Ming Pei


Affiliation: West Virginia University
Country: USA


  1. Pei M, Zhang Y, Li J, Chen D. Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis. Stem Cells Dev. 2013;22:889-900 pubmed publisher
    ..DSCM could be a promising cell expansion system to provide a large number of high-quality hSDSCs for cartilage regeneration in a harsh joint environment. ..
  2. Zhou S, Chen S, Jiang Q, Pei M. Determinants of stem cell lineage differentiation toward chondrogenesis versus adipogenesis. Cell Mol Life Sci. 2019;76:1653-1680 pubmed publisher
    ..An in-depth understanding of overlap and discrepancy between these two mesenchymal tissues in lineage differentiation would benefit regeneration of high-quality cartilage tissues and adipose tissues for clinical applications. ..
  3. Pei M, Shoukry M, Li J, Daffner S, France J, Emery S. Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration. Spine (Phila Pa 1976). 2012;37:1538-47 pubmed publisher
    ..Low oxygen in a pellet culture system enhanced NPC viability and redifferentiation. The in vitro microenvironment can be modulated by low oxygen and tissue-specific cell-based DECM to facilitate NP tissue regeneration. ..
  4. Pei M, He F, Wei L, Rawson A. Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes. J Pineal Res. 2009;46:181-7 pubmed publisher
    ..Melatonin may prove to be a highly valuable addition to current therapeutic models for degenerative cartilage repair. ..
  5. Zhang Y, Li J, Davis M, Pei M. Delineation of in vitro chondrogenesis of human synovial stem cells following preconditioning using decellularized matrix. Acta Biomater. 2015;20:39-50 pubmed publisher
  6. Sun Y, Yan L, Chen S, Pei M. Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources. Acta Biomater. 2018;74:56-73 pubmed publisher
    ..This information is expected to provide an update for dECM based cartilage regeneration. ..
  7. Zhang Y, Pizzute T, Li J, He F, Pei M. sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment - A feasible approach for autologous stem cell based osteoarthritic cartilage repair. Biomaterials. 2015;64:88-97 pubmed publisher
    ..Combined rejuvenation with sb203580 and dECM expansion can precondition hSDSCs' resurfacing capacity for osteoarthritic patients with cartilage defects. ..
  8. Jayasuriya C, Zhou F, Pei M, Wang Z, Lemme N, Haines P, et al. Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells. Int J Mol Sci. 2014;15:14555-73 pubmed publisher
    ..Our data suggest that chondroprogenitor cells should be considered as a potential target of chondrodysplasia therapy. ..
  9. Pei M, Li J, McConda D, Wen S, Clovis N, Danley S. A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats. Bone. 2015;78:1-10 pubmed publisher
    ..Our results indicated that ASC based tissue constructs are more beneficial for the repair of calvarial defects in NORM rats while implantation of PLGA scaffold contributed to defect regeneration in OVX rats. ..

More Information


  1. Pei M, He F, Kish V, Vunjak Novakovic G. Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study. Clin Orthop Relat Res. 2008;466:1880-9 pubmed publisher
    ..We thus propose functional cartilage constructs could be engineered in vitro through the use of negatively isolated SDSCs. ..
  2. Pei M, Li J, Zhang Y, Liu G, Wei L, Zhang Y. Expansion on a matrix deposited by nonchondrogenic urine stem cells strengthens the chondrogenic capacity of repeated-passage bone marrow stromal cells. Cell Tissue Res. 2014;356:391-403 pubmed publisher
    ..This study also provides an excellent model for investigating the effect of trophic factors released by stem cells on tissue regeneration without interference by stem cell differentiation. ..
  3. Pei M, He F. Extracellular matrix deposited by synovium-derived stem cells delays replicative senescent chondrocyte dedifferentiation and enhances redifferentiation. J Cell Physiol. 2012;227:2163-74 pubmed publisher
  4. Pei M. Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential. Biomaterials. 2017;117:10-23 pubmed publisher
  5. Chen S, Fu P, Wu H, Pei M. Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function. Cell Tissue Res. 2017;370:53-70 pubmed publisher
    ..The goal of this paper is to provide researchers with the fundamental knowledge to correctly engineer the meniscus, AC and NP without inadvertently developing the wrong tissue function or biochemistry. ..
  6. Li J, Pei M. A Protocol to Prepare Decellularized Stem Cell Matrix for Rejuvenation of Cell Expansion and Cartilage Regeneration. Methods Mol Biol. 2018;1577:147-154 pubmed publisher
    ..The decellularized stem cell matrix (DSCM) might be a powerful system for tissue engineering and regeneration. ..
  7. Pei M, Chen D, Li J, Wei L. Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy. Differentiation. 2009;78:260-8 pubmed publisher
    ..The mechanism underlying this process needs further investigation. ..
  8. Pei M, He F, Vunjak Novakovic G. Synovium-derived stem cell-based chondrogenesis. Differentiation. 2008;76:1044-56 pubmed publisher