Ming Pei

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc Expansion on a matrix deposited by nonchondrogenic urine stem cells strengthens the chondrogenic capacity of repeated-passage bone marrow stromal cells
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, One Medical Center Drive, Morgantown, WV, 26506 9196, USA
    Cell Tissue Res 356:391-403. 2014
  2. ncbi request reprint Repair of large animal partial-thickness cartilage defects through intraarticular injection of matrix-rejuvenated synovium-derived stem cells
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part A 19:1144-54. 2013
  3. pmc Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Stem Cells Dev 22:889-900. 2013
  4. pmc Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potential
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Tissue Eng Part A 17:3067-76. 2011
  5. ncbi request reprint Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Spine (Phila Pa 1976) 37:1538-47. 2012
  6. pmc Extracellular matrix deposited by synovium-derived stem cells delays replicative senescent chondrocyte dedifferentiation and enhances redifferentiation
    Ming Pei
    Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    J Cell Physiol 227:2163-74. 2012
  7. ncbi request reprint Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
  8. ncbi request reprint Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs
    M Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Osteoarthritis Cartilage 17:714-22. 2009
  9. ncbi request reprint Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    J Pineal Res 46:181-7. 2009
  10. pmc Synovium-derived stem cell-based chondrogenesis
    Ming Pei
    Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Differentiation 76:1044-56. 2008

