Affiliation: Wayne State University
- RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNSTDaochun Sun
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
Mol Cancer Res 11:616-27. 2013..The pathway-specific gene changes provide a greater understanding of the complex role of neurofibromin in MPNST pathology and novel targets for drug discovery...
- Detecting tumor-specific autoantibodies for cancer diagnosis: a technology overviewSteven P Dudas
Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute and Department of Pathology, Program in Molecular Biology and Genetics, 110 E Warren, Prentis 3115, Detroit, MI 48201 3917, USA 1 313 578 4340 1 313 832 7294
Expert Opin Med Diagn 3:251-61. 2009..The development of highly accurate reliable assays is a prerequisite for this technology to be integrated into clinically applicable strategies in patient care...
- Genomic and proteomic biomarkers for cancer: a multitude of opportunitiesMichael A Tainsky
Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, USA
Biochim Biophys Acta 1796:176-93. 2009..Novel genomic, proteomic and metabolomic technologies are being used to discover and validate tumor biomarkers individually and in panels...
- Ethnic differences in survival among women with ovarian carcinomaJill S Barnholtz-Sloan
Epidemiology Section, Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Cancer 94:1886-93. 2002..The objective of this study was to examine ethnic differences in survival after ovarian carcinoma in a population-based sample of women...
- Analysis of the expression of human tumor antigens in ovarian cancer tissuesRouba Ali-Fehmi
Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Biomark 6:33-48. 2010..Together, our results indicate that occurrence of humoral immune responses against some of these TAAs in OVCA patients is triggered by antigen protein overexpression...
- Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arraysMadhumita Chatterjee
Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University, 110 East Warren, Detroit, MI 48201, USA
Cancer Res 66:1181-90. 2006..Further work with larger panels of antigens should provide a comprehensive set of markers with sufficient sensitivity and specificity suitable for clinical testing in high-risk populations...
- Epigenetic and functional analysis of IGFBP3 and IGFBPrP1 in cellular immortalizationAviva Levine Fridman
Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, MI 48201, USA
Biochem Biophys Res Commun 357:785-91. 2007..Analysis of how IGFBPs regulate immortalization will lead to a better understanding of this process and may lead to novel methods for the prevention and treatment of cancer...
- Expression profiling identifies three pathways altered in cellular immortalization: interferon, cell cycle, and cytoskeletonAviva Levine Fridman
Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 110 East Warren Ave, Detroit, Michigan 48201, USA
J Gerontol A Biol Sci Med Sci 61:879-89. 2006..The identification of the genes and pathways regulating immortalization will lead to a better understanding of cellular immortalization and molecular targets in cancer and aging...
- Update on ovarian cancer screeningAdnan Munkarah
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Wayne State University School of Medicine, Detroit, MI, USA
Curr Opin Obstet Gynecol 19:22-6. 2007..There is therefore an ongoing need to identify new screening tests and strategies that should be readily available, relatively noninvasive, and achieve high sensitivity, specificity, and positive and negative predictive values...
- Discovery of antibody biomarkers using protein microarrays of tumor antigens cloned in high throughputMadhumita Chatterjee
Department of Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
Methods Mol Biol 520:21-38. 2009..Furthermore, validation of these antigens by different bioinformatics and biological approaches will reveal the diagnostic/prognostic utility of these antigens for personalized immunotherapy...
- Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot studyVitaly Balan
Department of Pathology, Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, USA
Cancer Res 68:10045-50. 2008..The data implicate galectin-3 H(64) in breast cancer and explain, in part, the noted racial disparity, thus providing a novel target for diagnosis and treatment...
- Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblastsQunfang Li
Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA
Mol Cancer Res 6:770-84. 2008..The IFN pathway may provide valuable molecular targets for therapeutic interventions at early stages of cancer development...
- Non-traditional immunogens and their application to immunotherapyMadhumita Chatterjee
Wayne State University, Karmanos Cancer Institute, Program in Molecular Biology and Genetics, 110 East Warren, Prentis 311, Detroit, MI 48201, USA
Curr Opin Mol Ther 10:62-7. 2008..This review summarizes the discovery and functional characteristics of non-traditional immunogens, in particular mimotopes in cancer immunotherapy...
- Stat1 expression is not sufficient to regulate the interferon signaling pathway in cellular immortalizationLin Tang
Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Interferon Cytokine Res 26:14-26. 2006..We concluded that factor(s) additional to Stat1 (whether IFN dependent or not) are required for the immortalization of LFS fibroblasts...
- Stochastic cancer progression driven by non-clonal chromosome aberrationsHenry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Cell Physiol 208:461-72. 2006..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
- Immunotheranostics: breaking tolerance in immunotherapy using tumor autoantigens identified on protein microarraysMadhumita Chatterjee
Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Program in Molecular Biology and Human Genetics, Detroit, MI 48201, USA
Curr Opin Drug Discov Devel 9:380-5. 2006....
- Microsatellite alterations in african americans with head and neck cancerGeorge H Yoo
Department of Otolaryngology Head and Neck Surgery, Wayne State University, Detroit, MI, USA
Laryngoscope 114:1619-24. 2004..To determine the genetic differences between African Americans (AA) and Non-African Americans (NAA) with head and neck squamous cell carcinoma (HNSCC)...
- Breast cancer genetics in African AmericansOlufunmilayo I Olopade
Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
Cancer 97:236-45. 2003..An overview of the state of genetic testing for BRCA1 and BRCA2 genes was presented at the Summit Meeting on Breast Cancer Among African American women...
- Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alphaSeiji Sumigama
Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
Oncogene 23:5496-504. 2004..The present data represent the first direct evidence that AP-2alpha plays a tumor suppressive role in ovarian cancer...
- Concerns and recommendations regarding inherited cancer risk: the perspectives of survivors and female relativesSuzanne Mellon
University of Detroit Mercy, Detroit, MI 48219 0900, USA
J Cancer Educ 22:168-73. 2007..Little research is available comparing differences in cancer risk perceptions between cancer survivors and family members at risk for hereditary breast/ovarian cancer...
- Communication and decision-making about seeking inherited cancer risk information: findings from female survivor-relative focus groupsSuzanne Mellon
University of Detroit Mercy, 4001 W McNichols Road, MI 48221 0900, USA
Psychooncology 15:193-208. 2006..Results from this study support inclusion of family members in addressing inherited cancer risk information and contextual family factors critical to consider in potentially high risk families...
- DYSREGULATION OF DIFFERENTIATION IN RAS TRANSFORMED CELLMICHAEL TAINSKY; Fiscal Year: 2002..abstract_text> ..
- Markers for the Early Detection of Ovarian CancerMICHAEL TAINSKY; Fiscal Year: 2007..The principle is that we clone epitopes reacting with IgG in patients sera and use them to detect antibodies in sera to discriminate cancer and healthy subjects and whether we can detect disease prior to standard diagnosis. ..
- Early Detection of Breast Cancer Using Autoantibody Mar*MICHAEL TAINSKY; Fiscal Year: 2007..Such an approach should provide an early detection assay for asymptomatic women. ..