Kabirullah Lutfy

Summary

Affiliation: Western University of Health Sciences
Country: USA

Publications

  1. doi request reprint The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction
    Kabirullah Lutfy
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA Electronic address
    Prog Mol Biol Transl Sci 137:149-81. 2016
  2. ncbi request reprint Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Neurosci 23:10331-7. 2003
  3. pmc Orphanin FQ/nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice
    David Bebawy
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA
    Biol Psychiatry 68:223-30. 2010
  4. pmc The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Psychopharmacology (Berl) 197:443-8. 2008
  5. pmc The role of endogenous beta-endorphin and enkephalins in ethanol reward
    Andy Tseng
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Neuropharmacology 73:290-300. 2013
  6. pmc Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake
    Xiuhai Ren
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Charles R Drew University of Medicine and Science and UCLA School of Medicine, 1731 E 120th Street, Los Angeles, CA 90059, USA
    J Obes 2013:764742. 2013
  7. pmc Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 164:168-76. 2002
  8. pmc The role of endogenous dynorphin in ethanol-induced state-dependent CPP
    Khanh Nguyen
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, United States
    Behav Brain Res 227:58-63. 2012
  9. pmc The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice
    Paul Marquez
    Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA
    Psychopharmacology (Berl) 204:457-63. 2009
  10. pmc The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 East 2nd Street, Pomona, CA 91766, USA
    Neuropharmacology 54:564-8. 2008

