Ming Pei

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. doi request reprint Repair of large animal partial-thickness cartilage defects through intraarticular injection of matrix-rejuvenated synovium-derived stem cells
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part A 19:1144-54. 2013
  2. pmc Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Stem Cells Dev 22:889-900. 2013
  3. pmc Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potential
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Tissue Eng Part A 17:3067-76. 2011
  4. doi request reprint Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Spine (Phila Pa 1976) 37:1538-47. 2012
  5. pmc Extracellular matrix deposited by synovium-derived stem cells delays replicative senescent chondrocyte dedifferentiation and enhances redifferentiation
    Ming Pei
    Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    J Cell Physiol 227:2163-74. 2012
  6. doi request reprint Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defects
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, P O Box 9196, One Medical Center Drive, Morgantown, West Virginia 26506 9196, USA
    J Orthop Res 28:1064-70. 2010
  7. doi request reprint Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
  8. pmc Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 3943 Health Sciences Center South, PO Box 9196, Morgantown, WV 26506 9196, USA
    Clin Orthop Relat Res 466:1880-9. 2008
  9. doi request reprint Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs
    M Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Osteoarthritis Cartilage 17:714-22. 2009
  10. doi request reprint Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    J Pineal Res 46:181-7. 2009

Collaborators

Detail Information

Publications29

  1. doi request reprint Repair of large animal partial-thickness cartilage defects through intraarticular injection of matrix-rejuvenated synovium-derived stem cells
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part A 19:1144-54. 2013
    ..Our approach could lead to a tissue-specific cell expansion system providing large-quantity and high-quality stem cells for the treatment of cartilage defects...
  2. pmc Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Stem Cells Dev 22:889-900. 2013
    ..DSCM could be a promising cell expansion system to provide a large number of high-quality hSDSCs for cartilage regeneration in a harsh joint environment...
  3. pmc Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potential
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Tissue Eng Part A 17:3067-76. 2011
    ..ECM deposited by hBMSCs may be a promising approach to expand BMSCs from elderly patients for the treatment of large-scale bone defects through endochondral bone formation...
  4. doi request reprint Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Spine (Phila Pa 1976) 37:1538-47. 2012
    ..Experiment 2 evaluated the effect of DECM deposited by SDSCs on NPC expansion and redifferentiation capacity. In both experiments, hypoxia was evaluated in DECM preparation and pellet culture...
  5. pmc Extracellular matrix deposited by synovium-derived stem cells delays replicative senescent chondrocyte dedifferentiation and enhances redifferentiation
    Ming Pei
    Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    J Cell Physiol 227:2163-74. 2012
    ....
  6. doi request reprint Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defects
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, P O Box 9196, One Medical Center Drive, Morgantown, West Virginia 26506 9196, USA
    J Orthop Res 28:1064-70. 2010
    ..Our study suggested that SDSC-based xenogeneic tissue constructs might cause delayed immune rejection. Xenotransplantation may not be an appropriate approach to repair osteochondral defects...
  7. doi request reprint Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
    ..The mechanism underlying this process needs further investigation...
  8. pmc Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 3943 Health Sciences Center South, PO Box 9196, Morgantown, WV 26506 9196, USA
    Clin Orthop Relat Res 466:1880-9. 2008
    ..We thus propose functional cartilage constructs could be engineered in vitro through the use of negatively isolated SDSCs...
  9. doi request reprint Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs
    M Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Osteoarthritis Cartilage 17:714-22. 2009
    ....
  10. doi request reprint Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    J Pineal Res 46:181-7. 2009
    ..Melatonin may prove to be a highly valuable addition to current therapeutic models for degenerative cartilage repair...
  11. pmc Synovium-derived stem cell-based chondrogenesis
    Ming Pei
    Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Differentiation 76:1044-56. 2008
    ....
  12. doi request reprint Extracellular matrix enhances differentiation of adipose stem cells from infrapatellar fat pad toward chondrogenesis
    Fan He
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, Morgantown, WV 26506, USA
    J Tissue Eng Regen Med 7:73-84. 2013
    ..Our study indicates that the sequential application of ECM for cell expansion and combined TGFβ3 with BMP-6 for chondrogenic differentiation may be a promising approach for ASC-based cartilage tissue engineering and regeneration...
  13. doi request reprint Creation of an in vitro microenvironment to enhance human fetal synovium-derived stem cell chondrogenesis
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, Morgantown, WV 26506 9196, USA
    Cell Tissue Res 345:357-65. 2011
    ..hfSDSCs might represent a promising cell source for cartilage tissue engineering and regeneration...
  14. doi request reprint Optimization of an in vitro three-dimensional microenvironment to reprogram synovium-derived stem cells for cartilage tissue engineering
    Jingting Li
    Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Tissue Eng Part A 17:703-12. 2011
    ..Our study indicates that the three-dimensional microenvironment for ex vivo expansion can be optimized to provide high-quality stem cells for stem cell-based cartilage defect repair...
