Archana Thakur

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi The role of nitric oxide in resistance to P. aeruginosa ocular infection
    Linda D Hazlett
    Department of Anatomy Cell Biology, Wayne State University, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 13:279-88. 2005
  2. pmc Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E, Warren Ave, Detroit, Michigan 48201, USA
    Mol Cancer 7:11. 2008
  3. ncbi Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice
    Archana Thakur
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 4820, USA
    Curr Eye Res 29:225-33. 2004
  4. ncbi c-Myc-induced chemosensitization is mediated by suppression of cyclin D1 expression and nuclear factor-kappa B activity in pancreatic cancer cells
    Hector Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Cancer Res 13:2811-21. 2007
  5. pmc Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells
    Archana Thakur
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Cancer Res 14:4427-36. 2008
  6. pmc Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway
    Archana Thakur
    Departments of Oncology and Medicine, Wayne State University and Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Transl Med 11:35. 2013
  7. pmc Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells
    Archana Thakur
    Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    PLoS ONE 7:e47520. 2012
  8. ncbi The role of X-linked genes in breast cancer
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Breast Cancer Res Treat 93:135-43. 2005
  9. ncbi Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice
    Yong Wang
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Hudson Webber Cancer Research Center, Wayne State University School of Medicine, Detroit, MI, USA
    Cancer Res 67:3698-707. 2007
  10. pmc Generation and immunologic functions of Th17 cells in malignant gliomas
    Manjeera Paladugu
    Department of Neurosurgery, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Cancer Immunol Immunother 62:75-86. 2013

