Jack D Sobel

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Vaginitis due to Candida krusei: epidemiology, clinical aspects, and therapy
    Shivani Singh
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Clin Infect Dis 35:1066-70. 2002
  2. ncbi request reprint Recurrent group A streptococcal vulvovaginitis in adult women: family epidemiology
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    Clin Infect Dis 44:e43-5. 2007
  3. ncbi request reprint Vulvovaginal candidosis
    Jack D Sobel
    Department of Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    Lancet 369:1961-71. 2007
  4. ncbi request reprint Boric acid addition to suppressive antimicrobial therapy for recurrent bacterial vaginosis
    Orna Reichman
    Division of Infectious Disease, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Sex Transm Dis 36:732-4. 2009
  5. pmc Guidelines for the treatment of bacterial vaginosis: focus on tinidazole
    Laura J Dickey
    Department of Pharmacy Services, Detroit Receiving Hospital, Detroit, MI, USA
    Ther Clin Risk Manag 5:485-9. 2009
  6. pmc Longitudinal analysis of vaginal microbiome dynamics in women with recurrent bacterial vaginosis: recognition of the conversion process
    Janet A Lambert
    Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan, United States of America Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 8:e82599. 2013
  7. doi request reprint Mixed vaginitis-more than coinfection and with therapeutic implications
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    Curr Infect Dis Rep 15:104-8. 2013
  8. doi request reprint Diagnostic techniques for bacterial vaginosis and vulvovaginal candidiasis - requirement for a simple differential test
    Jack D Sobel
    Professor of Internal Medicine, Wayne State University School of Medicine, Detroit Medical Centre, Division of Infectious Diseases, 3990 John R Street, Detroit, MI 48201, USA 1 313 745 7105
    Expert Opin Med Diagn 4:333-41. 2010
  9. ncbi request reprint Diagnosing vaginal infections through measurement of biogenic amines by ion mobility spectrometry
    Jack D Sobel
    Harper University Hospital, Division of Infectious Diseases, Wayne State University School of Medicine, MI 48201, USA
    Eur J Obstet Gynecol Reprod Biol 163:81-4. 2012
  10. pmc Effect of pH on in vitro susceptibility of Candida glabrata and Candida albicans to 11 antifungal agents and implications for clinical use
    Claire S Danby
    Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA
    Antimicrob Agents Chemother 56:1403-6. 2012

Detail Information

Publications81

  1. ncbi request reprint Vaginitis due to Candida krusei: epidemiology, clinical aspects, and therapy
    Shivani Singh
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Clin Infect Dis 35:1066-70. 2002
    ..C. krusei is a rare but important cause of refractory vaginitis and is unique because of its intrinsic resistance to fluconazole...
  2. ncbi request reprint Recurrent group A streptococcal vulvovaginitis in adult women: family epidemiology
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    Clin Infect Dis 44:e43-5. 2007
    ..These cases reiterate the necessity for adequate screening of the patient's family and contacts in cases of recurrent GAS infection by culturing all potential areas of GAS carriage...
  3. ncbi request reprint Vulvovaginal candidosis
    Jack D Sobel
    Department of Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    Lancet 369:1961-71. 2007
    ..I review the epidemiology and pathogenesis of this infection, and also discuss management strategies...
  4. ncbi request reprint Boric acid addition to suppressive antimicrobial therapy for recurrent bacterial vaginosis
    Orna Reichman
    Division of Infectious Disease, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Sex Transm Dis 36:732-4. 2009
    ..Accordingly, topical boric acid (BA) aimed at biofilm removal was added to nitroimidazole induction and maintenance therapy creating a triple phase regimen to reduce symptomatic recurrence of BV in high-risk patients...
  5. pmc Guidelines for the treatment of bacterial vaginosis: focus on tinidazole
    Laura J Dickey
    Department of Pharmacy Services, Detroit Receiving Hospital, Detroit, MI, USA
    Ther Clin Risk Manag 5:485-9. 2009
    ..Available data suggest tinidazole has a role in special populations particularly for refractory or relapsing BV...
  6. pmc Longitudinal analysis of vaginal microbiome dynamics in women with recurrent bacterial vaginosis: recognition of the conversion process
    Janet A Lambert
    Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan, United States of America Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 8:e82599. 2013
    ..Larger studies are warranted to evaluate the prognostic potential of detecting conversion and poor Lb-qPCR scores at the post-treatment visit of recurrent BV patients. ..
