James D Tucker

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Radiation cytogenetics: from chromosomes to single nucleotides and from metaphase cells to tissues
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA
    Cancer Metastasis Rev 23:341-9. 2004
  2. doi request reprint Accurate gene expression-based biodosimetry using a minimal set of human gene transcripts
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan Electronic address
    Int J Radiat Oncol Biol Phys 88:933-9. 2014
  3. ncbi request reprint Gene expression-based detection of radiation exposure in mice after treatment with granulocyte colony-stimulating factor and lipopolysaccharide
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Radiat Res 177:209-19. 2012
  4. doi request reprint Estimating the lowest detectable dose of ionizing radiation by FISH whole-chromosome painting
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 175:631-7. 2011
  5. pmc Cytogenetic analysis of an exposed-referent study: perchloroethylene-exposed dry cleaners compared to unexposed laundry workers
    James D Tucker
    Department of Biological Sciences, 2117 Biological Sciences Building, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202 3917, USA
    Environ Health 10:16. 2011
  6. doi request reprint Chromosome translocations and assessing human exposure to adverse environmental agents
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Environ Mol Mutagen 51:815-24. 2010
  7. doi request reprint Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder
    James D Tucker
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202 3917, United States
    Mutat Res 677:53-8. 2009
  8. doi request reprint Low-dose ionizing radiation and chromosome translocations: a review of the major considerations for human biological dosimetry
    James D Tucker
    Department of Biological Sciences, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202, USA
    Mutat Res 659:211-20. 2008
  9. ncbi request reprint Persistence of chromosome aberrations following acute radiation: I, PAINT translocations, dicentrics, rings, fragments, and insertions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Environ Mol Mutagen 45:229-48. 2005
  10. ncbi request reprint Persistence of chromosome aberrations following acute radiation: II, does it matter how translocations are scored?
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48109, USA
    Environ Mol Mutagen 45:249-57. 2005

Detail Information

Publications36

  1. ncbi request reprint Radiation cytogenetics: from chromosomes to single nucleotides and from metaphase cells to tissues
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA
    Cancer Metastasis Rev 23:341-9. 2004
    ..The final section provides a look towards the future and makes recommendations including suggestions for technological innovations that would enhance the field of radiation cytology...
  2. doi request reprint Accurate gene expression-based biodosimetry using a minimal set of human gene transcripts
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan Electronic address
    Int J Radiat Oncol Biol Phys 88:933-9. 2014
    ..The low cost and relative ease of PCR compared with existing dosimetry methods suggest that this approach may be useful in mass-casualty triage situations...
  3. ncbi request reprint Gene expression-based detection of radiation exposure in mice after treatment with granulocyte colony-stimulating factor and lipopolysaccharide
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Radiat Res 177:209-19. 2012
    ..These data suggest that PCR-based quantitative gene expression analyses may have utility in radiation biodosimetry in humans even in the presence of an infection or after treatment with G-CSF...
  4. doi request reprint Estimating the lowest detectable dose of ionizing radiation by FISH whole-chromosome painting
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 175:631-7. 2011
    ..05 and P  =  0.01, respectively. These results improve our understanding of the requirements and limitations for performing biological dosimetry when only the age of the exposed individual is known...
  5. pmc Cytogenetic analysis of an exposed-referent study: perchloroethylene-exposed dry cleaners compared to unexposed laundry workers
    James D Tucker
    Department of Biological Sciences, 2117 Biological Sciences Building, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202 3917, USA
    Environ Health 10:16. 2011
    ..Adverse health effects have been associated with PCE exposure. However, investigations of possible cumulative cytogenetic damage resulting from PCE exposure are lacking...
  6. doi request reprint Chromosome translocations and assessing human exposure to adverse environmental agents
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Environ Mol Mutagen 51:815-24. 2010
    ..This article concludes with an assessment of the future of translocation analyses...
  7. doi request reprint Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder
    James D Tucker
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202 3917, United States
    Mutat Res 677:53-8. 2009
    ..53, 0.28, 0.81, respectively). These results provide evidence in a large cohort that MPH does not induce cytogenetic anomalies in children, in contrast to the findings of the El-Zein study...
  8. doi request reprint Low-dose ionizing radiation and chromosome translocations: a review of the major considerations for human biological dosimetry
    James D Tucker
    Department of Biological Sciences, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202, USA
    Mutat Res 659:211-20. 2008
    ..This work would enhance our comprehension of the effects of low-dose radiation exposure and could lead to significant improvements in understanding the relationship between chromosome damage and human health...
