Research Topics
Genomes and Genes | Jia LuoSummaryAffiliation: West Virginia University Country: USA Publications
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Publications
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapyJia Luo
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
Cancer Lett 273:194-200. 2009..This mini-review discusses the role of GSK3beta in tumorigenesis/cancer progression as well as its modulation of cancer chemotherapy...
The role of matrix metalloproteinases in the morphogenesis of the cerebellar cortexJia Luo
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, West Virginia, USA
Cerebellum 4:239-45. 2005..The potential contributions of these enzymes to granule neuron migration, Purkinje cell dendritogenesis and synaptogenesis are discussed...- Induction or suppression of expression of cytochrome C oxidase subunit II by heregulin beta 1 in human mammary epithelial cells is dependent on the levels of ErbB2 expressionYanbo Sun
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9177, USA
J Cell Physiol 192:225-33. 2002..This is the first report demonstrating that the expression of mitochondria-encoded COXII is HRG-responsive. The levels of ErbB2 expression are decisive for the diverse biological activities of HRG... - Role of matrix metalloproteinase-2 in ethanol-induced invasion by breast cancer cellsJia Luo
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
J Gastroenterol Hepatol 21:S65-8. 2006..The conditioned medium collected from ethanol-exposed fibroblasts dramatically stimulates the invasion of breast cancer cells. The role of MMP-2 in ethanol-induced tumor promotion is discussed... - Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitroJia Luo
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Science Center, Morgantown, West Virginia 26506, USA
J Biol Chem 278:4542-51. 2003..Thus, JNK signaling plays a major role in vanadate-mediated activation of the Fas-FADD-caspase-8 pathway that accounts for vanadate-induced apoptosis of CGPs... 
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cellsCuiling Ma
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
J Biol Chem 283:9248-56. 2008..The formation of an ERK.GSK3beta complex retained pERK1/2 in the cytoplasm. In contrast, disruption of the ERK.GSK3beta complex resulted in nuclear translocation of pERK1/2 and offered protection...- Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitroCuiling Ma
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
Oncogene 22:5281-90. 2003..Our study suggests that overexpression of ErbB2 may augment ethanol-elicited signaling and promote ethanol-stimulated tumor metastasis... - Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stressGang Chen
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
J Neurosci Res 86:937-46. 2008..We further demonstrated that CHOP played an important role in ethanol-promoted cell death. Thus, the effect of ethanol may be mediated by the interaction between oxidative stress and ER stress... - The role of glycogen synthase kinase 3beta in the transformation of epidermal cellsCuiling Ma
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, WV, USA
Cancer Res 67:7756-64. 2007..Together, these results indicate that GSK3beta plays an important role in skin tumorigenesis... - Epidermal growth factor up-regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase- and phosphatidylinositol-3-kinase-dependent pathwaysYunfeng Zhu
Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown 26506, USA
Exp Cell Res 280:97-106. 2002..Disruption of mitochondrial homeostasis is a general characteristic of tumorigenic transformation. Thus, the role of Lon in tumor promotion warrants further study... - Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesisYong Qian
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Nihon Arukoru Yakubutsu Igakkai Zasshi 42:605-9. 2007 - Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal deathGang Chen
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
FASEB J 18:1162-4. 2004..These results suggest that GSK3beta is a critical intermediate in pro-apoptotic signaling cascades that are associated with neurodegenerative diseases, thus providing a potential target site amenable to pharmacological intervention... - The role of epidermal growth factor receptor in ethanol-mediated inhibition of activator protein-1 transactivationCuiling Ma
Department of Microbiology, Immunology and Cell Biology, West Virginia University, School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506, USA
Biochem Pharmacol 69:1785-94. 2005..Thus, EGFR plays a critical role in the interaction between ethanol and AP-1... - Brain-derived neurotrophic factor suppresses tunicamycin-induced upregulation of CHOP in neuronsGang Chen
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
J Neurosci Res 85:1674-84. 2007..Our study thus suggests that suppression of CHOP activation may contribute to BDNF-mediated neuroprotection during ER stress responses... - Vanadate activated Akt and promoted S phase entryZhuo Zhang
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Mol Cell Biochem 255:227-37. 2004..The present study indicates that Akt plays an essential role in vanadate-induced increase in cell number at S phase and transition from G1 to S phase through E2F-pRb pathway... - Ethanol-induced in vitro invasion of breast cancer cells: the contribution of MMP-2 by fibroblastsMoe Moe Aye
Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, WV, USA
Int J Cancer 112:738-46. 2004..Thus, ethanol-promoted breast cancer cell invasion may be mediated by the modulation of fibroblastic MMP-2... - Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neuronsGang Chen
Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
J Biol Chem 281:15909-15. 2006..Our results suggest that the interactions between PKR and PACT/RAX modulate the effect of ethanol on protein synthesis and cell survival in the central nervous system... - Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in mouse epidermal cellsCuiling Ma
Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Science Center, Morgantown, West Virginia 26506, USA