  7. doi request reprint Mixed vaginitis-more than coinfection and with therapeutic implications
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    Curr Infect Dis Rep 15:104-8. 2013
    ..Coexistence of BV pathogens and T. vaginalis is even more common, with coinfection rates of 60 %-80 %. Both coinfection and mixed vaginitis have significant clinical and therapeutic implications and are worthy of further investigation...
  8. doi request reprint Diagnostic techniques for bacterial vaginosis and vulvovaginal candidiasis - requirement for a simple differential test
    Jack D Sobel
    Professor of Internal Medicine, Wayne State University School of Medicine, Detroit Medical Centre, Division of Infectious Diseases, 3990 John R Street, Detroit, MI 48201, USA 1 313 745 7105
    Expert Opin Med Diagn 4:333-41. 2010
    ..This would be of use both to physicians and to women who wish to self-diagnose and self-medicate, and would also help educate women about the possible alternative causes of vaginitis and vulvovaginal symptoms...
  9. ncbi request reprint Diagnosing vaginal infections through measurement of biogenic amines by ion mobility spectrometry
    Jack D Sobel
    Harper University Hospital, Division of Infectious Diseases, Wayne State University School of Medicine, MI 48201, USA
    Eur J Obstet Gynecol Reprod Biol 163:81-4. 2012
    ..To compare diagnosis of bacterial vaginosis according to the Amsel criteria with measurement by ion mobility spectrometry (IMS) of the biogenic amines that are present in vaginal discharge fluid...
  10. pmc Effect of pH on in vitro susceptibility of Candida glabrata and Candida albicans to 11 antifungal agents and implications for clinical use
    Claire S Danby
    Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA
    Antimicrob Agents Chemother 56:1403-6. 2012
    ..In selecting agents for treatment of recurrent C. glabrata vaginitis, clinicians should recognize the limitations of in vitro susceptibility testing utilizing pH 7.0...
  11. ncbi request reprint Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, USA
    N Engl J Med 351:876-83. 2004
    ..No safe and convenient regimen has proved to be effective for the management of recurrent vulvovaginal candidiasis...
  12. ncbi request reprint Caspofungin in the treatment of symptomatic candiduria
    Jack D Sobel
    Department of Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    Clin Infect Dis 44:e46-9. 2007
    ..Because the urine concentrations achieved by echinocandin antifungal agents are low, drugs from this class are excluded from consideration when candiduria treatment is selected...
  13. doi request reprint Prognosis and treatment of desquamative inflammatory vaginitis
    Jack D Sobel
    Division of Infectious Diseases, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Obstet Gynecol 117:850-5. 2011
    ..We describe patient outcomes and treatment at follow-up in a case series of 98 women diagnosed with this syndrome...
  14. doi request reprint Candida urinary tract infections--epidemiology
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Infect Dis 52:S433-6. 2011
    ..In ICU patients, although candiduria is a marker for increased mortality, it is only rarely attributable to Candida urinary tract infection...
  15. ncbi request reprint What's new in bacterial vaginosis and trichomoniasis?
    Jack D Sobel
    Harper University Hospital, Division of Infectious Diseases, 3990 John R 5 Hudson, Detroit, MI 48201, USA
    Infect Dis Clin North Am 19:387-406. 2005
    ..New diagnostic tests may soon be available that will allow women to test self-obtained specimens. Treatment of BV has lagged, although innovative methods appear to be helpful in managing recurrent diseases...
  16. doi request reprint Fluconazole-resistant Candida albicans vulvovaginitis
    Dror Marchaim
    Division of Infectious Diseases, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    Obstet Gynecol 120:1407-14. 2012
    ..We report increased occurrence of secondary fluconazole resistance, analysis of risk factors thereof, and describe management of fluconazole-refractory vaginitis...
  17. pmc Fungicidal activity of fluconazole against Candida albicans in a synthetic vagina-simulative medium
    Mahomed Yunus S Moosa
    Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 48:161-7. 2004
    ..Elucidating the mechanism by which FLZ and acetate interact may disclose vulnerable pathways that could be exploited in drug development...
  18. ncbi request reprint A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40
    Mitchell Goldman
    Indiana University School of Medicine, Division of Infectious Diseases, Wishard Memorial Hospital, Indianapolis, IN 46202, USA
    Clin Infect Dis 41:1473-80. 2005
    ..However, concerns exist with regard to the use of fluconazole prophylaxis and the risk of development of fluconazole treatment-refractory infections...
