Research Topics
| Donald G StumpSummaryAffiliation: WIL Research Laboratories Country: USA Publications
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Detail Information
Publications
Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley ratsDonald G Stump
Developmental and Reproductive Toxicology, WIL Research Laboratories, LLC, Ashland, Ohio 44805 8946, USA
Toxicol Sci 115:167-82. 2010..There was no evidence that BPA is a developmental neurotoxicant in rats, and the NOAEL for developmental neurotoxicity was 2250 ppm, the highest dose tested (164 and 410 mg/kg/day during gestation and lactation, respectively)...
An oral two-generation reproductive toxicity study of S-111-S-WB in ratsDonald G Stump
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
Reprod Toxicol 25:7-20. 2008..025mg/(kgday) was considered to be the NOAEL for neonatal toxicity based on higher liver weights in the F(1) and F(2) pups at 0.125mg/(kgday) and higher...- Developmental toxicity and uterotrophic studies with di-2-ethylhexyl terephthalateWillem D Faber
WFTC, LLC, Victor, NY 14564, USA
Birth Defects Res B Dev Reprod Toxicol 80:396-405. 2007..In addition, a uterotrophic assay for estrogenic activity was conducted in sexually immature rats... - Two-generation reproduction study of di-2-ethylhexyl terephthalate in Crl:CD ratsWillem D Faber
WFTC, LLC, Victor, New York 14564, USA
Birth Defects Res B Dev Reprod Toxicol 80:69-81. 2007..This study was conducted to evaluate the potential adverse effects of di-2-ethylhexyl terephthalate (DEHT) on reproductive capability from exposure of F(0) and F(1) parental animals... - Inhalation developmental neurotoxicity study of ethylbenzene in Crl-CD ratsWillem D Faber
WFTC, LLC, Victor, New York 15464, USA
Birth Defects Res B Dev Reprod Toxicol 80:34-48. 2007.... - Mode of action: yolk sac poisoning and impeded histiotrophic nutrition--HBOC-related congenital malformationsJoseph F Holson
WIL Research, Ashland, Ohio, USA
Crit Rev Toxicol 35:739-45. 2005.... 
Safety assessment of dietary diacylglycerol oil: a two-generation reproductive toxicity study in ratsOsamu Morita
Kao Corporation, Tochigi ken 321 3497, Japan
Food Chem Toxicol 46:3059-68. 2008..Based on the results of this study, a dose level of 5.0 ml/kg (4630 mg/kg/day) was considered as the no-observed-adverse-effect level for reproductive and systemic toxicity, and neonatal toxicity...- Effects of the opioid analgesic oxymorphone hydrochloride on reproductive function in male and female ratsDana L Shuey
Endo Pharmaceuticals, Chadds Ford, Pennsylvania, USA
Birth Defects Res B Dev Reprod Toxicol 83:12-8. 2008..The effects of long-term oral administration of opioid analgesics on reproductive function have not been well characterized... - A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalationWaheed H Siddiqui
Dow Corning Corporation, Midland, MI, USA
Reprod Toxicol 23:202-15. 2007..If D(4) delays rather than causes a prolonged suppression or ablation of the LH surge, the reproductive mode of action of D(4) would not likely be relevant for humans... - Absence of reproductive and developmental toxicity in rats following oral dosing with nelfinavirLeigh Ann Burns-Naas
Worldwide Safety Sciences, Pfizer Global Research and Development, 10724 Science Center Drive, San Diego, CA 92064, USA
Regul Toxicol Pharmacol 38:304-16. 2003..Based on the results of this study, the no-observed-adverse-effect-level (NOAEL) for developmental and reproductive toxicity in rats was considered to be 1000mg/kg/day, the highest dose tested... - Two generation reproduction study of ethylbenzene by inhalation in Crl-CD ratsWillem D Faber
Victor, New York 14564, USA
Birth Defects Res B Dev Reprod Toxicol 77:10-21. 2006..This study was conducted to evaluate the potential adverse effects of ethylbenzene (EB) on reproductive capability from whole-body inhalation exposure of F0 and F1 parental animals... - An assessment of the potential developmental and reproductive toxicity of di-isoheptyl phthalate in rodentsRichard H McKee
ExxonMobil Biomedical Sciences, Inc, Annandale, NJ 08801 0971, USA
Reprod Toxicol 21:241-52. 2006..By comparison, estimated average human exposures in the general population are <1 microg/(kg/day)... - Effects of dietary diacylglycerol oil on embryo/fetal development in ratsOsamu Morita
Global R and D Safety Science, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi ken 321 3497, Japan
Food Chem Toxicol 46:2510-6. 2008..Based on the results of this study, a dose level of 5.0 ml/kg (4630 mg/kg/day) was considered as no-observed-adverse-effect level (NOAEL) for both maternal and developmental toxicity... - A two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalationWaheed H Siddiqui
Dow Corning Corporation, Midland, MI 48686, USA
Reprod Toxicol 23:216-25. 2007..Vaginal patency and balanopreputial separation were unchanged compared to controls. Thus, the No-Observed-Adverse-Effect-Level (NOAEL) for parental and reproductive toxicity was determined to be 160 ppm D(5)... - An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimensRobert G Meeks
Dow Corning Corporation, Midland, MI 48686, USA
Reprod Toxicol 23:192-201. 2007..Subsequent research, reported elsewhere, has elucidated the mode of action and assessed its potential relevance to humans... - Developmental neurotoxicity study of styrene by inhalation in Crl-CD ratsGeorge Cruzan
ToxWorks, Bridgeton, New Jersey 08302, USA
Birth Defects Res B Dev Reprod Toxicol 74:221-32. 2005..Based on the results of this study, an exposure level of 50 ppm was considered to be the NOAEL for growth of F2 offspring; an exposure level of 500 ppm was considered to be the NOAEL for F2 developmental neurotoxicity... - Two generation reproduction study of styrene by inhalation in Crl-CD ratsGeorge Cruzan
ToxWorks, Bridgeton, New Jersey 08302, USA
Birth Defects Res B Dev Reprod Toxicol 74:211-20. 2005..Based on the results of this study, an exposure level of 50 ppm was considered to be the NOAEL for F0 and F1 parental systemic toxicity; the NOAEL for F0 and F1 reproductive toxicity was 500 ppm or greater... - Absence of embryo-fetal toxicity in rats or rabbits following oral dosing with nelfinavirLeigh Ann Burns-Naas
Worldwide Safety Sciences, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA, USA
Regul Toxicol Pharmacol 38:291-303. 2003..Thus, under the conditions of this study, nelfinavir was not considered to be toxic to the rat or rabbit conceptus...