Paul H Wooley

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Immunotherapy in collagen-induced arthritis: past, present, and future
    Paul H Wooley
    Department of Orthopaedic Surgery, Wayne State University, Detroit, Michigan 48201, USA
    Am J Med Sci 327:217-26. 2004
  2. ncbi The usefulness and the limitations of animal models in identifying targets for therapy in arthritis
    Paul H Wooley
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, 1 South, Hutzel Hospital, 4707 St Antonie Blvd, Detroit, MI 48201, USA
    Best Pract Res Clin Rheumatol 18:47-58. 2004
  3. ncbi Blockade of vascular endothelial growth factor activity suppresses wear debris-induced inflammatory osteolysis
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Rheumatol 34:27-35. 2007
  4. ncbi Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model
    Weiping Ren
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan 48201, USA
    J Biomed Mater Res A 85:1043-51. 2008
  5. ncbi Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization
    Haiying Yu
    Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA
    Biomaterials 30:508-17. 2009
  6. ncbi Functional gait evaluation of collagen chitosan nerve guides for sciatic nerve repair
    Minal Patel
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA
    Tissue Eng Part C Methods 14:365-70. 2008
  7. ncbi Murine model of prosthesis failure for the long-term study of aseptic loosening
    Shang You Yang
    Department of Orthopaedic Surgery, Wayne State University, and the John D Dingell VA Medical Center, UHC 7C, 4201 St Antoine Boulevard, Detroit, Michigan 48201, USA
    J Orthop Res 25:603-11. 2007
  8. ncbi Effect of oral erythromycin therapy in patients with aseptic loosening of joint prostheses
    Weiping Ren
    Department of Biomedical Engineering, Wayne State University, 818 W Hancock, Detroit, MI 48201, USA
    Bone 44:671-7. 2009
  9. ncbi Collagen-chitosan nerve guides for peripheral nerve repair: a histomorphometric study
    Minal Patel
    Department of Biomedical Engineering, Wayne State University 818 W Hancock St, Detroit, MI 48201, USA
    J Biomater Appl 23:101-21. 2008
  10. ncbi Erythromycin inhibits wear debris-induced osteoclastogenesis by modulation of murine macrophage NF-kappaB activity
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine and the John D. Dingle VA Medical Center, 1 South, Hutzel Hospital, 4707 St. Antoine Blvd, Detroit, MI 48201, USA
    J Orthop Res 22:21-9. 2004

Collaborators

Detail Information

Publications38

  1. ncbi Immunotherapy in collagen-induced arthritis: past, present, and future
    Paul H Wooley
    Department of Orthopaedic Surgery, Wayne State University, Detroit, Michigan 48201, USA
    Am J Med Sci 327:217-26. 2004
    ..These approaches can be implemented through gene therapy, biological response mediators, or classic pharmacological intervention...
  2. ncbi The usefulness and the limitations of animal models in identifying targets for therapy in arthritis
    Paul H Wooley
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, 1 South, Hutzel Hospital, 4707 St Antonie Blvd, Detroit, MI 48201, USA
    Best Pract Res Clin Rheumatol 18:47-58. 2004
    ..In particular, we examine how the study of collagen-induced arthritis in rodents led to pioneering work in cytokine inhibitors for the successful therapy of RA...
  3. ncbi Blockade of vascular endothelial growth factor activity suppresses wear debris-induced inflammatory osteolysis
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Rheumatol 34:27-35. 2007
    ..Our study examined the hypothesis that wear debris may influence vascular endothelial grow factor (VEGF) expression, and that blocking VEGF bioactivity might improve wear debris-induced inflammatory osteolysis in a mouse model...
  4. ncbi Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model
    Weiping Ren
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan 48201, USA
    J Biomed Mater Res A 85:1043-51. 2008
    ....
  5. ncbi Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization
    Haiying Yu
    Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA
    Biomaterials 30:508-17. 2009
    ..These findings suggest that hybrid grafts have great potential for clinical use to treat large bone defects...
