Research Topics
Genomes and GenesSpecies | Linda Vona-DavisSummaryAffiliation: West Virginia University Country: USA Publications
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Publications
Type 2 diabetes and obesity metabolic interactions: common factors for breast cancer risk and novel approaches to prevention and therapyLinda Vona-Davis
Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, P O Box 9238, Morgantown, WV 26506, USA
Curr Diabetes Rev 8:116-30. 2012..These mechanistic considerations are consistent with metformin having high potential as a breast cancer chemopreventive and therapeutic agent...- Effect of creatine monohydrate on cardiac function in a rat model of endotoxemiaL Vona-Davis
Department of Surgery, West Virginia University, Morgantown, West Virginia 26506, USA
J Surg Res 103:1-7. 2002..This study was undertaken to investigate whether creatine (Cr) administered during perfusion could enhance myocardial protection and improve recovery of cardiac function in a rat model of endotoxemia... - Adiposity, type 2 diabetes and the metabolic syndrome in breast cancerL Vona-Davis
Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506 9238, USA
Obes Rev 8:395-408. 2007.... - Expression of STAT3 and SOCS3 in pancreatic acinar cellsLinda C Vona-Davis
Department of Surgery, West Virginia University, Morgantown, West Virginia 26506 9238, USA
J Surg Res 127:14-20. 2005..Because activation of STAT3 and SOCS3 is also linked to cytokine stimulation, we tested TNFalpha and LPS, either alone or in combination with IL-1beta or IL-6 in an in vitro model using rat pancreatic acinar cells... - Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progressionLinda Vona-Davis
Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9238, Morgantown, West Virginia 26506, USA
Endocr Relat Cancer 14:189-206. 2007..In contrast, adiponectin, an endogenous insulin sensitizer, exerts a direct growth-inhibitory effect on tumor cells by downregulating cell proliferation and upregulating apoptosis, and also inhibits tumor-related angiogenesis... 
Triple-negative breast cancer and obesity in a rural Appalachian populationLinda Vona-Davis
Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, P O Box 9238, Morgantown, WV 26506, USA
Cancer Epidemiol Biomarkers Prev 17:3319-24. 2008....- The influence of socioeconomic disparities on breast cancer tumor biology and prognosis: a reviewLinda Vona-Davis
Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Center of Excellence in Women s Health, P O Box 9238, Morgantown, WV 26506, USA
J Womens Health (Larchmt) 18:883-93. 2009..Furthermore, we examine the association between obesity and breast cancer within socioeconomic disparities... - Angiogenesis, adipokines and breast cancerLinda Vona-Davis
Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, United States
Cytokine Growth Factor Rev 20:193-201. 2009.... - COX-2 inhibition and cancer: experimental findings and clinical correlatesElizabeth Gail Roberts
West Virginia University School of Medicine, Morgantown, USA
W V Med J 100:96-101. 2004..Our study indicates that COX-2 inhibition reduces the growth of human breast and prostate cancer in vitro. Human studies are needed to evaluate the clinical utility of rofecoxib treatment in breast or prostate cancers... - Keyhole limpet hemocyanin, a novel immune stimulant with promising anticancer activity in Barrett's esophageal adenocarcinomaDavid W McFadden
Department of Surgery, Robert C Byrd Health Science Center, West Virginia University, P O Box 9238, Morgantown, WV 26506 9238, USA
Am J Surg 186:552-5. 2003..We hypothesized that KLH would be effective against Barrett's esophageal adenocarcinoma in an in vitro model... - Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42JKristine Robinson
Department of Surgery, West Virginia University, Morgantown, WV 26506, USA
J Am Coll Surg 202:788-96. 2006..We hypothesized that tumor necrosis factor (TNF)-alpha would induce STAT1 and STAT3, and PYY would attenuate their transcription factor binding... - MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitroLinda Vona-Davis
Department of Surgery, West Virginia University, Morgantown, West Virginia 26506-9238, USA
J Surg Res 127:53-8. 2005..Pro-apoptotic mechanisms prevail in the wild-type p53 cells. Further investigation is warranted to advance the clinical treatment of this devastating disease... - Peptide YY inhibits the growth of Barrett's esophageal adenocarcinoma in vitroDavid W McFadden
Department of Surgery, Robert C Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, USA
Am J Surg 188:516-9. 2004..Adenocarcinoma of the esophagus usually arises from Barrett's esophagus. We hypothesized that treatment of Barrett's adenocarcinoma with PYY would result in decreased proliferation... - In vitro effects of keyhole limpet hemocyanin in breast and pancreatic cancer in regards to cell growth, cytokine production, and apoptosisDale R Riggs
Department of Surgery, Robert C. Byrd Health Science Center, PO Box 9238, West Virginia University, Morgantown, WV 26506, USA
Am J Surg 189:680-4. 2005..CONCLUSIONS: KLH directly inhibits the growth of human breast and pancreas cancer in vitro by apoptotic and nonapoptotic mechanisms... - Peptide YY attenuates transcription factor activity in tumor necrosis factor-alpha-induced pancreatitisLinda Vona-Davis
Department of Surgery, West Virginia University, Morgantown, WV 26506, USA
J Am Coll Surg 199:87-95. 2004..Exposure to TNF-alpha activates transcription factors NF-kappaB, Smad3/4, and PPARalpha/gamma. PYY reduces this activation. Treatment with PYY may have therapeutic potential in improving AP... - Interaction between menopausal status and obesity in affecting breast cancer riskDavid P Rose
Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
Maturitas 66:33-8. 2010.... - Influence of obesity on breast cancer receptor status and prognosisDavid P Rose
Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
