Vazhaikkurichi M Rajendran

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc Identification of functionally distinct Na-HCO3 co-transporters in colon
    Christian Barmeyer
    Department of Internal Medicine, Yale University, New Haven, Connecticut, USA
    PLoS ONE 8:e62864. 2013
  2. pmc Cyclic AMP-induced K+ secretion occurs independently of Cl- secretion in rat distal colon
    Geoffrey I Sandle
    Leeds Institute of Molecular Medicine, Saint James s University Hospital, Leeds, United Kingdom
    Am J Physiol Cell Physiol 303:C328-33. 2012
  3. pmc Aldosterone induces active K⁺ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon
    Satish K Singh
    Department of Medicine, Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    Am J Physiol Cell Physiol 302:C1353-60. 2012
  4. pmc Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line
    Kanthesh M Basalingappa
    Department of Biochemistry, West Virginia Univ School of Medicine, Morgantown, 26506, USA
    Am J Physiol Gastrointest Liver Physiol 301:G905-11. 2011
  5. ncbi request reprint Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells
    Christian Barmeyer
    Department of Internal Medicine, Yale University, P O Box 208019, New Haven, CT 06520, USA
    Pflugers Arch 454:441-50. 2007
  6. ncbi request reprint Role of short-chain fatty acids in colonic HCO(3) secretion
    Sadasivan Vidyasagar
    Dept of Internal Medicine, Yale Univ, PO Box 208019, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1217-26. 2005
  7. pmc Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon
    Christian Barmeyer
    Department of Internal Medicine, Yale University, New Haven, Connecticut, USA
    Am J Physiol Cell Physiol 299:C251-63. 2010
  8. ncbi request reprint Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum
    Sandeep B Subramanya
    Dept of Internal Medicine, Yale Univ School of Medicine, New Haven, CT 06520 8010, USA
    Am J Physiol Gastrointest Liver Physiol 293:G857-63. 2007
  9. ncbi request reprint Regulation of anion exchanger Slc26a6 by protein kinase C
    Hatim A Hassan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Cell Physiol 292:C1485-92. 2007
  10. ncbi request reprint Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
    Kazi Mirajul Hoque
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 288:G956-63. 2005

