G W Konat

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. ncbi request reprint Higher order chromatin degradation in glial cells: the role of calcium
    G W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Neurochem Int 39:179-86. 2001
  2. ncbi request reprint Hydrogen peroxide mediates higher order chromatin degradation
    H Bai
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Neurochem Int 42:123-9. 2003
  3. doi request reprint Peripheral challenge with double-stranded RNA elicits global up-regulation of cytokine gene expression in the brain
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    J Neurosci Res 87:1381-8. 2009
  4. ncbi request reprint Generation of high efficiency ssDNA hybridization probes by linear polymerase chain reaction (LPCR)
    G W Konat
    Department of Anatomy, West Virginia University School of Medicine, Morgantown 26506 9128, USA
    Scanning Microsc Suppl 10:57-60. 1996
  5. pmc The role of Toll-like receptors in CNS response to microbial challenge
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    J Neurochem 99:1-12. 2006
  6. doi request reprint Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSCN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Metab Brain Dis 23:325-33. 2008
  7. ncbi request reprint H2O2-induced higher order chromatin degradation: a novel mechanism of oxidative genotoxicity
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, PO Box 9128 Morgantown, WV 26506 9128, USA
    J Biosci 28:57-60. 2003
  8. ncbi request reprint Toxicity of compound A to C6 rat glioma cells
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    Metab Brain Dis 18:11-5. 2003
  9. ncbi request reprint Higher order chromatin degradation: implications for neurodegeneration
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, West Virginia 26506 9128, USA
    Neurochem Res 27:1447-51. 2002
  10. ncbi request reprint Statins enhance toll-like receptor 4-mediated cytokine gene expression in astrocytes: implication of Rho proteins in negative feedback regulation
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    J Neurosci Res 86:603-9. 2008