  19. ncbi request reprint Tinidazole for the treatment of vaginal infections
    Michael D Nailor
    Detroit Receiving Hospital, Department of Pharmacy, Detroit, MI, USA
    Expert Opin Investig Drugs 16:743-51. 2007
    ..Although uncommon, high-level trichomonal metronidazole resistance can be reliably cured by using tinidazole, which is an invaluable advantage...
  20. doi request reprint Reduced fluconazole susceptibility of Candida albicans isolates in women with recurrent vulvovaginal candidiasis: effects of long-term fluconazole therapy
    Zainab Shahid
    Detroit Medical Center, Wayne State University, MI, USA
    Diagn Microbiol Infect Dis 64:354-6. 2009
    ..Accordingly, in patients with refractory vaginitis or breakthrough infections due to Candida albicans, in vitro susceptibility testing is essential to optimally manage vaginitis...
  21. ncbi request reprint Longitudinal study of mucosal Candida species colonization and candidiasis among human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women
    Suzanne E Ohmit
    Wayne State University School of Medicine, Detroit, Michigan, USA
    J Infect Dis 188:118-27. 2003
    ..In HIV-seropositive women, mucosal candidiasis is the consequence of multiple interacting factors...
  22. pmc Novel PCR-based methods enhance characterization of vaginal microbiota in a bacterial vaginosis patient before and after treatment
    Janet A Lambert
    Department of Medicine, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    Appl Environ Microbiol 79:4181-5. 2013
    ..To improve detection, we offer two approaches: quantitative PCR (qPCR) using phylogenetic branch-inclusive primers and sequencing of broad-spectrum amplicons generated with oligomers that block amplification of lactobacilli...
  23. doi request reprint Group B Streptococcus infections in non-pregnant adults: the role of immunosuppression
    Bharath Sunkara
    Division of Infectious Diseases, Detroit Medical Center, Wayne State University, 3990 John R Street, Detroit, MI 48201, USA
    Int J Infect Dis 16:e182-6. 2012
    ..Group B Streptococcus (GBS) is a known causative pathogen of neonatal sepsis, but the epidemiology in non-pregnant adults is less studied...
  24. ncbi request reprint Use of terbinafine in rare and refractory mycoses
    Sanjay G Revankar
    Wayne State University, Division of Infectious Diseases, Harper University Hospital, 3990 John R St, 5 Hudson Detroit, MI 48201, USA
    Future Microbiol 3:9-17. 2008
    ..We review the current literature with regard to in vitro data and clinical experience with terbinafine in the treatment of rare and refractory mycoses...
  25. ncbi request reprint Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis
    Jack D Sobel
    Department of Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Obstet Gynecol 194:1283-9. 2006
    ..Efficacy study of suppressive vaginal metronidazole in reducing recurrent symptomatic episodes of bacterial vaginosis...
  26. doi request reprint Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America
    Peter G Pappas
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 48:503-35. 2009
    ..This new information is incorporated into this revised document...
  27. doi request reprint Candida urinary tract infections--diagnosis
    Carol A Kauffman
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA
    Clin Infect Dis 52:S452-6. 2011
    ....
  28. ncbi request reprint Treatment of vaginal Candida infections
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    Expert Opin Pharmacother 3:1059-65. 2002
    ..In spite of the wide array of antifungal agents currently available, considerable limitations in available therapy exist in the effective management of complicated vaginitis...
  29. ncbi request reprint Growing prevalence of Providencia stuartii associated with the increased usage of colistin at a tertiary health care center
    Kayoko Hayakawa
    Division of Infectious Diseases, Detroit Medical Center, Wayne State University, 5 Hudson, Harper University Hospital, 3990 John R Street, Detroit, MI 48201, USA
    Int J Infect Dis 16:e646-8. 2012
    ..001). Facilities that frequently use colistin and tigecycline should closely monitor the prevalence of P. stuartii along with other Proteeae, since these organisms are intrinsically resistant to colistin and tigecycline...
  30. doi request reprint A case of high-level metronidazole-resistant trichomoniasis in pregnancy successfully treated
    Chithra Subramanian
    Division of Infectious Diseases, Wayne State University, Detroit, MI, USA
    J Low Genit Tract Dis 15:248-9. 2011
    ..We report a case of metronidazole-resistant trichomoniasis in pregnancy, successfully treated with a high dose of tinidazole...
