Kezhong Zhang

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
    EMBO J 30:1357-75. 2011
  2. ncbi ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways
    Guohui Wang
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    BMC Cancer 12:225. 2012
  3. ncbi Unfolded protein response in cancer: the physician's perspective
    Xuemei Li
    Lea s Foundation Center for Hematologic Disorders and Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Hematol Oncol 4:8. 2011
  4. ncbi ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
    Sung Hoon Back
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109-0650, USA
    Methods 35:395-416. 2005
  5. ncbi Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
    Chunbin Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hepatology 55:1070-82. 2012
  6. ncbi Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues
    Suzette Laing
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Cell Physiol 299:C736-49. 2010
  7. ncbi The unfolded protein response: a stress signaling pathway critical for health and disease
    Kezhong Zhang
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neurology 66:S102-9. 2006
  8. ncbi Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease
    Ze Zheng
    The Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, Michigan, USA
    Methods Enzymol 489:329-48. 2011
  9. ncbi Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model
    Jin Sook Lee
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicol Lett 211:29-38. 2012
  10. ncbi Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
    Jyoti D Malhotra
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:18525-30. 2008

Collaborators

Detail Information

Publications16

  1. ncbi The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
    EMBO J 30:1357-75. 2011
    ..The identification of IRE1α as a key regulator to prevent hepatic steatosis provides novel insights into ER stress mechanisms in fatty liver diseases associated with toxic liver injuries...
  2. ncbi ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways
    Guohui Wang
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    BMC Cancer 12:225. 2012
    ..Yet, the biological roles of ERLIN2 and molecular mechanisms by which ERLIN2 coordinates ER pathways in breast carcinogenesis remain unclear...
  3. ncbi Unfolded protein response in cancer: the physician's perspective
    Xuemei Li
    Lea s Foundation Center for Hematologic Disorders and Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Hematol Oncol 4:8. 2011
    ..In this review, we discuss the basic mechanisms of UPR and highlight the importance of UPR in cancer biology. We also update the UPR-targeted cancer therapeutics currently in clinical trials...
  4. ncbi ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
    Sung Hoon Back
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109-0650, USA
    Methods 35:395-416. 2005
    ..Especially we think the newly developed quantitative and qualitative methods to detect IRE1 activity-dependent XBP1 mRNA splicing will be fast and accurate tools to show the activation of the UPR...
  5. ncbi Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
    Chunbin Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hepatology 55:1070-82. 2012
    ..The identification of CREBH as a stress-inducible metabolic regulator has important implications in the understanding and treatment of metabolic disease...
  6. ncbi Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues
    Suzette Laing
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Cell Physiol 299:C736-49. 2010
    ..This work provides novel insights into the cellular and molecular basis by which ambient PM(2.5) exposure elicits its cytotoxic effects that may be related to air pollution-associated pathogenesis...
  7. ncbi The unfolded protein response: a stress signaling pathway critical for health and disease
    Kezhong Zhang
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neurology 66:S102-9. 2006
    ..This review summarizes the complex regulation of UPR signaling and its relevance to human physiology and disease...
  8. ncbi Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease
    Ze Zheng
    The Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, Michigan, USA
    Methods Enzymol 489:329-48. 2011
    ..In this chapter, we summarize reliable methods to quantitatively analyze the UPR and hepatic inflammation in the mouse model of NAFLD...
  9. ncbi Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model
    Jin Sook Lee
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicol Lett 211:29-38. 2012
    ..Our study not only confirmed that pharmacologic ER stress is a strong "hit" that triggers NASH, but also demonstrated crucial molecular links between ER stress, lipid metabolism, and inflammation in the liver in vivo...
  10. ncbi Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
    Jyoti D Malhotra
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:18525-30. 2008
    ..Genetic or chemical intervention to reduce reactive oxygen species improves protein folding and cell survival and may provide an avenue to treat and/or prevent diseases of protein misfolding...
  11. ncbi Regulation of apoptosis by the unfolded protein response
    Andrew Fribley
    Department of Biological Chemistry, The University of Michigan Medical Center, Ann Arbor, MI, USA
    Methods Mol Biol 559:191-204. 2009
    ..In this chapter, we summarize our current understanding of UPR-induced apoptosis and various methods to detect ER stress and apoptosis in mammalian cells...
  12. ncbi Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Cell 124:587-99. 2006
    ..Together, our studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response...
  13. ncbi From endoplasmic-reticulum stress to the inflammatory response
    Kezhong Zhang
    Department of Biological Chemistry, The University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Nature 454:455-62. 2008
    ..The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation...
  14. ncbi Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo
    Kezhong Zhang
    Department of Biological Chemistry, The University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Methods Enzymol 442:395-419. 2008
    ....
  15. ncbi The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis
    Kezhong Zhang
    Department of Biological Chemistry and Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 115:268-81. 2005
    ..These results suggest specific requirements of the IRE1alpha-mediated UPR subpathway in the early and late stages of B lymphopoiesis...
  16. ncbi Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes
    Xuebao Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Biochem Res Int 2012:247275. 2012
    ..This paper briefly summarizes the recent advances in ER stress-associated LD formation and its involvement in type II diabetes...