Linda Vona-Davis

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. ncbi request reprint The obesity-inflammation-eicosanoid axis in breast cancer
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, Robert C Byrd Health Sciences Center, West Virginia University, P O Box 9238, Morgantown, WV, 26506, USA
    J Mammary Gland Biol Neoplasia 18:291-307. 2013
  2. ncbi request reprint Type 2 diabetes and obesity metabolic interactions: common factors for breast cancer risk and novel approaches to prevention and therapy
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, P O Box 9238, Morgantown, WV 26506, USA
    Curr Diabetes Rev 8:116-30. 2012
  3. ncbi request reprint Effect of creatine monohydrate on cardiac function in a rat model of endotoxemia
    L Vona-Davis
    Department of Surgery, West Virginia University, Morgantown, West Virginia 26506, USA
    J Surg Res 103:1-7. 2002
  4. ncbi request reprint Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
    Linda Vona-Davis
    Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9238, Morgantown, West Virginia 26506, USA
    Endocr Relat Cancer 14:189-206. 2007
  5. ncbi request reprint Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer
    L Vona-Davis
    Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506 9238, USA
    Obes Rev 8:395-408. 2007
  6. ncbi request reprint Triple-negative breast cancer and obesity in a rural Appalachian population
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, P O Box 9238, Morgantown, WV 26506, USA
    Cancer Epidemiol Biomarkers Prev 17:3319-24. 2008
  7. doi request reprint The influence of socioeconomic disparities on breast cancer tumor biology and prognosis: a review
    Linda Vona-Davis
    Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Center of Excellence in Women s Health, P O Box 9238, Morgantown, WV 26506, USA
    J Womens Health (Larchmt) 18:883-93. 2009
  8. ncbi request reprint Angiogenesis, adipokines and breast cancer
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, United States
    Cytokine Growth Factor Rev 20:193-201. 2009
  9. ncbi request reprint Expression of STAT3 and SOCS3 in pancreatic acinar cells
    Linda C Vona-Davis
    Department of Surgery, West Virginia University, Morgantown, West Virginia 26506 9238, USA
    J Surg Res 127:14-20. 2005
  10. ncbi request reprint COX-2 inhibition and cancer: experimental findings and clinical correlates
    Elizabeth Gail Roberts
    West Virginia University School of Medicine, Morgantown, USA
    W V Med J 100:96-101. 2004

