The signet ring morphology at each site had an identical immunophenotype as the cells forming their glandular counterpart...
  14. ncbi request reprint Impact of young age on outcome in patients with ductal carcinoma-in-situ treated with breast-conserving therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 18:296-306. 2000
    ..We reviewed our institution's experience treating patients with ductal carcinoma-in-situ (DCIS) with breast-conserving therapy (BCT) to determine the impact of patient age on outcome...
  15. ncbi request reprint The influence of percentage of preradiation needle biopsies with adenocarcinoma and total radiation dose on the pathologic response of unfavorable prostate adenocarcinoma
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 117:927-34. 2002
    ..Gleason score and gland volume did not contribute significantly to this relationship...
  16. ncbi request reprint Accelerated treatment of breast cancer
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 19:1993-2001. 2001
    ..The goals of the study were to determine whether treatment time can be reduced and whether elective treatment of the entire breast is necessary...
  17. ncbi request reprint E-cadherin reactivity of 95 noninvasive ductal and lobular lesions of the breast. Implications for the interpretation of problematic lesions
    N S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 115:534-42. 2001
    ..Results suggest that the majority of morphologically nondiagnostic atypical lesions are lobular, including those associated with DCIS. E-cadherin seems to be absent in most lobular lesions...
  18. ncbi request reprint Pathologic and technical considerations in the treatment of ductal carcinoma in situ of the breast with lumpectomy and radiation therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Ann Oncol 10:883-90. 1999
    ..Multiple studies have attempted to identify factors associated with the development of local recurrences in these patients. Despite extensive reports examining this issue, no factor(s) has consistently been correlated with outcome...
  19. ncbi request reprint Relationship between excision volume, margin status, and tumor size with the development of local recurrence in patients with ductal carcinoma-in-situ treated with breast-conserving therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Surg Oncol 76:245-54. 2001
    ....
  20. ncbi request reprint Percentage of positive biopsy cores as predictor of clinical outcome in prostate cancer treated with radiotherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 168:1994-9. 2002
    ..We performed a complete pathology analysis of pretreatment biopsy specimens in an attempt to clarify their impact on clinical outcome following radiotherapy...
  21. doi request reprint Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: a matched-pair analysis with 10-year follow-up
    J Vito Antonucci
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 74:447-52. 2009
    ..e., accelerated partial breast irradiation, [APBI]) in selected patients treated with breast-conserving therapy (BCT) and compare them with results of matched BCT patients who underwent whole-breast irradiation (WBI)...
  22. ncbi request reprint Cytokeratins 7, 17, and 20 reactivity in pancreatic and ampulla of vater adenocarcinomas. Percentage of positivity and distribution is affected by the cut-point threshold
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI, USA
    Am J Clin Pathol 115:695-702. 2001
    ..CK17 staining occurs in approximately 50% of pancreaticobiliary adenocarcinomas and is usually patchy. Single antibody staining results, especially CK7 and CK20 coordinate reactivity, are influenced by the reactivity threshold used...
  23. ncbi request reprint The impact of lobular carcinoma in situ in association with invasive breast cancer on the rate of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy
    Shruti Jolly
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 66:365-71. 2006
    ..We examined the impact of the presence and extent of LCIS associated with invasive breast cancer on clinical outcome in BCT patients...
  24. ncbi request reprint Changes in management techniques and patterns of disease recurrence over time in patients with breast carcinoma treated with breast-conserving therapy at a single institution
    Helen Pass
    Department of Surgery, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 101:713-20. 2004
    ..The goals of the current study were to determine the frequency and use of optimal local and systemic therapy techniques and to evaluate the impact of these changes on treatment efficacy...
  25. ncbi request reprint WT1 is an integral component of an antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms
    N S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 116:246-52. 2001
    ..Extensive CK17 reactivity is supportive of a pancreaticobiliary adenocarcinoma when the differential diagnosis includes ovarian mucinous neoplasm. None of the antibodies positively identified ovarian mucinous neoplasms...
  26. doi request reprint Optimal use of re-excision in patients diagnosed with early-stage breast cancer by excisional biopsy treated with breast-conserving therapy
    Jamie L Caughran
    Department of Surgery, William Beaumont Hospital, Royal Oak, MI, USA
    Ann Surg Oncol 16:3020-7. 2009
    ....
  27. ncbi request reprint Factors associated with ipsilateral breast failure and distant metastases in patients with invasive breast carcinoma treated with breast-conserving therapy. A clinicopathologic study of 607 neoplasms from 583 patients
    Neal S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 120:500-27. 2003
    ..The amount of carcinoma near the margin and volume of excised parenchyma related directly to the amount of residual carcinoma in the adjacent breast parenchyma...
  28. ncbi request reprint Morphologic features suggestive of gluten sensitivity in architecturally normal duodenal biopsy specimens
    N S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 116:63-71. 2001
    ..Pathologists should be watchful for these morphologic features in small bowel biopsy specimens to suggest GS...
