Jason Huber

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. ncbi Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats
    Vincent A Dinapoli
    Department of Neurosurgery, West Virginia University, School of Medicine, Morgantown, WV 26506 9183, USA
    Neurobiol Aging 29:753-64. 2008
  2. ncbi Diabetes, cognitive function, and the blood-brain barrier
    J D Huber
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Curr Pharm Des 14:1594-600. 2008
  3. ncbi Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats
    Jason D Huber
    Dept of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 291:H2660-8. 2006
  4. ncbi Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after lambda-carrageenan-induced inflammatory pain
    J D Huber
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, USA
    Am J Physiol Heart Circ Physiol 290:H732-40. 2006
  5. ncbi Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations
    Tracy A Brooks
    Department of Medical Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Ave, Tucson, AZ 85724-5050, USA
    Am J Physiol Heart Circ Physiol 289:H738-43. 2005
  6. ncbi Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution
    Brian T Hawkins
    Program in Neuroscience, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Brain Res 1027:48-58. 2004
  7. ncbi Viability of microvascular endothelial cells to direct exposure of formalin, lambda-carrageenan, and complete Freund's adjuvant
    Jason D Huber
    Departments of Pharmacology, Physiology, and Neurosciences, The University of Arizona College of Medicine, 1501 N. Campbell Avenue, P.O. Box 24-5050, Tucson, AZ 85724, USA
    Eur J Pharmacol 450:297-304. 2002
  8. ncbi Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature
    Karen S Mark
    University of Arizona, 1501 N. Campbell, PO 245050, Tucson, AZ 85724-5050, USA
    Am J Physiol Heart Circ Physiol 286:H174-80. 2004
  9. ncbi Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB
    Rachel C Brown
    Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ, USA
    J Cell Sci 116:693-700. 2003
  10. ncbi Pain and the blood-brain barrier: obstacles to drug delivery
    Anne M Wolka
    Department of Pharmacology, University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA
    Adv Drug Deliv Rev 55:987-1006. 2003

Research Grants

  1. VARIOUS PAIN STATES ON OPIOID TRANSPORT ACROSS THE BBB
    Jason Huber; Fiscal Year: 2003
  2. Age influences neuropoietic signaling at the neurovascular unit following stroke
    Jason Huber; Fiscal Year: 2009
  3. Age influences neuropoietic signaling at the neurovascular unit following stroke
    Jason D Huber; Fiscal Year: 2010
  4. Age influences neuropoietic signaling at the neurovascular unit following stroke
    Jason D Huber; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. ncbi Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats
    Vincent A Dinapoli
    Department of Neurosurgery, West Virginia University, School of Medicine, Morgantown, WV 26506 9183, USA
    Neurobiol Aging 29:753-64. 2008
    ..Results indicate that aged rats suffer larger infarctions, reduced functional recovery and increased BBB disruption preceding observable neuronal injury...
  2. ncbi Diabetes, cognitive function, and the blood-brain barrier
    J D Huber
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Curr Pharm Des 14:1594-600. 2008
    ....
  3. ncbi Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats
    Jason D Huber
    Dept of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 291:H2660-8. 2006
    ..Overall, results of this study suggest that diabetes-induced perturbations to cerebral microvessels may disrupt homeostasis and contribute to long-term cognitive and functional deficits of the central nervous system...
  4. ncbi Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after lambda-carrageenan-induced inflammatory pain
    J D Huber
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, USA
    Am J Physiol Heart Circ Physiol 290:H732-40. 2006
    ....
  5. ncbi Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations
    Tracy A Brooks
    Department of Medical Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Ave, Tucson, AZ 85724-5050, USA
    Am J Physiol Heart Circ Physiol 289:H738-43. 2005
    ..This study demonstrates that during chronic inflammatory pain, alterations in BBB function are associated with changes in specific transmembrane TJ proteins...
  6. ncbi Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution
    Brian T Hawkins
    Program in Neuroscience, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Brain Res 1027:48-58. 2004
    ..It is proposed that nicotine leads to changes in BBB permeability via the modulation of TJ proteins...
  7. ncbi Viability of microvascular endothelial cells to direct exposure of formalin, lambda-carrageenan, and complete Freund's adjuvant
    Jason D Huber
    Departments of Pharmacology, Physiology, and Neurosciences, The University of Arizona College of Medicine, 1501 N. Campbell Avenue, P.O. Box 24-5050, Tucson, AZ 85724, USA
    Eur J Pharmacol 450:297-304. 2002
    ....
  8. ncbi Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature
    Karen S Mark
    University of Arizona, 1501 N. Campbell, PO 245050, Tucson, AZ 85724-5050, USA
    Am J Physiol Heart Circ Physiol 286:H174-80. 2004
    ..Results from this study suggest that hypoxia-induced blood-brain barrier breakdown can be diminished by inhibition of NO synthesis, decreased concentration of NO metabolites, and/or reoxygenation...
  9. ncbi Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB
    Rachel C Brown
    Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ, USA
    J Cell Sci 116:693-700. 2003
    ..Treatment with C6-conditioned media for 1 or 3 days protects against hypoxia-induced permeability increases, and this protective effect may be mediated by signal transduction pathways terminating at the transcription factor NFkappaB...
  10. ncbi Pain and the blood-brain barrier: obstacles to drug delivery
    Anne M Wolka
    Department of Pharmacology, University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA
    Adv Drug Deliv Rev 55:987-1006. 2003
    ....
  11. ncbi Differential effects of diabetes on rat choroid plexus ion transporter expression
    Richard D Egleton
    Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Diabetes 52:1496-501. 2003
    ..These changes in expression may affect choroid plexus ion balance and thus significantly affect CSF production in diabetic rats...
  12. ncbi Pluronic p85 block copolymer enhances opioid peptide analgesia
    Ken A Witt
    Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    J Pharmacol Exp Ther 303:760-7. 2002
    ..01% P85 increased (125)I-DPDPE and [(3)H]morphine uptake. In our examination, we determined that P85 enhanced the analgesic profile of biphalin, DPDPE, and morphine, both above and below the critical micelle concentration...
  13. ncbi Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II
    Vincent S Hau
    Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Avenue, Tucson, Arizona 85724, USA
    J Pharm Sci 91:2140-9. 2002
    ..The analgesic profiles show that both Pro(4)-substitution and cationization enhance i.v. analgesia and thus, are promising structural modifications for the development of successful opioid drugs...
  14. ncbi Effect of lambda-carrageenan-induced inflammatory pain on brain uptake of codeine and antinociception
    Vincent S Hau
    Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
    Brain Res 1018:257-64. 2004
    ....

Research Grants5

  1. VARIOUS PAIN STATES ON OPIOID TRANSPORT ACROSS THE BBB
    Jason Huber; Fiscal Year: 2003
    ..Ultimately, this grant may identify a pharmacological approach that could be used in conjunction with current therapies to alleviate pain with greater efficacy and fewer adverse side effects. ..
  2. Age influences neuropoietic signaling at the neurovascular unit following stroke
    Jason Huber; Fiscal Year: 2009
    ..Our results will lead to a better understanding of the role age, plays in stroke etiology, progression, and recovery. ..
  3. Age influences neuropoietic signaling at the neurovascular unit following stroke
    Jason D Huber; Fiscal Year: 2010
    ..Our results will lead to a better understanding of the role age, plays in stroke etiology, progression, and recovery. ..
  4. Age influences neuropoietic signaling at the neurovascular unit following stroke
    Jason D Huber; Fiscal Year: 2010
    ..Our results will lead to a better understanding of the role age, plays in stroke etiology, progression, and recovery. ..