MICHAEL TAINSKY

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families
    Ludmila Kaplun
    Program in Molecular Imaging and Biomarkers, Wayne State University School of Medicine, Detroit MI Department of Oncology, Wayne State University School of Medicine, Detroit MI
    Biomark Insights 7:151-7. 2012
  2. pmc Epigenetic silencing of IRF7 and/or IRF5 in lung cancer cells leads to increased sensitivity to oncolytic viruses
    Qunfang Li
    Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
    PLoS ONE 6:e28683. 2011
  3. pmc Multianalyte tests for the early detection of cancer: speedbumps and barriers
    Michael A Tainsky
    Program in Molecular Biology and Genetics, Karmanos Cancer Institute Wayne State University, 110 E Warren, Detroit, MI 48201
    Biomark Insights 2:261-7. 2007
  4. doi request reprint RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST
    Daochun Sun
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Mol Cancer Res 11:616-27. 2013
  5. doi request reprint Detecting tumor-specific autoantibodies for cancer diagnosis: a technology overview
    Steven P Dudas
    Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute and Department of Pathology, Program in Molecular Biology and Genetics, 110 E Warren, Prentis 3115, Detroit, MI 48201 3917, USA 1 313 578 4340 1 313 832 7294
    Expert Opin Med Diagn 3:251-61. 2009
  6. pmc Genomic and proteomic biomarkers for cancer: a multitude of opportunities
    Michael A Tainsky
    Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, USA
    Biochim Biophys Acta 1796:176-93. 2009
  7. ncbi request reprint Ethnic differences in survival among women with ovarian carcinoma
    Jill S Barnholtz-Sloan
    Epidemiology Section, Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer 94:1886-93. 2002
  8. pmc Analysis of the expression of human tumor antigens in ovarian cancer tissues
    Rouba Ali-Fehmi
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Biomark 6:33-48. 2010
  9. pmc Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays
    Madhumita Chatterjee
    Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University, 110 East Warren, Detroit, MI 48201, USA
    Cancer Res 66:1181-90. 2006
  10. ncbi request reprint Expression profiling identifies three pathways altered in cellular immortalization: interferon, cell cycle, and cytoskeleton
    Aviva Levine Fridman
    Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 110 East Warren Ave, Detroit, Michigan 48201, USA
    J Gerontol A Biol Sci Med Sci 61:879-89. 2006