  31. doi request reprint Improvement of a clinical prediction rule for clinical trials on prophylaxis for invasive candidiasis in the intensive care unit
    Luis Ostrosky-Zeichner
    Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Mycoses 54:46-51. 2011
    ..Modification of our original rule resulted in a more inclusive rule for studies...
  32. ncbi request reprint Design of clinical trials of empiric antifungal therapy in patients with persistent febrile neutropenia: considerations and critiques
    Jack D Sobel
    Wayne State University School of Medicine, and the Division of Infectious Disease, Detroit Medical Center, Detroit, Michigan, USA
    Pharmacotherapy 26:47S-54S. 2006
    ....
  33. ncbi request reprint Treatment of vaginitis caused by Candida glabrata: use of topical boric acid and flucytosine
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Harper Hospital, 3990 John R, Detroit, MI 48201, USA
    Am J Obstet Gynecol 189:1297-300. 2003
    ..The purpose of this study was to review the treatment outcome and safety of topical therapy with boric acid and flucytosine in women with Candida glabrata vaginitis...
  34. doi request reprint Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study
    Jinping Xu
    Department of Family Medicine and Public Health Sciences, Division of Practice Based Research, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Am Board Fam Med 21:261-8. 2008
    ..Vulvovaginal candidiasis (VVC) is believed common after systemic antibiotic therapy, yet few studies demonstrate this association. In this pilot study, we evaluate the effect of short-course oral antibiotic use on VVC...
  35. doi request reprint Use of the VS-sense swab in diagnosing vulvovaginitis
    Jack D Sobel
    Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA
    J Womens Health (Larchmt) 18:1467-70. 2009
    ..The purpose of this study was to determine the performance characteristics of the VS-Sense (pH test) swab (Common Sense, Ltd., Caesarea, Israel) in augmenting the diagnosis of vaginitis...
  36. ncbi request reprint Management of patients with recurrent vulvovaginal candidiasis
    Jack D Sobel
    Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Drugs 63:1059-66. 2003
    ..Maintenance suppressive azole antifungal regimens are highly effective in controlling symptoms, although cure is less common. Further advances in achieving higher cure rates await the availability of non-azole fungicidal agents...
  37. ncbi request reprint Tinidazole for bacterial vaginosis
    Michael D Nailor
    Wayne State University School of Medicine, Detroit Receiving Hospital, Department of Pharmacy, Detroit, MI 48201, USA
    Expert Rev Anti Infect Ther 5:343-8. 2007
    ..These studies should establish the role of tinidazole in the treatment of BV; however, cure rates are unlikely to be significantly different...
  38. ncbi request reprint Fluconazole for the treatment of candidiasis: 15 years experience
    Raymond Cha
    Eugene Applebaum College of Pharmacy and Health Sciences, School of Medicine, AntiInfective Research Laboratory, Wayne State University, Detroit, Michigan 48201, USA
    Expert Rev Anti Infect Ther 2:357-66. 2004
    ..This review will examine the contributions and limitations of fluconazole in the treatment of superficial and invasive candidiasis syndromes...
  39. ncbi request reprint Mucosal candidiasis
    Jose A Vazquez
    Division of Infectious Diseases, School of Medicine, Wayne State University, 3990 John R, 4 Brush Center, Detroit, MI 48201, USA
    Infect Dis Clin North Am 16:793-820, v. 2002
    ..Such issues as pathogenesis and host defenses, clinical manifestations, diagnosis, and treatment are discussed...
  40. ncbi request reprint Anidulafungin: a novel echinocandin
    Jose A Vazquez
    Division of Infectious Diseases, Henry Ford Hospital, Wayne State University School of Medicine, Detroit, Michigan 48202, USA
    Clin Infect Dis 43:215-22. 2006
    ..To date, anidulafungin appears to have an excellent safety profile. On the basis of early clinical experience, it appears that anidulafungin will be a valuable asset in the management of serious and difficult-to-treat fungal infections...
  41. pmc High-throughput identification and quantification of Candida species using high resolution derivative melt analysis of panfungal amplicons
    Tasneem Mandviwala
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Mol Diagn 12:91-101. 2010
    ..This tool can potentially detect, count, and identify fungi in hundreds of samples per day without further manipulation, costs, or delays, offering a major step forward in fungal molecular diagnostics...
