A Shisheva

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, 540 East Canfield Street, Detroit, Michigan 48201, USA
    Biochemistry 38:11711-21. 1999
  2. ncbi Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:11859-69. 2001
  3. ncbi Association of cytosolic Rab4 with GDI isoforms in insulin-sensitive 3T3-L1 adipocytes
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biochemistry 36:6564-70. 1997
  4. ncbi PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation
    D Sbrissa
    Department of Physiology, Wayne State University School of Medicine, 540 East Canfield Street, Detroit, Michigan 48201, USA
    Biochemistry 39:15980-9. 2000
  5. ncbi Molecular basis for the insulinomimetic effects of C-peptide
    G Grunberger
    Centre for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA
    Diabetologia 44:1247-57. 2001
  6. ncbi PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin
    D Sbrissa
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 274:21589-97. 1999
  7. ncbi Selective insulin-induced activation of class I(A) phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes
    D Sbrissa
    Department of Physiology, Wayne State University School of Medicine, 4237 Scott Mall, 540 E Canfield, Detroit, MI 48201, USA
    Mol Cell Endocrinol 181:35-46. 2001
  8. ncbi Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve
    O C Ikonomov
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:26141-7. 2001
  9. pmc Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mol Cell Biol 19:623-34. 1999
  10. ncbi Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO
    O C Ikonomov
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, 4237 Scott Hall, 540 E Canfield, Detroit, MI 48201, USA
    Brain Res Dev Brain Res 123:13-24. 2000

Detail Information

Publications13

  1. ncbi General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, 540 East Canfield Street, Detroit, Michigan 48201, USA
    Biochemistry 38:11711-21. 1999
    ....
  2. ncbi Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:11859-69. 2001
    ..We suggest the recruited PIKfyve specifies the site and timing of phosphoinositide signals that are relevant to the acute insulin action...
  3. ncbi Association of cytosolic Rab4 with GDI isoforms in insulin-sensitive 3T3-L1 adipocytes
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biochemistry 36:6564-70. 1997
    ..Taken together, these data suggest there is selective formation of Rab4-GDI-1 complexes in response to insulin which plays a role in the action of insulin on membrane trafficking...
  4. ncbi PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation
    D Sbrissa
    Department of Physiology, Wayne State University School of Medicine, 540 East Canfield Street, Detroit, Michigan 48201, USA
    Biochemistry 39:15980-9. 2000
    ....
  5. ncbi Molecular basis for the insulinomimetic effects of C-peptide
    G Grunberger
    Centre for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA
    Diabetologia 44:1247-57. 2001
    ..We assessed whether synthetic rat C-peptide stimulates insulin-like cellular effects in a classic insulin target tissue...
  6. ncbi PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin
    D Sbrissa
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 274:21589-97. 1999
    ..In conclusion, mouse p235 (renamed here PIKfyve) displays a strong in vitro activity for PtdIns 5-P and PtdIns 3,5-P(2) generation, implying PIKfyve has a key role in their biosynthesis...
  7. ncbi Selective insulin-induced activation of class I(A) phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes
    D Sbrissa
    Department of Physiology, Wayne State University School of Medicine, 4237 Scott Mall, 540 E Canfield, Detroit, MI 48201, USA
    Mol Cell Endocrinol 181:35-46. 2001
    ..Together, these results establish PIKfyve as a novel source of activated class I(A) PI 3-K molecules that may be relevant in the insulin-signal transduction pathway...
  8. ncbi Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve
    O C Ikonomov
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:26141-7. 2001
    ..Together, the results indicate that PIKfyve enzymatic activity, possibly through the generation of PtdIns 3,5-P(2), and/or yet to be identified endogenous phosphoproteins, is critical for cell morphology and endomembrane homeostasis...
  9. pmc Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells
    A Shisheva
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mol Cell Biol 19:623-34. 1999
    ..In conclusion, the mouse p235 protein determines an important novel class of phosphoinositide kinases that seems to be targeted to specific intracellular loci by a Zn-dependent mechanism...
  10. ncbi Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO
    O C Ikonomov
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, 4237 Scott Hall, 540 E Canfield, Detroit, MI 48201, USA
    Brain Res Dev Brain Res 123:13-24. 2000
    ..We propose that the induction of ETO expression, in concert with lithium-induced upregulation of other genes, such as PEBP2beta and bcl-2, is participating in the neuroprotective effect of chronic lithium treatment...
  11. ncbi Pericentriolar targeting of GDP-dissociation inhibitor isoform 2
    A Shisheva
    Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA
    Eur J Cell Biol 68:143-58. 1995
    ..The results suggest the presence of selective GDI-2 acceptors in this region and a possible role of pericentriolar GDI-2 in membrane recycling...
  12. ncbi Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes
    A Shisheva
    Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605
    J Biol Chem 269:23865-8. 1994
    ..Taken together, these data suggest functional differences for the GDI-1 and GDI-2 protein isoforms, as well as a potential role of GDI-2 in the action of insulin on membrane movements...
  13. pmc Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle
    A Shisheva
    Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605
    Mol Cell Biol 14:3459-68. 1994
    ..Taken together, these data demonstrate that the protein products of at least two genes regulate the membrane dynamics of Rab proteins in mice...