Collaborators

Detail Information

Publications35

  1. ncbi request reprint The obesity-inflammation-eicosanoid axis in breast cancer
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, Robert C Byrd Health Sciences Center, West Virginia University, P O Box 9238, Morgantown, WV, 26506, USA
    J Mammary Gland Biol Neoplasia 18:291-307. 2013
    ....
  2. ncbi request reprint Type 2 diabetes and obesity metabolic interactions: common factors for breast cancer risk and novel approaches to prevention and therapy
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, P O Box 9238, Morgantown, WV 26506, USA
    Curr Diabetes Rev 8:116-30. 2012
    ..These mechanistic considerations are consistent with metformin having high potential as a breast cancer chemopreventive and therapeutic agent...
  3. ncbi request reprint Effect of creatine monohydrate on cardiac function in a rat model of endotoxemia
    L Vona-Davis
    Department of Surgery, West Virginia University, Morgantown, West Virginia 26506, USA
    J Surg Res 103:1-7. 2002
    ..This study was undertaken to investigate whether creatine (Cr) administered during perfusion could enhance myocardial protection and improve recovery of cardiac function in a rat model of endotoxemia...
  4. ncbi request reprint Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
    Linda Vona-Davis
    Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9238, Morgantown, West Virginia 26506, USA
    Endocr Relat Cancer 14:189-206. 2007
    ..In contrast, adiponectin, an endogenous insulin sensitizer, exerts a direct growth-inhibitory effect on tumor cells by downregulating cell proliferation and upregulating apoptosis, and also inhibits tumor-related angiogenesis...
  5. ncbi request reprint Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer
    L Vona-Davis
    Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506 9238, USA
    Obes Rev 8:395-408. 2007
    ....
  6. ncbi request reprint Triple-negative breast cancer and obesity in a rural Appalachian population
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, P O Box 9238, Morgantown, WV 26506, USA
    Cancer Epidemiol Biomarkers Prev 17:3319-24. 2008
    ....
  7. doi request reprint The influence of socioeconomic disparities on breast cancer tumor biology and prognosis: a review
    Linda Vona-Davis
    Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University Center of Excellence in Women s Health, P O Box 9238, Morgantown, WV 26506, USA
    J Womens Health (Larchmt) 18:883-93. 2009
    ..Furthermore, we examine the association between obesity and breast cancer within socioeconomic disparities...
  8. ncbi request reprint Angiogenesis, adipokines and breast cancer
    Linda Vona-Davis
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, United States
    Cytokine Growth Factor Rev 20:193-201. 2009
    ....
  9. ncbi request reprint Expression of STAT3 and SOCS3 in pancreatic acinar cells
    Linda C Vona-Davis
    Department of Surgery, West Virginia University, Morgantown, West Virginia 26506 9238, USA
    J Surg Res 127:14-20. 2005
    ..Because activation of STAT3 and SOCS3 is also linked to cytokine stimulation, we tested TNFalpha and LPS, either alone or in combination with IL-1beta or IL-6 in an in vitro model using rat pancreatic acinar cells...
  10. ncbi request reprint COX-2 inhibition and cancer: experimental findings and clinical correlates
    Elizabeth Gail Roberts
    West Virginia University School of Medicine, Morgantown, USA
    W V Med J 100:96-101. 2004
    ..Our study indicates that COX-2 inhibition reduces the growth of human breast and prostate cancer in vitro. Human studies are needed to evaluate the clinical utility of rofecoxib treatment in breast or prostate cancers...
  11. ncbi request reprint Keyhole limpet hemocyanin, a novel immune stimulant with promising anticancer activity in Barrett's esophageal adenocarcinoma
    David W McFadden
    Department of Surgery, Robert C Byrd Health Science Center, West Virginia University, P O Box 9238, Morgantown, WV 26506 9238, USA
    Am J Surg 186:552-5. 2003
    ..We hypothesized that KLH would be effective against Barrett's esophageal adenocarcinoma in an in vitro model...
  12. ncbi request reprint MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro
    Linda Vona-Davis
    Department of Surgery, West Virginia University, Morgantown, West Virginia 26506 9238, USA
    J Surg Res 127:53-8. 2005
    ..We hypothesized that inhibition of these pathways in Barrett's adenocarcinoma would decrease cell proliferation and alter apoptosis in vitro...
  13. ncbi request reprint Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J
    Kristine Robinson
    Department of Surgery, West Virginia University, Morgantown, WV 26506, USA
    J Am Coll Surg 202:788-96. 2006
    ..We hypothesized that tumor necrosis factor (TNF)-alpha would induce STAT1 and STAT3, and PYY would attenuate their transcription factor binding...
  14. ncbi request reprint Peptide YY inhibits the growth of Barrett's esophageal adenocarcinoma in vitro
    David W McFadden
    Department of Surgery, Robert C Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, USA
    Am J Surg 188:516-9. 2004
    ..Adenocarcinoma of the esophagus usually arises from Barrett's esophagus. We hypothesized that treatment of Barrett's adenocarcinoma with PYY would result in decreased proliferation...
  15. ncbi request reprint Peptide YY attenuates transcription factor activity in tumor necrosis factor-alpha-induced pancreatitis
    Linda Vona-Davis
    Department of Surgery, West Virginia University, Morgantown, WV 26506, USA
    J Am Coll Surg 199:87-95. 2004
    ..We investigated TNF-alpha induction of Smad proteins, PPARalpha/gamma, and NF-kappaB by TNF-alpha, and hypothesized that PYY would attenuate this effect...
  16. ncbi request reprint In vitro effects of keyhole limpet hemocyanin in breast and pancreatic cancer in regards to cell growth, cytokine production, and apoptosis
    Dale R Riggs
    Department of Surgery, Robert C Byrd Health Science Center, PO Box 9238, West Virginia University, Morgantown, WV 26506, USA
    Am J Surg 189:680-4. 2005
    ..We have previously shown the inhibitory effects of keyhole limpet hemocyanin (KLH) against breast and pancreatic cancer in vitro. We hypothesize that its actions in breast and pancreas cancer cells are via apoptotic or cytokine pathways...
  17. doi request reprint Interaction between menopausal status and obesity in affecting breast cancer risk
    David P Rose
    Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
    Maturitas 66:33-8. 2010
    ....
  18. doi request reprint Influence of obesity on breast cancer receptor status and prognosis
    David P Rose
    Department of Surgery and Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
