Research Topics
Species | James D TuckerSummaryAffiliation: Wayne State University Country: USA Publications
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Publications
Radiation cytogenetics: from chromosomes to single nucleotides and from metaphase cells to tissuesJames D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA
Cancer Metastasis Rev 23:341-9. 2004..The final section provides a look towards the future and makes recommendations including suggestions for technological innovations that would enhance the field of radiation cytology...- Gene expression-based detection of radiation exposure in mice after treatment with granulocyte colony-stimulating factor and lipopolysaccharideJames D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
Radiat Res 177:209-19. 2012..These data suggest that PCR-based quantitative gene expression analyses may have utility in radiation biodosimetry in humans even in the presence of an infection or after treatment with G-CSF... 
Chromosome translocations and assessing human exposure to adverse environmental agentsJames D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
Environ Mol Mutagen 51:815-24. 2010..This article concludes with an assessment of the future of translocation analyses...- Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorderJames D Tucker
Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202 3917, United States
Mutat Res 677:53-8. 2009..53, 0.28, 0.81, respectively). These results provide evidence in a large cohort that MPH does not induce cytogenetic anomalies in children, in contrast to the findings of the El-Zein study... - Low-dose ionizing radiation and chromosome translocations: a review of the major considerations for human biological dosimetryJames D Tucker
Department of Biological Sciences, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202, USA
Mutat Res 659:211-20. 2008..This work would enhance our comprehension of the effects of low-dose radiation exposure and could lead to significant improvements in understanding the relationship between chromosome damage and human health... 
Cytogenetic analysis of an exposed-referent study: perchloroethylene-exposed dry cleaners compared to unexposed laundry workersJames D Tucker
Department of Biological Sciences, 2117 Biological Sciences Building, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202 3917, USA
Environ Health 10:16. 2011..Adverse health effects have been associated with PCE exposure. However, investigations of possible cumulative cytogenetic damage resulting from PCE exposure are lacking...- Estimating the lowest detectable dose of ionizing radiation by FISH whole-chromosome paintingJames D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
Radiat Res 175:631-7. 2011..05 and P = 0.01, respectively. These results improve our understanding of the requirements and limitations for performing biological dosimetry when only the age of the exposed individual is known... - Persistence of chromosome aberrations following acute radiation: I, PAINT translocations, dicentrics, rings, fragments, and insertionsJames D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
Environ Mol Mutagen 45:229-48. 2005..These data emphasize the importance of considering translocation loss in biological dosimetry long times after exposure... - Persistence of chromosome aberrations following acute radiation: II, does it matter how translocations are scored?James D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48109, USA
Environ Mol Mutagen 45:249-57. 2005..Despite these differences, the temporal frequency of translocation losses at both the high and low doses was similar for both subjects... - Multi-endpoint biological monitoring of phosphine workersJames D Tucker
Biology and Biotechnology Research Program, P O Box 808, L 448 Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
Mutat Res 536:7-14. 2003..The results are most easily interpreted as supporting the effectiveness of the personal protective equipment that is now worn by the workers but which was not employed prior to and during the earlier studies... - Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ionsJames D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
Radiat Res 161:648-55. 2004..The health effects of exposure to high-LET radiation in humans on prolonged space flights should remain a matter of concern... - Developing point of care and high-throughput biological assays for determining absorbed radiation doseMichael C Joiner
Dept of Radiation Oncology, Wayne State University, Detroit, MI 48201 2013, USA
Radiother Oncol 101:233-6. 2011..qPCR can rapidly analyze small blood samples and could be adopted into a field-portable instrument that provides a radiation dose readout within 30 min... - Bystander effects induced by chemicals and ionizing radiation: evaluation of changes in gene expression of downstream MAPK targetsRajalakshmi Asur
Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Suite 1370, Detroit, MI 48202 3917, USA
Mutagenesis 25:271-9. 2010..These results provide evidence for bystander-induced changes in MAPK proteins and downstream targets and suggest that the bystander effects are a part of a general stress response... - Involvement of MAPK proteins in bystander effects induced by chemicals and ionizing radiationRajalakshmi Asur
Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Suite 1370, Detroit, MI 48202 3917, USA
Mutat Res 686:15-29. 2010.... - Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the chernobyl nuclear reactor 6-13 years after exposureIrene M Jones
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94550, USA
