Zbigniew J Witczak
Affiliation: Wilkes University
Witczak Z, Sarnik J, Czubatka A, Forma E, Poplawski T. Thio-sugar motif of functional CARB-pharmacophore for antineoplastic activity. Part 2. Bioorg Med Chem Lett. 2014;24:5606-5611 pubmed publisher
..Future studies will determine the reasons for cell-type specificity of these compounds. The thio-sugar motif appears to be a promising lead for future developments. ..
Czubatka A, Sarnik J, Lucent D, Blasiak J, Witczak Z, Poplawski T. A novel carbohydrate derived compound FCP5 causes DNA strand breaks and oxidative modifications of DNA bases in cancer cells. Chem Biol Interact. 2015;227:77-88 pubmed publisher
..Thus, FCP5 may represent a novel lead for the design of new major groove-binding compounds. The results also confirmed the validity of functional carb-pharmacophores as a new source of innovative drugs. ..
Czubatka Bieńkowska A, Macieja A, Sarnik J, Witczak Z, Poplawski T. The oxidative induction of DNA lesions in cancer cells by 5-thio-d-glucose and 6-thio-d-fructopyranose and their genotoxic effects. Part 3. Bioorg Med Chem Lett. 2017;27:1210-1214 pubmed publisher
..The data indicates that thio-sugars may become drug alternatives for the cancer treatment but such undertaking needs further studies. ..
Sarnik J, Czubatka Bieńkowska A, Macieja A, Bielski R, Witczak Z, Poplawski T. The induction of oxidative stress in cervix carcinoma cells by levoglucosenone derived 4-S-salicyl derivative and (1-4)-S-thio-disaccharides. Part 4. Bioorg Med Chem Lett. 2017;27:1215-1219 pubmed publisher
..These findings demonstrate that the 1-4-thio bridge of disaccharide is a powerful anticancer pharmacophore, and its potential use needs further studies. ..
Czubatka Bieńkowska A, Sarnik J, Macieja A, Galita G, Witczak Z, Poplawski T. Thio-functionalized carbohydrate thiosemicarbazones and evaluation of their anticancer activity. Bioorg Med Chem Lett. 2017;27:2713-2720 pubmed publisher
..Upregulation of heat shock protein encoding genes suggest that our compounds induce stressful conditions. The nature of this phenomena (heat shock, pH shift or hypoxia) needs further study. ..
Korycka Machała M, Brzostek A, Dziadek B, Kawka M, Popławski T, Witczak Z, et al
. Evaluation of the Mycobactericidal Effect of Thio-functionalized Carbohydrate Derivatives. Molecules. 2017;22: pubmed publisher
..The selected thio-sugars are very promising compounds, thus making them candidates for further modifications that would decrease their cytotoxicity against eukaryotic cells without affecting their antimycobacterial potential. ..