Donald G Stump

Summary

Affiliation: WIL Research Laboratories
Country: USA

Publications

  1. pmc Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley rats
    Donald G Stump
    Developmental and Reproductive Toxicology, WIL Research Laboratories, LLC, Ashland, Ohio 44805 8946, USA
    Toxicol Sci 115:167-82. 2010
  2. ncbi request reprint An oral two-generation reproductive toxicity study of S-111-S-WB in rats
    Donald G Stump
    WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
    Reprod Toxicol 25:7-20. 2008
  3. ncbi request reprint Developmental toxicity and uterotrophic studies with di-2-ethylhexyl terephthalate
    Willem D Faber
    WFTC, LLC, Victor, NY 14564, USA
    Birth Defects Res B Dev Reprod Toxicol 80:396-405. 2007
  4. ncbi request reprint Two-generation reproduction study of di-2-ethylhexyl terephthalate in Crl:CD rats
    Willem D Faber
    WFTC, LLC, Victor, New York 14564, USA
    Birth Defects Res B Dev Reprod Toxicol 80:69-81. 2007
  5. ncbi request reprint Inhalation developmental neurotoxicity study of ethylbenzene in Crl-CD rats
    Willem D Faber
    WFTC, LLC, Victor, New York 15464, USA
    Birth Defects Res B Dev Reprod Toxicol 80:34-48. 2007
  6. ncbi request reprint Mode of action: yolk sac poisoning and impeded histiotrophic nutrition--HBOC-related congenital malformations
    Joseph F Holson
    WIL Research, Ashland, Ohio, USA
    Crit Rev Toxicol 35:739-45. 2005
  7. doi request reprint Safety assessment of dietary diacylglycerol oil: a two-generation reproductive toxicity study in rats
    Osamu Morita
    Kao Corporation, Tochigi ken 321 3497, Japan
    Food Chem Toxicol 46:3059-68. 2008
  8. ncbi request reprint Effects of the opioid analgesic oxymorphone hydrochloride on reproductive function in male and female rats
    Dana L Shuey
    Endo Pharmaceuticals, Chadds Ford, Pennsylvania, USA
    Birth Defects Res B Dev Reprod Toxicol 83:12-8. 2008
  9. ncbi request reprint A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation
    Waheed H Siddiqui
    Dow Corning Corporation, Midland, MI, USA
    Reprod Toxicol 23:202-15. 2007
  10. ncbi request reprint Absence of reproductive and developmental toxicity in rats following oral dosing with nelfinavir
    Leigh Ann Burns-Naas
    Worldwide Safety Sciences, Pfizer Global Research and Development, 10724 Science Center Drive, San Diego, CA 92064, USA
    Regul Toxicol Pharmacol 38:304-16. 2003