  29. ncbi request reprint Limited-field radiation therapy in the management of early-stage breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    J Natl Cancer Inst 95:1205-10. 2003
    ..e., limited-field radiation therapy) in selected patients treated with breast-conserving therapy and compared them with results of matched breast-conserving therapy patients who underwent whole-breast radiation therapy...
  30. ncbi request reprint Use of pathologic factors to assist in establishing adequacy of excision before radiotherapy in patients treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 60:86-94. 2004
    ..We reviewed our experience in patients with early-stage breast carcinoma treated with breast-conserving therapy (BCT) to identify pathologic factors useful in defining the adequacy of excision before radiotherapy (RT)...
  31. ncbi request reprint Pathologic evidence of dose-response and dose-volume relationships for prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:107-18. 2002
    ..We performed a detailed pathologic review of posttreatment biopsy specimens in an attempt to clarify their relationship with clinical outcome and radiation dose...
  32. ncbi request reprint Long-term efficacy and patterns of failure after accelerated partial breast irradiation: a molecular assay-based clonality evaluation
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 68:341-6. 2007
    ..To determine the long-term efficacy and cosmetic results of accelerated partial breast irradiation (APBI) by reviewing our institution's experience...
  33. ncbi request reprint Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Int J Radiat Oncol Biol Phys 57:1247-53. 2003
    ..We present our ongoing clinical experience utilizing 3D conformal radiation therapy (3D-CRT) to deliver partial-breast irradiation (PBI) in patients with early-stage breast cancer treated with breast-conserving therapy...
  34. ncbi request reprint Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1124-30. 2007
    ....
  35. doi request reprint Molecular evidence demonstrating local treatment failure is the source of distant metastases in some patients treated for breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 71:689-94. 2008
    ..To examine the clonality relationships among initial invasive breast carcinoma (IBC), ipsilateral breast failure (IBF), and distant metastasis (DM) to determine the effect of local tumor recurrence on the development of DMs...
  36. ncbi request reprint Defining the clinical target volume for patients with early-stage breast cancer treated with lumpectomy and accelerated partial breast irradiation: a pathologic analysis
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 60:722-30. 2004
    ..This pathologic analysis was conducted to help define the clinical target volume (CTV) for partial breast irradiation (PBI) by analyzing the amount and distance of residual disease found at reexcision after an initial lumpectomy...
  37. ncbi request reprint The effect of electrothermal cautery-assisted resection of diminutive colonic polyps on histopathologic diagnosis
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Miles Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 115:356-61. 2001
    ..This small size seems to make them especially susceptible to cytologically injurious forces...
  38. ncbi request reprint Molecular clonality determination of ipsilateral recurrence of invasive breast carcinomas after breast-conserving therapy: comparison with clinical and biologic factors
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 123:679-89. 2005
    ..Molecular clonality assays may provide a reliable means of identifying patients who might benefit from systemic chemotherapy at the time of IBF...
  39. ncbi request reprint Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 122:728-39. 2004
    ..Tubular carcinoma as a distinct morphologic entity should be restricted to neoplasms with 70% or more tubularity, pure grade 1 nuclei, and rare mitoses. Other definitions of tubular carcinoma do not guarantee the excellent prognosis...
  40. ncbi request reprint Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies
    N S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 116:319-25. 2001
    ..Mucinous and nonmucinous BACs have disparate staining patterns with TTF and CK20. Mucinous BACs are usually TTF nonreactive and CK20 reactive, but nonreactive with villin, which distinguishes them from mucinous colon adenocarcinomas...
  41. ncbi request reprint Immunophenotypic characterization of 225 prostate adenocarcinomas with intermediate or high Gleason scores
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 117:471-7. 2002
    ..The likelihood that a metastatic adenocarcinoma is from the prostate is low if reactivity with any of the cytokeratin antibodies, CEA, TTF-1, CA-125, WT1, or villin is extensive...
  42. ncbi request reprint Molecular clonality relationships in initial carcinomas, ipsilateral breast failures, and distant metastases in patients treated with breast-conserving therapy: evidence suggesting that some distant metastases are derived from ipsilateral breast failures
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 124:49-57. 2005
    ..The relationships of initial carcinomas, IBFs, and DMs are complex. DMs seem to be the direct result of IBFs in some cases. Some carcinomas seem to be composed of subclones with different and unrelated IBF and DM potential...
  43. ncbi request reprint Minimum formalin fixation time for consistent estrogen receptor immunohistochemical staining of invasive breast carcinoma
    Neal S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 120:86-92. 2003
    ..2 and 6.3 hours, respectively (P = .01). The minimum formalin fixation time for reliable immunohistochemical ER results is 6 to 8 hours in our laboratory, regardless of the type or size of specimen...
  44. ncbi request reprint Monomorphic epithelial proliferations: characterization and evidence suggesting they are the pool of partially transformed lesions from which some invasive carcinomas arise
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 128:1023-34. 2007
    ..Radiation therapy may reduce the IBF rate by eradicating these precursor lesions and preventing new carcinomas from emerging rather than eradicating microscopic residual disease...