Collaborators

Detail Information

Publications24

  1. pmc Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families
    Ludmila Kaplun
    Program in Molecular Imaging and Biomarkers, Wayne State University School of Medicine, Detroit MI Department of Oncology, Wayne State University School of Medicine, Detroit MI
    Biomark Insights 7:151-7. 2012
    ..Our observation provides a novel candidate genetic biomarker of elevated ovarian cancer risk in members of high-risk families without BRCA1/2 mutations, as well as a potential therapeutic target, TSAd...
  2. pmc Epigenetic silencing of IRF7 and/or IRF5 in lung cancer cells leads to increased sensitivity to oncolytic viruses
    Qunfang Li
    Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
    PLoS ONE 6:e28683. 2011
    ....
  3. pmc Multianalyte tests for the early detection of cancer: speedbumps and barriers
    Michael A Tainsky
    Program in Molecular Biology and Genetics, Karmanos Cancer Institute Wayne State University, 110 E Warren, Detroit, MI 48201
    Biomark Insights 2:261-7. 2007
    ..Here we discuss the technical and regulatory barriers inherent in development of clinical multianalyte biomarker assays...
  4. doi request reprint RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST
    Daochun Sun
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Mol Cancer Res 11:616-27. 2013
    ..The pathway-specific gene changes provide a greater understanding of the complex role of neurofibromin in MPNST pathology and novel targets for drug discovery...
  5. doi request reprint Detecting tumor-specific autoantibodies for cancer diagnosis: a technology overview
    Steven P Dudas
    Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute and Department of Pathology, Program in Molecular Biology and Genetics, 110 E Warren, Prentis 3115, Detroit, MI 48201 3917, USA 1 313 578 4340 1 313 832 7294
    Expert Opin Med Diagn 3:251-61. 2009
    ..The development of highly accurate reliable assays is a prerequisite for this technology to be integrated into clinically applicable strategies in patient care...
  6. pmc Genomic and proteomic biomarkers for cancer: a multitude of opportunities
    Michael A Tainsky
    Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, USA
    Biochim Biophys Acta 1796:176-93. 2009
    ..Novel genomic, proteomic and metabolomic technologies are being used to discover and validate tumor biomarkers individually and in panels...
  7. ncbi request reprint Ethnic differences in survival among women with ovarian carcinoma
    Jill S Barnholtz-Sloan
    Epidemiology Section, Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer 94:1886-93. 2002
    ..The objective of this study was to examine ethnic differences in survival after ovarian carcinoma in a population-based sample of women...
  8. pmc Analysis of the expression of human tumor antigens in ovarian cancer tissues
    Rouba Ali-Fehmi
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Biomark 6:33-48. 2010
    ..Together, our results indicate that occurrence of humoral immune responses against some of these TAAs in OVCA patients is triggered by antigen protein overexpression...
  9. pmc Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays
    Madhumita Chatterjee
    Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University, 110 East Warren, Detroit, MI 48201, USA
    Cancer Res 66:1181-90. 2006
    ..Further work with larger panels of antigens should provide a comprehensive set of markers with sufficient sensitivity and specificity suitable for clinical testing in high-risk populations...
  10. ncbi request reprint Expression profiling identifies three pathways altered in cellular immortalization: interferon, cell cycle, and cytoskeleton
    Aviva Levine Fridman
    Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 110 East Warren Ave, Detroit, Michigan 48201, USA
    J Gerontol A Biol Sci Med Sci 61:879-89. 2006
    ..The identification of the genes and pathways regulating immortalization will lead to a better understanding of cellular immortalization and molecular targets in cancer and aging...
  11. ncbi request reprint Update on ovarian cancer screening
    Adnan Munkarah
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Wayne State University School of Medicine, Detroit, MI, USA
    Curr Opin Obstet Gynecol 19:22-6. 2007
    ..There is therefore an ongoing need to identify new screening tests and strategies that should be readily available, relatively noninvasive, and achieve high sensitivity, specificity, and positive and negative predictive values...
  12. ncbi request reprint Epigenetic and functional analysis of IGFBP3 and IGFBPrP1 in cellular immortalization
    Aviva Levine Fridman
    Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, MI 48201, USA
    Biochem Biophys Res Commun 357:785-91. 2007
    ..Analysis of how IGFBPs regulate immortalization will lead to a better understanding of this process and may lead to novel methods for the prevention and treatment of cancer...
  13. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
    ..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
  14. doi request reprint Discovery of antibody biomarkers using protein microarrays of tumor antigens cloned in high throughput
    Madhumita Chatterjee
    Department of Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
    Methods Mol Biol 520:21-38. 2009
    ..Furthermore, validation of these antigens by different bioinformatics and biological approaches will reveal the diagnostic/prognostic utility of these antigens for personalized immunotherapy...
  15. pmc Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study
    Vitaly Balan
    Department of Pathology, Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Cancer Res 68:10045-50. 2008
    ..The data implicate galectin-3 H(64) in breast cancer and explain, in part, the noted racial disparity, thus providing a novel target for diagnosis and treatment...
  16. pmc Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts
    Qunfang Li
    Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA
    Mol Cancer Res 6:770-84. 2008
    ..The IFN pathway may provide valuable molecular targets for therapeutic interventions at early stages of cancer development...
  17. ncbi request reprint Non-traditional immunogens and their application to immunotherapy
    Madhumita Chatterjee
    Wayne State University, Karmanos Cancer Institute, Program in Molecular Biology and Genetics, 110 East Warren, Prentis 311, Detroit, MI 48201, USA
    Curr Opin Mol Ther 10:62-7. 2008
    ..This review summarizes the discovery and functional characteristics of non-traditional immunogens, in particular mimotopes in cancer immunotherapy...
  18. ncbi request reprint Stat1 expression is not sufficient to regulate the interferon signaling pathway in cellular immortalization
    Lin Tang
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Interferon Cytokine Res 26:14-26. 2006
    ..We concluded that factor(s) additional to Stat1 (whether IFN dependent or not) are required for the immortalization of LFS fibroblasts...
  19. ncbi request reprint Immunotheranostics: breaking tolerance in immunotherapy using tumor autoantigens identified on protein microarrays
    Madhumita Chatterjee
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Program in Molecular Biology and Human Genetics, Detroit, MI 48201, USA
    Curr Opin Drug Discov Devel 9:380-5. 2006
    ....
  20. ncbi request reprint Microsatellite alterations in african americans with head and neck cancer
    George H Yoo
    Department of Otolaryngology Head and Neck Surgery, Wayne State University, Detroit, MI, USA
    Laryngoscope 114:1619-24. 2004
    ..To determine the genetic differences between African Americans (AA) and Non-African Americans (NAA) with head and neck squamous cell carcinoma (HNSCC)...
  21. ncbi request reprint Communication and decision-making about seeking inherited cancer risk information: findings from female survivor-relative focus groups
    Suzanne Mellon
    University of Detroit Mercy, 4001 W McNichols Road, MI 48221 0900, USA
    Psychooncology 15:193-208. 2006
    ..Results from this study support inclusion of family members in addressing inherited cancer risk information and contextual family factors critical to consider in potentially high risk families...
  22. ncbi request reprint Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha
    Seiji Sumigama
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Oncogene 23:5496-504. 2004
    ..The present data represent the first direct evidence that AP-2alpha plays a tumor suppressive role in ovarian cancer...
  23. ncbi request reprint Breast cancer genetics in African Americans
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Cancer 97:236-45. 2003
    ..An overview of the state of genetic testing for BRCA1 and BRCA2 genes was presented at the Summit Meeting on Breast Cancer Among African American women...
  24. ncbi request reprint Concerns and recommendations regarding inherited cancer risk: the perspectives of survivors and female relatives
    Suzanne Mellon
    University of Detroit Mercy, Detroit, MI 48219 0900, USA
    J Cancer Educ 22:168-73. 2007
    ..Little research is available comparing differences in cancer risk perceptions between cancer survivors and family members at risk for hereditary breast/ovarian cancer...

