BONNIE F contact SLOANE

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
    Bernadette C Victor
    Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
    Breast Cancer Res 13:R115. 2011
  2. pmc The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer
    Mohammad Al Sorkhy
    Faculty of Pharmacy, Al Zyatoona Private University, Amman, Jordan
    BMC Cancer 12:45. 2012
  3. pmc Cathepsin B: a potential prognostic marker for inflammatory breast cancer
    Mohamed A Nouh
    Department of Pathology, National Cancer Institute, Cairo University, Giza 12613 Egypt
    J Transl Med 9:1. 2011
  4. ncbi request reprint I2 imaging: cancer biology and the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:11097-9. 2006
  5. ncbi request reprint Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006
  6. ncbi request reprint Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
  7. pmc Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells
    Dora Cavallo-Medved
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 5:507-19. 2003
  8. ncbi request reprint Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis
    Mansoureh Sameni
    Wayne State University School of Medicine, Detroit, MI, USA
    Mol Imaging 2:159-75. 2003
  9. pmc Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells
    Mansoureh Sameni
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Mol Imaging 7:199-213. 2008
  10. ncbi request reprint Interaction of human breast fibroblasts with collagen I increases secretion of procathepsin B
    Jennifer E Koblinski
    Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 277:32220-7. 2002

Research Grants

  1. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    BONNIE F contact SLOANE; Fiscal Year: 2010
  2. CATHEPSIN B AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1999
  3. CATHEPSINS IN MALIGNANT PROGRESSION
    Bonnie Sloane; Fiscal Year: 2004
  4. ABERRANT REGULATION OF CATHEPSIN B EXPRESSION IN TUMORS
    Bonnie Sloane; Fiscal Year: 2005
  5. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    Bonnie Sloane; Fiscal Year: 2009
  6. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    BONNIE F contact SLOANE; Fiscal Year: 2010
  7. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    Bonnie Sloane; Fiscal Year: 2009
  8. CATHEPSINS IN MALIGNANT PROGRESSION
    Bonnie Sloane; Fiscal Year: 2009
  9. CATHEPSINS IN MALIGNANT PROGRESSION
    Bonnie Sloane; Fiscal Year: 2007
  10. CATHEPSINS B AND L IN MALIGNANT PROGRESSION O MCF-10
    Bonnie Sloane; Fiscal Year: 1993