  45. ncbi request reprint Does the level of E-cadherin expression correlate with the primary breast carcinoma infiltration pattern and type of systemic metastases?
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 118:425-34. 2002
    ..The level of decreased E-cadherin expression at which a dyshesive growth pattern emerges in primary breast carcinomas may be less than the level associated with lobular carcinoma-type systemic metastases...
  46. ncbi request reprint An approach to interpreting immunohistochemical stains of adenocarcinoma in small needle core biopsy specimens: the impact of limited specimen size
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 127:273-81. 2007
    ..The positive result cut point should increase as the amount of stainable carcinoma available for interpretation decreases...
  47. ncbi request reprint Clinicopathologic analysis of extracapsular extension in prostate cancer: should the clinical target volume be expanded posterolaterally to account for microscopic extension?
    K Kenneth Chao
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, and Department of Radiaiton Oncology, University of Florida, Jacksonville, USA
    Int J Radiat Oncol Biol Phys 65:999-1007. 2006
    ....
  48. ncbi request reprint Clinicopathologic analysis of microscopic extension in lung adenocarcinoma: defining clinical target volume for radiotherapy
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:334-41. 2007
    ..To determine the gross tumor volume (GTV) to clinical target volume margin for non-small-cell lung cancer treatment planning...
  49. ncbi request reprint A centralized comparison of radical perineal and retropubic prostatectomy specimens: is there a difference according to the surgical approach?
    Howard J Korman
    Department of Urology, William Beaumont Hospital, Royal Oak, Michigan, USA
    J Urol 168:991-4. 2002
    ..We determined whether differences exist in the 2 approaches in regard to the ability to obtain adequate surgical margins around the tumor and adequate extracapsular tissue around the prostate, and avoid inadvertent capsular incision...
  50. ncbi request reprint An investigation of the mechanisms underlying the disparity between rate of residual endocervical adenocarcinoma in situ (AIS) in hysterectomy specimens and clinical failure rate following conservatively treated AIS
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 122:540-5. 2004
    ..Factors that impact postbiopsy AIS eradication might be unrelated to de novo AIS beginning at the nSCJ...
  51. ncbi request reprint Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 125:132-45. 2006
    ..Foci of adjacent crypts had similar cytologic features. Small proximal SSAs can transform into adenocarcinoma without a component of adenomatous dysplasia...
  52. ncbi request reprint Wedge resection margin distances and residual adenocarcinoma in lobectomy specimens
    Neal S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 120:720-4. 2003
    ....
  53. ncbi request reprint Association of eosinophilic inflammation with esophageal food impaction in adults
    Tusar K Desai
    Department of Medicine, Beaumont Hospital, Royal Oak, Michigan, USA
    Gastrointest Endosc 61:795-801. 2005
    ..The prevalence of eosinophilic esophagitis among patients with food impaction is unknown. To address this, we evaluated clinicopathologic features of adults with food impaction...
  54. ncbi request reprint Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas
    Neal S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 119:778-96. 2003
    ..The morphologic features described herein provide initial guidelines to identify this potentially important subset of premalignant serrated-like polyps...
  55. ncbi request reprint Non-gluten sensitivity-related small bowel villous flattening with increased intraepithelial lymphocytes: not all that flattens is celiac sprue
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 121:546-50. 2004
    ..The temporal aspects of symptom improvement and mucosal restitution in these 7 patients are similar to "acute self-limited colitis." An overly exuberant immune response to an infectious agent is possible...
  56. ncbi request reprint C-kit expression in small cell lung carcinomas
    Neal S Goldstein
    Hum Pathol 34:827; author reply 828. 2003
  57. ncbi request reprint Laser therapy for small breast cancers
    Neal S Goldstein
    Am J Surg 187:149; author reply 149-50. 2004
  58. ncbi request reprint WT-staining in endometrial serous carcinomas
    Neal S Goldstein
    Int J Gynecol Pathol 23:405-7; author reply 407-8. 2004
  59. ncbi request reprint Isolated ileal erosions in patients with mildly altered bowel habits. A follow-up study of 28 patients
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 125:838-46. 2006
    ..Persistent, mild morphologic abnormalities have a high likelihood of being CD...
  60. ncbi request reprint Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate
    Michael E Ray
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Urology 67:423.e5-423.e8. 2006
    ....
  61. ncbi request reprint Paucicellular and asymptomatic lymphocytic colitis: expanding the clinicopathologic spectrum of lymphocytic colitis
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 122:405-11. 2004
    ..LC in asymptomatic adults might be more common than previously thought and might not be associated with watery diarrhea syndrome...
  62. ncbi request reprint The gray area between heritable and cancer somatic (tumor phenotype) molecular genetic testing of colorectal adenocarcinomas
    Neal S Goldstein
    Am J Clin Pathol 125:813-4. 2006