Research Grants8

  1. Early Detection of Breast Cancer Using Autoantibody Mar*
    MICHAEL TAINSKY; Fiscal Year: 2007
    ..Such an approach should provide an early detection assay for asymptomatic women. ..
  2. DYSREGULATION OF DIFFERENTIATION IN RAS TRANSFORMED CELL
    MICHAEL TAINSKY; Fiscal Year: 1999
    ..abstract_text> ..
  3. Markers for the Early Detection of Ovarian Cancer
    MICHAEL TAINSKY; Fiscal Year: 2007
    ..The principle is that we clone epitopes reacting with IgG in patients sera and use them to detect antibodies in sera to discriminate cancer and healthy subjects and whether we can detect disease prior to standard diagnosis. ..
  4. DYSREGULATION OF DIFFERENTIATION IN RAS TRANSFORMED CELL
    MICHAEL TAINSKY; Fiscal Year: 2000
    ..abstract_text> ..
  5. DYSREGULATION OF DIFFERENTIATION IN RAS TRANSFORMED CELL
    MICHAEL TAINSKY; Fiscal Year: 2001
    ..abstract_text> ..
  6. DYSREGULATION OF DIFFERENTIATION IN RAS TRANSFORMED CELL
    MICHAEL TAINSKY; Fiscal Year: 2002
    ..abstract_text> ..