Mohammed A Nayeem

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ
    Mohammed A Nayeem
    Dept of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, USA
    Am J Physiol Regul Integr Comp Physiol 304:R23-32. 2013
  2. pmc High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases
    Mohammed A Nayeem
    Dept of Physiology and Pharmacology, Center for Interdisciplinary Research in Cardiovascular Sciences, Health Science Center North, 1 Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 296:R567-74. 2009
  3. pmc Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase
    Mohammed A Nayeem
    Department of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    Am J Physiol Regul Integr Comp Physiol 299:R325-33. 2010
  4. pmc Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase
    Mohammed A Nayeem
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA
    Mol Cell Biochem 350:101-11. 2011
  5. pmc Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice
    Mohammed A Nayeem
    Department of Physiology and Pharmacology, Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 295:H2068-78. 2008
  6. pmc Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice
    Dovenia S Ponnoth
    Dept of Physiology and Pharmacology, School of Medicine, West Virginia Univ, Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 302:R400-8. 2012
  7. pmc CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels
    Dovenia S Ponnoth
    Dept of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, West Virginia Univ, Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 303:R1003-10. 2012
  8. pmc Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2
    Swati S Kunduri
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506 9229, USA
    J Cardiovasc Pharmacol 62:78-83. 2013

Collaborators

Detail Information

Publications8

  1. pmc Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ
    Mohammed A Nayeem
    Dept of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, USA
    Am J Physiol Regul Integr Comp Physiol 304:R23-32. 2013
    ..4% to +9.40 ± 3.1) CGS 21680-induced relaxation in sEH(-/-). Our data suggest that adenosine-induced relaxation in sEH(-/-) may depend on the upregulation of A(2A) AR, CYP2J, and PPARγ, and the downregulation of A(1) AR and PPARα...
  2. pmc High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases
    Mohammed A Nayeem
    Dept of Physiology and Pharmacology, Center for Interdisciplinary Research in Cardiovascular Sciences, Health Science Center North, 1 Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 296:R567-74. 2009
    ..These data suggest that HS may activate CYP2C29 via A(2A) AR, causing relaxation, whereas NS may contribute to the upregulation of CYP4A causing contraction...
  3. pmc Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase
    Mohammed A Nayeem
    Department of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    Am J Physiol Regul Integr Comp Physiol 299:R325-33. 2010
    ..However, in mice fed HS-containing diet, upregulation of A(2A) receptor protein triggers vascular relaxation through ATP-sensitive (K(+)) channels via upregulation of CYP2J2 enzyme...
  4. pmc Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase
    Mohammed A Nayeem
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA
    Mol Cell Biochem 350:101-11. 2011
    ..05). These data suggest that NS causes reduced-vasodilation in both eNOS(+/+) and eNOS(-/-) via sEH and CYP4A. However, HS triggers possible A(2A)AR-induced relaxation through CYP epoxygenase in both eNOS(+/+) and eNOS(-/-)...
  5. pmc Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice
    Mohammed A Nayeem
    Department of Physiology and Pharmacology, Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 295:H2068-78. 2008
    ..It is concluded that CYP epoxygenases play an important role in A2A AR-mediated relaxation, and the deletion of the A2A AR leads to contraction through Cyp4a...
  6. pmc Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice
    Dovenia S Ponnoth
    Dept of Physiology and Pharmacology, School of Medicine, West Virginia Univ, Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 302:R400-8. 2012
    ..These data suggest that, in the absence of A(2A)AR, Cyp4a induces vasoconstriction through MAPK via upregulation of A(1)AR and PKC-α...
  7. pmc CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels
    Dovenia S Ponnoth
    Dept of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, West Virginia Univ, Morgantown, WV 26506, USA
    Am J Physiol Regul Integr Comp Physiol 303:R1003-10. 2012
    ..Our data suggest that A(2A)AR-mediated vasorelaxation occurs through opening of sarcolemmal K(ATP) channels via CYP-epoxygenases and possibly, nitric oxide, contributing to pinacidil-induced responses...
  8. pmc Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2
    Swati S Kunduri
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506 9229, USA
    J Cardiovasc Pharmacol 62:78-83. 2013
    ..Our data indicate that A1AR mediates smooth muscle contraction via CYP4a and a PKC-α-ERK1/2 pathway...