Collaborators

Detail Information

Publications18

  1. pmc Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley rats
    Donald G Stump
    Developmental and Reproductive Toxicology, WIL Research Laboratories, LLC, Ashland, Ohio 44805 8946, USA
    Toxicol Sci 115:167-82. 2010
    ..There was no evidence that BPA is a developmental neurotoxicant in rats, and the NOAEL for developmental neurotoxicity was 2250 ppm, the highest dose tested (164 and 410 mg/kg/day during gestation and lactation, respectively)...
  2. ncbi request reprint An oral two-generation reproductive toxicity study of S-111-S-WB in rats
    Donald G Stump
    WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
    Reprod Toxicol 25:7-20. 2008
    ..025mg/(kgday) was considered to be the NOAEL for neonatal toxicity based on higher liver weights in the F(1) and F(2) pups at 0.125mg/(kgday) and higher...
  3. ncbi request reprint Developmental toxicity and uterotrophic studies with di-2-ethylhexyl terephthalate
    Willem D Faber
    WFTC, LLC, Victor, NY 14564, USA
    Birth Defects Res B Dev Reprod Toxicol 80:396-405. 2007
    ..In addition, a uterotrophic assay for estrogenic activity was conducted in sexually immature rats...
  4. ncbi request reprint Two-generation reproduction study of di-2-ethylhexyl terephthalate in Crl:CD rats
    Willem D Faber
    WFTC, LLC, Victor, New York 14564, USA
    Birth Defects Res B Dev Reprod Toxicol 80:69-81. 2007
    ..This study was conducted to evaluate the potential adverse effects of di-2-ethylhexyl terephthalate (DEHT) on reproductive capability from exposure of F(0) and F(1) parental animals...
  5. ncbi request reprint Inhalation developmental neurotoxicity study of ethylbenzene in Crl-CD rats
    Willem D Faber
    WFTC, LLC, Victor, New York 15464, USA
    Birth Defects Res B Dev Reprod Toxicol 80:34-48. 2007
    ....
  6. ncbi request reprint Mode of action: yolk sac poisoning and impeded histiotrophic nutrition--HBOC-related congenital malformations
    Joseph F Holson
    WIL Research, Ashland, Ohio, USA
    Crit Rev Toxicol 35:739-45. 2005
    ....
  7. doi request reprint Safety assessment of dietary diacylglycerol oil: a two-generation reproductive toxicity study in rats
    Osamu Morita
    Kao Corporation, Tochigi ken 321 3497, Japan
    Food Chem Toxicol 46:3059-68. 2008
    ..Based on the results of this study, a dose level of 5.0 ml/kg (4630 mg/kg/day) was considered as the no-observed-adverse-effect level for reproductive and systemic toxicity, and neonatal toxicity...
  8. ncbi request reprint Effects of the opioid analgesic oxymorphone hydrochloride on reproductive function in male and female rats
    Dana L Shuey
    Endo Pharmaceuticals, Chadds Ford, Pennsylvania, USA
    Birth Defects Res B Dev Reprod Toxicol 83:12-8. 2008
    ..The effects of long-term oral administration of opioid analgesics on reproductive function have not been well characterized...
  9. ncbi request reprint A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation
    Waheed H Siddiqui
    Dow Corning Corporation, Midland, MI, USA
    Reprod Toxicol 23:202-15. 2007
    ..If D(4) delays rather than causes a prolonged suppression or ablation of the LH surge, the reproductive mode of action of D(4) would not likely be relevant for humans...
  10. ncbi request reprint Absence of reproductive and developmental toxicity in rats following oral dosing with nelfinavir
    Leigh Ann Burns-Naas
    Worldwide Safety Sciences, Pfizer Global Research and Development, 10724 Science Center Drive, San Diego, CA 92064, USA
    Regul Toxicol Pharmacol 38:304-16. 2003
    ..Based on the results of this study, the no-observed-adverse-effect-level (NOAEL) for developmental and reproductive toxicity in rats was considered to be 1000mg/kg/day, the highest dose tested...
  11. ncbi request reprint Two generation reproduction study of ethylbenzene by inhalation in Crl-CD rats
    Willem D Faber
    Victor, New York 14564, USA
    Birth Defects Res B Dev Reprod Toxicol 77:10-21. 2006
    ..This study was conducted to evaluate the potential adverse effects of ethylbenzene (EB) on reproductive capability from whole-body inhalation exposure of F0 and F1 parental animals...
  12. ncbi request reprint An assessment of the potential developmental and reproductive toxicity of di-isoheptyl phthalate in rodents
    Richard H McKee
    ExxonMobil Biomedical Sciences, Inc, Annandale, NJ 08801 0971, USA
    Reprod Toxicol 21:241-52. 2006
    ..By comparison, estimated average human exposures in the general population are <1 microg/(kg/day)...
  13. doi request reprint Effects of dietary diacylglycerol oil on embryo/fetal development in rats
    Osamu Morita
    Global R and D Safety Science, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi ken 321 3497, Japan
    Food Chem Toxicol 46:2510-6. 2008
    ..Based on the results of this study, a dose level of 5.0 ml/kg (4630 mg/kg/day) was considered as no-observed-adverse-effect level (NOAEL) for both maternal and developmental toxicity...
  14. ncbi request reprint A two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation
    Waheed H Siddiqui
    Dow Corning Corporation, Midland, MI 48686, USA
    Reprod Toxicol 23:216-25. 2007
    ..Vaginal patency and balanopreputial separation were unchanged compared to controls. Thus, the No-Observed-Adverse-Effect-Level (NOAEL) for parental and reproductive toxicity was determined to be 160 ppm D(5)...
  15. ncbi request reprint An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens
    Robert G Meeks
    Dow Corning Corporation, Midland, MI 48686, USA
    Reprod Toxicol 23:192-201. 2007
    ..Subsequent research, reported elsewhere, has elucidated the mode of action and assessed its potential relevance to humans...
  16. ncbi request reprint Developmental neurotoxicity study of styrene by inhalation in Crl-CD rats
    George Cruzan
    ToxWorks, Bridgeton, New Jersey 08302, USA
    Birth Defects Res B Dev Reprod Toxicol 74:221-32. 2005
    ..Based on the results of this study, an exposure level of 50 ppm was considered to be the NOAEL for growth of F2 offspring; an exposure level of 500 ppm was considered to be the NOAEL for F2 developmental neurotoxicity...
  17. ncbi request reprint Two generation reproduction study of styrene by inhalation in Crl-CD rats
    George Cruzan
    ToxWorks, Bridgeton, New Jersey 08302, USA
    Birth Defects Res B Dev Reprod Toxicol 74:211-20. 2005
    ..Based on the results of this study, an exposure level of 50 ppm was considered to be the NOAEL for F0 and F1 parental systemic toxicity; the NOAEL for F0 and F1 reproductive toxicity was 500 ppm or greater...
  18. ncbi request reprint Absence of embryo-fetal toxicity in rats or rabbits following oral dosing with nelfinavir
    Leigh Ann Burns-Naas
    Worldwide Safety Sciences, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA, USA
    Regul Toxicol Pharmacol 38:291-303. 2003
    ..Thus, under the conditions of this study, nelfinavir was not considered to be toxic to the rat or rabbit conceptus...