  42. doi request reprint Genital malodor in women: a modern reappraisal
    Chithra Subramanian
    Division of Infectious Diseases, Detroit Medical Center, Detroit, MI, USA
    J Low Genit Tract Dis 16:49-55. 2012
    ..We also provide an algorithm for the management of this symptom beyond vaginal infections...
  43. doi request reprint Antibiotics for gram-positive bacterial infections: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, dalbavancin, and telavancin
    Michael D Nailor
    Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Infect Dis Clin North Am 23:965-82, ix. 2009
    ..Newer antimicrobial agents that have activity against vancomycin-resistant organisms are now available and play a critical role in the treatment of life-threatening infections...
  44. ncbi request reprint Shuttle vectors for Candida albicans: control of plasmid copy number and elevated expression of cloned genes
    Wenjin Du
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Genet 45:390-8. 2004
    ..These shuttle vectors should facilitate global genomics approaches in C. albicans that have been hampered by its diploid genome...
  45. ncbi request reprint Selecting antifungal agents for the treatment of invasive fungal infections in patients with renal failure
    Varsha V Moudgal
    Division of Infectious Diseases, Harper Hospital, 3990 John R, 4 Brush Center, Detroit, MI 48201, USA
    Curr Opin Investig Drugs 5:873-8. 2004
    ..This review will focus on the currently available data on this subject, providing guidelines for the use of antifungals in patients with renal failure...
  46. pmc Vulvovaginal trichosporonosis
    Paul Makela
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Infect Dis Obstet Gynecol 11:131-3. 2003
    ..Isolation of Trichosporon species from vaginal secretions is a rare event, and no data are available on its pathogenic role. A case series is presented to determine the pathogenic role of Trichosporon species in vulvovaginal infections...
  47. ncbi request reprint Guidelines for treatment of candidiasis
    Peter G Pappas
    Division of Infectious Diseases, University of Alabama at Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 38:161-89. 2004
  48. doi request reprint Prevalence of recurrent vulvovaginal candidiasis in 5 European countries and the United States: results from an internet panel survey
    Betsy Foxman
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    J Low Genit Tract Dis 17:340-5. 2013
    ..This study aimed to estimate prevalence of vulvovaginal candidiasis (VVC) and recurring VVC (RVVC)...
  49. doi request reprint Valvular perforation in left-sided native valve infective endocarditis
    Khaled Bachour
    Division of Cardiology, Wayne State University, Detroit, Michigan, USA
    Clin Cardiol 32:E55-62. 2009
    ..Left-sided native valve infective endocarditis (LNVIE) can result in mitral (MP) and aortic (AP) valve perforation, the prognostic significance of which remains poorly defined...
  50. ncbi request reprint Non-albicans Candida infections in patients with hematologic malignancies
    Mahomed Yunus S Moosa
    Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Semin Respir Infect 17:91-8. 2002
    ..This article addresses the biology, epidemiology, prognostic factors, and management of an emerging group of pathogens such as non-albicans Candida...
  51. ncbi request reprint Combination therapy for invasive mycoses: evaluation of past clinical trial designs
    Jack D Sobel
    Department of Internal Medicine, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Infect Dis 39:S224-7. 2004
    ..Combination therapy offers potentially higher cure rates, especially for resistant organisms. In vitro studies and experimental animal models have provided conflicting data...
  52. ncbi request reprint Emerging azole antifungals
    Anne Chen
    Wayne State University, Detroit Medical Center, 3990 Harper Street, 5 Hudson, Detroit, MI 48201, USA
    Expert Opin Emerg Drugs 10:21-33. 2005
    ..This review highlights the emerging azole antifungals, both those available and in clinical development, and discusses their prospects for the future...
  53. doi request reprint Candida kefyr endocarditis in a patient with hypertrophic obstructive cardiomyopathy
    Teena Chopra
    Wayne State University, Detroit, Michigan 48201, USA
    Am J Med Sci 339:188-9. 2010
    ..Repeat echocardiogram showed small vegetation, preserved leaflet mobility and mild regurgitation. Patient received 10 days of micafungin, followed by 6 weeks of fluconazole...
  54. ncbi request reprint Current trends and challenges in candidiasis
    Jack D Sobel
    Wayne State University, School of Medicine, Detroit, Michigan, USA
    Oncology (Williston Park) 18:7-8. 2004
  55. doi request reprint A case of Conidiobolus coronatus in the vagina
    Chithra Subramanian
    Division of Infectious Diseases, Wayne State University, Detroit, Michigan 48201, USA
    Med Mycol 49:427-9. 2011
    ..Infections are reported mostly from West Africa and South East Asia. Vaginal involvement in humans has not been described before. We report a case of C. coronatus infection involving the vagina that was successfully treated...