  9. ncbi request reprint Persistence of chromosome aberrations following acute radiation: I, PAINT translocations, dicentrics, rings, fragments, and insertions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Environ Mol Mutagen 45:229-48. 2005
    ..These data emphasize the importance of considering translocation loss in biological dosimetry long times after exposure...
  10. ncbi request reprint Persistence of chromosome aberrations following acute radiation: II, does it matter how translocations are scored?
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48109, USA
    Environ Mol Mutagen 45:249-57. 2005
    ..Despite these differences, the temporal frequency of translocation losses at both the high and low doses was similar for both subjects...
  11. ncbi request reprint Multi-endpoint biological monitoring of phosphine workers
    James D Tucker
    Biology and Biotechnology Research Program, P O Box 808, L 448 Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Mutat Res 536:7-14. 2003
    ..The results are most easily interpreted as supporting the effectiveness of the personal protective equipment that is now worn by the workers but which was not employed prior to and during the earlier studies...
  12. ncbi request reprint Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 161:648-55. 2004
    ..The health effects of exposure to high-LET radiation in humans on prolonged space flights should remain a matter of concern...
  13. doi request reprint Developing point of care and high-throughput biological assays for determining absorbed radiation dose
    Michael C Joiner
    Dept of Radiation Oncology, Wayne State University, Detroit, MI 48201 2013, USA
    Radiother Oncol 101:233-6. 2011
    ..qPCR can rapidly analyze small blood samples and could be adopted into a field-portable instrument that provides a radiation dose readout within 30 min...
  14. doi request reprint Bystander effects induced by chemicals and ionizing radiation: evaluation of changes in gene expression of downstream MAPK targets
    Rajalakshmi Asur
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Suite 1370, Detroit, MI 48202 3917, USA
    Mutagenesis 25:271-9. 2010
    ..These results provide evidence for bystander-induced changes in MAPK proteins and downstream targets and suggest that the bystander effects are a part of a general stress response...
  15. doi request reprint Involvement of MAPK proteins in bystander effects induced by chemicals and ionizing radiation
    Rajalakshmi Asur
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Suite 1370, Detroit, MI 48202 3917, USA
    Mutat Res 686:15-29. 2010
    ....
  16. ncbi request reprint Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the chernobyl nuclear reactor 6-13 years after exposure
    Irene M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94550, USA
    Radiat Res 158:424-42. 2002
    ..Based on this estimated dose, the risk of exposure-related cancer is expected to be low...
  17. doi request reprint Relationships among micronuclei, nucleoplasmic bridges and nuclear buds within individual cells in the cytokinesis-block micronucleus assay
    Han S J Cheong
    Department of Biological Sciences, 5047 Gullen Mall, Wayne State University, Detroit, MI 48202 3917, USA
    Mutagenesis 28:433-40. 2013
    ....
  18. pmc Gene expression-based dosimetry by dose and time in mice following acute radiation exposure
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 8:e83390. 2013
    ..These results suggest that similar analyses in humans may be advantageous for use in a field-portable device designed to assess exposures in mass casualty situations. ..
  19. doi request reprint Mitochondrial gene expression changes in normal and mitochondrial mutant cells after exposure to ionizing radiation
    Rohan Kulkarni
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Radiat Res 173:635-44. 2010
    ..The altered sensitivity of mitochondrial mutant cells to ionizing radiation can lead to decreased DNA repair, which may put individuals with mtDNA mutations at greater risk for cancer and other diseases...
  20. doi request reprint Chemical induction of the bystander effect in normal human lymphoblastoid cells
    Rajalakshmi S Asur
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202 3917, USA
    Mutat Res 676:11-6. 2009
    ..We conclude that the bystander effect is not restricted to ionizing radiation, suggesting it may be a part of a general cellular stress response...
  21. ncbi request reprint Adaptive response induction and variation in human lymphoblastoid cell lines
    Karen J Sorensen
    Biology and Biotechnology Research Program, L 448 Lawrence Livermore National Laboratory, P O Box 808, 7000 East Ave, CA 94551 9900, USA
    Mutat Res 519:15-24. 2002
    ..In both cell lines, the direction of the response was altered when the distribution of cells within the cell cycle was changed, suggesting that the adaptive response can be affected by cell cycle stage at the time of irradiation...
