Gabriel Sosne

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Detroit, MI, USA
    Clin Ophthalmol 1:201-7. 2007
  2. doi request reprint Thymosin β4: a potential novel dry eye therapy
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 1270:45-50. 2012
  3. doi request reprint Thymosin beta4 and corneal wound healing: visions of the future
    Gabriel Sosne
    Department of Ophthalmology and Anatomy, Wayne State University School of Medicine, Kresge Eye Institute, Detroit, Michigan, USA
    Ann N Y Acad Sci 1194:190-8. 2010
  4. ncbi request reprint Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 293:175-83. 2004
  5. doi request reprint Biological activities of thymosin beta4 defined by active sites in short peptide sequences
    Gabriel Sosne
    Department of Opthalmology and Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    FASEB J 24:2144-51. 2010
  6. ncbi request reprint Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan, 48201, USA
    Invest Ophthalmol Vis Sci 46:2388-95. 2005
  7. ncbi request reprint Thymosin beta-4 and the eye: I can see clearly now the pain is gone
    Gabriel Sosne
    Department of Ophthalmology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall 8314, Detroit, MI 48201, USA
    Ann N Y Acad Sci 1112:114-22. 2007
  8. ncbi request reprint Thymosin beta4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Scott Hall 8314, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Exp Eye Res 83:502-7. 2006
  9. pmc Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, 540 E Canfield, Scott Hall 8314, Detroit, MI 48201, USA
    Exp Eye Res 84:663-9. 2007
  10. ncbi request reprint Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration
    Ping Qiu
    Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan 48201, USA
    J Cell Physiol 212:165-73. 2007

Research Grants

  1. Thymosin beta 4 and Autoimmune Ocular Surface Disease
    Gabriel Sosne; Fiscal Year: 2004
  2. Thymosin beta 4 and Corneal Wound Healing
    Gabriel Sosne; Fiscal Year: 2005