Expert Rev Anticancer Ther 9:1091-101. 2009..Weight control is important, not only to target breast cancer progression, but also to reduce the risk of nonbreast cancer mortality risk associated with excess adiposity... - Proteomic analysis of SEG-1 human Barrett's-associated esophageal adenocarcinoma cells treated with keyhole limpet hemocyaninLinda Vona-Davis
Department of Surgery, West Virginia University, Morgantown, WV 26506-9238, USA
J Gastrointest Surg 8:1018-23. 2004..The use of KLH as adjuvant or topical therapy for Barrett's adenocarcinoma provides a promising development in the treatment of this disease... - Differential effects of leptin on cancer in vitroPonnandai Somasundar
Louis A Johnson VA Medical Center 26506, Morgantown, West Virginia 26506, USA
J Surg Res 113:50-5. 2003..Both leptin and leptin antagonism have potential efficacy in cancer therapy, based on cellular origin. Further studies are warranted and ongoing... - Peptide YY reverses TNF-alpha induced transcription factor binding of interferon regulatory factor-1 and p53 in pancreatic acinar cellsIrfan A Rizvi
Department of Surgery, West Virginia University, Morgantown, West Virginia 26506 9238, USA
J Surg Res 136:25-30. 2006..We hypothesized that TNF-alpha would induce IRF-1 and p53 protein binding in pancreatic acinar cells and that PYY would attenuate the effect... - Triple-negative breast cancer in West VirginiaJame Abraham
Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, USA
W V Med J 105:54-9. 2009..Other factors such as obesity, diabetes, poverty and access to mammography screening could be influencing the poorer outcomes for women with breast cancer in West Virginia... - Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancerPonnandai Somasundar
Louis A. Johnson VA Medical Center, Clarksburg, West Virginia; Department of Surgery, West Virginia University, Morgantown, West Virginia, USA
J Surg Res 126:199-203. 2005..Further in vivo and human studies are needed to evaluate safety and clinical utility of this agent in patients with pancreatic cancer... - Leptin stimulates esophageal adenocarcinoma growth by nonapoptotic mechanismsPonnandai Somasundar
Department of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV, USA
Am J Surg 186:575-8. 2003..The data suggest that leptin stimulates esophageal adenocarcinoma growth by nonapoptotic mechanisms. Leptin antagonism may have potential efficacy in esophageal cancer therapy... - PYY and the pancreas: inhibition of tumor growth and inflammationLinda Vona Davis
Department of Surgery, West Virginia University, PO Box 9238, Morgantown, WV 26506, USA
Peptides 28:334-8. 2007..The present paper reviews our current findings with PYY and examines the therapeutic implications of its utility in treating inflammation and cancer... - Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1)Linda Vona-Davis
Department of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, West Virginia, USA
J Surg Res 119:143-8. 2004..Further in vivo and human studies are warranted to evaluate the safety and clinical utility of these agents in patients with all cancers of the esophagus... - Leptin is a growth factor in cancerPonnandai Somasundar
West Virginia University, Department of Surgery, PO Box 9238, Morgantown, West Virginia 26506, USA
J Surg Res 116:337-49. 2004 - Modulation of interleukin-6 in cardiac myoblasts during endotoxemiaLinda Vona-Davis
Department of Surgery, West Virginia University Morgantown, West Virginia 26506, USA
J Surg Res 112:91-6. 2003..CONCLUSIONS: In cardiac myoblasts, IL-6 is either enhanced or reduced depending on interactions between LPS and cytokine challenge. Enhanced nuclear translocation of NF-kappaB in response to LPS was evident in a myogenic cell line... - Phosphocreatine restores high-energy phosphates in ischemic myocardium: implication for off-pump cardiac revascularizationGanga Prabhakar
West Virginia University, Department of Surgery, Morgantown, WV 26506-9238, USA
J Am Coll Surg 197:786-91. 2003..CONCLUSIONS: PCr restores high-energy phosphates and attenuates metabolic stress during periods of myocardial ischemia in the rat. Preconditioning with PCr may serve as a useful adjunct to off-pump coronary revascularization... - Factors influencing adherence to mammography screening guidelines in Appalachian women participating in a mobile mammography programAmi Vyas
Department of Pharmaceutical Systems and Policy, School of Pharmacy, Robert C Byrd Health Sciences Center North, West Virginia University, Morgantown, WV 26506 9510, USA
J Community Health 37:632-46. 2012..Increasing adherence to mammography screening may require targeted, community-based educational interventions that precede and complement visits by the mobile mammography unit... - The cellular and molecular mechanisms by which insulin influences breast cancer risk and progressionDavid P Rose
Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9238, Morgantown, West Virginia 26506, USA
Endocr Relat Cancer 19:R225-41. 2012..Understanding the various mechanisms by which insulin participates in breast cancer cell biology provides opportunities for novel approaches to treatment... - In vitro anticancer effects of a novel immunostimulant: keyhole limpet hemocyaninDale R Riggs
Department of Surgery, West Virginia University, PO Box 9238, Morgantown, 26506, USA
J Surg Res 108:279-84. 2002..Investigation into the efficacy and mechanism of response could directly lead to more effective treatment regimens for patients suffering from these diseases... - Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemiaLinda Vona-Davis
Department of Surgery, West Virginia University, C Byrd Health Sciences Center, Morgantown 26506-9238, USA
Shock 17:404-10. 2002..We conclude that selective inhibition of iNOS and the reduction of NO production do not prevent cardiac dysfunction at an early stage in an acute model of endotoxemia...