Research Topics
Genomes and Genes | Ming PeiSummaryAffiliation: West Virginia University Country: USA Publications
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Publications
Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesisMing Pei
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
Stem Cells Dev 22:889-900. 2013..DSCM could be a promising cell expansion system to provide a large number of high-quality hSDSCs for cartilage regeneration in a harsh joint environment...- Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potentialMing Pei
Stem Cell and Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
Tissue Eng Part A 17:3067-76. 2011..ECM deposited by hBMSCs may be a promising approach to expand BMSCs from elderly patients for the treatment of large-scale bone defects through endochondral bone formation... 
Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regenerationMing Pei
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
Spine (Phila Pa 1976) 37:1538-47. 2012..Experiment 2 evaluated the effect of DECM deposited by SDSCs on NPC expansion and redifferentiation capacity. In both experiments, hypoxia was evaluated in DECM preparation and pellet culture...- Extracellular matrix deposited by synovium-derived stem cells delays replicative senescent chondrocyte dedifferentiation and enhances redifferentiationMing Pei
Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
J Cell Physiol 227:2163-74. 2012.... - Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defectsMing Pei
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, P O Box 9196, One Medical Center Drive, Morgantown, West Virginia 26506 9196, USA
J Orthop Res 28:1064-70. 2010..Our study suggested that SDSC-based xenogeneic tissue constructs might cause delayed immune rejection. Xenotransplantation may not be an appropriate approach to repair osteochondral defects... - Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructsM Pei
Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
Osteoarthritis Cartilage 17:714-22. 2009.... - Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytesMing Pei
Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
J Pineal Res 46:181-7. 2009..Melatonin may prove to be a highly valuable addition to current therapeutic models for degenerative cartilage repair... - Synovium-derived stem cell-based chondrogenesisMing Pei
Department of Orthopaedics, West Virginia University, Morgantown, WV 26506, USA
Differentiation 76:1044-56. 2008.... - Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary studyMing Pei
Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 3943 Health Sciences Center South, PO Box 9196, Morgantown, WV 26506 9196, USA
Clin Orthop Relat Res 466:1880-9. 2008..We thus propose functional cartilage constructs could be engineered in vitro through the use of negatively isolated SDSCs... - Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophyMing Pei
Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, Morgantown, WV 26506, USA
Differentiation 78:260-8. 2009..The mechanism underlying this process needs further investigation... - Optimization of an in vitro three-dimensional microenvironment to reprogram synovium-derived stem cells for cartilage tissue engineeringJingting Li
Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, WV 26506 9196, USA
Tissue Eng Part A 17:703-12. 2011..Our study indicates that the three-dimensional microenvironment for ex vivo expansion can be optimized to provide high-quality stem cells for stem cell-based cartilage defect repair... - Creation of an in vitro microenvironment to enhance human fetal synovium-derived stem cell chondrogenesisJingting Li
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, Morgantown, WV 26506 9196, USA
Cell Tissue Res 345:357-65. 2011..hfSDSCs might represent a promising cell source for cartilage tissue engineering and regeneration... - Reconstruction of an in vitro tissue-specific microenvironment to rejuvenate synovium-derived stem cells for cartilage tissue engineeringFan He
Tissue Engineering Laboratory, Division of Exercise Physiology, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506, USA
Tissue Eng Part A 15:3809-21. 2009..The ability to reconstitute the in vitro stem cell niche will greatly benefit SDSC-based therapy for cartilage defects... - Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IVYingjie Guan
Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
Am J Physiol Cell Physiol 303:C33-40. 2012..Thus, CaMKIV plays an important regulatory role during chondrocyte differentiation... - Coculture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of transforming growth factor-beta1: a potential application of tissue-specific stem cells in disc regenerationSong Chen