Research Grants

  1. Toll-Like Receptor 3 Activation in Astrocytes
    GREGORY KONAT; Fiscal Year: 2006

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Higher order chromatin degradation in glial cells: the role of calcium
    G W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Neurochem Int 39:179-86. 2001
    ....
  2. ncbi request reprint Hydrogen peroxide mediates higher order chromatin degradation
    H Bai
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Neurochem Int 42:123-9. 2003
    ....
  3. doi request reprint Peripheral challenge with double-stranded RNA elicits global up-regulation of cytokine gene expression in the brain
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    J Neurosci Res 87:1381-8. 2009
    ..However, the endothelial NOS message was initially down-regulated and subsequently up-regulated, indicating stimulation of cerebral vasculature...
  4. ncbi request reprint Generation of high efficiency ssDNA hybridization probes by linear polymerase chain reaction (LPCR)
    G W Konat
    Department of Anatomy, West Virginia University School of Medicine, Morgantown 26506 9128, USA
    Scanning Microsc Suppl 10:57-60. 1996
    ..The ssDNA probes may be particularly suitable for nucleic acid detection in tissues by in situ hybridization...
  5. pmc The role of Toll-like receptors in CNS response to microbial challenge
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    J Neurochem 99:1-12. 2006
    ..Although Toll-like receptor signaling is essential in antimicrobial defense, it may also lead to bystander injury of CNS tissue...
  6. doi request reprint Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSCN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Metab Brain Dis 23:325-33. 2008
    ..Moreover, the results strongly indicate that the damaging effect is mediated by oxidative stress, as memory dysfunction is preventable by the co-administration of NAC...
  7. ncbi request reprint H2O2-induced higher order chromatin degradation: a novel mechanism of oxidative genotoxicity
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, PO Box 9128 Morgantown, WV 26506 9128, USA
    J Biosci 28:57-60. 2003
    ..Although H2O2-induced HOCD can efficiently dismantle the genome leading to cell death, under sublethal oxidative stress conditions H2O2-induced HOCD may be the major source of somatic mutations...
  8. ncbi request reprint Toxicity of compound A to C6 rat glioma cells
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    Metab Brain Dis 18:11-5. 2003
    ..However, the relatively high doses of Compound A used to observe its effects do not support the toxicity of Compound A to glial cells under clinical conditions...
  9. ncbi request reprint Higher order chromatin degradation: implications for neurodegeneration
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, West Virginia 26506 9128, USA
    Neurochem Res 27:1447-51. 2002
    ..If unrepaired of improperly repaired, such a partial fragmentation leads to the generation and accumulation of somatic mutations that are likely to play the key role in delayed degeneration and death of neural cells...
  10. ncbi request reprint Statins enhance toll-like receptor 4-mediated cytokine gene expression in astrocytes: implication of Rho proteins in negative feedback regulation
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    J Neurosci Res 86:603-9. 2008
    ..These results indicate that the Rho proteins are involved in the activation of negative feedback inhibition of TLR4 signaling in astrocytes...
  11. doi request reprint Rho proteins are negative regulators of TLR2, TLR3, and TLR4 signaling in astrocytes
    Elizabeth Borysiewicz
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Neurosci Res 87:1565-72. 2009
    ..These results suggest that Rho proteins control TLR-mediated up-regulation of inflammatory genes in astrocytes by interfering with multiple events along the signaling pathways...
  12. doi request reprint TLR3 ligation protects human astrocytes against oxidative stress
    E Borysiewicz
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 1 Medical Center Dr, Morgantown, WV 26506, USA
    J Neuroimmunol 255:54-9. 2013
    ..Out of 13 major antioxidative genes only the gene encoding superoxide dismutase 2 (SOD2) was postligationally upregulated suggesting that SOD2 is the major enzyme responsible for this protection...
  13. ncbi request reprint Kinetics of inflammatory response of astrocytes induced by TLR 3 and TLR4 ligation
    Alicja Krasowska-Zoladek
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    J Neurosci Res 85:205-12. 2007
    ..The cells also became refractory to subsequent stimulation by the ligands indicating the existence of negative feedback mechanisms that control proinflammatory response in astrocytes...
  14. pmc Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels
    Deya S Darwish
    Department of Neurobiology and Anatomy, Blanchette Rockefeller Neurosciences Institute, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Behav Neurosci 124:115-23. 2010
    ....
  15. doi request reprint Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis
    Harvinder S Dod
    Section of Cardiology, Department of Medicine, West Virginia University, Morgantown, West Virginia, USA
    Am J Cardiol 105:362-7. 2010
    ..Significant improvement in FMD, C-reactive protein, and interleukin-6 with intensive lifestyle changes in the experimental group suggests > or = 1 potential mechanism underlying the clinical benefits seen in previous trials...
  16. doi request reprint Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes
    Elizabeth Borysiewicz
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Metab Brain Dis 24:481-91. 2009
    ..These results demonstrate that the phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes, and that its up-regulation at the protein level is controlled by complex mechanisms...
  17. ncbi request reprint Nucleotides induce higher order chromatin degradation
    Monika Banaszewska
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, 26506 9128, USA
    Mol Cell Biochem 282:39-43. 2006
    ..Furthermore, other nucleotides including NADP(+), ATP, UTP, GTP, and CTP were also found to induce HOCD in isolated nuclei indicating that HOCD is controlled by nucleotide-related ligands...
  18. pmc Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1
    Islam R Younis
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    J Pharmacol Exp Ther 327:770-6. 2008
    ....
  19. doi request reprint Insulin enhances proliferation and viability of human umbilical vein endothelial cells
    Carl D Shrader
    Department of Neurobiology and Anatomy, School of Medicine, West Virginia University, Morgantown, WV 26506 9128, USA
    Arch Dermatol Res 301:159-66. 2009
    ..These data provide new insights into the beneficial effects of insulin on vascularization and tissue viability, providing a mechanistic link to the enhancement of healing in acutely stretched skin...
  20. ncbi request reprint Vulnerability of brain tissue to inflammatory oxidant, hypochlorous acid
    Alicja Krasowska
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSCN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Brain Res 997:176-84. 2004
    ....
  21. ncbi request reprint Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation
    Madhu Sanga
    Department of Basic Pharmaceutical Sciences, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 211:148-56. 2006
    ..Exposure of cultured C6 glial cells to (S,S)-phenylpropylene oxide produced a cytotoxic response in a concentration-dependent manner based on cell degeneration and death...
  22. ncbi request reprint BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven
    Timothy Wiltshire
    Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV 26506 9300, USA
    Mol Pharmacol 71:1051-60. 2007
    ..Furthermore, we found that BRCA1 deficiency results in increased chromosome damage and chemosensitivity after irofulven treatment...

Research Grants1

  1. Toll-Like Receptor 3 Activation in Astrocytes
    GREGORY KONAT; Fiscal Year: 2006
    ..Moreover, because TLR3 can also be activated by RNA released from damaged cells, the outcomes of this study will also be applicable to neurodegenerative conditions of non-viral etiology. ..