Research Grants

Collaborators

Detail Information

Publications32

  1. doi request reprint The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction
    Kabirullah Lutfy
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA Electronic address
    Prog Mol Biol Transl Sci 137:149-81. 2016
    ..Furthermore, the effects of novel small-molecule NOPr ligands on these actions of cocaine are discussed. Overall, a review of the literature suggests that NOPr could be an emerging target for cocaine addiction pharmacotherapy. ..
  2. ncbi request reprint Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Neurosci 23:10331-7. 2003
    ..Our results indicate that the antinociceptive effect of buprenorphine in mice is micro-opioid receptor-mediated yet severely compromised by concomitant activation of ORL-1 receptors...
  3. pmc Orphanin FQ/nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice
    David Bebawy
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA
    Biol Psychiatry 68:223-30. 2010
    ..We also examined whether OFQ/N, given to cocaine-sensitized mice, would reverse the sensitized response and whether it would prevent the amplified sensitized response induced by a second cocaine-sensitizing regimen in sensitized mice...
  4. pmc The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Psychopharmacology (Berl) 197:443-8. 2008
    ..Opioid receptor antagonists have been shown to attenuate the rewarding and addictive effects of cocaine. Furthermore, cocaine has been shown to cause the release of beta-endorphin, an endogenous opioid peptide...
  5. pmc The role of endogenous beta-endorphin and enkephalins in ethanol reward
    Andy Tseng
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Neuropharmacology 73:290-300. 2013
    ..These findings provide the first evidence illustrating that ethanol induces its rewarding action, at least in part, via a joint action of β-endorphin and enkephalins, possibly involving both mu and delta opioid receptors...
  6. pmc Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake
    Xiuhai Ren
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Charles R Drew University of Medicine and Science and UCLA School of Medicine, 1731 E 120th Street, Los Angeles, CA 90059, USA
    J Obes 2013:764742. 2013
    ....
  7. pmc Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 164:168-76. 2002
    ..Dynorphin and other kappa opioid receptor agonists have been shown to block cocaine sensitization...
  8. pmc The role of endogenous dynorphin in ethanol-induced state-dependent CPP
    Khanh Nguyen
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, United States
    Behav Brain Res 227:58-63. 2012
    ..However, these mice compared to their respective controls exhibited a greater CPP response following an ethanol (1g/kg) challenge, suggesting that the endogenous DYN/KOP system may negatively regulate ethanol-induced state-dependent CPP...
  9. pmc The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice
    Paul Marquez
    Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA
    Psychopharmacology (Berl) 204:457-63. 2009
    ....
  10. pmc The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 East 2nd Street, Pomona, CA 91766, USA
    Neuropharmacology 54:564-8. 2008
    ..Together, the present results suggest that the endogenous OFQ/N/ORL-1 receptor system is involved in the rewarding action of acute cocaine...
  11. pmc The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice
    Alexander T Nguyen
    Department of Pharm Sci, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Eur J Pharmacol 686:50-4. 2012
    ..These results illustrate that β-endorphin is essential for the rewarding action of acute cocaine, but the μ opioid receptor may not mediate the regulatory action of endogenous β-endorphin...
  12. pmc Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice
    Hanze Du
    Division of Internal Medicine, Charles R Drew University of Medicine and Science, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Mol Endocrinol 50:167-78. 2013
    ..These findings suggest that G6PT plays an important role in the modulation of pre-receptor activation of glucocorticoids and provides new insights into the role of G6PT in the development of type 2 diabetes...
  13. pmc Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors
    Kabirullah Lutfy
    Division of Endocrinology, Molecular Medicine and Metabolism, Department of Internal Medicine, Charles R Drew University of Medicine and Sciences David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurochem 120:1108-16. 2012
    ..These results argue in favor of the development of specific antagonists that block both AVP and CRH receptors to decrease the pleasurable component of nicotine, which may be mediated by corticosterone...
  14. pmc Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice
    Yanjun Liu
    Division of Endocrinology, Metabolism and Molecular Medicine, UCLA School of Medicine, The Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Mol Endocrinol 41:53-64. 2008
    ..These findings suggest that CBX exerts some of its beneficial effects, at least in part, by inhibiting hepatic GR and H6PDH expression...
  15. pmc 11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue
    Ying Wang
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Sciences, University of California Los Angeles UCLA School of Medicine, Los Angeles, California
    Am J Physiol Endocrinol Metab 308:E84-95. 2015
    ..These findings suggest that elevated adipose 11β-HSD1 expression may contribute to glucocorticoid-induced insulin resistance and adipolysis. ..
  16. pmc The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Neuropharmacology 52:1336-41. 2007
    ..Together, the present results suggest that the ability of buprenorphine to increase motor activity and induce locomotor sensitization and CPP is mediated via the MOP...
  17. pmc Alterations in the level of OFQ/N-IR in rat brain regions by cocaine
    Kabirullah Lutfy
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 East 2nd Street, Pomona, CA 91766, United States
    Neuropharmacology 55:198-203. 2008
    ..These findings suggest that endogenous OFQ/N may be involved in the actions of cocaine and possibly in cocaine-induced motor stimulation and locomotor sensitization...
  18. pmc Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration
    Drupad Parikh
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 East 2nd Street, Pomona, CA 91766, USA
    Eur J Pharmacol 650:563-7. 2011
    ..Together, our results suggest that the endogenous opioid peptide beta-endorphin not only mediates antinociception induced by the short swim but also prevents the delayed hyperalgesic response elicited by either swim paradigm...
  19. pmc The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons
    Borzoo Farhang
    College of Osteopathic Medicine, Western University of Health Sciences, Pomona, CA 91766, USA
    Neuropharmacology 59:190-200. 2010
    ..Taken together, these results demonstrate the contribution of the NOP receptor in controlling food intake and meal pattern, as well as glutamate release and GIRK1 channel activity at POMC synapses...
  20. pmc Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Behav Neurosci 120:10-5. 2006
    ..Taken together, the results suggest that enkephalins may be important for the development of analgesic tolerance but not for conditioned place preference or behavioral sensitization induced by morphine...
  21. pmc The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice
    Paul Marquez
    Department Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Eur J Pharmacol 707:41-5. 2013
    ..Together, the present results suggest that the endogenous OFQ/N/NOP receptor system may modulate the development of cocaine-induced locomotor sensitization...
  22. pmc Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats
    Shridhar Narayanan
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA, USA
    J Psychiatry Neurosci 29:116-23. 2004
    ....
  23. pmc The role of mu opioid receptors in psychomotor stimulation and conditioned place preference induced by morphine-6-glucuronide
    Alexander T Nguyen
    Department of Pharmacy Science, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Eur J Pharmacol 682:86-91. 2012
    ..None of these actions of M6G was detected in mice lacking the mu opioid receptor. Together, the current results suggest that M6G induces psychomotor stimulation and a weaker rewarding action via the mu opioid receptor...
  24. pmc Effect of nicotine on body composition in mice
    Michael Mangubat
    Division of Endocrinology, Department of Medicine, Charles R Drew University of Medicine and Sciences UCLA School of Medicine, 1731 East 120th Street, Los Angeles, California 90059, USA
    J Endocrinol 212:317-26. 2012
    ..We conclude that nicotine is effective in preventing HFD-induced weight gain and abdominal fat accumulation...
  25. ncbi request reprint Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1579, USA
    Brain Res Bull 58:7-12. 2002
    ..Overall, our data suggest that while cocaine enhanced the antinociceptive effect of morphine, sensitization did not develop to this action of cocaine...
  26. pmc Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2
    Ying Nie
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Peptides 47:99-109. 2013
    ....
  27. pmc The endocrine effects of nicotine and cigarette smoke
    Jesse Oliver Tweed
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Trends Endocrinol Metab 23:334-42. 2012
    ....
  28. ncbi request reprint Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis
    Kabirullah Lutfy
    Division of Endocrinology, Molecular Medicine and Metabolism, Department of Medicine, Charles R Drew University of Medicine and Sciences David Geffen School of Medicine at UCLA, Los Angeles, California 90059, USA
    J Neurochem 99:1321-7. 2006
    ..05), but not ACTH and beta-END. The present results suggest that chronic stress leads to an enhanced sensitivity of some components of the HPA axis to a subsequent nicotine challenge...
  29. ncbi request reprint Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice
    Yanjun Liu
    Division of Endocrinology, Charles R Drew University of Medicine and Sciences, University of California, Los Angeles, School of Medicine, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 147:5061-8. 2006
    ..These findings suggest that some of antidiabetic actions of LXR agonist T0901317 may be mediated, at least in part, through the suppression of hepatic GR gene expression...
  30. ncbi request reprint Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism
    Veronica Paez Espinosa
    Charles R Drew Univ of Medicine and Sciences, Division of Endocrinology, 1731 E 120th St, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 292:E175-86. 2007
    ..PTU did not regulate colocalization in the VMH or LH. Regulation of colocalization of processing enzyme and prohormone expression is a novel mechanism to alter hormonal biosynthesis...
  31. pmc The effects of opioids and opioid analogs on animal and human endocrine systems
    Cassidy Vuong
    Division of Endocrinology, Charles Drew University of Medicine and Sciences, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocr Rev 31:98-132. 2010
    ..Additionally, opioids may act through the sympathetic nervous system to cause hyperglycemia and impaired insulin secretion. In this review, recent information regarding endocrine disorders among opioid abusers is presented...
  32. ncbi request reprint Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin
    Shridhar Narayanan
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 760, Westwood Plaza, Los Angeles, CA 90024, USA
    Behav Brain Res 131:97-103. 2002
    ....

Research Grants1

  1. THE OFQ/N/ORL-1 RECEPTOR SYSTEM & COCAINE SENSITIZATION
    Kabirullah Lutfy; Fiscal Year: 2006
    ..The studies proposed in this grant will elucidate the role of OFQ/N/ORL-1 receptor system in cocaine sensitization and possibly provide important and useful information toward developing possible treatments for cocaine addiction. ..