Tissue Engineering Laboratory, Department of Orthopaedics, WV University, Morgantown, WV 26506 9196, USA
Spine (Phila Pa 1976) 34:1272-80. 2009..Cultures of either SDSCs or NPCs alone served as controls... - Rejuvenation of nucleus pulposus cells using extracellular matrix deposited by synovium-derived stem cellsFan He
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
Spine (Phila Pa 1976) 37:459-69. 2012..After plating for 6 passages on either plastic flasks or extracellular matrix (ECM) deposited by synovium-derived stem cells (SDSCs), expanded nucleus pulposus (NP) cells were evaluated for redifferentiation capacity... - Meniscus reconstruction through coculturing meniscus cells with synovium-derived stem cells on small intestine submucosa--a pilot study to engineer meniscus tissue constructsYunbing Tan
Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia, USA
Tissue Eng Part A 16:67-79. 2010..This pilot study demonstrates the advantages of coculturing MCs with SDSCs on SIS for meniscus tissue engineering and regeneration... - Synovium-derived stem cells: a tissue-specific stem cell for cartilage engineering and regenerationBrendan A Jones
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
Tissue Eng Part B Rev 18:301-11. 2012.... - Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formationLei Wei
Department of Orthopaedics, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Suite 402A, 1 Hoppin Street, Providence RI 02903, USA
Dev Biol 341:236-45. 2010..This suggests a positive feedback loop of stimulation of chondrocyte hypertrophy by SDF-1/CXCR4, which is mediated by Runx2... - CD14-negative isolation enhances chondrogenesis in synovial fibroblastsBahar Bilgen
Department of Orthopaedics, Alpert Medical School of Brown University and Center for Restorative and Regenerative Medicine, Providence VA Medical Center and Brown University, Providence, Rhode Island 02903, USA
Tissue Eng Part A 15:3261-70. 2009..This study demonstrates that the CD14-negative isolation yields an enhanced cell population SFB that is more potent than MSCP as a cell source for cartilage tissue engineering... - Cell senescence: a challenge in cartilage engineering and regenerationJingting Li
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
Tissue Eng Part B Rev 18:270-87. 2012..Some potential signaling pathways in cell senescence will also be discussed for their potential involvement in cartilage regeneration despite the fact that comprehensive mechanisms are still under investigation... - Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regenerationMark Shoukry
1 Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia
Stem Cells Dev 22:1162-76. 2013..Many aspects of NP behavior are still unknown, which could lead to future work yielding key information on producing sufficient numbers of a high-quality NP-specific population that is able to regenerate deteriorated NP in vivo... - Repair of large animal partial-thickness cartilage defects through intraarticular injection of matrix-rejuvenated synovium-derived stem cellsMing Pei
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506 9196, USA
Tissue Eng Part A 19:1144-54. 2013..Our approach could lead to a tissue-specific cell expansion system providing large-quantity and high-quality stem cells for the treatment of cartilage defects... - Extracellular matrix enhances differentiation of adipose stem cells from infrapatellar fat pad toward chondrogenesisFan He
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, Morgantown, WV 26506, USA
J Tissue Eng Regen Med 7:73-84. 2013..Copyright © 2011 John Wiley & Sons, Ltd... 
Morphology controllable nanostructured chitosan matrix and its cytocompatibilityLifeng Qi
Department of Orthopaedics, Tissue Engineering Laboratory, West Virginia University, Morgantown, WV 26506, USA
J Biomed Mater Res A 87:236-44. 2008..CSM was found to be cytocompatible with human foreskin fibroblasts suggesting that the nanofibrous surface morphology and crystalline structure of CSM could favor cell spread and growth...- Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabricJan Boublik
Division of Health Sciences and Technology, Center for Space Research, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
Tissue Eng 11:1122-32. 2005..Together, the data showed that hybrid cardiac constructs initially exhibited supraphysiologic UTS, epsilon(f), and E, and remodeled in response to serum and stretch in vitro and in an ectopic in vivo model... - Bioreactors mediate the effectiveness of tissue engineering scaffoldsMing Pei
Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
FASEB J 16:1691-4. 2002..The data imply that interactions between bioreactors and 3D tissue engineering scaffolds can be utilized to improve the structure, function, and molecular properties of in vitro-generated cartilage...