  56. doi request reprint Miconazole mucoadhesive tablets: a novel delivery system
    Jose A Vazquez
    Department of Medicine, Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI 48201, USA
    Clin Infect Dis 54:1480-4. 2012
    ..MBT, although more expensive, offers an effective, safe, and well-tolerated topical treatment option for OPC that is administered as a convenient once-daily dose...
  57. pmc Prevalence and risk factors for vaginal Candida colonization in women with type 1 and type 2 diabetes
    Ella M de Leon
    Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA
    BMC Infect Dis 2:1. 2002
    ..Diabetes mellitus increases the rate of vaginal colonization and infection with Candida species..
  58. pmc Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis
    Ronald F Lamont
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 205:177-90. 2011
    ..However, a deeper understanding of the vaginal microbiome, mucosal immunity, and the biology of BV will be needed to inform the design of such trials...
  59. doi request reprint Chronic vulvar fissure--a rare manifestation of mycosis fungoides
    Orna Reichman
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
    J Low Genit Tract Dis 14:65-7. 2010
    ..Mycosis fungoides, the dominant component of cutaneous T-cell lymphoma, rarely present as fissures. We report a case of a chronic vulvar fissure due to mycosis fungoides...
  60. doi request reprint Vulvovaginal pellagra and lichen sclerosus complicating carcinoid syndrome
    Orna Reichman
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA
    Obstet Gynecol 113:543-5. 2009
    ..Pellagra is a rare clinical syndrome caused by niacin deficiency, and although most commonly nutritional in origin, may be secondary to carcinoid syndrome...
  61. ncbi request reprint Antifungal drugs in pregnancy: a review
    Varsha V Moudgal
    Division of Infectious Diseases, Harper Hospital, 3990 John R, 4 Brush Center, Detroit, MI 48201, USA
    Expert Opin Drug Saf 2:475-83. 2003
    ..These drugs are contraindicated in pregnancy. There are insufficient data regarding the use of caspofungin in pregnancy. This article will review available data regarding the safety of antifungal drug use in pregnant women...
  62. ncbi request reprint High-dose vaginal maintenance metronidazole for recurrent bacterial vaginosis: a pilot study
    Tina Aguin
    From the Departments of Obstetrics and Gynecology, Biochemistry and Molecular Biology, and Infectious Diseases, Wayne State University School of Medicine, Detroit, MI
    Sex Transm Dis 41:290-1. 2014
    ..High-dose metronidazole intravaginally was associated with rare clinical recurrence during the period of use. After cessation of suppression therapy, recurrence was high...
  63. ncbi request reprint High-dose vaginal metronidazole for recurrent bacterial vaginosis--a pilot study
    Tina J Aguin
    Departments of 1Obstetrics and Gynecology, 2Biochemistry and Molecular Biology, and 3Infectious Diseases, Wayne State University School of Medicine, Detroit, MI
    J Low Genit Tract Dis 18:156-61. 2014
    ..The purpose of this study was to evaluate high-dose intravaginal metronidazole, with or without miconazole, in enhancing cure rates in women with recurrent BV...
  64. doi request reprint Sepsis associated with a new Atopobium species, provisionally named Atopobium detroiti: case report and review of the current status of the species Atopobium
    Hossein Salimnia
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Scand J Infect Dis 40:679-81. 2008
    ....
  65. ncbi request reprint Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america
    John R Perfect
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 50:291-322. 2010
    ..However, if the diagnosis is made early, if clinicians adhere to the basic principles of these guidelines, and if the underlying disease is controlled, then cryptococcosis can be managed successfully in the vast majority of patients...
  66. ncbi request reprint Onset of vulvodynia in a woman ultimately diagnosed with Creutzfeldt-Jakob disease
    Orna Reichman
    Division of Infectious Diseases, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Obstet Gynecol 115:423-5. 2010
    ..Vulvodynia, defined as vulvar pain or burning in the presence of normal vulvar appearance, is common and is associated with chronic pain syndromes and psychiatric disorders...
