C Eric Hack

Summary

Affiliation: Wilford Hall Medical Center
Country: USA

Publications

  1. doi request reprint A Bayesian network model for biomarker-based dose response
    C Eric Hack
    Toxicology Excellence for Risk Assessment TERA, Cincinnati, OH, USA
    Risk Anal 30:1037-51. 2010
  2. ncbi request reprint Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites
    C Eric Hack
    Toxicology Excellence for Risk Assessment TERA, Cincinnati, OH, USA
    Regul Toxicol Pharmacol 46:63-83. 2006
  3. ncbi request reprint An approach for the quantitative consideration of genetic polymorphism data in chemical risk assessment: examples with warfarin and parathion
    P Robinan Gentry
    ENVIRON International Corporation, 602 East Georgia Avenue, Ruston, Louisiana 71270 Toxicology Excellence for Risk Assessment, Cincinnati, Ohio 45223, USA
    Toxicol Sci 70:120-39. 2002
  4. ncbi request reprint Bayesian analysis of physiologically based toxicokinetic and toxicodynamic models
    C Eric Hack
    Toxicology Excellence for Risk Assessment, 2300 Montana Ave, Cincinnati, OH 45211, USA
    Toxicology 221:241-8. 2006

Collaborators

Detail Information

Publications4

  1. doi request reprint A Bayesian network model for biomarker-based dose response
    C Eric Hack
    Toxicology Excellence for Risk Assessment TERA, Cincinnati, OH, USA
    Risk Anal 30:1037-51. 2010
    ..Such linkage can provide a scientifically valid point of departure that incorporates precursor dose-response information without being dependent on the difficult issue of a definition of adversity for precursors...
  2. ncbi request reprint Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites
    C Eric Hack
    Toxicology Excellence for Risk Assessment TERA, Cincinnati, OH, USA
    Regul Toxicol Pharmacol 46:63-83. 2006
    ..This analysis provides an important step toward estimating uncertainty of dose-response relationships in noncancer and cancer risk assessment, improving the extrapolation of toxic TCE doses from experimental animals to humans...
  3. ncbi request reprint An approach for the quantitative consideration of genetic polymorphism data in chemical risk assessment: examples with warfarin and parathion
    P Robinan Gentry
    ENVIRON International Corporation, 602 East Georgia Avenue, Ruston, Louisiana 71270 Toxicology Excellence for Risk Assessment, Cincinnati, Ohio 45223, USA
    Toxicol Sci 70:120-39. 2002
    ..Implications of alternatives in the calculation of CSAFs are explored. Key decision points for applying the PBPK-Monte Carlo approach to evaluate toxicokinetic variability for other chemicals are also discussed...
  4. ncbi request reprint Bayesian analysis of physiologically based toxicokinetic and toxicodynamic models
    C Eric Hack
    Toxicology Excellence for Risk Assessment, 2300 Montana Ave, Cincinnati, OH 45211, USA
    Toxicology 221:241-8. 2006
    ..The goal of this paper is to give the non-mathematician a brief description of the Bayesian approach and Markov chain Monte Carlo analysis, how this technique is used in risk assessment, and the issues associated with this approach...