J Biol Chem 278:44265-72. 2003.... - Effects of prenatal exposure to ethanol on the cyclin-dependent kinase system in the developing rat cerebellumZheng Li
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Science Center, P O Box 9177, Morgantown, WV 26506, USA
Brain Res Dev Brain Res 139:237-45. 2002..Thus, prenatal exposure to ethanol disturbed the expression of cell cycle machineries in the postnatal cerebellum. This may account for the teratogenic effects of ethanol on the developing cerebellum... - Acute stretch promotes endothelial cell proliferation in wounded healing mouse skinCarl D Shrader
Department of Neurobiology and Anatomy, School of Medicine, West Virginia University, Morgantown, WV, 26506 9128, USA
Arch Dermatol Res 300:495-504. 2008.... - Activation of nuclear factor kappa B by diesel exhaust particles in mouse epidermal cells through phosphatidylinositol 3-kinase/Akt signaling pathwayCuiling Ma
Department of Microbiology, Immunology and Cell Biology, Robert C. Byrd Health Science Center, West Virginia University School of Medicine, Morgantown, WV 26506, USA
Biochem Pharmacol 67:1975-83. 2004..DEP had little effect on the phosphorylation of ERKs and p38 MAPK. Thus, DEP-induced transactivation of NF-kappaB is mediated by PI3K/Akt signaling pathway... - Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesisYong Qian
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J Biol Chem 278:16189-97. 2003..Taken together, our results suggest that ethanol stimulation can induce H(2)O(2) production through the activation of Cdc42, which results in reorganizing actin filaments and increasing cell motility and in vitro angiogenesis... - Developmental expression of matrix metalloproteinases 2 and 9 and their potential role in the histogenesis of the cerebellar cortexAlbert E Ayoub
Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
J Comp Neurol 481:403-15. 2005..Thus, MMP-2 and MMP-9 play a role in the postnatal cerebellar morphogenesis... - Identification of genes induced by rapid intraoperative tissue expansion in mouse skinYunfeng Zhu
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown 26506-9177, USA
Arch Dermatol Res 293:560-8. 2002..This is the first reported study to show that L1, myotubularin and insulin I are responsive to rapid hemispherical and not rapid linear stretch... - Effects of ethanol and transforming growth factor beta (TGF beta) on neuronal proliferation and nCAM expressionMichael W Miller
Department of Neuroscience and Physiology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Alcohol Clin Exp Res 26:1281-5. 2002..Ethanol alters these phenomena as well. Thus, in neurons, as in astrocytes, TGFbeta1 and ethanol may interact... - MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2Zunji Ke
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China
Int J Cancer 119:8-16. 2006..Thus, ethanol-stimulated invasion of cells over-expressing ErbB2 was mediated, at least partially, by MMP-2 activation... - Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cellsHua Yao
Graduate Center for Toxicology, College of Medicine, The University of Kentucky, Lexington, KY 40503, USA
Int J Cancer 123:1255-61. 2008.... - Oxidative stress and chromium(VI) carcinogenesisHua Yao
Graduate Center for Toxicology, College of Medicine, The University of Kentucky, Lexington, KY 40515, USA
J Environ Pathol Toxicol Oncol 27:77-88. 2008..This article also covers the relationship between Cr(VI)-induced oxidative stress and activation of transcription factors NF-kappaB, AP-1, p53, and hypoxia-inducible factor 1, regulation of cell cycle, and induction of apoptosis... - GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cellsYuan Yuan Chen
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, PR China
Biochem Pharmacol 76:128-38. 2008..Taken together, the results suggest that GSK3beta activation and ER stress contribute separately to rotenone cytotoxicity... - Effects of ethanol and basic fibroblast growth factor on the transforming growth factor beta1 regulated proliferation of cortical astrocytes and C6 astrocytoma cellsMichael W Miller
Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Alcohol Clin Exp Res 26:671-6. 2002..The effects of ethanol on transforming growth factor beta1 (TGFbeta1)-regulated proliferation of primary cultured cortical astrocytes and C6 astrocytoma cells were determined... - Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoterJing Liu
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China
Int J Oncol 21:661-6. 2002..These results indicated that hTERT promoter could target the suicidal effect of CD gene to tumor cells, and therefore, may be a novel and promising targeting approach to the treatment of cancer... - [Effects of Carthamus tinctorius injection on bcl-2, caspase-3 expression related to neurons apoptosis after local cerebral ischemia]Jia Luo
Pharmacology Department, West China Medical Center of Sichuan University, Chengdu 610041, China
Zhongguo Zhong Yao Za Zhi 29:977-80. 2004..05). CONCLUSION: C. tinctorius injection can reduce the volume of cerebral infarction, and increased bcl-2 and decreased caspase-3 expression... - Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neuronsXin Wang
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Neurochem 103:2380-90. 2007..Antioxidant vitamin E dramatically decreased the RAX/PKR association and ameliorated TD-induced cell death. Our results indicate that TD-induced neuronal death is at least partially mediated by the activation of PKR... - Subthalamic GAD gene therapy in a Parkinson's disease rat modelJia Luo
Functional Genomics and Translational Neuroscience Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Science 298:425-9. 2002..This strategy suggests that there is plasticity between excitatory and inhibitory neurotransmission in the mammalian brain that could be exploited for therapeutic benefit... - Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPAJingxia Li
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Oncogene 22:211-9. 2003....
Research Grants
- The rpL7a in neuronal developmentJia Luo; Fiscal Year: 2006..Furthermore, the studies will provide an important insight into the mechanisms of extra-ribosomal function of ribosomal proteins. ..