DIANA BEATTIE

Summary

Affiliation: West Virginia University
Country: USA

Publications

  1. ncbi request reprint Expanding the view of scholarship: introduction
    D S Beattie
    Department of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia, USA
    Acad Med 75:871-6. 2000
  2. ncbi request reprint External alternative NADH dehydrogenase of Saccharomyces cerevisiae: a potential source of superoxide
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506 9142, USA
    Free Radic Biol Med 34:478-88. 2003
  3. ncbi request reprint Alternative oxidase present in procyclic Trypanosoma brucei may act to lower the mitochondrial production of superoxide
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University, School of Medicine, PO Box 9142, Morgantown, WV 26506 9142, USA
    Arch Biochem Biophys 414:294-302. 2003
  4. ncbi request reprint Expression of a familial amyotrophic lateral sclerosis-associated mutant human superoxide dismutase in yeast leads to decreased mitochondrial electron transport
    Michael R Gunther
    Department of Biochemistry and Molecular Pharmacology, West Virginia University, Morgantown, WV 26506, USA
    Arch Biochem Biophys 431:207-14. 2004
  5. ncbi request reprint Rotenone-insensitive NADH dehydrogenase is a potential source of superoxide in procyclic Trypanosoma brucei mitochondria
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, P O Box 9142, West Virginia University School of Medicine, Morgantown, WV 26506 9142, USA
    Mol Biochem Parasitol 123:135-42. 2002
  6. ncbi request reprint Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9142, USA
    Biochemistry 41:3065-72. 2002
  7. ncbi request reprint Aspartate-186 in the head group of the yeast iron-sulfur protein of the cytochrome bc1 complex contributes to the protein conformation required for efficient electron transfer
    C Edward Ebert
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, P O Box 9142, Morgantown, WV 26506 9142, USA
    Biochim Biophys Acta 1607:65-78. 2003
  8. ncbi request reprint A compensatory double mutation of the alanine-86 to leucine mutant located in the hinge region of the iron-sulfur protein of the yeast cytochrome bc1 complex
    C Edward Ebert
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506 9142, USA
    Arch Biochem Biophys 429:16-22. 2004
  9. ncbi request reprint Identification of a gene encoding a 54 kDa alternative NADH dehydrogenase in Trypanosoma brucei
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, P O Box 9142, Morgantown, WV 26506 9142, USA
    Mol Biochem Parasitol 127:73-7. 2003
  10. ncbi request reprint Molecular modeling studies of the DCCD-treated cytochrome bc1 complex: predicted conformational changes and inhibition of proton translocation
    Yudong Wang
    Department of Biochemistry and Molecular Pharmacology, School of Medicine, West Virginia University, Morgantown 26505 9142, USA
    J Bioenerg Biomembr 34:81-8. 2002

Research Grants

  1. BIOENERGETICS OF THE CYTOCHROME BC1 COMPLEX
    DIANA BEATTIE; Fiscal Year: 2001

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Expanding the view of scholarship: introduction
    D S Beattie
    Department of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia, USA
    Acad Med 75:871-6. 2000
    ..In addition, these articles will stimulate continuing discussions that will definite equitable methods for the continued assessment of the scholarly accomplishments of medical school faculty...
  2. ncbi request reprint External alternative NADH dehydrogenase of Saccharomyces cerevisiae: a potential source of superoxide
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506 9142, USA
    Free Radic Biol Med 34:478-88. 2003
    ..These results suggest that the external NADH dehydrogenase is a potential source of superoxide in S. cerevisiae mitochondria...
  3. ncbi request reprint Alternative oxidase present in procyclic Trypanosoma brucei may act to lower the mitochondrial production of superoxide
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University, School of Medicine, PO Box 9142, Morgantown, WV 26506 9142, USA
    Arch Biochem Biophys 414:294-302. 2003
    ..We suggest that one function of TAO in procyclic cells may be to prevent ROS production by removing excess reducing equivalents and transferring them to oxygen...
  4. ncbi request reprint Expression of a familial amyotrophic lateral sclerosis-associated mutant human superoxide dismutase in yeast leads to decreased mitochondrial electron transport
    Michael R Gunther
    Department of Biochemistry and Molecular Pharmacology, West Virginia University, Morgantown, WV 26506, USA
    Arch Biochem Biophys 431:207-14. 2004
    ....
  5. ncbi request reprint Rotenone-insensitive NADH dehydrogenase is a potential source of superoxide in procyclic Trypanosoma brucei mitochondria
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, P O Box 9142, West Virginia University School of Medicine, Morgantown, WV 26506 9142, USA
    Mol Biochem Parasitol 123:135-42. 2002
    ..These results suggest that the rotenone-insensitive NADH dehydrogenase in addition to NADH fumarate reductase is a potential source of superoxide production in procyclic trypanosome mitochondria...
  6. ncbi request reprint Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9142, USA
    Biochemistry 41:3065-72. 2002
    ..Kinetic analysis of the enzyme indicated that the enzyme followed a ping-pong mechanism. The enzyme conducts a one-electron transfer and can reduce molecular oxygen forming superoxide radical...
  7. ncbi request reprint Aspartate-186 in the head group of the yeast iron-sulfur protein of the cytochrome bc1 complex contributes to the protein conformation required for efficient electron transfer
    C Edward Ebert
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, P O Box 9142, Morgantown, WV 26506 9142, USA
    Biochim Biophys Acta 1607:65-78. 2003
    ..1, respectively. EEDQ was bound to the iron-sulfur protein and core protein II in both the wild type and the D186A mutant, indicating that Asp-186 of the iron-sulfur protein is not required for proton translocation in the bc(1) complex...
  8. ncbi request reprint A compensatory double mutation of the alanine-86 to leucine mutant located in the hinge region of the iron-sulfur protein of the yeast cytochrome bc1 complex
    C Edward Ebert
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506 9142, USA
    Arch Biochem Biophys 429:16-22. 2004
    ..Molecular modeling studies of these mutants compared to the wild type have suggested that the hydrophobic residues located in the hinge region are critical to the motion of the head group of the iron-sulfur protein during catalysis...
  9. ncbi request reprint Identification of a gene encoding a 54 kDa alternative NADH dehydrogenase in Trypanosoma brucei
    Jing Fang
    Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, P O Box 9142, Morgantown, WV 26506 9142, USA
    Mol Biochem Parasitol 127:73-7. 2003
  10. ncbi request reprint Molecular modeling studies of the DCCD-treated cytochrome bc1 complex: predicted conformational changes and inhibition of proton translocation
    Yudong Wang
    Department of Biochemistry and Molecular Pharmacology, School of Medicine, West Virginia University, Morgantown 26505 9142, USA
    J Bioenerg Biomembr 34:81-8. 2002
    ..Formation of these new hydrogen bonds would restrict the rotation and protonation of glutamate 272, which may be necessary for the release of the second electrogenic proton obtained during ubiquinol oxidation in the bc1 complex...

Research Grants4

  1. BIOENERGETICS OF THE CYTOCHROME BC1 COMPLEX
    DIANA BEATTIE; Fiscal Year: 2001
    ..performed to determine whether charged amino acid residues ar required for efficient assembly of the ISP into the bc1 complex and for enzymatic activity. ..