Nancy Lan Guo

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. pmc Association of arsenic exposure with lung cancer incidence rates in the United States
    Joseph J Putila
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 6:e25886. 2011
  2. pmc The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells
    Maricica Pacurari
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26505, USA
    Int J Oncol 43:548-60. 2013
  3. pmc A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis
    Ying Wooi Wan
    Mary Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
    Int J Oncol 41:1387-96. 2012
  4. pmc Combining clinical, pathological, and demographic factors refines prognosis of lung cancer: a population-based study
    Joseph Putila
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 6:e17493. 2011
  5. pmc Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Part Fibre Toxicol 10:35. 2013
  6. pmc Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival
    Nancy Lan Guo
    Department of Community Medicine, West Virginia University, Morgantown, WV 26506, USA
    Artif Intell Med 55:97-105. 2012
  7. ncbi request reprint Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma
    Lan Guo
    Mary Babb Randolph Cancer Center, Department of Community Medicine, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Clin Cancer Res 12:3344-54. 2006
  8. pmc A novel network model identified a 13-gene lung cancer prognostic signature
    Nancy Lan Guo
    Mary Babb Randolph Cancer Centre, Department of Community Medicine, West Virginia University, Morgantown, WV 26506 9300, USA
    Int J Comput Biol Drug Des 4:19-39. 2011
  9. pmc Impact and interactions between smoking and traditional prognostic factors in lung cancer progression
    Nancy L Guo
    Mary Babb Randolph Cancer Center Department of Community Medicine, West Virginia University, Morgantown, WV 26506 9300, USA
    Lung Cancer 66:386-92. 2009
  10. pmc Confirmation of gene expression-based prediction of survival in non-small cell lung cancer
    Nancy L Guo
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Clin Cancer Res 14:8213-20. 2008

