Kezhong Zhang

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
    EMBO J 30:1357-75. 2011
  2. pmc PM2.5 in Beijing - temporal pattern and its association with influenza
    Yijia Liang
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, 424 Cunz Hall, 1841 Neil Avenue, Columbus, OH 43210, USA
    Environ Health 13:102. 2014
  3. pmc Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes
    Xuebao Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Biochem Res Int 2012:247275. 2012
  4. pmc Unfolded protein response in cancer: the physician's perspective
    Xuemei Li
    Lea s Foundation Center for Hematologic Disorders and Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Hematol Oncol 4:8. 2011
  5. pmc Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21
    Hyunbae Kim
    Center for Molecular Medicine and Genetics H K, R M, Z Z, J C, R Z, K Z, Department of Immunology and Microbiology K Z, the Wayne State University School of Medicine, Detroit, Michigan 48201 and Cardiovascular Center L C, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109
    Endocrinology 155:769-82. 2014
  6. pmc Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model
    Ze Zheng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hepatol 58:148-54. 2013
  7. pmc ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways
    Guohui Wang
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    BMC Cancer 12:225. 2012
  8. pmc Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
    Chunbin Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hepatology 55:1070-82. 2012
  9. ncbi request reprint ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
    Sung Hoon Back
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Methods 35:395-416. 2005
  10. pmc Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues
    Suzette Laing
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Cell Physiol 299:C736-49. 2010

