Gen Wu

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line
    Gen Sheng Wu
    Program in Developmental Therapeutics, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oncogene 21:1-8. 2002
  2. pmc Sp1-mediated TRAIL induction in chemosensitization
    Jing Xu
    Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 68:6718-26. 2008
  3. ncbi request reprint Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer
    Gen Sheng Wu
    Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Metastasis Rev 26:579-85. 2007
  4. ncbi request reprint The functional interactions between the p53 and MAPK signaling pathways
    Gen Sheng Wu
    Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Room E216, The Prentis Building, 110 East Warren Avenue, Detroit, Michigan 48201, USA
    Cancer Biol Ther 3:156-61. 2004
  5. doi request reprint TRAIL as a target in anti-cancer therapy
    Gen Sheng Wu
    Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Lett 285:1-5. 2009
  6. ncbi request reprint Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan, USA
    Cancer Biol Ther 7:1774-82. 2008
  7. ncbi request reprint Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell lines
    Zhenhua Ding
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit 48201, USA
    Oncogene 21:4530-8. 2002
  8. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand is required for tumor necrosis factor alpha-mediated sensitization of human breast cancer cells to chemotherapy
    Jing Xu
    Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:10092-9. 2006
  9. ncbi request reprint Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells
    Juan Wang
    Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
    Cell Cycle 8:3191-8. 2009
  10. pmc High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcoma
    Zhihong Wang
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Blood Cancer 51:754-9. 2008

