Research Topics
| Gen WuSummaryAffiliation: Wayne State University Country: USA Publications
Research Grants
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Detail Information
Publications
Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell lineGen Sheng Wu
Program in Developmental Therapeutics, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Oncogene 21:1-8. 2002..Our results suggest that caspase 9 may be an important target for anticancer drug development. Thus, identifying novel compounds that can activate caspase 9 may be a strategy for overcoming a defect in the p53 apoptosis pathway...
Sp1-mediated TRAIL induction in chemosensitizationJing Xu
Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 68:6718-26. 2008....- Role of mitogen-activated protein kinase phosphatases (MKPs) in cancerGen Sheng Wu
Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Metastasis Rev 26:579-85. 2007..Thus, understanding the roles of MKPs in the development of cancer and their impact on chemotherapy can be exploited for therapeutic benefits for the treatment of human cancer... - The functional interactions between the p53 and MAPK signaling pathwaysGen Sheng Wu
Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Room E216, The Prentis Building, 110 East Warren Avenue, Detroit, Michigan 48201, USA
Cancer Biol Ther 3:156-61. 2004.... 
TRAIL as a target in anti-cancer therapyGen Sheng Wu
Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Lett 285:1-5. 2009..Thus, understanding the regulation of the TRAIL apoptosis pathway can help develop more selective TRAIL-based agents for the treatment of human cancer...- Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell deathMalathy P V Shekhar
Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan, USA
Cancer Biol Ther 7:1774-82. 2008..It is possible that spontaneous apoptosis facilitates elimination of cells thus permitting expansion and malignant transformation of cancer cells that are resistant to spontaneous apoptosis... - Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell linesZhenhua Ding
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit 48201, USA
Oncogene 21:4530-8. 2002..Thus, our study defines a possible mechanism, at least in part, underlying XK469-induced anti-cancer activity... - Tumor necrosis factor-related apoptosis-inducing ligand is required for tumor necrosis factor alpha-mediated sensitization of human breast cancer cells to chemotherapyJing Xu
Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 66:10092-9. 2006..Collectively, our results suggest that induction of TRAIL by TNFalpha is critical for sensitization of breast cancer cells to chemotherapy... - Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cellsJuan Wang
Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
Cell Cycle 8:3191-8. 2009..Therefore, our data suggest that the mechanisms of acquired cisplatin resistance vary among ovarian cancer cells, which involve upregulation of molecules associated with the cell survival pathways... - High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcomaZhihong Wang
Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
Pediatr Blood Cancer 51:754-9. 2008..Despite aggressive treatment, 25% of patients with OS continue to die from their disease. Since cisplatin based regimens have been uniformly used in OS therapy, treatment failure is likely due, at least in part, to cisplatin resistance... - Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycinJing Xu
Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Res 67:1203-11. 2007..Taken together, our results suggest that induction of TRAIL by 5-aza-CdR is critical for enhancing chemosensitivity of breast cancer cells to Adriamycin... - Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cellsDong Jun Peng
Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, 110 East Warren Ave, Detroit, MI 48201, USA
Biochem Biophys Res Commun 394:600-5. 2010..Therefore, our study suggests that cisplatin resistance can be overcome by targeting the Akt/mTOR survival pathway in human ovarian cancer cells... - The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatmentKelly K Haagenson
Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA
Cancer Metastasis Rev 29:143-9. 2010..Growing evidence suggests that modulating MKP-1 activity could be a viable option to make breast cancer chemotherapy more effective... - Colony growth suppression by tumor suppressor genesGen Sheng Wu
Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
Methods Mol Biol 223:207-10. 2003 - p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elementsHuanjie Yang
Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Biol Ther 3:1277-82. 2004..These results suggest that each element sufficiently confers p53 responsiveness and that both elements are required for its full activation. Thus, our results provide the mechanism by which p53 controls transcription of the MKP1 gene... - ERK-dependent MKP-1-mediated cisplatin resistance in human ovarian cancer cellsJuan Wang
Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 67:11933-41. 2007..Thus, our results suggest that targeting ERK-MKP-1 signaling could overcome cisplatin resistance in human ovarian cancer... - The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell deathJun-ying Zhou
Program in Molecular Biology and Human Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 66:4888-94. 2006..Thus, these results suggest that activation of MKP-1 is a survival mechanism against oxidative damage... - Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistanceZhaoqing Wang
Program in Molecular Biology and Human Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Res 66:8870-7. 2006..Collectively, our results establish a critical role of JNK in cisplatin-induced apoptosis and suggest that MKP-1 is required for cisplatin resistance... - The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulationMaoxiang Li
Departments of Pathology and Pharmacology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Biol Chem 278:41059-68. 2003..Thus, these results provide a novel mechanism by which p53 controls the cell cycle in response to the MAPK signaling in the absence of DNA damage and suggest that p53 may negatively control the MAKP pathway via MKP1... - Mitotic cell death by chromosome fragmentationJoshua B Stevens
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 67:7686-94. 2007..Paradoxically, this process could result in genome aberrations common in cancer. The characterization of chromosome fragmentation may also shine light on the mechanism of chromosomal pulverization... - Stochastic cancer progression driven by non-clonal chromosome aberrationsHenry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Cell Physiol 208:461-72. 2006..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications... - Mitogen activated protein kinase phosphatases and cancerKelly K Haagenson
Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA
Cancer Biol Ther 9:337-40. 2010..Expression of MKPs has been shown to be altered in many different types of cancer. Most of what is known centers on MKP-1, MKP-2 and MKP-3. This review will focus on their role in cancer development and progression... - Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cellsKevin B Kim
Department of Thoracic/Head and Neck Medical Oncology, Box 432, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Ther 1:177-84. 2002..Our results demonstrate that CDDO-Me may be a good candidate for additional evaluation as a potential therapeutic agent for human lung cancers and possibly other types of cancer... - DR5 knockout mice are compromised in radiation-induced apoptosisNiklas Finnberg
University of Pennsylvania, 415 Curie Blvd, CRB 437, Philadelphia, PA 19104, USA
Mol Cell Biol 25:2000-13. 2005..These results indicate that DR5 has a limited role during embryogenesis and early stages of development but plays an organ-specific role in the response to DNA-damaging stimuli...
Research Grants
- The Role of Phosphatase CL100/MKP1 in Human CancerGen Wu; Fiscal Year: 2009..Collectively, our studies will provide important and novel insights into the role of CL100/MKP1 in cell cycle and apoptosis control in human cancer. ..