  6. ncbi Functional gait evaluation of collagen chitosan nerve guides for sciatic nerve repair
    Minal Patel
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA
    Tissue Eng Part C Methods 14:365-70. 2008
    ..From this study, we conclude that collagen-blended chitosan nerve guides enhanced motor and sensory nerve recovery assayed through gait and behavioral testing compared to unblended nerve guides...
  7. ncbi Murine model of prosthesis failure for the long-term study of aseptic loosening
    Shang You Yang
    Department of Orthopaedic Surgery, Wayne State University, and the John D Dingell VA Medical Center, UHC 7C, 4201 St Antoine Boulevard, Detroit, Michigan 48201, USA
    J Orthop Res 25:603-11. 2007
    ....
  8. ncbi Effect of oral erythromycin therapy in patients with aseptic loosening of joint prostheses
    Weiping Ren
    Department of Biomedical Engineering, Wayne State University, 818 W Hancock, Detroit, MI 48201, USA
    Bone 44:671-7. 2009
    ..05). Our results suggest that EM represents a biological cure or prevention for those patients who might need repeated revision surgeries and/or show the early signs of progressive osteolysis after TJR...
  9. ncbi Collagen-chitosan nerve guides for peripheral nerve repair: a histomorphometric study
    Minal Patel
    Department of Biomedical Engineering, Wayne State University 818 W Hancock St, Detroit, MI 48201, USA
    J Biomater Appl 23:101-21. 2008
    ..These findings indicate that the collagen-chitosan nerve guides can be applied to repair severed peripheral nerve ends...
  10. ncbi Erythromycin inhibits wear debris-induced osteoclastogenesis by modulation of murine macrophage NF-kappaB activity
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine and the John D. Dingle VA Medical Center, 1 South, Hutzel Hospital, 4707 St. Antoine Blvd, Detroit, MI 48201, USA
    J Orthop Res 22:21-9. 2004
    ..It appears that EM represents a potential therapeutic candidate for the treatment and prevention of aseptic loosening...
  11. ncbi Promotion of osteogenesis in tissue-engineered bone by pre-seeding endothelial progenitor cells-derived endothelial cells
    Haiying Yu
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA
    J Orthop Res 26:1147-52. 2008
    ..The integration of bone marrow-derived ECs and osteoblasts in porous scaffold is a useful strategy to achieve engineered bone...
  12. ncbi Implant wear induces inflammation, but not osteoclastic bone resorption, in RANK(-/-) mice
    Weiping Ren
    Department of Orthopedic Surgery, Wayne State University School of Medicine, University Health Center 7C, 4201 St Antoine Boulevard, Detroit, Michigan 48201, USA
    J Orthop Res 24:1575-86. 2006
    ..This indicates that RANK signaling is essential for UHMWPE particle-induced osteoclastic bone resorption, but does not participate in UHMWPE particle-induced inflammatory response...
  13. ncbi Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo
    Wei Ping Ren
    Department of Orthopedic Surgery, Wayne State University School of Medicine, University Health Center 7C, 4201 St Antoine Blvd, Detroit, MI 48201, USA
    Biomaterials 27:5161-9. 2006
    ..This study suggests that VEGF has a role in the regulation of RANK/RANKL-mediated osteoclastogenesis, and warrant future investigations to elucidate the role of VEGF signaling in the pathogenesis of prosthetic loosening...
  14. ncbi Polyethylene and methyl methacrylate particle-stimulated inflammatory tissue and macrophages up-regulate bone resorption in a murine neonatal calvaria in vitro organ system
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, John D. Dingle VAMC, Detroit, MI 48201, USA
    J Orthop Res 20:1031-7. 2002
    ..This simple in vitro bone resorption system allows us to investigate the fundamental cellular and molecular mechanism of wear debris induced bone resorption and to screen potential therapeutic approaches for aseptic loosening...
  15. ncbi Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites
    Haiying Yu
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA
    J Biomed Mater Res B Appl Biomater 86:541-7. 2008
    ..This provided means to manipulate the properties of biocompatible cell-supporting scaffolds for use as bone graft substitutes...
  16. ncbi Morphological characteristics of total joint arthroplasty-derived ultra-high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammation
    Allison Sieving
    Department of Orthopaedic Surgery, School of Medicine, Detroit, MI 48201, USA
    J Biomed Mater Res A 64:457-64. 2003
    ....
