Stanley M Hileman

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout
    Carolyn Ferguson
    Departments of Anesthesiology and Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BMC Neurosci 8:85. 2007
  2. pmc Neurons of the lateral preoptic area/rostral anterior hypothalamic area are required for photoperiodic inhibition of estrous cyclicity in sheep
    Stanley M Hileman
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506, USA
    Biol Reprod 85:1057-65. 2011
  3. pmc Evidence that orphanin FQ mediates progesterone negative feedback in the ewe
    Casey C Nestor
    Department of Physiology and Pharmacology, PO Box 9229, West Virginia University, Morgantown, West Virginia 26506
    Endocrinology 154:4249-58. 2013
  4. pmc Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep
    Casey C Nestor
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506, USA
    Endocrinology 153:2756-65. 2012
  5. pmc Evidence that the arcuate nucleus is an important site of progesterone negative feedback in the ewe
    Robert L Goodman
    Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
    Endocrinology 152:3451-60. 2011
  6. pmc Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes
    Robert L Goodman
    PhD, Department of Physiology and Pharmacology, PO Box 9229, West Virginia University, Morgantown, West Virginia 26506
    Endocrinology 154:4259-69. 2013
  7. pmc Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes
    Robert L Goodman
    Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
    Endocrinology 153:5918-27. 2012
  8. pmc Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep
    Heather J Billings
    Department of Neurobiology and Anatomy, West Virginia University, Health Sciences Center, Morgantown, West Virginia 26506 9128, USA
    Endocrinology 151:3836-46. 2010
  9. pmc Estradiol negative feedback regulation by glutamatergic afferents to A15 dopaminergic neurons: variation with season
    Sushma R Singh
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Endocrinology 150:4663-71. 2009
  10. pmc Evidence that gamma-aminobutyric acid is part of the neural circuit mediating estradiol negative feedback in anestrous ewes
    Adrienne L Bogusz
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Endocrinology 149:2762-72. 2008

Collaborators

Detail Information

Publications13

  1. pmc New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout
    Carolyn Ferguson
    Departments of Anesthesiology and Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BMC Neurosci 8:85. 2007
    ..To overcome many of these limitations, a mouse line with a conditionally inactivated beta3 gene was engineered...
  2. pmc Neurons of the lateral preoptic area/rostral anterior hypothalamic area are required for photoperiodic inhibition of estrous cyclicity in sheep
    Stanley M Hileman
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506, USA
    Biol Reprod 85:1057-65. 2011
    ....
  3. pmc Evidence that orphanin FQ mediates progesterone negative feedback in the ewe
    Casey C Nestor
    Department of Physiology and Pharmacology, PO Box 9229, West Virginia University, Morgantown, West Virginia 26506
    Endocrinology 154:4249-58. 2013
    ..Therefore, we conclude that OFQ mediates, at least in part, the negative feedback action of P on GnRH/LH pulse frequency in sheep. ..
  4. pmc Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep
    Casey C Nestor
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506, USA
    Endocrinology 153:2756-65. 2012
    ..These results support the hypothesis that kisspeptin is a gatekeeper to female ovine puberty and raise the possibility that NKB may also play a role, albeit through different means...
  5. pmc Evidence that the arcuate nucleus is an important site of progesterone negative feedback in the ewe
    Robert L Goodman
    Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
    Endocrinology 152:3451-60. 2011
    ..These data, which are the first evidence on the neural sites in which progesterone inhibits GnRH pulse frequency in any species, are consistent with the hypothesis that ARC dynorphin neurons mediate this action of progesterone...
  6. pmc Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes
    Robert L Goodman
    PhD, Department of Physiology and Pharmacology, PO Box 9229, West Virginia University, Morgantown, West Virginia 26506
    Endocrinology 154:4259-69. 2013
    ....
  7. pmc Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes
    Robert L Goodman
    Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
    Endocrinology 153:5918-27. 2012
    ..These results support the hypothesis that DA acts to inhibit GnRH (and LH) secretion in anestrus by suppressing the activity of ARC kisspeptin neurons...
  8. pmc Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep
    Heather J Billings
    Department of Neurobiology and Anatomy, West Virginia University, Health Sciences Center, Morgantown, West Virginia 26506 9128, USA
    Endocrinology 151:3836-46. 2010
    ..Based on these data, and the effects of NK3R mutations in humans, we hypothesize that NKB plays an important stimulatory role in the control of GnRH and LH secretion in nonrodent species...
  9. pmc Estradiol negative feedback regulation by glutamatergic afferents to A15 dopaminergic neurons: variation with season
    Sushma R Singh
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Endocrinology 150:4663-71. 2009
    ....
  10. pmc Evidence that gamma-aminobutyric acid is part of the neural circuit mediating estradiol negative feedback in anestrous ewes
    Adrienne L Bogusz
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Endocrinology 149:2762-72. 2008
    ..Based on these data, we propose that in anestrous ewes, E2 inhibits release of GABA from afferents to A15 DA neurons, increasing the activity of these DA neurons and thus suppressing episodic secretion of GnRH and LH...
  11. ncbi request reprint Inhibition of luteinizing hormone secretion by localized administration of estrogen, but not dihydrotestosterone, is enhanced in the ventromedial hypothalamus during feed restriction in the young wether
    Christina J McManus
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, 26506 9229, USA
    Biol Reprod 73:781-9. 2005
    ..We suggest that increased sensitivity within the VMH to E, but not to DHT, is important for suppressing LH secretion in undernourished male sheep...
  12. ncbi request reprint Neuropeptide Y gene expression in male sheep: influence of photoperiod and testosterone
    Adam Dobbins
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA
    Neuroendocrinology 79:82-9. 2004
    ..Our data are consistent with the idea that NPY is involved in the seasonal regulation of GnRH and LH release in the male sheep...
  13. ncbi request reprint Effects of lipopolysaccharide on leptin transport across the blood-brain barrier
    Naoko Nonaka
    Department of Physiology, West Virginia University, Morgantown, WV, USA
    Brain Res 1016:58-65. 2004
    ..In conclusion, a single dose of LPS has long-lasting effects on the transport of serum leptin across the BBB that are likely mediated through self-inhibition and triglycerides...