Research Grants

  1. MOLECULAR AND PHYSIOLOGIC STUDIES OF A COLONIC K ATPASE
    Vazhaikkurichi Rajendran; Fiscal Year: 2002
  2. MOLECULAR AND PHYSIOLOGIC STUDIES OF A COLONIC K ATPASE
    Vazhaikkurichi Rajendran; Fiscal Year: 2005
  3. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2006
  4. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2007
  5. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2006
  6. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2009
  7. Role of IK channels in rat distal colon
    Vazhaikkurichi M Rajendran; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. pmc Identification of functionally distinct Na-HCO3 co-transporters in colon
    Christian Barmeyer
    Department of Internal Medicine, Yale University, New Haven, Connecticut, USA
    PLoS ONE 8:e62864. 2013
    ..We also conclude that NBCn1C/D regulates HCO3-dependent HOE694-insensitive Na-HCO3 cotransport and plays a critical role in pHi regulation in colonic epithelial cells...
  2. pmc Cyclic AMP-induced K+ secretion occurs independently of Cl- secretion in rat distal colon
    Geoffrey I Sandle
    Leeds Institute of Molecular Medicine, Saint James s University Hospital, Leeds, United Kingdom
    Am J Physiol Cell Physiol 303:C328-33. 2012
    ..On the other hand, cAMP-induced colonic Cl(-) secretion requires the activity of Kcnn4b channels located in the basolateral membrane and is not dependent on the concurrent activation of apical Kcnma1 channels...
  3. pmc Aldosterone induces active K⁺ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon
    Satish K Singh
    Department of Medicine, Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    Am J Physiol Cell Physiol 302:C1353-60. 2012
    ..These observations indicate that aldosterone induces active K(+) secretion by enhancing mucosal Kcnn4c and Kcnma1 expression at the transcriptional level...
  4. pmc Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line
    Kanthesh M Basalingappa
    Department of Biochemistry, West Virginia Univ School of Medicine, Morgantown, 26506, USA
    Am J Physiol Gastrointest Liver Physiol 301:G905-11. 2011
    ..The expression of both isoforms in IEC-18 cells was confirmed by RT-PCR and Western blot analyses. This is the first characterization of Kcnn4 channels in the apical membrane of intestinal epithelial cells...
  5. ncbi request reprint Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells
    Christian Barmeyer
    Department of Internal Medicine, Yale University, P O Box 208019, New Haven, CT 06520, USA
    Pflugers Arch 454:441-50. 2007
    ..We speculate that, in addition to mediating pH-sensitive Cl(-) uptake, rDRA may function as a modifier of other anion transport proteins...
  6. ncbi request reprint Role of short-chain fatty acids in colonic HCO(3) secretion
    Sadasivan Vidyasagar
    Dept of Internal Medicine, Yale Univ, PO Box 208019, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1217-26. 2005
    ....
  7. pmc Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon
    Christian Barmeyer
    Department of Internal Medicine, Yale University, New Haven, Connecticut, USA
    Am J Physiol Cell Physiol 299:C251-63. 2010
    ..6 +/- 0.1 and 7.8 +/- 0.4 muM, respectively. We conclude that apical and basolateral KCNN4 K(+) channels that regulate K(+) and anion secretion are encoded by distinct isoforms in colonic epithelial cells...
  8. ncbi request reprint Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum
    Sandeep B Subramanya
    Dept of Internal Medicine, Yale Univ School of Medicine, New Haven, CT 06520 8010, USA
    Am J Physiol Gastrointest Liver Physiol 293:G857-63. 2007
    ..Butyrate restores both CT-inhibited NHE2 and NHE3 activities to normal levels but via different mechanisms...
  9. ncbi request reprint Regulation of anion exchanger Slc26a6 by protein kinase C
    Hatim A Hassan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Cell Physiol 292:C1485-92. 2007
    ..We conclude that multiple modes of anion exchange mediated by Slc26a6 are negatively regulated by PKC-delta activation...
  10. ncbi request reprint Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
    Kazi Mirajul Hoque
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 288:G956-63. 2005
    ..Zn had no effect on bumetanide-sensitive 86Rb uptake, Na-K-ATPase, or CFTR. We conclude from these studies that Zn inhibits cAMP-induced Cl secretion by blocking basolateral membrane K channels...
  11. ncbi request reprint Three distinct mechanisms of HCO3- secretion in rat distal colon
    Sadasivan Vidyasagar
    Dept of Internal Medicine, Yale University, PO Box 208019, New Haven, CT 06520, USA
    Am J Physiol Cell Physiol 287:C612-21. 2004
    ....
  12. ncbi request reprint Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon
    Selvi Krishnan
    Department of Internal Medicine, Yale University, PO Box 208019, New Haven, CT 06520 8019, USA
    Am J Physiol Cell Physiol 285:C1246-54. 2003
    ..Dibutyryl cAMP does not inhibit butyrate-stimulated Na absorption as a result of its differential effects on NHE-2 and NHE-3 isoforms...
  13. ncbi request reprint Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon
    Mutsuhiro Ikuma
    Department of Internal Medicine, Yale University, 333 Cedar St, New Haven, Connecticut 06520, USA
    Am J Physiol Cell Physiol 285:C912-21. 2003
    ....
  14. pmc Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans
    S Sendhil Velan
    Center for Advanced Imaging and Radiology, West Virginia Univ, Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1060-5. 2008
    ..We conclude that important aspects of lipid metabolism can be evaluated by two-dimensional MRS and propose that degree of unsaturation measured noninvasively may serve as a biomarker for lipid metabolic defects associated with obesity...
  15. ncbi request reprint Cloning and expression of a chloride-dependent Na+-H+ exchanger
    Pitchai Sangan
    Department of Internal Medicine, Yale University, New Haven, Connecticut 06520 8019, USA
    J Biol Chem 277:9668-75. 2002
    ..Based on these results we predict that chloride-dependent Na(+)-H(+) exchange represents a new class of Na(+)-H(+) exchangers that may regulate ion transport in several organs...
  16. ncbi request reprint Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon
    William J Joiner
    Department of Internal Medicine, Yale University, 333 Cedar Street, P O Box 208019, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 285:G185-96. 2003
    ..These results suggest that the rSK4 channel mediates K+ secretion induced by muscarinic agonists in the rat proximal colon and that transcription of the rSK4 channel is downregulated to prevent K+ loss during dietary K+ depletion...
  17. ncbi request reprint Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6
    Zhirong Jiang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 38:474-8. 2006
    ..We conclude that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis...

Research Grants8

  1. MOLECULAR AND PHYSIOLOGIC STUDIES OF A COLONIC K ATPASE
    Vazhaikkurichi Rajendran; Fiscal Year: 2002
    ..This proposal certainly has relevance to clinical medicine and would enhance our knowledge of potassium transport. ..
  2. MOLECULAR AND PHYSIOLOGIC STUDIES OF A COLONIC K ATPASE
    Vazhaikkurichi Rajendran; Fiscal Year: 2005
    ..This proposal certainly has relevance to clinical medicine and would enhance our knowledge of potassium transport. ..
  3. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2006
    ..Therefore, the apparent distinct roles of CCH-induced K+ channels will be investigated and correlated with functional studies. ..
  4. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2007
    ..Therefore, the apparent distinct roles of CCH-induced K+ channels will be investigated and correlated with functional studies. ..
  5. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2006
    ..Therefore, the apparent distinct roles of CCH-induced K+ channels will be investigated and correlated with functional studies. ..
  6. Role of IK channels in rat distal colon
    Vazhaikkurichi Rajendran; Fiscal Year: 2009
    ..Therefore, the apparent distinct roles of CCH-induced K+ channels will be investigated and correlated with functional studies. ..
  7. Role of IK channels in rat distal colon
    Vazhaikkurichi M Rajendran; Fiscal Year: 2010
    ..Therefore, the apparent distinct roles of CCH-induced K+ channels will be investigated and correlated with functional studies. ..