Collaborators

Detail Information

Publications52

  1. pmc Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
    Bernadette C Victor
    Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
    Breast Cancer Res 13:R115. 2011
    ..Breast cancer invasion has been linked to proteolytic activity at the tumor cell surface. Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC...
  2. pmc The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer
    Mohammad Al Sorkhy
    Faculty of Pharmacy, Al Zyatoona Private University, Amman, Jordan
    BMC Cancer 12:45. 2012
    ..Spy1 protein levels are tightly regulated during normal mammary development and forced overexpression in mammary mouse models accelerates mammary tumorigenesis...
  3. pmc Cathepsin B: a potential prognostic marker for inflammatory breast cancer
    Mohamed A Nouh
    Department of Pathology, National Cancer Institute, Cairo University, Giza 12613 Egypt
    J Transl Med 9:1. 2011
    ..In non-IBC, the cysteine protease cathepsin B (CTSB) is known to be involved in cancer progression and invasion; however, very little is known about its role in IBC...
  4. ncbi request reprint I2 imaging: cancer biology and the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:11097-9. 2006
    ....
  5. ncbi request reprint Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006
    ..These should be useful clinically as surrogate endpoints for therapies that alter protease activities...
  6. ncbi request reprint Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
    ..Using a confocal assay to analyze the contribution of tumor-stromal interactions to proteolysis, we have been able to confirm enhanced degradation of extracellular matrices by all three classes of proteases...
  7. pmc Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells
    Dora Cavallo-Medved
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 5:507-19. 2003
    ..g., urokinase plasminogen activator and urokinase plasminogen activator receptor) are also present in HCT 116 caveolae...
  8. ncbi request reprint Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis
    Mansoureh Sameni
    Wayne State University School of Medicine, Detroit, MI, USA
    Mol Imaging 2:159-75. 2003
    ..Imaging of living tumor and stromal cells has, thus, allowed us to establish that tumor proteolysis occurs pericellularly and intracellularly and that tumor, stromal, and inflammatory cells all contribute to degradative processes...
  9. pmc Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells
    Mansoureh Sameni
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Mol Imaging 7:199-213. 2008
    ..This is the first study to demonstrate through functional live-cell imaging that downregulation of beta1-integrin expression and function reduces proteolysis of collagen IV by breast and prostate cancer cells...
  10. ncbi request reprint Interaction of human breast fibroblasts with collagen I increases secretion of procathepsin B
    Jennifer E Koblinski
    Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 277:32220-7. 2002
    ....
  11. pmc Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ
    Christopher Jedeszko
    Department of Pharmacology, Wayne State University, Detroit, Michigan, USA
    Cancer Res 69:9148-55. 2009
    ....
  12. pmc Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue
    Zhong Dong
    Department of Urology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Am J Pathol 166:1173-86. 2005
    ..These data suggest that osteoclast-derived MMP-9 may represent a potential therapeutic target in bone metastasis and provide a rationale for the development of MMP-9-specific inhibitors...
  13. pmc Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin
    Jonathan W Wojtkowiak
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Pharmacol Exp Ther 337:65-74. 2011
    ..These studies indicate that cotreatment of STS-26T cells with lovastatin and FTI-1 induces an abortive autophagic program and nonapoptotic cell death...
  14. ncbi request reprint Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment
    Donald R Schwartz
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Mol Cancer Res 5:443-54. 2007
    ....
  15. ncbi request reprint Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    J Cell Sci 118:1493-503. 2005
    ....
  16. pmc Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis
    Izabela Podgorski
    Wayne State University School of Medicine, Department of Pharmacology, 540 E Canfield, Detroit, MI 48201, USA
    Am J Pathol 175:1255-69. 2009
    ..This is the first study implicating bone marrow cathepsin K in regulation of biological activity of SPARC in bone metastasis...
  17. pmc Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 7:207-23. 2005
    ..Our results suggest that tumor-stromal interactions in the context of the bone microenvironment can modulate the expression of the cysteine protease cathepsin B...
  18. pmc p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
    Quanwen Li
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University, 540 East Canfield Ave, Detroit, MI 48201, USA
    Neoplasia 10:314-29. 2008
    ..Our conclusion is that overexpressed and activated PAK1 may be a key coordinator of aberrant cell survival and proteolysis in breast cancer progression...
  19. ncbi request reprint Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function
    Bernadette C Victor
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biol Chem 388:1131-40. 2007
    ..Mechanisms for altered localization are not well understood, but do include the interaction of cysteine cathepsins with binding partners that modulate intracellular trafficking and association with specific regions on the cell surface...
  20. ncbi request reprint Loss of caspase-8 in tumor cells: mechanism to overcome integrin-mediated death?
    Izabela Podgorski
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Interv 6:132-6. 2006