  67. ncbi request reprint CAN-296-P is effective against cutaneous candidiasis in guinea pigs
    Avital M Ben-Josef
    Division of Infectious Diseases, Department of Medicine, Wayne State University, 427 Lande Building, 505E Canfield, Detroit, MI 48201, USA
    Int J Antimicrob Agents 22:168-71. 2003
    ..Effectiveness in eradicating candidiasis with CAN-296-P was concentration-dependent and free of local adverse effects. Can-296-P is a novel, highly active topical fungicidal agent, with broad potential for clinical use...
  68. ncbi request reprint Incident and persistent vulvovaginal candidiasis among human immunodeficiency virus-infected women: Risk factors and severity
    Ann Duerr
    National Center for Chronic Disease Prevention and Health Promotion, Division of Reproductive Health HIV Section, Centers for Disease Control and Prevention, Mailstop K 34, 4770 Buford Highway NE, Atlanta, GA 30341 3717, USA
    Obstet Gynecol 101:548-56. 2003
    ..To examine risk factors for vulvovaginal candidiasis among women with or at risk for human immunodeficiency virus (HIV) infection...
  69. ncbi request reprint Desquamative inflammatory vaginitis: an exploratory case-control study
    E Claire Newbern
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, USA
    Ann Epidemiol 12:346-52. 2002
    ..To investigate potential risk factors for desquamative inflammatory vaginitis (DIV), a rare but severe form of vaginitis. We are aware of no other controlled studies of DIV...
  70. ncbi request reprint Empirical fluconazole versus placebo for intensive care unit patients: a randomized trial
    Mindy G Schuster
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 149:83-90. 2008
    ..Invasive infection with Candida species is an important cause of morbidity and mortality in intensive care unit (ICU) patients. Optimal preventive strategies have not been clearly defined...
  71. ncbi request reprint Changing epidemiology of invasive candidiasis in intensive care units--much ado about nothing?
    Jack D Sobel
    Crit Care Med 36:2188-9. 2008
  72. ncbi request reprint Vulvovaginal candidiasis: a comparison of HIV-positive and -negative women
    Jack D Sobel
    Int J STD AIDS 13:358-62. 2002
    ..Ongoing concerns include vaginal acquisition of non-albicans Candida species and the development of antimycotic drug resistance in C. albicans vaginal isolates...
  73. ncbi request reprint Echinocandins--first-choice or first-line therapy for invasive candidiasis?
    Jack D Sobel
    N Engl J Med 356:2525-6. 2007
  74. ncbi request reprint The VI-SENSE-vaginal discharge self-test to facilitate management of vaginal symptoms
    Adam Geva
    SBC Women s Health Centers of Lin, Israel
    Am J Obstet Gynecol 195:1351-6. 2006
    ..This study was undertaken to evaluate a diagnostic panty liner (VI-SENSE) (Common Sense, Caesarea, Israel) developed to facilitate diagnosis of vaginal infections by detecting disordered acidity level...
  75. ncbi request reprint Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study
    Divya A Patel
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Mich, USA
    Am J Obstet Gynecol 190:644-53. 2004
    ....
  76. ncbi request reprint Over-the-counter antifungal drug misuse associated with patient-diagnosed vulvovaginal candidiasis
    Daron G Ferris
    Department of Family Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Obstet Gynecol 99:419-25. 2002
    ..To estimate what proportion of symptomatic women purchasing over-the-counter antifungal products for immediate treatment of presumed vulvovaginal candidiasis have vulvovaginal candidiasis or other genitourinary conditions...
  77. ncbi request reprint Vulvovaginal candidiasis
    Paul Nyirjesy
    Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA, USA
    Obstet Gynecol Clin North Am 30:671-84. 2003
    ..Future advances, particularly in the area of home diagnostics, may help to optimize use of currently available medicines...
  78. pmc Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) C
    Ben de Pauw
    Department of Blood Transfusion Service and Transplant Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 46:1813-21. 2008
    ..Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies...
  79. ncbi request reprint Influence of sex hormones, HIV status, and concomitant sexually transmitted infection on cervicovaginal inflammation
    Khalil G Ghanem
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Infect Dis 191:358-66. 2005
    ..Progesterone-based contraceptives, younger age, and race have an independent effect on cervicovaginal inflammatory cells...
  80. ncbi request reprint Failure of nitazoxanide to cure trichomoniasis in three women
    Michael Dan
    Infectious Diseases Unit, E Wolfson Hospital, Holon, Israel
    Sex Transm Dis 34:813-4. 2007