Collaborators

Detail Information

Publications35

  1. pmc Expansion on a matrix deposited by nonchondrogenic urine stem cells strengthens the chondrogenic capacity of repeated-passage bone marrow stromal cells
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, One Medical Center Drive, Morgantown, WV, 26506 9196, USA
    Cell Tissue Res 356:391-403. 2014
    ..This study also provides an excellent model for investigating the effect of trophic factors released by stem cells on tissue regeneration without interference by stem cell differentiation. ..
  2. ncbi request reprint Repair of large animal partial-thickness cartilage defects through intraarticular injection of matrix-rejuvenated synovium-derived stem cells
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part A 19:1144-54. 2013
    ..Our approach could lead to a tissue-specific cell expansion system providing large-quantity and high-quality stem cells for the treatment of cartilage defects...
  3. pmc Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Stem Cells Dev 22:889-900. 2013
    ..DSCM could be a promising cell expansion system to provide a large number of high-quality hSDSCs for cartilage regeneration in a harsh joint environment...
  4. pmc Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potential
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Tissue Eng Part A 17:3067-76. 2011
    ..ECM deposited by hBMSCs may be a promising approach to expand BMSCs from elderly patients for the treatment of large-scale bone defects through endochondral bone formation...
  5. ncbi request reprint Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Spine (Phila Pa 1976) 37:1538-47. 2012
    ..Experiment 2 evaluated the effect of DECM deposited by SDSCs on NPC expansion and redifferentiation capacity. In both experiments, hypoxia was evaluated in DECM preparation and pellet culture...
  6. pmc Extracellular matrix deposited by synovium-derived stem cells delays replicative senescent chondrocyte dedifferentiation and enhances redifferentiation
    Ming Pei
    Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    J Cell Physiol 227:2163-74. 2012
    ....
  7. ncbi request reprint Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
    Differentiation 78:260-8. 2009
    ..The mechanism underlying this process needs further investigation...
  8. ncbi request reprint Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs
    M Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Osteoarthritis Cartilage 17:714-22. 2009
    ....
  9. ncbi request reprint Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    J Pineal Res 46:181-7. 2009
    ..Melatonin may prove to be a highly valuable addition to current therapeutic models for degenerative cartilage repair...
  10. pmc Synovium-derived stem cell-based chondrogenesis
    Ming Pei
    Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
    Differentiation 76:1044-56. 2008
    ....
  11. pmc Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 3943 Health Sciences Center South, PO Box 9196, Morgantown, WV 26506 9196, USA
    Clin Orthop Relat Res 466:1880-9. 2008
    ..We thus propose functional cartilage constructs could be engineered in vitro through the use of negatively isolated SDSCs...
  12. ncbi request reprint Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defects
    Ming Pei
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, P O Box 9196, One Medical Center Drive, Morgantown, West Virginia 26506 9196, USA
    J Orthop Res 28:1064-70. 2010
    ..Our study suggested that SDSC-based xenogeneic tissue constructs might cause delayed immune rejection. Xenotransplantation may not be an appropriate approach to repair osteochondral defects...
  13. ncbi request reprint Can arthroscopically harvested synovial stem cells be preferentially sorted using stage-specific embryonic antigen 4 antibody for cartilage, bone, and adipose regeneration?
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia, U S A Department of Exercise Physiology, West Virginia University, Morgantown, West Virginia, U S A
    Arthroscopy 30:352-61. 2014
    ..The aim of this study was to investigate the relation between stage-specific embryonic antigen 4 (SSEA4) expression and synovium-derived stem cell (SDSC) lineage differentiation...
  14. ncbi request reprint Extracellular matrix enhances differentiation of adipose stem cells from infrapatellar fat pad toward chondrogenesis
    Fan He
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, Morgantown, WV 26506, USA
    J Tissue Eng Regen Med 7:73-84. 2013
    ..Our study indicates that the sequential application of ECM for cell expansion and combined TGFβ3 with BMP-6 for chondrogenic differentiation may be a promising approach for ASC-based cartilage tissue engineering and regeneration...
  15. ncbi request reprint Optimization of an in vitro three-dimensional microenvironment to reprogram synovium-derived stem cells for cartilage tissue engineering
    Jingting Li
    Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
    Tissue Eng Part A 17:703-12. 2011
    ..Our study indicates that the three-dimensional microenvironment for ex vivo expansion can be optimized to provide high-quality stem cells for stem cell-based cartilage defect repair...
  16. ncbi request reprint Creation of an in vitro microenvironment to enhance human fetal synovium-derived stem cell chondrogenesis
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, Morgantown, WV 26506 9196, USA
    Cell Tissue Res 345:357-65. 2011
    ..hfSDSCs might represent a promising cell source for cartilage tissue engineering and regeneration...
  17. ncbi request reprint Reconstruction of an in vitro tissue-specific microenvironment to rejuvenate synovium-derived stem cells for cartilage tissue engineering
    Fan He
    Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506, USA
    Tissue Eng Part A 15:3809-21. 2009
    ..The ability to reconstitute the in vitro stem cell niche will greatly benefit SDSC-based therapy for cartilage defects...
  18. ncbi request reprint Rejuvenation of chondrogenic potential in a young stem cell microenvironment
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, One Medical Center Drive, Morgantown, WV 26506, USA Department of Exercise Physiology, West Virginia University, Morgantown, WV 26506, USA
    Biomaterials 35:642-53. 2014
    ..MAPK and noncanonical Wnt signals were actively involved in ECM-mediated adult SDSC rejuvenation...
  19. pmc Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV
    Yingjie Guan
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Am J Physiol Cell Physiol 303:C33-40. 2012
    ..Thus, CaMKIV plays an important regulatory role during chondrocyte differentiation...
  20. ncbi request reprint Coculture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of transforming growth factor-beta1: a potential application of tissue-specific stem cells in disc regeneration
    Song Chen
    Tissue Engineering Laboratory, Department of Orthopaedics, WV University, Morgantown, WV 26506 9196, USA
    Spine (Phila Pa 1976) 34:1272-80. 2009
    ..Cultures of either SDSCs or NPCs alone served as controls...
