Yon Rojanasakul

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells
    Djordje Medan
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 7:e37045. 2012
  2. pmc Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes
    Sudjit Luanpitpong
    Pharmaceutical and Pharmacological Sciences Program, West Virginia University, Morgantown, WV 26506, USA
    Part Fibre Toxicol 11:22. 2014
  3. pmc Mechanisms of nanoparticle-induced oxidative stress and toxicity
    Amruta Manke
    Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
    Biomed Res Int 2013:942916. 2013
  4. pmc Linking JNK-STAT3-Akt signaling axis to EZH2 phosphorylation: A novel pathway of carcinogenesis
    Yon Rojanasakul
    Mary Babb Randolph Cancer Center West Virginia University Morgantown, WV USA
    Cell Cycle 12:202. 2013
  5. pmc Digitoxin and its analogs as novel cancer therapeutics
    Hosam A Elbaz
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA
    Exp Hematol Oncol 1:4. 2012
  6. pmc Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes
    Nicole B Bryan
    Division of Rheumatology, Department of Medicine and Robert H, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 240 E, Huron St, Chicago, IL 60611, USA
    J Inflamm (Lond) 7:23. 2010
  7. pmc Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production
    Yongju Lu
    West Virginia University, Department of Pharmaceutical Sciences, P O Box 9530, Morgantown, WV 26506, USA
    Am J Respir Cell Mol Biol 42:432-41. 2010
  8. ncbi request reprint S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis
    Neelam Azad
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 281:34124-34. 2006
  9. pmc Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
    Sudjit Luanpitpong
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Mol Biol Cell 24:858-69. 2013
  10. ncbi request reprint Vanadium-induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Cell Physiol 195:99-107. 2003

Collaborators

Detail Information

Publications56

  1. pmc Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells
    Djordje Medan
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 7:e37045. 2012
    ..Together, our results indicate the novel and multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of human lung epithelial cells chronically exposed to Cr(VI)...
  2. pmc Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes
    Sudjit Luanpitpong
    Pharmaceutical and Pharmacological Sciences Program, West Virginia University, Morgantown, WV 26506, USA
    Part Fibre Toxicol 11:22. 2014
    ..We hypothesized that the acquisition of cancer stem cells (CSC), a subpopulation that drive tumor initiation and progression, may contribute to CNT carcinogenesis...
  3. pmc Mechanisms of nanoparticle-induced oxidative stress and toxicity
    Amruta Manke
    Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
    Biomed Res Int 2013:942916. 2013
    ..Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP-induced injury can be developed. ..
  4. pmc Linking JNK-STAT3-Akt signaling axis to EZH2 phosphorylation: A novel pathway of carcinogenesis
    Yon Rojanasakul
    Mary Babb Randolph Cancer Center West Virginia University Morgantown, WV USA
    Cell Cycle 12:202. 2013
    ..Comment on: Chen B, et al. Cell Cycle 2013; 12:112-21...
  5. pmc Digitoxin and its analogs as novel cancer therapeutics
    Hosam A Elbaz
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA
    Exp Hematol Oncol 1:4. 2012
    ..Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs...
  6. pmc Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes
    Nicole B Bryan
    Division of Rheumatology, Department of Medicine and Robert H, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 240 E, Huron St, Chicago, IL 60611, USA
    J Inflamm (Lond) 7:23. 2010
    ..However, the precise regulation of inflammasomes at the level of ASC is still not completely understood. In this study we identified and characterized three novel ASC isoforms for their ability to function as an inflammasome adaptor...
  7. pmc Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production
    Yongju Lu
    West Virginia University, Department of Pharmaceutical Sciences, P O Box 9530, Morgantown, WV 26506, USA
    Am J Respir Cell Mol Biol 42:432-41. 2010
    ..Together, our results indicate a novel role of PI3K/Akt in fibrogenesis of human lung fibroblasts and its regulation by ROS, which could be exploited for the treatment of pulmonary fibrosis and related disorders...