Collaborators

Detail Information

Publications37

  1. ncbi The role of nitric oxide in resistance to P. aeruginosa ocular infection
    Linda D Hazlett
    Department of Anatomy Cell Biology, Wayne State University, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 13:279-88. 2005
    ..This study determined the role of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) in the resistance response of BALB/c mice to P. aeruginosa-induced keratitis...
  2. pmc Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E, Warren Ave, Detroit, Michigan 48201, USA
    Mol Cancer 7:11. 2008
    ..To further evaluate the relevance of some of the selected differentially expressed genes, we investigated their expression pattern in human pancreatic cancer cell lines with high and low metastatic potentials...
  3. ncbi Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice
    Archana Thakur
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 4820, USA
    Curr Eye Res 29:225-33. 2004
    ..To elucidate these mechanisms, caspase-1 knockout (ICE(-/-)) mice, that do not release mature IL-1 beta after endotoxin challenge, were tested...
  4. ncbi c-Myc-induced chemosensitization is mediated by suppression of cyclin D1 expression and nuclear factor-kappa B activity in pancreatic cancer cells
    Hector Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Cancer Res 13:2811-21. 2007
    ....
  5. pmc Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells
    Archana Thakur
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Cancer Res 14:4427-36. 2008
    ..In this study, we further investigated whether RSK4 inhibits or promotes breast tumor growth and progression...
  6. pmc Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway
    Archana Thakur
    Departments of Oncology and Medicine, Wayne State University and Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Transl Med 11:35. 2013
    ..In this study, we investigated the mechanism(s) of bispecific antibody armed ATC mediated inhibition of MDSC in the presence or absence of Th1 microenvironment...
  7. pmc Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells
    Archana Thakur
    Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    PLoS ONE 7:e47520. 2012
    ..Our results verify enhanced cytotoxicity after a novel chemotherapy conditioning strategy against PC that warrants further in vivo and clinical investigations...
  8. ncbi The role of X-linked genes in breast cancer
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Breast Cancer Res Treat 93:135-43. 2005
    ..Increased understanding of the role of X-linked genes and genetic pathways will provide the strategies to develop the molecular therapeutics to treat and prevent reproductive related cancers...
  9. ncbi Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice
    Yong Wang
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Hudson Webber Cancer Research Center, Wayne State University School of Medicine, Detroit, MI, USA
    Cancer Res 67:3698-707. 2007
    ..In summary, overexpression of cyclin D1 may commit mammary epithelia to a tumor-prone phenotype in which cooperation with other genes, such as synergy with c-myc, may lead to a more aggressive phenotype...
  10. pmc Generation and immunologic functions of Th17 cells in malignant gliomas
    Manjeera Paladugu
    Department of Neurosurgery, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Cancer Immunol Immunother 62:75-86. 2013
    ..Further studies on the mechanism of tumor-infiltration, developmental pathways, and pro-/anti-tumor functions of Th17 cells will provide rationale for developing novel adjuvant immunotherapeutic strategies for malignant gliomas...
  11. ncbi Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
    Mol Cancer Res 5:171-81. 2007
    ..The activation status of the X-chromosome may influence the expression levels of X-linked oncogenes or tumor suppressor genes...
  12. pmc Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies
    Ian M Zitron
    Department of Neurosurgery, Wayne State University, Karmanos Cancer Institute, Detroit, MI, USA
    BMC Cancer 13:83. 2013
    ..Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2...
  13. ncbi Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line
    Hector Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 11:6075-86. 2005
    ..Because pancreatic cancer is invariably resistant to chemotherapy, the goal of this study was to examine whether the drug resistance of pancreatic cancer cells is in part attributed to cyclin D1 overexpression...
  14. pmc CD20-targeted T cells after stem cell transplantation for high risk and refractory non-Hodgkin's lymphoma
    Lawrence G Lum
    Department of Oncology, Wayne State University, Detroit, Michigan, USA
    Biol Blood Marrow Transplant 19:925-33. 2013
    ..Polyclonal and specific antibodies were near normal 3 months after SCT. aATC infusions were safe and increased innate and specific antilymphoma cell immunity without impairing antibody recovery after SCT...
  15. ncbi Caspase-1 inhibitor reduces severity of pseudomonas aeruginosa keratitis in mice
    Archana Thakur
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48230, USA
    Invest Ophthalmol Vis Sci 45:3177-84. 2004
    ..To test an inhibitor of IL-1beta converting enzyme (ICE), with or without ciprofloxacin, in a C57BL/6 mouse model of keratitis induced by Pseudomonas aeruginosa in which corneal perforation is expected...
  16. pmc The immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent
    Bin Bao
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Biochim Biophys Acta 1825:160-72. 2012
    ....
  17. pmc A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells
    Archana Thakur
    Department of Oncology, Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Institute, 723 Hudson Webber Cancer Research Center, 4100 John R, Detroit, MI 48201, USA
    Cancer Immunol Immunother 61:497-509. 2012
    ....
  18. pmc Identification of the cyclin D1b mRNA variant in mouse
    Jack Wu
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Mol Biol Rep 36:953-7. 2009
    ..It appears to be expressed ubiquitously and differentially in various mouse cell lines and tissues and its level might be proportional to that of the canonical endogenous cyclin D1a mRNA...
  19. pmc Targeting cytomegalovirus-infected cells using T cells armed with anti-CD3 × anti-CMV bispecific antibody
    Lawrence G Lum
    Bone Marrow Transplantation and Immunotherapy Program, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA
    Biol Blood Marrow Transplant 18:1012-22. 2012
    ..This nonmajor histocompatibility complex restricted strategy for targeting CMV could be used to prevent or treat CMV infections after allogeneic stem cell transplantation or organ transplantation...
  20. pmc Anti-CD3 × anti-GD2 bispecific antibody redirects T-cell cytolytic activity to neuroblastoma targets
    Maxim Yankelevich
    Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Pediatr Blood Cancer 59:1198-205. 2012
    ..We tested a unique bispecific antibody anti-CD3 × anti-GD2 (3F8BiAb) for its ability to redirect activated T cells (ATC) to target GD2-positive neuroblastomas...
  21. pmc In vitro synthesis of primary specific anti-breast cancer antibodies by normal human peripheral blood mononuclear cells
    Archana Thakur