  17. ncbi Adeno-associated virus-mediated osteoprotegerin gene transfer protects against particulate polyethylene-induced osteolysis in a murine model
    Shang-You Yang
    Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Arthritis Rheum 46:2514-23. 2002
    ..Data suggest that gene transfer using rAAV-OPG may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis and aseptic loosening...
  18. ncbi Diverse cellular and apoptotic responses to variant shapes of UHMWPE particles in a murine model of inflammation
    Shang-You Yang
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biomaterials 23:3535-43. 2002
    ..Our results suggest that cellular responses to UHMWPE wear debris are dependent on the shape of the particles...
  19. ncbi Erythromycin inhibits wear debris-induced inflammatory osteolysis in a murine model
    Weiping Ren
    Department of Orthopedic Surgery, Wayne State University School of Medicine and the John D Dingle VA Medical Center, 4201 St Antoine Boulevard, Detroit, Michigan 48201, USA
    J Orthop Res 24:280-90. 2006
    ..In conclusion, this study provides the evidence that EM inhibits the UHMWPE particles-induced inflammatory osteolysis in a murine model, and represents a promising therapeutic candidate for the prevention and treatment of AL...
  20. ncbi Distinct gene expression of receptor activator of nuclear factor-kappaB and rank ligand in the inflammatory response to variant morphologies of UHMWPE particles
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, 1 South, Hutzel Hospital, 4707 St. Antoine Blvd, Detroit, MI 48201, USA
    Biomaterials 24:4819-26. 2003
    ..Overall, these data suggest that the morphology of wear debris may be a critical factor in the pathogenesis of prosthetic loosening...
  21. ncbi Effects of SU5416 and a vascular endothelial growth factor neutralizing antibody on wear debris-induced inflammatory osteolysis in a mouse model
    Weiping Ren
    Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA
    J Inflamm Res 4:29-38. 2011
    ..The purpose of this study was to investigate whether R2/Fc (a VEGF neutralizing antibody) and SU5416 (a VEGF receptor II [Flk-1] inhibitor) could ameliorate particle-induced inflammatory osteolysis in a mouse model...
  22. ncbi Inflammatory responses to orthopaedic biomaterials in the murine air pouch
    Paul H Wooley
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, Hutzel Hospital, Detroit, MI 48201, USA
    Biomaterials 23:517-26. 2002
    ..The data suggest that synergism in the inflammatory response to biomaterials may be important in adverse responses to orthopaedic wear debris...
  23. ncbi Immune reactions associated with silicone-based ventriculo-peritoneal shunt malfunctions in children
    Pamela J VandeVord
    Departments of Pediatric Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biomaterials 25:3853-60. 2004
    ....
  24. ncbi The effects of epidural application of allografted nucleus pulposus in rats on cytokine expression, limb withdrawal and nerve root discharge
    Srinivasu Kallakuri
    Bioengineering Center, Wayne State University, 818 West Hancock, Detroit, MI 48202, USA
    Eur Spine J 14:956-64. 2005
    ..05) but not higher than fat and sham rats. These results support the inflammatory nature of NP but offer limited support to NP-mediated thermal behavioral changes...
  25. ncbi Effects of nucleus pulposus on nerve root neural activity, mechanosensitivity, axonal morphology, and sodium channel expression
    Chaoyang Chen
    Spine Research Laboratory, Bioengineering Center, Wayne State University, Detroit, MI 48202, USA
    Spine (Phila Pa 1976) 29:17-25. 2004
    ..This study analyzed the effects of autografted nucleus pulposus on nerve root axon morphology, neurophysiologic function, and sodium channel expression...
  26. ncbi Evaluation of the biocompatibility of a chitosan scaffold in mice
    Pamela J VandeVord
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan 48202, USA
    J Biomed Mater Res 59:585-90. 2002
    ..This preliminary study demonstrates that chitosan has a high degree of biocompatibility in this animal model. Overall, the findings suggest that chitosan may be suitable for the development of implantable materials...