  21. ncbi request reprint Rejuvenation of nucleus pulposus cells using extracellular matrix deposited by synovium-derived stem cells
    Fan He
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Spine (Phila Pa 1976) 37:459-69. 2012
    ..After plating for 6 passages on either plastic flasks or extracellular matrix (ECM) deposited by synovium-derived stem cells (SDSCs), expanded nucleus pulposus (NP) cells were evaluated for redifferentiation capacity...
  22. ncbi request reprint Meniscus reconstruction through coculturing meniscus cells with synovium-derived stem cells on small intestine submucosa--a pilot study to engineer meniscus tissue constructs
    Yunbing Tan
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia, USA
    Tissue Eng Part A 16:67-79. 2010
    ..This pilot study demonstrates the advantages of coculturing MCs with SDSCs on SIS for meniscus tissue engineering and regeneration...
  23. pmc Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration
    Mark Shoukry
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Stem Cells Dev 22:1162-76. 2013
    ..Many aspects of NP behavior are still unknown, which could lead to future work yielding key information on producing sufficient numbers of a high-quality NP-specific population that is able to regenerate deteriorated NP in vivo...
  24. ncbi request reprint Synovium-derived stem cells: a tissue-specific stem cell for cartilage engineering and regeneration
    Brendan A Jones
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part B Rev 18:301-11. 2012
    ....
  25. pmc CD14-negative isolation enhances chondrogenesis in synovial fibroblasts
    Bahar Bilgen
    Department of Orthopaedics, Alpert Medical School of Brown University and Center for Restorative and Regenerative Medicine, Providence VA Medical Center and Brown University, Providence, Rhode Island 02903, USA
    Tissue Eng Part A 15:3261-70. 2009
    ..This study demonstrates that the CD14-negative isolation yields an enhanced cell population SFB that is more potent than MSCP as a cell source for cartilage tissue engineering...
  26. pmc Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation
    Lei Wei
    Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
    Dev Biol 341:236-45. 2010
    ..This suggests a positive feedback loop of stimulation of chondrocyte hypertrophy by SDF-1/CXCR4, which is mediated by Runx2...
  27. ncbi request reprint Cell senescence: a challenge in cartilage engineering and regeneration
    Jingting Li
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
    Tissue Eng Part B Rev 18:270-87. 2012
    ..Some potential signaling pathways in cell senescence will also be discussed for their potential involvement in cartilage regeneration despite the fact that comprehensive mechanisms are still under investigation...
  28. ncbi request reprint Anti-inflammatory strategies in cartilage repair
    Ying Zhang
    1 Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia
    Tissue Eng Part B Rev 20:655-68. 2014
    ..These strategies could be combined to boost cartilage repair under inflammatory conditions. ..
  29. ncbi request reprint Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells
    Chathuraka T Jayasuriya
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, CORO West, Suite 402A, 1 Hoppin Street, Providence, RI 02903, USA
    Int J Mol Sci 15:14555-73. 2014
    ..Our data suggest that chondroprogenitor cells should be considered as a potential target of chondrodysplasia therapy. ..
  30. ncbi request reprint Extracellular matrix modulates the biological effects of melatonin in mesenchymal stem cells
    Fan He
    School of EngineeringSun Yat sen University, No 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, ChinaOrthopaedic InstituteSoochow University, No 708 Renmin Road, Suzhou, Jiangsu 215007, ChinaDepartment of OrthopaedicsThe First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaNanfang HospitalSouthern Medical University, Guangzhou 510515, ChinaStem Cell and Tissue Engineering LaboratoryDepartment of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506, USA School of EngineeringSun Yat sen University, No 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, ChinaOrthopaedic InstituteSoochow University, No 708 Renmin Road, Suzhou, Jiangsu 215007, ChinaDepartment of OrthopaedicsThe First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaNanfang HospitalSouthern Medical University, Guangzhou 510515, ChinaStem Cell and Tissue Engineering LaboratoryDepartment of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506, USA School of EngineeringSun Yat sen University, No 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, Philadelphia
    J Endocrinol 223:167-80. 2014
    ..Moreover, a better understanding of the enhancement of MSC growth and osteogenic differentiation resulting from the combination of ECM and melatonin could improve the design of graft substitutes for skeletal tissue engineering. ..
  31. ncbi request reprint A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration
    Ying Zhang
    Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, One Medical Center Drive, Morgantown, WV 26506 9196, USA
    Cell Tissue Res 358:633-49. 2014
    ..We also discuss the interactions between MAPK and Wnt signaling with respect to cartilage-related diseases such as osteoarthritis and explore potential therapeutic targets for disease treatments...
  32. pmc Significance of epigenetic landscape in cartilage regeneration from the cartilage development and pathology perspective
    Jingting Li
    1 Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia
    Stem Cells Dev 23:1178-94. 2014
    ..Progress in understanding epigenetic regulatory mechanisms could benefit cartilage regeneration and engineering on a larger scale and provide more promising therapeutic applications. ..
  33. ncbi request reprint Morphology controllable nanostructured chitosan matrix and its cytocompatibility
    Lifeng Qi
    Department of Orthopaedics, Tissue Engineering Laboratory, West Virginia University, Morgantown, WV 26506, USA
    J Biomed Mater Res A 87:236-44. 2008
    ..CSM was found to be cytocompatible with human foreskin fibroblasts suggesting that the nanofibrous surface morphology and crystalline structure of CSM could favor cell spread and growth...
  34. ncbi request reprint Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabric
    Jan Boublik
    Division of Health Sciences and Technology, Center for Space Research, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Tissue Eng 11:1122-32. 2005
    ..Together, the data showed that hybrid cardiac constructs initially exhibited supraphysiologic UTS, epsilon(f), and E, and remodeled in response to serum and stretch in vitro and in an ectopic in vivo model...
  35. ncbi request reprint Bioreactors mediate the effectiveness of tissue engineering scaffolds
    Ming Pei
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    FASEB J 16:1691-4. 2002
    ..The data imply that interactions between bioreactors and 3D tissue engineering scaffolds can be utilized to improve the structure, function, and molecular properties of in vitro-generated cartilage...