Collaborators

Detail Information

Publications18

  1. pmc Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Detroit, MI, USA
    Clin Ophthalmol 1:201-7. 2007
    ..The clinical implications of the use of Tbeta(4) as a wound healing and anti-inflammatory agent are discussed...
  2. doi request reprint Thymosin β4: a potential novel dry eye therapy
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 1270:45-50. 2012
    ..Herein, we discuss the scientific and clinical rationales that make Tβ4 a potential ideal candidate therapeutic for DES...
  3. doi request reprint Thymosin beta4 and corneal wound healing: visions of the future
    Gabriel Sosne
    Department of Ophthalmology and Anatomy, Wayne State University School of Medicine, Kresge Eye Institute, Detroit, Michigan, USA
    Ann N Y Acad Sci 1194:190-8. 2010
    ..Herein, we discuss some of our new basic scientific directions that may lead to the use of Tbeta(4) as a novel corneal wound healing and anti-inflammatory therapy...
  4. ncbi request reprint Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 293:175-83. 2004
    ..Tbeta(4) and TGFbeta-1 increase LM-5 gamma2 chain expression by independent pathways. Suppression of TGFbeta-1 further increases LM-5 gamma2 chain expression...
  5. doi request reprint Biological activities of thymosin beta4 defined by active sites in short peptide sequences
    Gabriel Sosne
    Department of Opthalmology and Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    FASEB J 24:2144-51. 2010
    ..This review details these important physiologically and pathologically active sites and their potential therapeutic uses...
  6. ncbi request reprint Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan, 48201, USA
    Invest Ophthalmol Vis Sci 46:2388-95. 2005
    ..The purpose of this study was to investigate the ability of thymosin-beta4 (Taubeta4) to promote healing in an alkali injury model and the mechanisms involved in that process...
  7. ncbi request reprint Thymosin beta-4 and the eye: I can see clearly now the pain is gone
    Gabriel Sosne
    Department of Ophthalmology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall 8314, Detroit, MI 48201, USA
    Ann N Y Acad Sci 1112:114-22. 2007
    ..These results have important clinical implications for the potential role of Tbeta-4 as a corneal anti-inflammatory and wound-healing agent...
  8. ncbi request reprint Thymosin beta4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Scott Hall 8314, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Exp Eye Res 83:502-7. 2006
    ..This study suggests that Tbeta(4) may be able to overcome the apoptotic side effect of BAK, and may be a useful additive to solutions containing this preservative...
  9. pmc Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway
    Gabriel Sosne
    Department of Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, 540 E Canfield, Scott Hall 8314, Detroit, MI 48201, USA
    Exp Eye Res 84:663-9. 2007
    ..These results have important clinical implications for the potential role of Tbeta4 as a corneal anti-inflammatory agent...
  10. ncbi request reprint Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration
    Ping Qiu
    Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan 48201, USA
    J Cell Physiol 212:165-73. 2007
    ..From these results we conclude that MMP catalytic activity is necessary for Tbeta(4) promotion of epithelial cell migration. These novel findings are the first to demonstrate a functional link between the two...
  11. ncbi request reprint Thymosin-beta4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 45:1095-100. 2004
    ..The efficacy of Tbeta(4) in preventing mitochondrial disruption and in inhibiting caspase-mediated apoptosis was examined...
  12. doi request reprint Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta4
    Steven P Dunn
    Department of Ophthalmology, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA
    Ann N Y Acad Sci 1194:199-206. 2010
    ..Results from these compassionate use cases indicate that Tbeta4 may provide a novel, topical approach to wound healing in chronic nonhealing neurotrophic corneal ulcers...
  13. ncbi request reprint Plasminogen activator inhibitor-1 (PAI-1) stimulates human corneal epithelial cell adhesion and migration in vitro
    Zhiyu Wang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Eye Res 80:1-8. 2005
    ..Initially PAI-1 may function to stimulate migration and facilitate the reepithelialization of the wound bed. Post-reepithelization, PAI-1 may ensure corneal epithelial cell adhesion to matrix to promote successful wound healing...
  14. ncbi request reprint Thymosin beta4 promotes human conjunctival epithelial cell migration
    Gabriel Sosne
    Kresge Eye Institute, Detroit, MI, USA
    Curr Eye Res 24:268-73. 2002
    ..In this study the effects of thymosin beta4 (Tbeta4) on migration and production of laminin-5 in the human conjunctival cell line HC0597 was analyzed...
  15. pmc Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK
    Ping Qiu
    Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan, USA
    FASEB J 25:1815-26. 2011
    ..In addition, the results of this study serve as a foundation for developing Tβ(4) as a new anti-inflammatory therapy...
  16. doi request reprint Thymosin beta4 is cytoprotective in human gingival fibroblasts
    Robert Reti
    Department of Biomedical Sciences, University of Detroit Mercy School of Dentistry, Detroit, MI, USA
    Eur J Oral Sci 116:424-30. 2008
    ....
  17. pmc Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas
    Mehrnoosh Saghizadeh
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Invest Ophthalmol Vis Sci 46:3604-15. 2005
    ..To identify proteinases and growth factors abnormally expressed in human corneas of donors with diabetic retinopathy (DR), additional to previously described matrix metalloproteinase (MMP)-10 and -3 and insulin-like growth factor (IGF)-I...
  18. ncbi request reprint Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury
    Gabriel Sosne
    Eye Care Services Department, Henry Ford Hospital, 2799 West Grand Boulevard K10, Detroit, MI 48202, U S A
    Exp Eye Res 74:293-9. 2002
    ..Thus, Tbeta(4) may provide a new clinical treatment for severe traumatic corneal wound disorders by promoting rapid corneal wound healing and decreasing both PMN infiltration and inflammatory cytokine and chemokine mRNA levels...

Research Grants2

  1. Thymosin beta 4 and Autoimmune Ocular Surface Disease
    Gabriel Sosne; Fiscal Year: 2004
    ..abstract_text> ..
  2. Thymosin beta 4 and Corneal Wound Healing
    Gabriel Sosne; Fiscal Year: 2005
    ..abstract_text> ..