  27. ncbi Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor
    Shang You Yang
    Department of Orthopaedic Surgery, Wayne State University, University Health Center 7C, 4201 St Antoine Boulevard, Detroit, Michigan 48201, USA
    J Bone Joint Surg Am 87:1088-97. 2005
    ..This study evaluated a retrovirus-mediated gene therapy with use of a novel xenograft-based animal model...
  28. ncbi Immunological responses to bone soluble proteins in recipients of bone allografts
    Pamela J VandeVord
    Department of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA
    J Orthop Res 23:1059-64. 2005
    ..The removal of these antigenic proteins from the allografts prior to surgery may alleviate this immunological reactivity and improve graft outcome...
  29. ncbi High VEGF with rapid growth and early metastasis in a mouse osteosarcoma model
    Shang You Yang
    Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA
    Sarcoma 2007:95628. 2007
    ..Interestingly, VEGF expression correlates with the early establishment, rapid tumor growth, and the development of pulmonary metastasis...
  30. ncbi Biocompatibility of Poly-epsilon-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cells
    Haiying Yu
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA
    J Orthop Surg Res 4:5. 2009
    ..abstract:..
  31. ncbi Genetic determinants of bone mass do not relate with breast cancer risk in US white and African-American women
    Pamela J VandeVord
    Department of Biomedical Engineering, Wayne State University, 2202 Bioengineering Center, 818 W Hancock, Detroit, MI 48201, USA
    Breast Cancer Res Treat 100:103-7. 2006
    ..Thus, we examined these polymorphisms for association with increased breast cancer risk among US African-American and white women...
  32. ncbi Video-gait analysis of functional recovery of nerve repaired with chitosan nerve guides
    Minal Patel
    Department of Biomedical Engineering, Wayne State University School of Medicine, Detroit, Michigan, USA
    Tissue Eng 12:3189-99. 2006
    ..Histological analysis revealed that the chitosan nerve guide provided significantly increased axonal growth. The functional results indicated that chitosan nerve guides enhanced functional improvement over no repair processes...
  33. ncbi Immune response in patients receiving fresh osteochondral allografts
    Wesley P Phipatanakul
    Department of Orthopaedics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Am J Orthop 33:345-8. 2004
    ..These data indicate the presence of antibodies to CSP--which supports the concept of immunologic response to the cartilage component of osteochondral allografts...
  34. ncbi Immune reactivity to connective tissue antigens in pristane induced arthritis
    Rebecca Morgan
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Rheumatol 31:1497-505. 2004
    ..The data suggest that the development of pristane arthritis is not dependent upon reactivity against a single connective tissue antigen, but is a polyspecific autoimmune response to joint components elicited in pristane injected mice...
  35. ncbi VEGF blockade decelerates the growth of a murine experimental osteosarcoma
    Dezhen Yin
    Shandong University School of Medicine, Jinan 250010, PR China
    Int J Oncol 33:253-9. 2008
    ..Overall, data suggest that retrovirus-mediated sFLT-1 gene modification decelerates the osteosarcoma tumor growth in this murine model...
  36. ncbi Anti-TNF-alpha antibody allows healing of joint damage in polyarthritic transgenic mice
    David J Shealy
    Centocor, Inc, Malvern, Pennsylvania, USA
    Arthritis Res 4:R7. 2002
    ..Repair of cartilage was age dependent: reversal of cartilage degradation after anti-TNF-alpha treatment was observed in young mice but not in aged mice...
  37. ncbi Immune modulation of collagen-induced arthritis by intranasal cytokine gene delivery: a model for the therapy of rheumatoid arthritis
    Andrew M Woods
    King's College London School of Medicine at Guy's, St. Thomas' Hospital, London, UK
    Arthritis Rheum 52:3761-71. 2005
    ....
  38. ncbi Treatment of murine collagen-induced arthritis by the stress protein BiP via interleukin-4-producing regulatory T cells: a novel function for an ancient protein
    Rebecca J Brownlie
    King's College London, London, UK
    Arthritis Rheum 54:854-63. 2006
    ..Thus, BiP is a potential immunotherapeutic agent for the treatment of patients with rheumatoid arthritis...