  21. ncbi request reprint Isolation of a novel USF2 isoform: repressor of cathepsin B expression
    Shiqing Yan
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Gene 337:199-206. 2004
    ..These results suggest that USF2c regulates expression of cathepsin B by binding to the E box element in the cathepsin B promoter as a repressor...
  22. ncbi request reprint Transcription of cathepsin B in glioma cells: regulation by an E-box adjacent to the transcription initiation site
    Shiqing Yan
    Department of Pharmacology, Wayne State University, 540 E Canfield Ave, Detroit, MI 48201, USA
    Biol Chem 384:1421-7. 2003
    ....
  23. pmc Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 315:1234-46. 2009
    ..Our findings are the first to demonstrate through live-cell imaging ECM degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation...
  24. ncbi request reprint Cell-surface cathepsin B: understanding its functional significance
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Curr Top Dev Biol 54:313-41. 2003
  25. pmc Imaging and quantifying the dynamics of tumor-associated proteolysis
    Mansoureh Sameni
    Department of Pharmacology, School of Medicine, Wayne State University, 540 E Canfield, Detroit, MI 48201, USA
    Clin Exp Metastasis 26:299-309. 2009
    ..The assays and models described here could serve as screening platforms for the identification of proteolytic pathways that are potential therapeutic targets and for further development of technologies and imaging probes for in vivo use...
  26. ncbi request reprint Pericellular cathepsin B and malignant progression
    Stefanie Roshy
    Program in Cancer Biology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Cancer Metastasis Rev 22:271-86. 2003
    ..Our working hypothesis is that pericellular cathepsin B through its proximity to other proteases in caveolae participates in, perhaps even initiates, a proteolytic cascade on the tumor cell surface...
  27. ncbi request reprint Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B
    Meng Guo
    Institute of Environmental Health Sciences, Wayne State University and the Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 277:14829-37. 2002
    ..Subsequently, extracellular cathepsin B initiates a proteolytic cascade involving uPA, plasminogen, and plasmin that activates serum-derived latent TGF-beta...
  28. ncbi request reprint Molecular regulation of human cathepsin B: implication in pathologies
    Shiqing Yan
    Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Biol Chem 384:845-54. 2003
    ..Here we focus on the molecular regulation of cathepsin B and attendant implications for tumor progression and arthritis. The potential of cathepsin B as a therapeutic target is also discussed...
  29. pmc Visualizing protease activity in living cells: from two dimensions to four dimensions
    Christopher Jedeszko
    Department of Pharmacology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Curr Protoc Cell Biol . 2008
    ..Using confocal microscopy and advanced imaging software, the fluorescence is detected and accurate measurements of proteolytic degradation in three and four dimensions can be assessed...
  30. ncbi request reprint Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells
    Ravi Shridhar
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Oncogene 23:2206-15. 2004
    ..This study provides the first evidence that cystatin M may play important roles in safeguarding against human breast cancer...
  31. ncbi request reprint Analysis of a truncated form of cathepsin H in human prostate tumor cells
    Anuradha Waghray
    Department of Pathology, Barbara Ann Karmanos Cancer Institute and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 277:11533-8. 2002
    ..Therefore, an increase in overall cathepsin H expression, particularly in the truncated form with a high secretion propensity, may affect cell biological behaviors such as those associated with tumor progression...
  32. ncbi request reprint Cysteine cathepsins: multifunctional enzymes in cancer
    Mona Mostafa Mohamed
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Nat Rev Cancer 6:764-75. 2006
    ....
  33. ncbi request reprint Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1
    Xu Wen Liu
    Department of Pathology, Wayne State University School of Medicine, Karmanos Cancer Institute, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Cancer Res 65:898-906. 2005
    ..Taken together, these studies suggest that TIMP-1 may exert oncogenic activity in breast cancer through inhibition of both intrinsic and extrinsic apoptosis involving the FAK survival signal transduction pathway...
  34. ncbi request reprint Cysteine cathepsins in human cancer
    Christopher Jedeszko
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Biol Chem 385:1017-27. 2004
    ..Understanding the roles that cysteine proteases play in cancer could lead to the development of more efficacious therapies...
  35. ncbi request reprint Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents
    Joseph A Caruso
    Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Mol Pharmacol 65:1016-28. 2004
    ..They also suggest that the AhR, in the absence of exogenous ligand, may affect the trafficking/processing of proteases normally found in endosomes/lysosomes...
  36. pmc Functional expression of recombinant human stefin A in mammalian and bacterial cells
    Catharine C Calkins
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield, Detroit, MI 48201, USA
    Protein Expr Purif 52:463-71. 2007
    ..Expression in the mammalian cells, on the other hand, can provide a significant research tool to study the functional roles of stefin A in mammalian systems such as regulation of cysteine proteases...
  37. ncbi request reprint Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas
    Jianxin Mai
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Biol Chem 383:1407-13. 2002