Radiat Res 158:424-42. 2002..Based on this estimated dose, the risk of exposure-related cancer is expected to be low... - Mitochondrial gene expression changes in normal and mitochondrial mutant cells after exposure to ionizing radiationRohan Kulkarni
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
Radiat Res 173:635-44. 2010..The altered sensitivity of mitochondrial mutant cells to ionizing radiation can lead to decreased DNA repair, which may put individuals with mtDNA mutations at greater risk for cancer and other diseases... - Chemical induction of the bystander effect in normal human lymphoblastoid cellsRajalakshmi S Asur
Department of Biological Sciences, Wayne State University, Detroit, MI 48202 3917, USA
Mutat Res 676:11-6. 2009..We conclude that the bystander effect is not restricted to ionizing radiation, suggesting it may be a part of a general cellular stress response... - Adaptive response induction and variation in human lymphoblastoid cell linesKaren J Sorensen
Biology and Biotechnology Research Program, L 448 Lawrence Livermore National Laboratory, P O Box 808, 7000 East Ave, CA 94551 9900, USA
Mutat Res 519:15-24. 2002..In both cell lines, the direction of the response was altered when the distribution of cells within the cell cycle was changed, suggesting that the adaptive response can be affected by cell cycle stage at the time of irradiation... - Expression of DNA repair and apoptosis genes in mitochondrial mutant and normal cells following exposure to ionizing radiationRohan Kulkarni
Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA
Environ Mol Mutagen 52:229-37. 2011..This study provides information that might be useful in characterizing energy dependent processes following exposure to stress or genotoxic agents... - Evaluation and validation of housekeeping genes in response to ionizing radiation and chemical exposure for normalizing RNA expression in real-time PCRMalathi Banda
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
Mutat Res 649:126-34. 2008.... - The role of mitochondria in the radiation-induced bystander effect in human lymphoblastoid cellsSountharia Rajendran
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
Radiat Res 175:159-71. 2011..Adding the inhibitors just prior to irradiation and removing them immediately after irradiation was uneventful. Fully functional mitochondrial metabolic capability may therefore be essential for the bystander effect... - The cellular lethality of radiation-induced chromosome translocations in human lymphocytesShea N Gardner
Biology and Biotechnology Research Program, L-448, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
Radiat Res 157:539-52. 2002..Within the limits of these models, these findings indicate that both postulated mechanisms, i.e. inherent lethality and selection against dicentrics in the same cells, contribute to the loss of both one-way and two-way translocations... - Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive responseMatthew A Coleman
Biology and Biotechnology Research Program, Lawrence Livermore, National Laboratory, Livermore, California 94551, USA
Radiat Res 164:369-82. 2005.... - Mitochondrial mutant cells are hypersensitive to ionizing radiation, phleomycin and mitomycin CRohan Kulkarni
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
Mutat Res 663:46-51. 2009.... - Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signatureAllen T Christian
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, L 452 Livermore, CA 94551, USA
Mutat Res 506:113-9. 2002..This indicates that PhIP has a recognizable cytogenetic signature in rat mammary gland carcinomas... - Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rateDiane C Cabelof
Karmanos Cancer Institute, Developmental Therapeutics Program, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA
Cancer Res 66:7460-5. 2006..Thus, the beta-pol(+/-) mouse represents a model in which mortality rate and tumor development are accelerated and provides evidence supporting the role of genomic maintenance in both aging and carcinogenesis... - Cigarette smoking during pregnancy: chromosome translocations and phenotypic susceptibility in mothers and newbornsL Michelle Bennett
Physical and Life Sciences Directorate, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, United States
Mutat Res 696:81-8. 2010..However, peripheral lymphocytes in pregnant women are more susceptible to genetic damage than peripheral lymphocytes in newborns... - Sensitivity, specificity, and persistence of chromosome translocations for radiation biodosimetryJames D Tucker
Biology and Biotechnology Research Program, 7000 East Avenue, P.O. Box 808, L-448, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
Mil Med 167:8-9. 2002..This paper provides a brief evaluation of the use of translocation analyses by chromosome painting for biological dosimetry following chronic or low-dose exposure to ionizing radiation... - Retrospective biodosimetry among United States radiologic technologistsParveen Bhatti
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Radiat Res 167:727-34. 2007..S. radiologic technologists... - International study of factors affecting human chromosome translocationsAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Mutat Res 652:112-21. 2008..Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes... - Human population studies with cytogenetic biomarkers: review of the literature and future prospectivesStefano Bonassi
Unit of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
Environ Mol Mutagen 45:258-70. 2005..The role of susceptibility and its potential impact on genotoxic damage are discussed with special attention to the effect of major genetic polymorphisms on the baseline frequency of CAs and micronuclei...