Kabirullah Lutfy

Summary

Affiliation: Western University of Health Sciences
Country: USA

Publications

  1. ncbi request reprint Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Neurosci 23:10331-7. 2003
  2. pmc Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 164:168-76. 2002
  3. pmc Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice
    Hanze Du
    Division of Internal Medicine, Charles R Drew University of Medicine and Science, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Mol Endocrinol 50:167-78. 2013
  4. pmc Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors
    Kabirullah Lutfy
    Division of Endocrinology, Molecular Medicine and Metabolism, Department of Internal Medicine, Charles R Drew University of Medicine and Sciences David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurochem 120:1108-16. 2012
  5. pmc Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice
    Yanjun Liu
    Division of Endocrinology, Metabolism and Molecular Medicine, UCLA School of Medicine, The Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Mol Endocrinol 41:53-64. 2008
  6. pmc Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake
    Xiuhai Ren
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Charles R Drew University of Medicine and Science and UCLA School of Medicine, 1731 E 120th Street, Los Angeles, CA 90059, USA
    J Obes 2013:764742. 2013
  7. pmc Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats
    Shridhar Narayanan
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA, USA
    J Psychiatry Neurosci 29:116-23. 2004
  8. pmc Effect of nicotine on body composition in mice
    Michael Mangubat
    Division of Endocrinology, Department of Medicine, Charles R Drew University of Medicine and Sciences UCLA School of Medicine, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Endocrinol 212:317-26. 2012
  9. ncbi request reprint Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1579, USA
    Brain Res Bull 58:7-12. 2002
  10. pmc Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2
    Ying Nie
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Peptides 47:99-109. 2013

Research Grants

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Neurosci 23:10331-7. 2003
    ..Our results indicate that the antinociceptive effect of buprenorphine in mice is micro-opioid receptor-mediated yet severely compromised by concomitant activation of ORL-1 receptors...
  2. pmc Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 164:168-76. 2002
    ..Dynorphin and other kappa opioid receptor agonists have been shown to block cocaine sensitization...
  3. pmc Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice
    Hanze Du
    Division of Internal Medicine, Charles R Drew University of Medicine and Science, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Mol Endocrinol 50:167-78. 2013
    ..These findings suggest that G6PT plays an important role in the modulation of pre-receptor activation of glucocorticoids and provides new insights into the role of G6PT in the development of type 2 diabetes...
  4. pmc Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors
    Kabirullah Lutfy
    Division of Endocrinology, Molecular Medicine and Metabolism, Department of Internal Medicine, Charles R Drew University of Medicine and Sciences David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurochem 120:1108-16. 2012
    ..These results argue in favor of the development of specific antagonists that block both AVP and CRH receptors to decrease the pleasurable component of nicotine, which may be mediated by corticosterone...
  5. pmc Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice
    Yanjun Liu
    Division of Endocrinology, Metabolism and Molecular Medicine, UCLA School of Medicine, The Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Mol Endocrinol 41:53-64. 2008
    ..These findings suggest that CBX exerts some of its beneficial effects, at least in part, by inhibiting hepatic GR and H6PDH expression...
  6. pmc Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake
    Xiuhai Ren
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Charles R Drew University of Medicine and Science and UCLA School of Medicine, 1731 E 120th Street, Los Angeles, CA 90059, USA
    J Obes 2013:764742. 2013
    ....
  7. pmc Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats
    Shridhar Narayanan
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA, USA
    J Psychiatry Neurosci 29:116-23. 2004
    ....
  8. pmc Effect of nicotine on body composition in mice
    Michael Mangubat
    Division of Endocrinology, Department of Medicine, Charles R Drew University of Medicine and Sciences UCLA School of Medicine, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Endocrinol 212:317-26. 2012
    ..We conclude that nicotine is effective in preventing HFD-induced weight gain and abdominal fat accumulation...
  9. ncbi request reprint Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1579, USA
    Brain Res Bull 58:7-12. 2002
    ..Overall, our data suggest that while cocaine enhanced the antinociceptive effect of morphine, sensitization did not develop to this action of cocaine...
  10. pmc Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2
    Ying Nie
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Peptides 47:99-109. 2013
    ....
  11. pmc The endocrine effects of nicotine and cigarette smoke
    Jesse Oliver Tweed
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Trends Endocrinol Metab 23:334-42. 2012
    ....
  12. ncbi request reprint Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis
    Kabirullah Lutfy
    Division of Endocrinology, Molecular Medicine and Metabolism, Department of Medicine, Charles R Drew University of Medicine and Sciences David Geffen School of Medicine at UCLA, Los Angeles, California 90059, USA
    J Neurochem 99:1321-7. 2006
    ..05), but not ACTH and beta-END. The present results suggest that chronic stress leads to an enhanced sensitivity of some components of the HPA axis to a subsequent nicotine challenge...
  13. ncbi request reprint Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism
    Veronica Paez Espinosa
    Charles R Drew Univ of Medicine and Sciences, Division of Endocrinology, 1731 E 120th St, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 292:E175-86. 2007
    ..PTU did not regulate colocalization in the VMH or LH. Regulation of colocalization of processing enzyme and prohormone expression is a novel mechanism to alter hormonal biosynthesis...
  14. pmc The effects of opioids and opioid analogs on animal and human endocrine systems
    Cassidy Vuong
    Division of Endocrinology, Charles Drew University of Medicine and Sciences, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocr Rev 31:98-132. 2010
    ..Additionally, opioids may act through the sympathetic nervous system to cause hyperglycemia and impaired insulin secretion. In this review, recent information regarding endocrine disorders among opioid abusers is presented...
  15. ncbi request reprint Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin
    Shridhar Narayanan
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 760, Westwood Plaza, Los Angeles, CA 90024, USA
    Behav Brain Res 131:97-103. 2002
    ....
  16. ncbi request reprint Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice
    Yanjun Liu
    Division of Endocrinology, Charles R Drew University of Medicine and Sciences, University of California, Los Angeles, School of Medicine, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 147:5061-8. 2006
    ..These findings suggest that some of antidiabetic actions of LXR agonist T0901317 may be mediated, at least in part, through the suppression of hepatic GR gene expression...
  17. pmc The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Neuropharmacology 52:1336-41. 2007
    ..Together, the present results suggest that the ability of buprenorphine to increase motor activity and induce locomotor sensitization and CPP is mediated via the MOP...
  18. pmc Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Behav Neurosci 120:10-5. 2006
    ..Taken together, the results suggest that enkephalins may be important for the development of analgesic tolerance but not for conditioned place preference or behavioral sensitization induced by morphine...
  19. pmc The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 East 2nd Street, Pomona, CA 91766, USA
    Neuropharmacology 54:564-8. 2008
    ..Together, the present results suggest that the endogenous OFQ/N/ORL-1 receptor system is involved in the rewarding action of acute cocaine...
  20. pmc The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Psychopharmacology (Berl) 197:443-8. 2008
    ..Opioid receptor antagonists have been shown to attenuate the rewarding and addictive effects of cocaine. Furthermore, cocaine has been shown to cause the release of beta-endorphin, an endogenous opioid peptide...

Research Grants3

  1. THE OFQ/N/ORL-1 RECEPTOR SYSTEM & COCAINE SENSITIZATION
    Kabirullah Lutfy; Fiscal Year: 2006
    ..The studies proposed in this grant will elucidate the role of OFQ/N/ORL-1 receptor system in cocaine sensitization and possibly provide important and useful information toward developing possible treatments for cocaine addiction. ..