    Expert Rev Anticancer Ther 9:1091-101. 2009
    ..Weight control is important, not only to target breast cancer progression, but also to reduce the risk of nonbreast cancer mortality risk associated with excess adiposity...
  19. ncbi request reprint Triple-negative breast cancer in West Virginia
    Jame Abraham
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, USA
    W V Med J 105:54-9. 2009
    ..Other factors such as obesity, diabetes, poverty and access to mammography screening could be influencing the poorer outcomes for women with breast cancer in West Virginia...
  20. ncbi request reprint Differential effects of leptin on cancer in vitro
    Ponnandai Somasundar
    Louis A Johnson VA Medical Center 26506, Morgantown, West Virginia 26506, USA
    J Surg Res 113:50-5. 2003
    ..Recent studies have shown that leptin stimulates proliferation of human colon cancer in vitro. We hypothesized that leptin would have stimulatory effects on other human cancers...
  21. ncbi request reprint Proteomic analysis of SEG-1 human Barrett's-associated esophageal adenocarcinoma cells treated with keyhole limpet hemocyanin
    Linda Vona-Davis
    Department of Surgery, West Virginia University, Morgantown, WV 26506 9238, USA
    J Gastrointest Surg 8:1018-23. 2004
    ..The use of KLH as adjuvant or topical therapy for Barrett's adenocarcinoma provides a promising development in the treatment of this disease...
  22. ncbi request reprint Peptide YY reverses TNF-alpha induced transcription factor binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells
    Irfan A Rizvi
    Department of Surgery, West Virginia University, Morgantown, West Virginia 26506 9238, USA
    J Surg Res 136:25-30. 2006
    ..We hypothesized that TNF-alpha would induce IRF-1 and p53 protein binding in pancreatic acinar cells and that PYY would attenuate the effect...
  23. ncbi request reprint Leptin stimulates esophageal adenocarcinoma growth by nonapoptotic mechanisms
    Ponnandai Somasundar
    Department of Surgery, Robert C Byrd Health Science Center, West Virginia University, Morgantown, WV, USA
    Am J Surg 186:575-8. 2003
    ..One risk factor associated with adenocarcinoma of the esophagus is obesity. We hypothesized that leptin would have stimulatory effects on esophageal adenocarcinoma and alter apoptosis in vitro...
  24. ncbi request reprint Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancer
    Ponnandai Somasundar
    Louis A Johnson VA Medical Center, Clarksburg, West Virginia Department of Surgery, West Virginia University, Morgantown, West Virginia, USA
    J Surg Res 126:199-203. 2005
    ..The effects of IP6 have not been evaluated in pancreatic cancer. We hypothesized that IP6 would significantly inhibit cell growth and increase the apoptotic rate of pancreatic cancer in vitro...
  25. ncbi request reprint Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1)
    Linda Vona-Davis
    Department of Surgery, Robert C Byrd Health Science Center, West Virginia University, Morgantown, West Virginia, USA
    J Surg Res 119:143-8. 2004
    ..Additional comparison studies were performed with commercially available COX-2 and COX-1 inhibitors...
  26. ncbi request reprint Leptin is a growth factor in cancer
    Ponnandai Somasundar
    West Virginia University, Department of Surgery, PO Box 9238, Morgantown, West Virginia 26506, USA
    J Surg Res 116:337-49. 2004
  27. ncbi request reprint PYY and the pancreas: inhibition of tumor growth and inflammation
    Linda Vona-Davis
    Department of Surgery, West Virginia University, PO Box 9238, Morgantown, WV 26506, USA
    Peptides 28:334-8. 2007
    ..The present paper reviews our current findings with PYY and examines the therapeutic implications of its utility in treating inflammation and cancer...
  28. doi request reprint The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression
    David P Rose
    Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, 26506, USA
    Endocr Relat Cancer 19:R225-41. 2012
    ..Understanding the various mechanisms by which insulin participates in breast cancer cell biology provides opportunities for novel approaches to treatment...
  29. ncbi request reprint Modulation of interleukin-6 in cardiac myoblasts during endotoxemia
    Linda Vona-Davis
    Department of Surgery, West Virginia University Morgantown, West Virginia 26506, USA
    J Surg Res 112:91-6. 2003
    ..We hypothesized that IL-6 production is enhanced with LPS and cytokine challenge and that LPS stimulates NF-kappaB intranuclear translocation in a myogenic cell line...
  30. ncbi request reprint Phosphocreatine restores high-energy phosphates in ischemic myocardium: implication for off-pump cardiac revascularization
    Ganga Prabhakar
    West Virginia University, Department of Surgery, Morgantown, WV 26506 9238, USA
    J Am Coll Surg 197:786-91. 2003
    ..High-energy phosphate metabolism is altered in the ischemic myocardium. We investigated the effects of in vivo administration of phosphocreatine (PCr) in a transient ischemic rat model to emulate off-pump myocardial revascularization...
  31. doi request reprint Factors influencing adherence to mammography screening guidelines in Appalachian women participating in a mobile mammography program
    Ami Vyas
    Department of Pharmaceutical Systems and Policy, School of Pharmacy, Robert C Byrd Health Sciences Center North, West Virginia University, Morgantown, WV 26506 9510, USA
    J Community Health 37:632-46. 2012
    ..Increasing adherence to mammography screening may require targeted, community-based educational interventions that precede and complement visits by the mobile mammography unit...
  32. ncbi request reprint Biochemical and molecular mechanisms for the association between obesity, chronic Inflammation, and breast cancer
    David P Rose
    Department of Surgery and Breast Cancer Research Program, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA
    Biofactors 40:1-12. 2014
    ..2013 BioFactors, 40(1):1-12, 2014. ..
  33. ncbi request reprint Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemia
    Linda Vona-Davis
    Department of Surgery, West Virginia University, C Byrd Health Sciences Center, Morgantown 26506 9238, USA
    Shock 17:404-10. 2002
    ..We conclude that selective inhibition of iNOS and the reduction of NO production do not prevent cardiac dysfunction at an early stage in an acute model of endotoxemia...
  34. ncbi request reprint In vitro anticancer effects of a novel immunostimulant: keyhole limpet hemocyanin
    Dale R Riggs
    Department of Surgery, West Virginia University, PO Box 9238, Morgantown, 26506, USA
    J Surg Res 108:279-84. 2002
    ..We hypothesized that KLH would be effective against other cancer cells in vitro...