Research Topics
Genomes and Genes | Monica UddinSummaryAffiliation: Wayne State University Country: USA Publications
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Publications
Molecular evolution of the cytochrome c oxidase subunit 5A gene in primatesMonica Uddin
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit MI 48201, USA
BMC Evol Biol 8:8. 2008..Here, we test the hypothesis that COX5A, the ETC gene that encodes cytochrome c oxidase subunit 5A, shows a pattern of anthropoid-specific adaptive evolution, and investigate the distribution of this protein in catarrhine brains...
The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factorCaoyi Chen
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
Mol Phylogenet Evol 47:637-49. 2008..Positive selection provides the basis for the hypothesis that changes in structure and function of the progesterone receptor during evolution contribute to the diversity of primate reproductive biology, especially in parturition...
Phylogenomic analyses reveal convergent patterns of adaptive evolution in elephant and human ancestriesMorris Goodman
Center for Molecular Medicine and Genetics, Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 106:20824-9. 2009....
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profilesMonica Uddin
Center for Molecular Medicine and Genetics, Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 101:2957-62. 2004....
Ancient origin of placental expression in the growth hormone genes of anthropoid primatesZack Papper
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 106:17083-8. 2009..e., the roles played by placenta-expressed GHs in human pregnancy may have a longer evolutionary history than previously appreciated)...
Distinct genomic signatures of adaptation in pre- and postnatal environments during human evolutionMonica Uddin
Center for Molecular Medicine and Genetics and Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 105:3215-20. 2008..Comparing adaptively evolving genes from pre- and postnatal-stage tissues suggests that different selective pressures act on the development vs. the maintenance of the human phenotype...
Coadaptive evolution in cytochrome c oxidase: 9 of 13 subunits show accelerated rates of nonsynonymous substitution in anthropoid primatesJeffrey W Doan
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
Mol Phylogenet Evol 33:944-50. 2004
Rapid electrostatic evolution at the binding site for cytochrome c on cytochrome c oxidase in anthropoid primatesTimothy R Schmidt
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 102:6379-84. 2005..We suggest that reducing the electrostatic interaction between COX and CYC was part of the adaptive evolution underlying the emergence of anthropoid primates...
OCPAT: an online codon-preserved alignment tool for evolutionary genomic analysis of protein coding sequencesGuozhen Liu
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine Detroit, MI 48201, USA
Source Code Biol Med 2:5. 2007..Since this feature is not available in most alignment tools, codon reading frames often must be checked manually before evolutionary analyses can commence...
Phylogenetic comparisons suggest that distance from the locus control region guides developmental expression of primate beta-type globin genesRobert M Johnson
Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 103:3186-91. 2006....
Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes)Derek E Wildman
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
PLoS ONE 6:e24509. 2011..Preterm birth is a leading cause of perinatal mortality, yet the evolutionary history of this obstetrical syndrome is largely unknown in nonhuman primate species...
Implications of natural selection in shaping 99.4% nonsynonymous DNA identity between humans and chimpanzees: enlarging genus HomoDerek E Wildman
Center for Molecular Medicine and Genetics and Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 100:7181-8. 2003....
Genomics, biogeography, and the diversification of placental mammalsDerek E Wildman
Perinatology Research Branch, National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:14395-400. 2007..Crown placental mammalian diversification appears to be largely the result of ancient plate tectonic events that allowed time for convergent phenotypes to evolve in the descendant clades...
Dynamic gene expression in the human cerebral cortex distinguishes children from adultsKirstin N Sterner
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
PLoS ONE 7:e37714. 2012....
Functionally important glycosyltransferase gain and loss during catarrhine primate emergenceChihiro Koike
Department of Surgery and Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 104:559-64. 2007..However, we emphasize that positively selected regulatory changes in sugar chain metabolism might well have contributed in a major way to catarrhine origins...