    ..We suggest that interactions between cathepsin B and tenascin-C are involved in the progression of gliomas including the angiogenesis that is a hallmark of anaplastic astrocytomas...
  38. doi request reprint Microarrays for protease detection in tissues and cells
    Kamiar Moin
    Department of Pharmacology, Wayne State University, 540 E Canfield, Detroit, MI, USA
    Methods Mol Biol 539:49-57. 2009
    ..Here we outline a protocol for using the Hu/Mu ProtIn chip to profile proteases, protease inhibitors, and protease interactors in tissues and cells...
  39. ncbi request reprint Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene expression during human myoblast differentiation
    Derek T Jane
    Department of Biological Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada
    Biol Chem 383:1833-44. 2002
    ..Collectively, these data support myogenic transcription factor-mediated activation of cathepsin B expression during myogenesis...
  40. ncbi request reprint High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells
    Marina Demoz
    Dipartimento di Scienze Mediche, Università A Avogadro, Via Solaroli 17, 28100 Novara, Italy
    Protein Expr Purif 45:157-67. 2006
    ..This system can therefore be exploited for the synthesis of large quantities of human proCD, allowing further studies on the structure and function of this interesting protein...
  41. pmc Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells
    Rebecca S Henkhaus
    Department of Cancer Biology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Neoplasia 10:140-8. 2008
    ..This study demonstrates that proteins such as CAV-1 and AKT, which are known to be altered in colon cancer, affect KLK6 expression and KLK6 secretion...
  42. ncbi request reprint Dynamic imaging of protease activity with fluorescently quenched activity-based probes
    Galia Blum
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, California 94305, USA
    Nat Chem Biol 1:203-9. 2005
    ..This probe is used to monitor real-time protease activity in live human cells with fluorescence microscopy techniques as well as standard biochemical methods...
  43. ncbi request reprint Cathepsin L splice variants in human breast cell lines
    Simon Caserman
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Vecna pot 111, SI 1000 Ljubljana, Slovenia
    Biol Chem 387:629-34. 2006
    ..We propose that posttranscriptional regulation of cathepsin L expression is altered during breast tumour progression...
  44. ncbi request reprint Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B
    Anita Reisenauer
    Probiodrug AG, Weinbergweg 22, D 06120 Halle, Germany
    Biol Chem 388:639-50. 2007
    ..In conclusion, alterations in the TGF-beta1 signaling pathway lead to upregulation of CathB, which contributes to the carcinogenic potential of tumor cells...
  45. ncbi request reprint Evidence for the involvement of cathepsin B in skeletal myoblast differentiation
    Derek T Jane
    Department of Biological Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada
    J Cell Biochem 84:520-31. 2002
    ..Collectively, these results support a functional link between catB expression and skeletal myogenesis and suggest a role for active pericellular/secreted catB in myoblast fusion...
  46. ncbi request reprint Selective inhibition of cathepsin B with cell-permeable CA074Me negatively affects L6 rat myoblast differentiation
    Derek T Jane
    Department of Biological Sciences, University of Windsor, ON, Canada
    Biochem Cell Biol 80:457-65. 2002
    ..Collectively, these data suggest that active cathepsin B plays a role in myoblast-myoblast fusion and consequently may be necessary for the complete expression of those genes associated with the fusion process...
  47. ncbi request reprint Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients
    Andreas Scorilas
    NCSR Demokritos IPC, Athens, Greece
    Biol Chem 383:1297-303. 2002
    ..Accordingly, cathepsin B can be regarded as unfavorable and as an independent tumor marker for progression-free survival and overall survival in ovarian cancer patients with long follow-up...
  48. ncbi request reprint Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors
    Ales Bervar
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Vecna pot 111, SI 1000 Ljubljana, Slovenia
    Biol Chem 384:447-55. 2003
    ....
  49. ncbi request reprint Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH
    Derek T Jane
    Biological Sciences, University of Windsor, Windsor N9B 3P4, ON, Canada
    Biol Chem 387:223-34. 2006
    ..Collectively, these studies support an association of active cathepsin B with plasma membrane caveolae and the secretion of active cathepsin B from differentiating myoblasts during myoblast fusion...
  50. pmc Proteases, extracellular matrix, and cancer: a workshop of the path B study section
    Yves A DeClerck
    Department of Pediatrics and Biochemistry, University of Southern California Keck School of Medicine and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    Am J Pathol 164:1131-9. 2004
    ..This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002...
  51. ncbi request reprint Cystatin m: a novel candidate tumor suppressor gene for breast cancer
    Jun Zhang
    Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Cancer Res 64:6957-64. 2004
    ..Immunohistochemical studies confirmed that expression of cystatin M in IDCs was partially or completely lost. We propose cystatin M as a novel candidate tumor suppressor gene for breast cancer...
  52. ncbi request reprint Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer
    Heath B Acuff
    Vanderbilt Ingram Cancer Center and Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Cancer Res 66:7968-75. 2006
    ..The use of the Hu/Mu ProtIn chip allows us to distinguish tumor- and host-derived proteases and guides the further analysis of the significance of these genes in tumor progression...