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line
    Gen Sheng Wu
    Program in Developmental Therapeutics, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oncogene 21:1-8. 2002
    ..Our results suggest that caspase 9 may be an important target for anticancer drug development. Thus, identifying novel compounds that can activate caspase 9 may be a strategy for overcoming a defect in the p53 apoptosis pathway...
  2. pmc Sp1-mediated TRAIL induction in chemosensitization
    Jing Xu
    Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 68:6718-26. 2008
    ....
  3. ncbi request reprint Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer
    Gen Sheng Wu
    Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Metastasis Rev 26:579-85. 2007
    ..Thus, understanding the roles of MKPs in the development of cancer and their impact on chemotherapy can be exploited for therapeutic benefits for the treatment of human cancer...
  4. ncbi request reprint The functional interactions between the p53 and MAPK signaling pathways
    Gen Sheng Wu
    Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Room E216, The Prentis Building, 110 East Warren Avenue, Detroit, Michigan 48201, USA
    Cancer Biol Ther 3:156-61. 2004
    ....
  5. doi request reprint TRAIL as a target in anti-cancer therapy
    Gen Sheng Wu
    Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Lett 285:1-5. 2009
    ..Thus, understanding the regulation of the TRAIL apoptosis pathway can help develop more selective TRAIL-based agents for the treatment of human cancer...
  6. ncbi request reprint Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan, USA
    Cancer Biol Ther 7:1774-82. 2008
    ..It is possible that spontaneous apoptosis facilitates elimination of cells thus permitting expansion and malignant transformation of cancer cells that are resistant to spontaneous apoptosis...
  7. ncbi request reprint Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell lines
    Zhenhua Ding
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit 48201, USA
    Oncogene 21:4530-8. 2002
    ..Thus, our study defines a possible mechanism, at least in part, underlying XK469-induced anti-cancer activity...
  8. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand is required for tumor necrosis factor alpha-mediated sensitization of human breast cancer cells to chemotherapy
    Jing Xu
    Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:10092-9. 2006
    ..Collectively, our results suggest that induction of TRAIL by TNFalpha is critical for sensitization of breast cancer cells to chemotherapy...
  9. ncbi request reprint Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells
    Juan Wang
    Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
    Cell Cycle 8:3191-8. 2009
    ..Therefore, our data suggest that the mechanisms of acquired cisplatin resistance vary among ovarian cancer cells, which involve upregulation of molecules associated with the cell survival pathways...
  10. pmc High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcoma
    Zhihong Wang
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Blood Cancer 51:754-9. 2008
    ..Despite aggressive treatment, 25% of patients with OS continue to die from their disease. Since cisplatin based regimens have been uniformly used in OS therapy, treatment failure is likely due, at least in part, to cisplatin resistance...
  11. ncbi request reprint Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin
    Jing Xu
    Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Res 67:1203-11. 2007
    ..Taken together, our results suggest that induction of TRAIL by 5-aza-CdR is critical for enhancing chemosensitivity of breast cancer cells to Adriamycin...
  12. doi request reprint Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells
    Dong Jun Peng
    Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, 110 East Warren Ave, Detroit, MI 48201, USA
    Biochem Biophys Res Commun 394:600-5. 2010
    ..Therefore, our study suggests that cisplatin resistance can be overcome by targeting the Akt/mTOR survival pathway in human ovarian cancer cells...
  13. doi request reprint The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment
    Kelly K Haagenson
    Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA
    Cancer Metastasis Rev 29:143-9. 2010
    ..Growing evidence suggests that modulating MKP-1 activity could be a viable option to make breast cancer chemotherapy more effective...
  14. ncbi request reprint Colony growth suppression by tumor suppressor genes
    Gen Sheng Wu
    Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
    Methods Mol Biol 223:207-10. 2003
  15. ncbi request reprint p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elements
    Huanjie Yang
    Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Biol Ther 3:1277-82. 2004
    ..These results suggest that each element sufficiently confers p53 responsiveness and that both elements are required for its full activation. Thus, our results provide the mechanism by which p53 controls transcription of the MKP1 gene...
  16. ncbi request reprint ERK-dependent MKP-1-mediated cisplatin resistance in human ovarian cancer cells
    Juan Wang
    Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:11933-41. 2007
    ..Thus, our results suggest that targeting ERK-MKP-1 signaling could overcome cisplatin resistance in human ovarian cancer...
  17. ncbi request reprint The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death
    Jun Ying Zhou
    Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:4888-94. 2006
    ..Thus, these results suggest that activation of MKP-1 is a survival mechanism against oxidative damage...
  18. ncbi request reprint Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance
    Zhaoqing Wang
    Program in Molecular Biology and Human Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Res 66:8870-7. 2006
    ..Collectively, our results establish a critical role of JNK in cisplatin-induced apoptosis and suggest that MKP-1 is required for cisplatin resistance...
  19. ncbi request reprint The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation
    Maoxiang Li
    Departments of Pathology and Pharmacology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:41059-68. 2003
    ..Thus, these results provide a novel mechanism by which p53 controls the cell cycle in response to the MAPK signaling in the absence of DNA damage and suggest that p53 may negatively control the MAKP pathway via MKP1...
  20. ncbi request reprint Mitotic cell death by chromosome fragmentation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:7686-94. 2007
    ..Paradoxically, this process could result in genome aberrations common in cancer. The characterization of chromosome fragmentation may also shine light on the mechanism of chromosomal pulverization...
  21. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
    ..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
  22. ncbi request reprint Mitogen activated protein kinase phosphatases and cancer
    Kelly K Haagenson
    Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA
    Cancer Biol Ther 9:337-40. 2010
    ..Expression of MKPs has been shown to be altered in many different types of cancer. Most of what is known centers on MKP-1, MKP-2 and MKP-3. This review will focus on their role in cancer development and progression...
  23. ncbi request reprint Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells
    Kevin B Kim
    Department of Thoracic Head and Neck Medical Oncology, Box 432, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 1:177-84. 2002
    ..Our results demonstrate that CDDO-Me may be a good candidate for additional evaluation as a potential therapeutic agent for human lung cancers and possibly other types of cancer...
  24. pmc DR5 knockout mice are compromised in radiation-induced apoptosis
    Niklas Finnberg
    University of Pennsylvania, 415 Curie Blvd, CRB 437, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:2000-13. 2005
    ..These results indicate that DR5 has a limited role during embryogenesis and early stages of development but plays an organ-specific role in the response to DNA-damaging stimuli...

Research Grants6

  1. The Role of Phosphatase CL100/MKP1 in Human Cancer
    Gen Wu; Fiscal Year: 2009
    ..Collectively, our studies will provide important and novel insights into the role of CL100/MKP1 in cell cycle and apoptosis control in human cancer. ..