Collaborators

Detail Information

Publications32

  1. pmc The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
    EMBO J 30:1357-75. 2011
    ..The identification of IRE1α as a key regulator to prevent hepatic steatosis provides novel insights into ER stress mechanisms in fatty liver diseases associated with toxic liver injuries...
  2. pmc PM2.5 in Beijing - temporal pattern and its association with influenza
    Yijia Liang
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, 424 Cunz Hall, 1841 Neil Avenue, Columbus, OH 43210, USA
    Environ Health 13:102. 2014
    ..5 on the impact of diseases in Beijing. In this study, we aimed to characterize temporal pattern of PM2.5 and its potential association with human influenza in Beijing...
  3. pmc Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes
    Xuebao Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Biochem Res Int 2012:247275. 2012
    ..This paper briefly summarizes the recent advances in ER stress-associated LD formation and its involvement in type II diabetes...
  4. pmc Unfolded protein response in cancer: the physician's perspective
    Xuemei Li
    Lea s Foundation Center for Hematologic Disorders and Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Hematol Oncol 4:8. 2011
    ..In this review, we discuss the basic mechanisms of UPR and highlight the importance of UPR in cancer biology. We also update the UPR-targeted cancer therapeutics currently in clinical trials...
  5. pmc Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21
    Hyunbae Kim
    Center for Molecular Medicine and Genetics H K, R M, Z Z, J C, R Z, K Z, Department of Immunology and Microbiology K Z, the Wayne State University School of Medicine, Detroit, Michigan 48201 and Cardiovascular Center L C, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109
    Endocrinology 155:769-82. 2014
    ..The functional relationship between CREBH and PPARα in regulating FGF21 may represent an important transcriptional coactivation mechanism that orchestrates the processes of energy supply upon metabolic alteration. ..
  6. pmc Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model
    Ze Zheng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hepatol 58:148-54. 2013
    ..5 μm (PM(2.5)) to the development of metabolic diseases. In this study, we investigated the effect of PM(2.5) exposure on liver pathogenesis and the mechanism by which ambient PM(2.5) modulates hepatic pathways and glucose homeostasis...
  7. pmc ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways
    Guohui Wang
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    BMC Cancer 12:225. 2012
    ..Yet, the biological roles of ERLIN2 and molecular mechanisms by which ERLIN2 coordinates ER pathways in breast carcinogenesis remain unclear...
  8. pmc Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
    Chunbin Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hepatology 55:1070-82. 2012
    ..Supporting the role of CREBH in lipogenesis and lipolysis, forced expression of an activated form of CREBH protein in the liver significantly increases accumulation of hepatic lipids, but reduces plasma TG levels in mice...
  9. ncbi request reprint ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
    Sung Hoon Back
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Methods 35:395-416. 2005
    ..Especially we think the newly developed quantitative and qualitative methods to detect IRE1 activity-dependent XBP1 mRNA splicing will be fast and accurate tools to show the activation of the UPR...
  10. pmc Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues
    Suzette Laing
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Cell Physiol 299:C736-49. 2010
    ..This work provides novel insights into the cellular and molecular basis by which ambient PM(2.5) exposure elicits its cytotoxic effects that may be related to air pollution-associated pathogenesis...
  11. ncbi request reprint The unfolded protein response: a stress signaling pathway critical for health and disease
    Kezhong Zhang
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neurology 66:S102-9. 2006
    ..This review summarizes the complex regulation of UPR signaling and its relevance to human physiology and disease...
  12. doi request reprint Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models
    Ze Zheng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hepatol 63:1397-404. 2015
    ..5) correlates with pulmonary dysfunction, cardiovascular disease, and metabolic syndrome. In this study, we investigated the effect and mechanism of PM2.5 exposure on hepatic fibrogenesis...
  13. doi request reprint Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease
    Ze Zheng
    The Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, Michigan, USA
    Methods Enzymol 489:329-48. 2011
    ..In this chapter, we summarize reliable methods to quantitatively analyze the UPR and hepatic inflammation in the mouse model of NAFLD...
  14. pmc COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis
    Jingye Fang
    Department of Physiology J F, B P J, F S, J W, T B, X C and Center for Molecular Medicine and Genetics X Z, K Z, School of Medicine, Department of Physics and Astronomy T S, College of Liberal Arts and Sciences, and Department of Pharmaceutical Sciences A K, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, and John D Dingell VA Medical Center A K, Detroit, Michigan 48201 Department of Internal Medicine M L, University of Michigan, Ann Arbor, Michigan 48109 and Department of Pathology D J T, Microscopy Imaging Center, University of Vermont College of Medicine, Burlington, Vermont 05405
    Mol Endocrinol 29:1156-69. 2015
    ..Collectively, results from the study demonstrate that COPII-dependent ER export plays a vital role in insulin biogenesis, ER homeostasis, and β-cell survival. ..
  15. pmc Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells
    Guohui Wang
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem J 446:415-25. 2012
    ..The identification of ERLIN2 as a regulator of cytosolic lipid content in cancer cells has important implications for understanding the molecular basis of tumorigenesis and the treatment of cancer...
  16. pmc Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model
    Jin Sook Lee
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicol Lett 211:29-38. 2012
    ..Our study not only confirmed that pharmacologic ER stress is a strong "hit" that triggers NASH, but also demonstrated crucial molecular links between ER stress, lipid metabolism, and inflammation in the liver in vivo...
  17. pmc Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
    Jyoti D Malhotra
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:18525-30. 2008
    ..Genetic or chemical intervention to reduce reactive oxygen species improves protein folding and cell survival and may provide an avenue to treat and/or prevent diseases of protein misfolding...
  18. pmc Regulation of apoptosis by the unfolded protein response
    Andrew Fribley
    Department of Biological Chemistry, The University of Michigan Medical Center, Ann Arbor, MI, USA
    Methods Mol Biol 559:191-204. 2009
    ..In this chapter, we summarize our current understanding of UPR-induced apoptosis and various methods to detect ER stress and apoptosis in mammalian cells...
  19. pmc Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue
    Roberto Mendez
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine Detroit, MI 48201, USA
    Am J Transl Res 5:224-34. 2013
    ..These results provide novel insights into PM2.5-triggered cell stress response in adipose tissue and increase our understanding of pathophysiological effects of particulate air pollution on the development of metabolic disorders...
  20. ncbi request reprint Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Cell 124:587-99. 2006
    ..Together, our studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response...
  21. pmc From endoplasmic-reticulum stress to the inflammatory response
    Kezhong Zhang
    Department of Biological Chemistry, The University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Nature 454:455-62. 2008
    ..The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation...
  22. pmc Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism
    Hyunbae Kim
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Mol Cell Biol 35:4121-34. 2015
    ..In summary, our study reveals a molecular mechanism by which fasting or glucagon stimulation modulates lipid homeostasis through acetylation of CREBH. ..
  23. pmc Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area
    Ze Zheng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 8:e84776. 2013
    ..Therefore, it is necessary to further delineate the involvement of DM, together with other related risk factors, in HCC with large sample size and strict analysis methodology...
  24. ncbi request reprint The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum
    Xiaohua Shen
    Howard Hughes Medical Institute, The University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    J Chem Neuroanat 28:79-92. 2004
    ..This review summarizes our understanding of the UPR signaling developed in the recent years...
  25. pmc Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo
    Kezhong Zhang
    Department of Biological Chemistry, The University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Methods Enzymol 442:395-419. 2008
    ....
  26. pmc Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells
    Jin Sook Lee
    Department of Physiology, Wayne State University, Detroit, MI, USA
    Proteomics 15:1508-11. 2015
    ..All MS data have been deposited in the ProteomeXchange with identifier PXD001081 (http://proteomecentral.proteomexchange.org/dataset/PXD001081). ..
  27. pmc The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis
    Kezhong Zhang
    Department of Biological Chemistry and Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 115:268-81. 2005
    ..These results suggest specific requirements of the IRE1alpha-mediated UPR subpathway in the early and late stages of B lymphopoiesis...
  28. ncbi request reprint Signaling the unfolded protein response from the endoplasmic reticulum
    Kezhong Zhang
    Department of Biological Chemistry and Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:25935-8. 2004
  29. doi request reprint Cross talk between ER stress, oxidative stress, and inflammation in health and disease
    Aditya Dandekar
    Department of Immunology and Microbiology, Karmanos Cancer Institute, Wayne State University School of Medicine, 3202 Scott Hall, 540 East Canfield, Detroit, MI, 48201, USA
    Methods Mol Biol 1292:205-14. 2015
    ..In this review, we summarize the recent advance in our understanding of the cross talk between ER stress response, oxidative stress, and inflammation in immunity and in inflammatory and metabolic diseases. ..
  30. pmc Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study
    Lisa Nevell
    Wayne State University School of Medicine, Center for Molecular Medicine and Genetics, Detroit, MI 48201, USA
    Psychoneuroendocrinology 43:62-70. 2014
    ..This study tests for systemic changes in ER stress response associated with Major Depressive Disorder (MDD) or post-traumatic stress disorder (PTSD) among community-dwelling individuals...
  31. pmc Aquaporin-assisted and ER-mediated mitochondrial fission: a hypothesis
    Jin Sook Lee
    Department of Physiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Micron 47:50-8. 2013
    ....
  32. pmc Role of unfolded protein response in lipogenesis
    Ze Zheng
    Ze Zheng, Chunbin Zhang, Kezhong Zhang, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, United States
    World J Hepatol 2:203-7. 2010
    ..Recent studies suggest that the UPR plays crucial roles in modulating lipogenesis under metabolic conditions. Here we address some of recent representative evidence regarding the role of the UPR in lipogenesis...