Han Gang Yu

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc Rescue of a trafficking defective human pacemaker channel via a novel mechanism: roles of Src, Fyn, and Yes tyrosine kinases
    Yen Chang Lin
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Center for Cardiovascular and Respiratory Sciences, Morgantown, West Virginia 26506, USA
    J Biol Chem 284:30433-40. 2009
  2. pmc Defective calcium inactivation causes long QT in obese insulin-resistant rat
    Yen Chang Lin
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26056, USA
    Am J Physiol Heart Circ Physiol 302:H1013-22. 2012
  3. ncbi request reprint Racing of the biological pacemaker
    Han Gang Yu
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology, West Virginia University, Morgantown, WV 26506, USA
    Recent Pat DNA Gene Seq 3:193-200. 2009
  4. pmc Inactivation of L-type calcium channel modulated by HCN2 channel
    Yen Chang Lin
    Center for Cardiovascular and Respiratory Sciences, West Virginia Univ School of Medicine, Morgantown, 26506, USA
    Am J Physiol Cell Physiol 298:C1029-37. 2010
  5. pmc Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531
    Chen Hong Li
    Department of Physiology and Pharmacology, Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Am J Physiol Cell Physiol 294:C355-62. 2008
  6. pmc Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha
    Jianying Huang
    Center for Interdisciplinary Research in Cardiovascular Sciences, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Biol Chem 283:29912-9. 2008
  7. pmc PP2 Prevents β-Adrenergic Stimulation of Cardiac Pacemaker Activity
    Jianying Huang
    Center for Cardiovascular and Respiratory Science, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan Mary Babb Randolph Cancer Center and Department of Neurobiology and Anatomy, West Virginia University, Morgantown, WV and Heart Institute of Health Sciences Center, West Virginia University, Morgantown, WV J Huang is now with the Department of Neurology, and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT and Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT
    J Cardiovasc Pharmacol 63:533-43. 2014
  8. pmc Integration of skeletal muscle resistance arteriolar reactivity for perfusion responses in the metabolic syndrome
    Jefferson C Frisbee
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology and Pharmacology, PO Box 9105, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1771-82. 2009
  9. pmc Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes
    Qi Zhang
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Biochim Biophys Acta 1788:1138-47. 2009

Collaborators

Detail Information

Publications9

  1. pmc Rescue of a trafficking defective human pacemaker channel via a novel mechanism: roles of Src, Fyn, and Yes tyrosine kinases
    Yen Chang Lin
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Center for Cardiovascular and Respiratory Sciences, Morgantown, West Virginia 26506, USA
    J Biol Chem 284:30433-40. 2009
    ..In conclusion, we demonstrate a novel mechanism using three endogenous Src kinases to rescue a trafficking defective HCN4 mutant channel (D553N) by enhancing the tyrosine phosphorylation of the mutant channel protein...
  2. pmc Defective calcium inactivation causes long QT in obese insulin-resistant rat
    Yen Chang Lin
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26056, USA
    Am J Physiol Heart Circ Physiol 302:H1013-22. 2012
    ..These results also provided mechanistic insights into a remodeled cardiac electrophysiology under the condition of insulin resistance, enhancing our understanding of long QT associated with obese type 2 diabetic patients...
  3. ncbi request reprint Racing of the biological pacemaker
    Han Gang Yu
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology, West Virginia University, Morgantown, WV 26506, USA
    Recent Pat DNA Gene Seq 3:193-200. 2009
    ..Possible future development and precautions for creation of an effective biological pacemaker superior to the electronic counterpart are also discussed along with recent patents...
  4. pmc Inactivation of L-type calcium channel modulated by HCN2 channel
    Yen Chang Lin
    Center for Cardiovascular and Respiratory Sciences, West Virginia Univ School of Medicine, Morgantown, 26506, USA
    Am J Physiol Cell Physiol 298:C1029-37. 2010
    ..Collectively, these results revealed a potentially novel protection mechanism for achieving the LTCC inactivation via interaction with HCN2...
  5. pmc Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531
    Chen Hong Li
    Department of Physiology and Pharmacology, Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Am J Physiol Cell Physiol 294:C355-62. 2008
    ..The tyrosine residue that mediates most of Src's actions on HCN4 channels is Tyr(531)...
  6. pmc Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha
    Jianying Huang
    Center for Interdisciplinary Research in Cardiovascular Sciences, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Biol Chem 283:29912-9. 2008
    ..In conclusion, we showed a critical role RPTPalpha plays in HCN channel function via tyrosine dephosphorylation. These findings are also important to neurons where HCN and RPTPalpha are richly expressed...
  7. pmc PP2 Prevents β-Adrenergic Stimulation of Cardiac Pacemaker Activity
    Jianying Huang
    Center for Cardiovascular and Respiratory Science, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan Mary Babb Randolph Cancer Center and Department of Neurobiology and Anatomy, West Virginia University, Morgantown, WV and Heart Institute of Health Sciences Center, West Virginia University, Morgantown, WV J Huang is now with the Department of Neurology, and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT and Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT
    J Cardiovasc Pharmacol 63:533-43. 2014
    ..These effects are mediated, at least partially, by a cAMP-independent attenuation of channel activity and cell surface expression of HCN4, the main channel protein that controls the heart rate. ..
  8. pmc Integration of skeletal muscle resistance arteriolar reactivity for perfusion responses in the metabolic syndrome
    Jefferson C Frisbee
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology and Pharmacology, PO Box 9105, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1771-82. 2009
    ....
  9. pmc Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes
    Qi Zhang
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Biochim Biophys Acta 1788:1138-47. 2009
    ..These data suggested that different ratios of HCN2 and HCN4 transcripts overlapping in different tissues also contribute to the tissue-specific properties of I(f)...

Research Grants4

  1. Tyrosine Phosphorylation Mechanism of Pacemaker Channels
    Han Gang Yu; Fiscal Year: 2004
    ..I(f) is an important contributor to the regulation of cardiac pacemaker activity. Understanding the modulation of HCN channels that encode i(f) should have significant diagnostic and therapeutic implications. ..
  2. Tyrosine Phosphorylation Mechanism of Pacemaker Channels
    Han Gang Yu; Fiscal Year: 2005
    ..I(f) is an important contributor to the regulation of cardiac pacemaker activity. Understanding the modulation of HCN channels that encode i(f) should have significant diagnostic and therapeutic implications. ..
  3. Tyrosine Phosphorylation Mechanism of Pacemaker Channels
    Han Gang Yu; Fiscal Year: 2006
    ..I(f) is an important contributor to the regulation of cardiac pacemaker activity. Understanding the modulation of HCN channels that encode i(f) should have significant diagnostic and therapeutic implications. ..
  4. Tyrosine Phosphorylation Mechanism of Pacemaker Channels
    Han Gang Yu; Fiscal Year: 2007
    ..I(f) is an important contributor to the regulation of cardiac pacemaker activity. Understanding the modulation of HCN channels that encode i(f) should have significant diagnostic and therapeutic implications. ..