    Departments of Oncology, Medicine, Immunology and Microbiology, Wayne State University School of Medicine, 731 Hudson Webber Cancer Research Center, 4100 John R, Detroit, MI 48201, USA
    Cancer Immunol Immunother 60:1707-20. 2011
    ..This model provides a unique opportunity to evaluate the interactions of T-cells, B-cells, and antigen-presenting cells leading to specific anti-tumor antibody responses...
  22. pmc Activated T cells from umbilical cord blood armed with anti-CD3 × anti-CD20 bispecific antibody mediate specific cytotoxicity against CD20+ targets with minimal allogeneic reactivity: a strategy for providing antitumor effects after cord blood transplants
    Archana Thakur
    Department of Oncology, Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Transfusion 52:63-75. 2012
    ....
  23. ncbi Regulation of intracellular calcium release and PP1alpha in a mechanism for 4-hydroxytamoxifen-induced cytotoxicity
    Aliccia Bollig
    Karmanos Cancer Institute, Wayne State University, 110 E Warren, HWCRC room 731, Detroit, MI 48201, USA
    Mol Cell Biochem 305:45-54. 2007
    ..Results from these investigations strongly suggest a role for PP1alpha upregulation in a mechanism for 4OHT-induced changes to Ca2+ signaling that ultimately contribute to the cytotoxic effects of 4OHT...
  24. pmc The Predominant Proteins that React to the MC-20 Estrogen Receptor Alpha Antibody Differ in Molecular Weight between the Mammary Gland and Uterus in the Mouse and Rat
    Aliccia Bollig-Fischer
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Int J Biomed Sci 8:51-63. 2012
    ..These results suggest that while the lactating specific wt ERα alone or together with the MC20RP may sustain lactation, the MC20RP may support proliferation of the mammary gland and some mammary tumors...
  25. pmc Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity
    Sagar Dandawate
    Department of Neurosurgery, Wayne State University, Detroit, MI 48201, USA
    Cancer Immunol Immunother 61:701-11. 2012
    ....
  26. pmc Induction of specific cellular and humoral responses against renal cell carcinoma after combination therapy with cryoablation and granulocyte-macrophage colony stimulating factor: a pilot study
    Archana Thakur
    Department of Oncology, Wayne State University, Karmanos Cancer Institute, Detroit, MI, USA
    J Immunother 34:457-67. 2011
    ..These pilot data show that CI can induce robust and brisk cellular and humoral immune responses in patients with metastatic RCC, but requires further evaluation in optimized protocols...
  27. pmc Targeting T cells with bispecific antibodies for cancer therapy
    Lawrence G Lum
    Department of Oncology, Wayne State University and Barbara Ann Karmanos Cancer Center, Detroit, MI, USA
    BioDrugs 25:365-79. 2011
    ..This review focuses on arming T cells with BiAbs to create the 'poor man's cytotoxic lymphocyte'...
  28. ncbi Gene expression of pro-inflammatory cytokines and chemokines in mouse eye infected with Pseudomonas aeruginosa
    Mei Lang Xue
    Cooperative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, New South Wales, Australia
    Clin Experiment Ophthalmol 30:196-9. 2002
    ..aeruginosa challenge. These data indicate that over-expression of pro-inflammatory cytokines and chemokines may represent a vigorous immune response and therefore may contribute to corneal damage during P. aeruginosa infection...
  29. ncbi Macrophage inflammatory protein-2 and vascular endothelial growth factor regulate corneal neovascularization induced by infection with Pseudomonas aeruginosa in mice
    Mei Lang Xue
    Cooperative Research Centre for Eye Research and Technology, School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
    Immunol Cell Biol 80:323-7. 2002
    ..The present study demonstrates that both MIP-2 and VEGF are important mediators in the regulation of corneal neovascularization caused by P. aeruginosa infection, and that MIP-2 regulates the production of VEGF...
  30. ncbi Pseudomonas aeruginosa keratitis in IL-6-deficient mice
    Nerida Cole
    Co operative Research Centre for Eye Research and Technology, Cornea and Contact Lens Research Unit and School of Optometry, University of New South Wales, Sydney, Australia
    Int Arch Allergy Immunol 130:165-72. 2003
    ..Using IL-6-/- mice, we have explored the role of IL-6 in P. aeruginosa keratitis...
  31. ncbi Regulation of MMPs and TIMPs by IL-1beta during corneal ulceration and infection
    Mei Lang Xue
    Cooperative Research Centre for Eye Research and Technology and Cornea and Contact Lens Research Unit, School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 44:2020-5. 2003
    ..This study was conducted to investigate the role of IL-1beta in the regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in a mouse model of experimental keratitis and corneal injury...
  32. ncbi Effects of alpha-toxin-deficient Staphylococcus aureus on the production of peripheral corneal ulceration in an animal model
    Peter Z J Wu
    Vision Cooperative Research Centre and Cornea and Contact Lens Research Unit, School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia
    Curr Eye Res 30:63-70. 2005
    ..To examine the role of Staphylococcus aureus alpha-toxin in contact lens-induced peripheral ulceration (CLPU)...
  33. ncbi Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection
    Nerida Cole
    Institute for Eye Research, Kensington, NSW, Australia
    Curr Eye Res 30:535-42. 2005
    ..To determine the contribution of interleukin-4 (IL-4) to the initial host response during corneal infection with Pseudomonas aeruginosa in a mouse model...
  34. ncbi A critical role for CCL2 and CCL3 chemokines in the regulation of polymorphonuclear neutrophils recruitment during corneal infection in mice
    Mei Lang Xue
    Vision Cooperative Research Centre, Sydney, NSW, Australia
    Immunol Cell Biol 85:525-31. 2007
    ..Our findings provide strong evidence that CCL2 and CCL3 are critical regulators of PMN recruitment, and may lead to therapeutic strategies via targeting of the CC chemokines, CCL2 and CCL3, in the management of P. aeruginosa keratitis...
  35. ncbi The induction and suppression of the apoptotic response of HSV-1 in human corneal epithelial cells
    David H Miles
    Vision Cooperative Research Centre, Sydney, Australia
    Invest Ophthalmol Vis Sci 48:789-96. 2007
    ..The purpose of this study was to determine whether HSV-1 infection of human corneal epithelial (HCE) cells alone induces an early proapoptotic response and whether this response is subsequently downregulated during the infection...
  36. ncbi 1 alpha,25-Dihydroxyvitamin D3 inhibits pro-inflammatory cytokine and chemokine expression in human corneal epithelial cells colonized with Pseudomonas aeruginosa
    Mei Lang Xue
    Cooperative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, New South Wales, Australia
    Immunol Cell Biol 80:340-5. 2002
    ..aeruginosa-induced expression of IL-1 beta, IL-6 and IL-8 in HCE cells, suggesting that this vitamin may have the potential to become a novel anti-inflammatory agent in ocular disease...
  37. ncbi Perspectives on c-Myc, Cyclin D1, and their interaction in cancer formation, progression, and response to chemotherapy
    D Joshua Liao
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    Crit Rev Oncog 13:93-158. 2007
    ....