  8. ncbi request reprint S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis
    Neelam Azad
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 281:34124-34. 2006
    ..These findings indicate a novel function of NO and its regulation of Bcl-2, which provides a key mechanism for the control of apoptotic cell death and cancer development...
  9. pmc Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
    Sudjit Luanpitpong
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Mol Biol Cell 24:858-69. 2013
    ..This new finding reveals crucial redox regulatory mechanisms that control the antiapoptotic function of Bcl-2...
  10. ncbi request reprint Vanadium-induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Cell Physiol 195:99-107. 2003
    ..These results indicate that multiple oxidative species are involved in V (V)-induced lung inflammation and apoptosis, and that H(2)O(2) plays a major role in this process...
  11. pmc Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells
    Neelam Azad
    Department of Pharmaceutical Sciences, Hampton University, Hampton, Virginia 23668, USA
    Am J Respir Cell Mol Biol 42:578-85. 2010
    ....
  12. ncbi request reprint Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
    Jirapan Moungjaroen
    West Virginia University, Department of Pharmaceutical Sciences, Morgantown, WV 26506, USA
    J Pharmacol Exp Ther 319:1062-9. 2006
    ..Together, our findings indicate a novel pro-oxidant role of LA in apoptosis induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders...
  13. doi request reprint Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation
    Neelam Azad
    Department of Pharmaceutical Sciences, School of Pharmacy, Hampton University, Hampton, Virginia, USA
    Ann N Y Acad Sci 1203:1-6. 2010
    ..We describe a novel mechanism of Bcl-2 regulation by *O(2)(-) and NO, providing a new dimension to reactive species-mediated Bcl-2 stability, apoptotic cell death, and cancer development...
  14. ncbi request reprint Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells
    Bin Lu
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    J Immunol 176:6785-93. 2006
    ..Together, our results indicate that the PI3K/Akt, in addition to its normal prosurvival role, also plays an apoptotic role in Fas-mediated cell death through a mechanism that involves transcriptional activation of Fas receptor...
  15. pmc Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells
    Todd A Stueckle
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 261:204-16. 2012
    ..In conclusion, transformed B-As cells with their whole genome expression profile provide an in vitro arsenic model for future lung cancer signaling research and data for chronic arsenic exposure risk assessment...
  16. ncbi request reprint Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats
    Liying Wang
    National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 290:L695-L702. 2006
    ..Together, our results demonstrate a direct effect of apoptotic cell accumulation on inflammatory and fibrotic pulmonary responses and the continuous induction of lung cell apoptosis by apoptotic cell instillation...
  17. ncbi request reprint A Shope Fibroma virus PYRIN-only protein modulates the host immune response
    Andrea Dorfleutner
    Mary Babb Randolph Cancer Center and Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, 1826 MBRCC, 1 Medical Center Drive, Morgantown, WV 26506 9300, USA
    Virus Genes 35:685-94. 2007
    ....
  18. ncbi request reprint Peroxide is a key mediator of Bcl-2 down-regulation and apoptosis induction by cisplatin in human lung cancer cells
    Liying Wang
    West Virginia University, Department of Pharmaceutical Sciences, P O Box 9530, Morgantown, WV 26506, USA
    Mol Pharmacol 73:119-27. 2008
    ..Because aberrant expression of Bcl-2 has been associated with death resistance of cancer cells to chemotherapy, the results of this study could be used to aid the design of more effective strategies for cancer treatment...
  19. pmc Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, WV 26505, USA
    Part Fibre Toxicol 7:31. 2010
    ..The aims of this study were to develop a simple and rapid method of nanoparticle dispersion using a natural lung surfactant and to evaluate the effect of dispersion status of SWCNT on cytotoxicity and fibrogenicity in vitro and in vivo...