Collaborators

Detail Information

Publications20

  1. pmc Association of arsenic exposure with lung cancer incidence rates in the United States
    Joseph J Putila
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 6:e25886. 2011
    ..We sought to determine if the low-level exposures to arsenic seen in the U.S. are associated with lung cancer incidence after controlling for possible confounders, and to assess the interaction with smoking behavior...
  2. pmc The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells
    Maricica Pacurari
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26505, USA
    Int J Oncol 43:548-60. 2013
    ..These results provide new insights into miR-200 regulation in lung cancer metastasis and consequent clinical outcome, and may provide a potential basis for innovative therapeutic approaches for the treatment of this deadly disease...
  3. pmc A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis
    Ying Wooi Wan
    Mary Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
    Int J Oncol 41:1387-96. 2012
    ....
  4. pmc Combining clinical, pathological, and demographic factors refines prognosis of lung cancer: a population-based study
    Joseph Putila
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 6:e17493. 2011
    ..It is important to develop a prognostic stratification model which combines clinical, pathological and demographic factors for individualized clinical decision making...
  5. pmc Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Part Fibre Toxicol 10:35. 2013
    ..This study aimed to determine if an alveolar-capillary co-culture model could determine changes in the vascular endothelium after epithelial exposure to MWCNT...
  6. pmc Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival
    Nancy Lan Guo
    Department of Community Medicine, West Virginia University, Morgantown, WV 26506, USA
    Artif Intell Med 55:97-105. 2012
    ..This study sought to identify a smoking associated gene signature in order to provide a more precise diagnosis and prognosis of lung cancer in smokers...
  7. ncbi request reprint Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma
    Lan Guo
    Mary Babb Randolph Cancer Center, Department of Community Medicine, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Clin Cancer Res 12:3344-54. 2006
    ..Here, we propose a computational model system which accurately predicts the clinical outcome of individual patients based on their gene expression profiles...
  8. pmc A novel network model identified a 13-gene lung cancer prognostic signature
    Nancy Lan Guo
    Mary Babb Randolph Cancer Centre, Department of Community Medicine, West Virginia University, Morgantown, WV 26506 9300, USA
    Int J Comput Biol Drug Des 4:19-39. 2011
    ..Using this approach, a 13-gene lung cancer prognosis signature was identified, which generated significant prognostic stratifications (log-rank P < 0.05) in Director's Challenge Study (n = 442)...
  9. pmc Impact and interactions between smoking and traditional prognostic factors in lung cancer progression
    Nancy L Guo
    Mary Babb Randolph Cancer Center Department of Community Medicine, West Virginia University, Morgantown, WV 26506 9300, USA
    Lung Cancer 66:386-92. 2009
    ..We sought to investigate the effect of smoking intensity on lung cancer treatment failure (represented by overall survival), and the interactions between smoking and clinicopathological factors in lung cancer progression...
  10. pmc Confirmation of gene expression-based prediction of survival in non-small cell lung cancer
    Nancy L Guo
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Clin Cancer Res 14:8213-20. 2008
    ..Accurate gene expression signatures are needed to classify patients into high- and low-risk groups to improve the selection of patients for adjuvant therapy...
  11. ncbi request reprint Individualized survival and treatment response predictions for breast cancers using phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-IGF-IR/In, phospho-MAPK, and phospho-p70S6K proteins
    L Guo
    MBR Cancer Center Department of Community Medicine, West Virginia University, Morgantown, West Virginia 26505, USA
    Int J Biol Markers 22:1-11. 2007
    ..The prediction system combines multiple signal protein activation profiles and relevant clinical information, and provides a unique guideline to aid individualized decision-making in the clinical management of breast cancer...
  12. pmc Hybrid models identified a 12-gene signature for lung cancer prognosis and chemoresponse prediction
    Ying Wooi Wan
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e12222. 2010
    ..The recurrence rate ranges from 35-50% among early stage non-small cell lung cancer patients. To date, there is no fully-validated and clinically applied prognostic gene signature for personalized treatment...
  13. pmc A breast cancer prognostic signature predicts clinical outcomes in multiple tumor types
    Ying Wooi Wan
    Mary Babb Randolph Cancer Center Community Medicine, West Virginia University, Morgantown, WV 26506 9300, USA
    Oncol Rep 24:489-94. 2010
    ....
  14. pmc Signaling pathway-based identification of extensive prognostic gene signatures for lung adenocarcinoma
    Ying Wooi Wan
    Department of Community Medicine Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506 9300, USA
    Lung Cancer 76:98-105. 2012
    ..This study is an important step toward personalized prognosis of tumor recurrence and patient selection for adjuvant chemotherapy, with significant impact on down-stream clinical applications...
  15. pmc Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling
    Patrick L Apopa
    The Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 6:1. 2009
    ..abstract:..
  16. pmc A 12-gene genomic instability signature predicts clinical outcomes in multiple cancer types
    Rama K R Mettu
    Mary Babb Randolph Cancer Center Community Medicine, West Virginia University, Morgantown, WV, USA
    Int J Biol Markers 25:219-28. 2010
    ..This prompted us to investigate whether this genomic instability signature could also predict clinical outcome in other cancer types of epithelial origin, including colorectal tumors, non-small cell lung carcinomas, and ovarian cancer...
  17. pmc Combining COPD with clinical, pathological and demographic information refines prognosis and treatment response prediction of non-small cell lung cancer
    Joseph Putila
    Department of Environmental and Occupational Health Sciences, School of Public Health, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 9:e100994. 2014
    ..This study extends a previously described non-small cell lung cancer prognostic model by the addition of chemotherapy and co-morbidities through the use of linked SEER-Medicare data...
  18. ncbi request reprint Population-based molecular prognosis of breast cancer by transcriptional profiling
    Yan Ma
    Mary Babb Randolph Cancer Center, Department of Statistics, Division of Hematology, West Virginia University, Morgantown, WV 26506 9300, USA
    Clin Cancer Res 13:2014-22. 2007
    ..The purpose of this study is to predict breast cancer recurrence and metastases and to identify gene signatures indicative of clinicopathologic characteristics using gene expression patterns derived from cDNA microarray...
  19. pmc Histone modifications and expression of light-regulated genes in Arabidopsis are cooperatively influenced by changing light conditions
    Lan Guo
    Peking Yale Joint Center of Plant Molecular Genetics and Agrobiotechnology, College of Life Sciences, Peking University, Beijing 100871, China
    Plant Physiol 147:2070-83. 2008
    ..Thus, it is possible that variations in histone modifications are an important physiological component of plant responses to changing light environments...
  20. ncbi request reprint Predicting cancer drug response by proteomic profiling
    Yan Ma
    Department of Statistics, West Virginia University, USA
    Clin Cancer Res 12:4583-9. 2006
    ..However, proteomic profiling will more directly solve the current functional and pharmacologic problems. We sought to determine whether proteomic signatures of untreated cells were sufficient for the prediction of drug response...

Research Grants3

  1. A Novel Computational Framework for Individualized Clinical Decision-Making
    Nancy Guo; Fiscal Year: 2009
    ..This study will advance the computational modeling of human genome data in disease for clinical decision-making. ..
  2. A Novel Computational Framework for Individualized Clinical Decision-Making
    Nancy Lan Guo; Fiscal Year: 2010
    ..This study will advance the computational modeling of human genome data in disease for clinical decision-making. ..