Zbigniew J Witczak

Summary

Affiliation: Wilkes University
Country: USA

Publications

  1. ncbi request reprint A click chemistry approach to glycomimetics: Michael addition of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose to 4-deoxy-1,2-O-isopropylidene-L-glycero-pent-4-enopyranos-3-ulose--a convenient route to novel 4-deoxy-(1-->5)-5-C-thiodisaccharides
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W South Street, Wilkes Barre, PA 18766, USA
    Carbohydr Res 342:1929-33. 2007
  2. ncbi request reprint Thio-sugars VII. Effect of 3-deoxy-4-S-(beta-D-gluco- and beta-D-galactopyranosyl)-4-thiodisaccharides and their sulfoxides and sulfones on the viability and growth of selected murine and human tumor cell lines
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, Wilkes Barre, PA 18766, USA
    Carbohydr Res 338:11-8. 2003
  3. ncbi request reprint Thiosugars: new perspectives regarding availability and potential biochemical and medicinal applications
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, Wilkes Barre, PA 18766, USA
    Appl Microbiol Biotechnol 69:237-44. 2005
  4. ncbi request reprint Mycalamides, pederin and psymberin as natural carbohydrates and potential antitumor agents: past and future perspectives
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W South Street, Wilkes Barre, PA 18766, USA
    Mini Rev Med Chem 12:1520-32. 2012
  5. ncbi request reprint Functionalized S-thio-di- and S-oligosaccharide precursors as templates for novel SLex/a mimetic antimetastatic agents
    P Markus Dey
    Department of Pharmaceutical Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Mini Rev Med Chem 3:271-80. 2003

Collaborators

Detail Information

Publications5

  1. ncbi request reprint A click chemistry approach to glycomimetics: Michael addition of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose to 4-deoxy-1,2-O-isopropylidene-L-glycero-pent-4-enopyranos-3-ulose--a convenient route to novel 4-deoxy-(1-->5)-5-C-thiodisaccharides
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W South Street, Wilkes Barre, PA 18766, USA
    Carbohydr Res 342:1929-33. 2007
    ..This approach constitutes a new general two-step click chemistry route to the previously unknown class of 4-deoxy-(1-->5)-5-C-thiodisaccharides as stable and biologically important glycomimetics...
  2. ncbi request reprint Thio-sugars VII. Effect of 3-deoxy-4-S-(beta-D-gluco- and beta-D-galactopyranosyl)-4-thiodisaccharides and their sulfoxides and sulfones on the viability and growth of selected murine and human tumor cell lines
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, Wilkes Barre, PA 18766, USA
    Carbohydr Res 338:11-8. 2003
    ..These results indicate that deoxythio-disaccharide analogs generated by functionalization of the universal chiral precursor levoglucosenone may have cytotoxic properties and therapeutic potential as anticancer agents...
  3. ncbi request reprint Thiosugars: new perspectives regarding availability and potential biochemical and medicinal applications
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, Wilkes Barre, PA 18766, USA
    Appl Microbiol Biotechnol 69:237-44. 2005
    ..These new developments and representative examples of functionalized thiosugar prototypes as potential new targets are presented in this mini review...
  4. ncbi request reprint Mycalamides, pederin and psymberin as natural carbohydrates and potential antitumor agents: past and future perspectives
    Zbigniew J Witczak
    Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W South Street, Wilkes Barre, PA 18766, USA
    Mini Rev Med Chem 12:1520-32. 2012
    ..We review new synthetic approaches to this new family of natural products with remarkable biological activity. Some biological evaluation data are compiled and compared to other structurally similar molecular targets...
  5. ncbi request reprint Functionalized S-thio-di- and S-oligosaccharide precursors as templates for novel SLex/a mimetic antimetastatic agents
    P Markus Dey
    Department of Pharmaceutical Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Mini Rev Med Chem 3:271-80. 2003
    ..These functionalized S-thio di- and S-oligosaccharide precursors have direct application for use as templates in the synthesis of novel SLe(x/a)mimetics...