  20. doi request reprint Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells
    Lalana Kongkaneramit
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    J Pharmacol Exp Ther 325:969-77. 2008
    ..In demonstrating the role of FLIP and ROS in LF death signaling, we document a novel mechanism of apoptosis regulation that may be exploited to decrease cytotoxicity and increase gene transfection efficiency of cationic liposomes...
  21. ncbi request reprint Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages
    Djordje Medan
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    J Cell Physiol 203:78-84. 2005
    ..Because the Fas death pathway is implicated in various inflammatory and immunologic disorders, utilization of antioxidants and apoptosis inhibitors as potential therapeutic agents may be advantageous...
  22. ncbi request reprint Role of neutrophil apoptosis in vanadium-induced pulmonary inflammation in mice
    Liying Wang
    National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Morgantown, WV 26505, USA
    J Environ Pathol Toxicol Oncol 21:343-50. 2002
    ..We conclude that apoptosis of neutrophils and clearance by alveolar macrophages are important mechanisms in the resolution of vanadium-induced lung inflammation...
  23. pmc Mitochondrial superoxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination
    Sudjit Luanpitpong
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Biochem Pharmacol 83:1643-54. 2012
    ....
  24. pmc The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunol 180:3072-80. 2008
    ....
  25. pmc Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses
    Neelam Azad
    Department of Pharmaceutical Sciences, Hampton University, Hampton, VA 23668, USA
    Nanotoxicology 7:157-68. 2013
    ..This interplay of fibrogenic and angiogenic mediators led to increased angiogenesis in response to SWCNTs. Overall this study reveals key signalling molecules involved in SWCNT-induced fibrogenesis and angiogenesis...
  26. pmc Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis
    Neelam Azad
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Carcinogenesis 29:1538-45. 2008
    ..This study reveals a novel mechanism linking .O(-)(2) with Bcl-2 stability and provides a new dimension to ROS-mediated Bcl-2 downregulation and apoptosis induction...
  27. doi request reprint Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 73:410-22. 2010
    ..The results obtained may aid in the development of in vitro models for rapid screening of the potential fibrogenicity of carbon nanotubes, which are lacking and urgently needed...
  28. ncbi request reprint Essential role of p53 in silica-induced apoptosis
    Liying Wang
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 288:L488-96. 2005
    ..This finding may provide an important link in understanding the molecular mechanisms of silica-induced carcinogenesis and pathogenesis in the lung...
  29. doi request reprint Pulmonary toxicity and fibrogenic response of carbon nanotubes
    Amruta Manke
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Mech Methods 23:196-206. 2013
    ..We also discuss the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis...
  30. pmc Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation
    Varisa Pongrakhananon
    Cell Based Drug and Health Product Development Research Unit, Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, United States
    Biochem Pharmacol 88:23-35. 2014
    ..These results identify a novel cardiac glycoside (CG) sensitizing anoikis mechanism and provide a promising anti-metastatic target for lung cancer therapy...
  31. pmc Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner
    Anand Krishnan V Iyer
    Department of Pharmaceutical Sciences, Hampton University, Hampton, VA 23668, USA
    J Immunol 187:3256-66. 2011
    ..Taken together, our study reveals a novel link between NF-κB and PI3K/Akt and establishes c-FLIP as an important regulator of FasL-mediated cell death...
  32. ncbi request reprint Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Lab Invest 86:458-66. 2006
    ....
  33. pmc Role of S-nitrosylation in apoptosis resistance and carcinogenesis
    Anand Krishnan V Iyer
    Department of Pharmaceutical Sciences, West Virginia University, P O Box 9530, Morgantown, WV 26506, USA
    Nitric Oxide 19:146-51. 2008
    ..We propose that such post-translational modifications of proteins by NO may be a general mechanism that tumor cells exploit to tilt the scales towards survival and proliferation by evading cell death...
  34. ncbi request reprint Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
    Qiao Meng
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
    Cell Signal 18:2262-71. 2006
    ..This study demonstrates the important role of the PI3K/AKT/mTOR/p70S6K1 pathway in cell proliferation, migration, and invasion in ovarian cancer cells by using siRNA-mediated gene silencing as a reverse genetic method...
