Affiliation: West Virginia University
Pei M, Shoukry M, Li J, Daffner S, France J, Emery S. Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration. Spine (Phila Pa 1976). 2012;37:1538-47 pubmed publisher
..Low oxygen in a pellet culture system enhanced NPC viability and redifferentiation. The in vitro microenvironment can be modulated by low oxygen and tissue-specific cell-based DECM to facilitate NP tissue regeneration. ..
Pei M, He F, Wei L, Rawson A. Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes. J Pineal Res. 2009;46:181-7 pubmed publisher
..Melatonin may prove to be a highly valuable addition to current therapeutic models for degenerative cartilage repair. ..
Zhang Y, Li J, Davis M, Pei M. Delineation of in vitro chondrogenesis of human synovial stem cells following preconditioning using decellularized matrix. Acta Biomater. 2015;20:39-50 pubmed publisher
Zhang Y, Pizzute T, Li J, He F, Pei M. sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment - A feasible approach for autologous stem cell based osteoarthritic cartilage repair. Biomaterials. 2015;64:88-97 pubmed publisher
..Combined rejuvenation with sb203580 and dECM expansion can precondition hSDSCs' resurfacing capacity for osteoarthritic patients with cartilage defects. ..
Sun Y, Yan L, Chen S, Pei M. Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources. Acta Biomater. 2018;74:56-73 pubmed publisher
..This information is expected to provide an update for dECM based cartilage regeneration. ..
Pei M, He F, Kish V, Vunjak Novakovic G. Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study. Clin Orthop Relat Res. 2008;466:1880-9 pubmed publisher
..We thus propose functional cartilage constructs could be engineered in vitro through the use of negatively isolated SDSCs. ..
Pei M, Li J, Zhang Y, Liu G, Wei L, Zhang Y. Expansion on a matrix deposited by nonchondrogenic urine stem cells strengthens the chondrogenic capacity of repeated-passage bone marrow stromal cells. Cell Tissue Res. 2014;356:391-403 pubmed publisher
..This study also provides an excellent model for investigating the effect of trophic factors released by stem cells on tissue regeneration without interference by stem cell differentiation. ..
Jayasuriya C, Zhou F, Pei M, Wang Z, Lemme N, Haines P, et al
. Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-Î² in chondroprogenitor cells. Int J Mol Sci. 2014;15:14555-73 pubmed publisher
..Our data suggest that chondroprogenitor cells should be considered as a potential target of chondrodysplasia therapy. ..
Pei M, Li J, McConda D, Wen S, Clovis N, Danley S. A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats. Bone. 2015;78:1-10 pubmed publisher
..Our results indicated that ASC based tissue constructs are more beneficial for the repair of calvarial defects in NORM rats while implantation of PLGA scaffold contributed to defect regeneration in OVX rats. ..