Research Grants42

  1. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    BONNIE F contact SLOANE; Fiscal Year: 2010
    ..We anticipate that our studies will identify biomarkers to distinguish premalignant lesions that will progress to invasive cancers and define targets that will abrogate that progression. ..
  2. CATHEPSIN B AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1999
    ..The eventual goal is to use the information obtained in these four aims to manipulate the expression and localization of cathepsin B and determine whether this has a direct effect on the malignant phenotype. ..
  3. CATHEPSINS IN MALIGNANT PROGRESSION
    Bonnie Sloane; Fiscal Year: 2004
    ..abstract_text> ..
  4. ABERRANT REGULATION OF CATHEPSIN B EXPRESSION IN TUMORS
    Bonnie Sloane; Fiscal Year: 2005
    ....
  5. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    Bonnie Sloane; Fiscal Year: 2009
    ..We anticipate that our studies will identify biomarkers to distinguish premalignant lesions that will progress to invasive cancers and define targets that will abrogate that progression. ..
  6. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    BONNIE F contact SLOANE; Fiscal Year: 2010
    ..We anticipate that our studies will identify biomarkers to distinguish premalignant lesions that will progress to invasive cancers and define targets that will abrogate that progression. ..
  7. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    Bonnie Sloane; Fiscal Year: 2009
    ..We anticipate that our studies will identify biomarkers to distinguish premalignant lesions that will progress to invasive cancers and define targets that will abrogate that progression. ..
  8. CATHEPSINS IN MALIGNANT PROGRESSION
    Bonnie Sloane; Fiscal Year: 2009
    ..g., targeting more than one catalytic-type of protease, targeting stromal as well as tumor proteases, and targeting proteases at times to be defined during progression. ..
  9. CATHEPSINS IN MALIGNANT PROGRESSION
    Bonnie Sloane; Fiscal Year: 2007
    ..g., targeting more than one catalytic-type of protease, targeting stromal as well as tumor proteases, and targeting proteases at times to be defined during progression. ..
  10. CATHEPSINS B AND L IN MALIGNANT PROGRESSION O MCF-10
    Bonnie Sloane; Fiscal Year: 1993
    ..Once secreted, the cysteine proteinases can degrade basement membrane directly or indirectly via activation of other proteolytic enzymes, thus facilitating tumor cell invasion...
  11. CATHEPSIN B AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1993
    ..Upon secretion from malignant cells, cathepsin B can facilitate the invasion of those cells either directly by degrading basement membrane proteins or indirectly via activating other proteolytic enzymes...
  12. CATHEPSINS IN MALIGNANT PROGRESSION OF MCF 10
    Bonnie Sloane; Fiscal Year: 1999
    ..The present studies may provide information that is important not only to breast carcinoma, but also to other human tumors in whose malignant progression ras has been implicated. ..
  13. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND TUMOR INVASION
    Bonnie Sloane; Fiscal Year: 1991
    ..It might be possible to interrupt this cascade by designing therapeutic interventions to inhibit cathepsin B and/or to correct the proposed defect in processing, i.e., direct tumor cathepsin B to lysosmes...