  35. pmc Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells
    Hosam A Elbaz
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 258:51-60. 2012
    ..In summary, digitoxin and D6-MA exert anti-cancer effects on NCI-H460 cells through apoptosis or cell cycle arrest, with D6-MA showing at least 5-fold greater potency relative to digitoxin...
  36. ncbi request reprint Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination
    Pithi Chanvorachote
    Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, WV 26506, USA
    Cancer Res 66:6353-60. 2006
    ..These findings indicate a novel pathway for NO regulation of Bcl-2, which provides a key mechanism for cisplatin resistance and its potential modulation for improved cancer chemotherapy...
  37. ncbi request reprint Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells
    Liying Wang
    HELD PPRB, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Nanotoxicology 8:485-507. 2014
    ..These results provide novel toxicogenomic information and suggest distinct particle-associated mechanisms of neoplasia promotion induced by CNTs and asbestos...
  38. pmc Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States
    Nano Lett 11:2796-803. 2011
    ..This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process...
  39. doi request reprint Methods to analyze S-nitrosylation of proteins involved in apoptosis
    Neelam Azad
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA
    Methods Mol Biol 559:117-30. 2009
    ..To detect protein S-nitrosylation, we isolated the protein by immunoprecipitation and analyzed cysteine nitrosylation by Western blotting or spectrofluorometry...
  40. ncbi request reprint Nitric oxide negatively regulates Fas CD95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of FLICE inhibitory protein
    Pithi Chanvorachote
    Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 280:42044-50. 2005
    ..These findings indicate a novel pathway for NO regulation of FLIP that provides a key mechanism for apoptosis regulation and a potential new target for intervention in death receptor-associated diseases...
  41. ncbi request reprint Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophages
    Bin Lu
    Department of Basic Pharmaceutical Sciences, Health Sciences Center, West Virginia University, Morgantown 26506, USA
    Am J Physiol Cell Physiol 283:C831-8. 2002
    ....
  42. doi request reprint Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite
    Cody J Peer
    Department of Basic Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
    Xenobiotica 42:1170-7. 2012
    ....
  43. ncbi request reprint Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3
    Yongju Lu
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Cell Cycle 8:2101-9. 2009
    ..The pronounced expression of mdig in lung cancer tissues but not normal lung tissues, thus, suggests that mdig possesses oncogenic property through antagonizing tri-methyl lysine 9 on histone H3 and promoting ribosomal RNA synthesis...
  44. ncbi request reprint Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis
    Liying Wang
    National Institute for Occupational Safety and Health, Physiology and Pathology Research Branch, Morgantown, West Virginia 26505, USA
    J Cell Physiol 194:215-24. 2003
    ..Published 2002 Wiley-Liss, Inc...
  45. ncbi request reprint Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis
    Sudjit Luanpitpong
    Pharmaceutical and Pharmacological Sciences Program Mary Babb Randolph Cancer Center, West Virginia University, WV 26506, USA
    Oncotarget 5:3541-54. 2014
    ..Since CSCs are crucial to the initiation and early development of carcinogenesis, our findings on CSC induction by SWCNTs and Cav-1 could aid in the early detection and risk assessment of the disease. ..
  46. pmc Effect of fiber length on carbon nanotube-induced fibrogenesis
    Amruta Manke
    Department of Pharmaceutical Sciences, West Virginia University, 1, Medical Center Drive, Morgantown, WV 26506, USA
    Int J Mol Sci 15:7444-61. 2014
    ....
  47. pmc Chronic exposure to carbon nanotubes induces invasion of human mesothelial cells through matrix metalloproteinase-2
    Warangkana Lohcharoenkal
    Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, Department of Chemical Engineering, and Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, West Virginia 26506, United States
    ACS Nano 7:7711-23. 2013
    ..Knockdown of MMP-2 in CNT and asbestos-exposed cells by shRNA-mediated gene silencing effectively inhibited the aggressive phenotypes. This study demonstrates CNT-induced cell invasion and indicates the role of MMP-2 in the process. ..