  22. doi request reprint Expression of DNA repair and apoptosis genes in mitochondrial mutant and normal cells following exposure to ionizing radiation
    Rohan Kulkarni
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA
    Environ Mol Mutagen 52:229-37. 2011
    ..This study provides information that might be useful in characterizing energy dependent processes following exposure to stress or genotoxic agents...
  23. ncbi request reprint The cellular lethality of radiation-induced chromosome translocations in human lymphocytes
    Shea N Gardner
    Biology and Biotechnology Research Program, L 448, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Radiat Res 157:539-52. 2002
    ..Within the limits of these models, these findings indicate that both postulated mechanisms, i.e. inherent lethality and selection against dicentrics in the same cells, contribute to the loss of both one-way and two-way translocations...
  24. ncbi request reprint The role of mitochondria in the radiation-induced bystander effect in human lymphoblastoid cells
    Sountharia Rajendran
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Radiat Res 175:159-71. 2011
    ..Adding the inhibitors just prior to irradiation and removing them immediately after irradiation was uneventful. Fully functional mitochondrial metabolic capability may therefore be essential for the bystander effect...
  25. ncbi request reprint Evaluation and validation of housekeeping genes in response to ionizing radiation and chemical exposure for normalizing RNA expression in real-time PCR
    Malathi Banda
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mutat Res 649:126-34. 2008
    ....
  26. doi request reprint Mitochondrial mutant cells are hypersensitive to ionizing radiation, phleomycin and mitomycin C
    Rohan Kulkarni
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mutat Res 663:46-51. 2009
    ....
  27. ncbi request reprint Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response
    Matthew A Coleman
    Biology and Biotechnology Research Program, Lawrence Livermore, National Laboratory, Livermore, California 94551, USA
    Radiat Res 164:369-82. 2005
    ....
  28. doi request reprint Estimating the lowest detectable dose of ionizing radiation by the cytokinesis-block micronucleus assay
    James D Tucker
    a Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202
    Radiat Res 180:284-91. 2013
    ....
  29. doi request reprint Long-term exposure to depleted uranium in Gulf-War veterans does not induce chromosome aberrations in peripheral blood lymphocytes
    Marina V Bakhmutsky
    Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, United States
    Mutat Res 757:132-9. 2013
    ..These results indicate that chronic exposure to DU does not induce significant levels of chromosome damage in these Veterans. ..
  30. ncbi request reprint Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signature
    Allen T Christian
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, L 452 Livermore, CA 94551, USA
    Mutat Res 506:113-9. 2002
    ..This indicates that PhIP has a recognizable cytogenetic signature in rat mammary gland carcinomas...
  31. ncbi request reprint Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate
    Diane C Cabelof
    Karmanos Cancer Institute, Developmental Therapeutics Program, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA
    Cancer Res 66:7460-5. 2006
    ..Thus, the beta-pol(+/-) mouse represents a model in which mortality rate and tumor development are accelerated and provides evidence supporting the role of genomic maintenance in both aging and carcinogenesis...
  32. pmc Cigarette smoking during pregnancy: chromosome translocations and phenotypic susceptibility in mothers and newborns
    L Michelle Bennett
    Physical and Life Sciences Directorate, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, United States
    Mutat Res 696:81-8. 2010
    ..However, peripheral lymphocytes in pregnant women are more susceptible to genetic damage than peripheral lymphocytes in newborns...
  33. ncbi request reprint Sensitivity, specificity, and persistence of chromosome translocations for radiation biodosimetry
    James D Tucker
    Biology and Biotechnology Research Program, 7000 East Avenue, P O Box 808, L 448, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Mil Med 167:8-9. 2002
    ..This paper provides a brief evaluation of the use of translocation analyses by chromosome painting for biological dosimetry following chronic or low-dose exposure to ionizing radiation...
  34. ncbi request reprint Retrospective biodosimetry among United States radiologic technologists
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Radiat Res 167:727-34. 2007
    ..S. radiologic technologists...
  35. pmc International study of factors affecting human chromosome translocations
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Mutat Res 652:112-21. 2008
    ..Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes...
  36. ncbi request reprint Human population studies with cytogenetic biomarkers: review of the literature and future prospectives
    Stefano Bonassi
    Unit of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Environ Mol Mutagen 45:258-70. 2005
    ..The role of susceptibility and its potential impact on genotoxic damage are discussed with special attention to the effect of major genetic polymorphisms on the baseline frequency of CAs and micronuclei...