  15. doi request reprint Reconstruction of an in vitro tissue-specific microenvironment to rejuvenate synovium-derived stem cells for cartilage tissue engineering
    Fan He
    Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506, USA
    Tissue Eng Part A 15:3809-21. 2009
    ..The ability to reconstitute the in vitro stem cell niche will greatly benefit SDSC-based therapy for cartilage defects...
  16. pmc Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV
    Yingjie Guan
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Am J Physiol Cell Physiol 303:C33-40. 2012
    ..Thus, CaMKIV plays an important regulatory role during chondrocyte differentiation...
  17. doi request reprint Coculture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of transforming growth factor-beta1: a potential application of tissue-specific stem cells in disc regeneration
    Song Chen
    Tissue Engineering Laboratory, Department of Orthopaedics, WV University, Morgantown, WV 26506 9196, USA
    Spine (Phila Pa 1976) 34:1272-80. 2009
    ..Cultures of either SDSCs or NPCs alone served as controls...
  18. doi request reprint Rejuvenation of nucleus pulposus cells using extracellular matrix deposited by synovium-derived stem cells
    Fan He
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Spine (Phila Pa 1976) 37:459-69. 2012
    ..After plating for 6 passages on either plastic flasks or extracellular matrix (ECM) deposited by synovium-derived stem cells (SDSCs), expanded nucleus pulposus (NP) cells were evaluated for redifferentiation capacity...
  19. pmc Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration
    Mark Shoukry
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Stem Cells Dev 22:1162-76. 2013
    ..Many aspects of NP behavior are still unknown, which could lead to future work yielding key information on producing sufficient numbers of a high-quality NP-specific population that is able to regenerate deteriorated NP in vivo...
  20. doi request reprint Meniscus reconstruction through coculturing meniscus cells with synovium-derived stem cells on small intestine submucosa--a pilot study to engineer meniscus tissue constructs
    Yunbing Tan
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia, USA
    Tissue Eng Part A 16:67-79. 2010
    ..This pilot study demonstrates the advantages of coculturing MCs with SDSCs on SIS for meniscus tissue engineering and regeneration...
  21. doi request reprint Synovium-derived stem cells: a tissue-specific stem cell for cartilage engineering and regeneration
    Brendan A Jones
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part B Rev 18:301-11. 2012
    ....
  22. pmc Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation
    Lei Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
    Dev Biol 341:236-45. 2010
    ..This suggests a positive feedback loop of stimulation of chondrocyte hypertrophy by SDF-1/CXCR4, which is mediated by Runx2...
  23. pmc CD14-negative isolation enhances chondrogenesis in synovial fibroblasts
    Bahar Bilgen
    Department of Orthopaedics, Alpert Medical School of Brown University and Center for Restorative and Regenerative Medicine, Providence VA Medical Center and Brown University, Providence, Rhode Island 02903, USA
    Tissue Eng Part A 15:3261-70. 2009
    ..This study demonstrates that the CD14-negative isolation yields an enhanced cell population SFB that is more potent than MSCP as a cell source for cartilage tissue engineering...
  24. doi request reprint Cell senescence: a challenge in cartilage engineering and regeneration
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part B Rev 18:270-87. 2012
    ..Some potential signaling pathways in cell senescence will also be discussed for their potential involvement in cartilage regeneration despite the fact that comprehensive mechanisms are still under investigation...
  25. doi request reprint Rejuvenation of chondrogenic potential in a young stem cell microenvironment
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, One Medical Center Drive, Morgantown, WV 26506, USA Department of Exercise Physiology, West Virginia University, Morgantown, WV 26506, USA
    Biomaterials 35:642-53. 2014
    ..MAPK and noncanonical Wnt signals were actively involved in ECM-mediated adult SDSC rejuvenation...
  26. doi request reprint Can arthroscopically harvested synovial stem cells be preferentially sorted using stage-specific embryonic antigen 4 antibody for cartilage, bone, and adipose regeneration?
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia, U S A Department of Exercise Physiology, West Virginia University, Morgantown, West Virginia, U S A
    Arthroscopy 30:352-61. 2014
    ..The aim of this study was to investigate the relation between stage-specific embryonic antigen 4 (SSEA4) expression and synovium-derived stem cell (SDSC) lineage differentiation...
  27. ncbi request reprint Morphology controllable nanostructured chitosan matrix and its cytocompatibility
    Lifeng Qi
    Department of Orthopaedics, Tissue Engineering Laboratory, West Virginia University, Morgantown, WV 26506, USA
    J Biomed Mater Res A 87:236-44. 2008
    ..CSM was found to be cytocompatible with human foreskin fibroblasts suggesting that the nanofibrous surface morphology and crystalline structure of CSM could favor cell spread and growth...
  28. ncbi request reprint Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabric
    Jan Boublik
    Division of Health Sciences and Technology, Center for Space Research, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Tissue Eng 11:1122-32. 2005
    ..Together, the data showed that hybrid cardiac constructs initially exhibited supraphysiologic UTS, epsilon(f), and E, and remodeled in response to serum and stretch in vitro and in an ectopic in vivo model...
  29. ncbi request reprint Bioreactors mediate the effectiveness of tissue engineering scaffolds
    Ming Pei
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    FASEB J 16:1691-4. 2002
    ..The data imply that interactions between bioreactors and 3D tissue engineering scaffolds can be utilized to improve the structure, function, and molecular properties of in vitro-generated cartilage...