  48. doi request reprint Inflammation and lung cancer: roles of reactive oxygen/nitrogen species
    Neelam Azad
    Department of Pharmaceutical and Pharmacological Sciences, West Virginia University, Morgantown, West Virginia, USA
    J Toxicol Environ Health B Crit Rev 11:1-15. 2008
    ..This review describes the complex relationship between lung inflammation and carcinogenesis, and highlights the role of ROS/RNS in cancer development...
  49. pmc AC927, a σ receptor ligand, blocks methamphetamine-induced release of dopamine and generation of reactive oxygen species in NG108-15 cells
    Nidhi Kaushal
    Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    Mol Pharmacol 81:299-308. 2012
    ..Together, the data suggest that modulation of σ receptors can mitigate methamphetamine-induced cytotoxicity, ROS/RNS generation, and dopamine release in cultured cells...
  50. ncbi request reprint Induction of neutrophil apoptosis and secondary necrosis during endotoxin-induced pulmonary inflammation in mice
    Djordje Medan
    Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    J Cell Physiol 191:320-6. 2002
    ..Because necrosis is associated with cell damage and release of histotoxic contents, this development is likely to play a role in determining the severity and duration of lung toxicity induced by endotoxin...
  51. pmc Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation
    Andrea Dorfleutner
    Mary Babb Randolph Cancer Center and Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, 2826 MBRCC, 1 Medical Center Drive, Morgantown, WV 26506 9300, USA
    Infect Immun 75:1484-92. 2007
    ..Existence of a second cPOP provides additional insights into inflammasome formation and suggests that POPs might be a common regulatory mechanism to "fine-tune" the activity of specific PYD-NLR family protein-containing inflammasomes...
  52. ncbi request reprint The effects of carbon nanotubes on lung and dermal cellular behaviors
    Sudjit Luanpitpong
    Pharmaceutical and Pharmacological Sciences Program, West Virginia University, WV 26506, USA
    Nanomedicine (Lond) 9:895-912. 2014
    ..We then examine the linkage of cellular behaviors and disease pathogenesis, and discuss the pertinent mechanisms. ..
  53. pmc Protein nanoparticles as drug delivery carriers for cancer therapy
    Warangkana Lohcharoenkal
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Biomed Res Int 2014:180549. 2014
    ..Finally, we discuss the applications of protein nanoparticles in cancer therapy. ..
  54. doi request reprint Exposure to carbon nanotubes leads to changes in the cellular biomechanics
    Chenbo Dong
    Department of Chemical Engineering, West Virginia University, Morgantown WV, 26506, USA
    Adv Healthc Mater 2:945-51. 2013
    ..Using nanoindentation, it is observed that the exposed cells have significantly higher stiffness when compared to controls, especially at the nuclear region, and significant increases in surface area. ..
  55. ncbi request reprint Protective roles of NF-kappa B for chromium(VI)-induced cytotoxicity is revealed by expression of Ikappa B kinase-beta mutant
    Fei Chen
    Health Effects Laboratory Division, NIOSH, Morgantown, West Virginia 26505, USA
    J Biol Chem 277:3342-9. 2002
    ..Such inhibition may involve up-regulation of the expression of anti-death proteins including cIAP1 that prevents spontaneous caspase activation and subsequent cleavage of Bcl-xL protein...
  56. ncbi request reprint Vaccine delivery--current trends and future
    Neelam Azad
    West Virginia University, School of Pharmacy, Department of Pharmaceutical Sciences, Morgantown, WV 26506, USA
    Curr Drug Deliv 3:137-46. 2006
    ..This review will focus on the current development of some novel vaccine delivery systems and will explore the non-parenteral routes of vaccine administration...