DOUGLAS YINGST

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump
    D R Yingst
    Department of Physiology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201 1928, USA
    Eur J Pharmacol 406:49-52. 2000
  2. ncbi Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells
    D R Yingst
    Department of Physiology, Wayne State University School of Medicine and the John D Dingell Veterans Medical Center, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 280:C119-25. 2001
  3. ncbi Angiotensin II directly stimulates activity and alters the phosphorylation of Na-K-ATPase in rat proximal tubule with a rapid time course
    Douglas R Yingst
    Dept of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 287:F713-21. 2004
  4. ncbi Angiotensin II stimulates elution of Na-K-ATPase from a digoxin-affinity column by increasing the kinetic response to ligands that trigger the decay of E2-P
    Douglas R Yingst
    Dept of Physiology, Wayne State Univ School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 294:F990-F1000. 2008
  5. ncbi Decreased renal perfusion rapidly increases plasma membrane Na-K-ATPase in rat cortex by an angiotensin II-dependent mechanism
    Douglas R Yingst
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 297:F1324-9. 2009

Research Grants

  1. Mechanisms of Renal Na+ Pump Stimulation by Angiotensin
    DOUGLAS YINGST; Fiscal Year: 2005

Detail Information

Publications5

  1. ncbi Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump
    D R Yingst
    Department of Physiology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201 1928, USA
    Eur J Pharmacol 406:49-52. 2000
    ..5 microM)] did not. Thus, angiotensin II inhibition of the Na(+) pump may in part be mediated by a tyrosine phosphatase...
  2. ncbi Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells
    D R Yingst
    Department of Physiology, Wayne State University School of Medicine and the John D Dingell Veterans Medical Center, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 280:C119-25. 2001
    ..The resulting increase in [Ca(2+)](i) may stimulate the sodium pump by activating CaM and/or CaMKII...
  3. ncbi Angiotensin II directly stimulates activity and alters the phosphorylation of Na-K-ATPase in rat proximal tubule with a rapid time course
    Douglas R Yingst
    Dept of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 287:F713-21. 2004
    ..We suggest that the physiological role for rapid direct activation of Na-K-ATPase is greater control of intracellular sodium during sodium reabsorption...
  4. ncbi Angiotensin II stimulates elution of Na-K-ATPase from a digoxin-affinity column by increasing the kinetic response to ligands that trigger the decay of E2-P
    Douglas R Yingst
    Dept of Physiology, Wayne State Univ School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 294:F990-F1000. 2008
    ..These data suggest that ANG II regulates both the kinetic properties of Na-K-ATPase and its interaction with other proteins by a mechanism(s) involving its NH(2) terminus...
  5. ncbi Decreased renal perfusion rapidly increases plasma membrane Na-K-ATPase in rat cortex by an angiotensin II-dependent mechanism
    Douglas R Yingst
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 297:F1324-9. 2009
    ..46). These results confirm our hypothesis: rapid changes in blood pressure regulate trafficking of Na-K-ATPase in the kidney cortex...

Research Grants4

  1. Mechanisms of Renal Na+ Pump Stimulation by Angiotensin
    DOUGLAS YINGST; Fiscal Year: 2005
    ..These results have important implications for understanding normal kidney function, as well as the development of hypertension and heart failure. ..