M P Shekhar

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup
    Malathy P V Shekhar
    Department of Oncology, Wayne State University, Detroit, MI, USA
    Oncotarget 4:231-41. 2013
  2. pmc Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization
    Matthew A Sanders
    Department of Oncology, Karmanos Cancer Institute, Wayne State University, 110 E Warren Avenue, Detroit, MI 48201, USA
    Mol Cancer Ther 12:373-83. 2013
  3. ncbi request reprint Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan, USA
    Cancer Biol Ther 7:1774-82. 2008
  4. pmc Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Pathol 170:1546-60. 2007
  5. doi request reprint Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
    Med Oncol 27:466-73. 2010
  6. ncbi request reprint Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Mol Cancer Res 4:729-45. 2006
  7. pmc Alterations in galectin-3 expression and distribution correlate with breast cancer progression: functional analysis of galectin-3 in breast epithelial-endothelial interactions
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Ave, Detroit, Michigan 48201, USA
    Am J Pathol 165:1931-41. 2004
  8. ncbi request reprint Drug resistance: challenges to effective therapy
    Malathy P V Shekhar
    Karmanos Cancer Institute, Departments of Oncology and Pathology, Wayne State University School of Medicine, 2204, Prentis Building, 110 East Warren Avenue, Detroit, Michigan 48201, USA
    Curr Cancer Drug Targets 11:613-23. 2011
  9. pmc Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Breast Cancer Res 5:130-5. 2003
  10. pmc Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target
    Brigitte Gerard
    Department of Oncology, Wayne State University, 110 East Warren Avenue, Detroit, 48201, Michigan
    J Mol Signal 6:6. 2011

Collaborators

Detail Information

Publications22

  1. pmc Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup
    Malathy P V Shekhar
    Department of Oncology, Wayne State University, Detroit, MI, USA
    Oncotarget 4:231-41. 2013
    ....
  2. pmc Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization
    Matthew A Sanders
    Department of Oncology, Karmanos Cancer Institute, Wayne State University, 110 E Warren Avenue, Detroit, MI 48201, USA
    Mol Cancer Ther 12:373-83. 2013
    ..Together these results describe identification of the first Rad6 SMIs...
  3. ncbi request reprint Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan, USA
    Cancer Biol Ther 7:1774-82. 2008
    ..It is possible that spontaneous apoptosis facilitates elimination of cells thus permitting expansion and malignant transformation of cancer cells that are resistant to spontaneous apoptosis...
  4. pmc Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Pathol 170:1546-60. 2007
    ....
  5. doi request reprint Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
    Med Oncol 27:466-73. 2010
    ..This is an exploratory study and larger studies utilizing interim evaluations of Rad6B expression, its subcellular localization and repair activity are required to confirm its utility as a predictor of chemotherapeutic response...
  6. ncbi request reprint Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Mol Cancer Res 4:729-45. 2006
    ....
  7. pmc Alterations in galectin-3 expression and distribution correlate with breast cancer progression: functional analysis of galectin-3 in breast epithelial-endothelial interactions
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Ave, Detroit, Michigan 48201, USA
    Am J Pathol 165:1931-41. 2004
    ..Such a localized expression of galectin-3 in cancer cells proximal to the stroma could lead to increased invasive potential by inducing novel or better interactions with the stromal counterparts...
  8. ncbi request reprint Drug resistance: challenges to effective therapy
    Malathy P V Shekhar
    Karmanos Cancer Institute, Departments of Oncology and Pathology, Wayne State University School of Medicine, 2204, Prentis Building, 110 East Warren Avenue, Detroit, Michigan 48201, USA
    Curr Cancer Drug Targets 11:613-23. 2011
    ....
  9. pmc Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Breast Cancer Res 5:130-5. 2003
    ..The role of stromally derived microenvironmental epigenetic effectors in modulating epithelial growth, hormonal response, morphogenesis and epithelial plasticity is discussed...
  10. pmc Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target
    Brigitte Gerard
    Department of Oncology, Wayne State University, 110 East Warren Avenue, Detroit, 48201, Michigan
    J Mol Signal 6:6. 2011
    ..abstract:..
  11. ncbi request reprint Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 62:2115-24. 2002
    ....
  12. ncbi request reprint Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression
    M P Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 61:1320-6. 2001
    ..These data illustrate the importance of structural and functional interactions between breast stromal and epithelial cells in the regulation of breast epithelial growth and progression...
  13. doi request reprint Rad6B is a positive regulator of beta-catenin stabilization
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Detroit, MI 4820, USA
    Cancer Res 68:1741-50. 2008
    ....
  14. pmc Direct action of estrogen on sequence of progression of human preneoplastic breast disease
    M P Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Pathol 152:1129-32. 1998
    ....
  15. ncbi request reprint Interaction with endothelial cells is a prerequisite for branching ductal-alveolar morphogenesis and hyperplasia of preneoplastic human breast epithelial cells: regulation by estrogen
    M P Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer Res 60:439-49. 2000
    ..This three-dimensional culture model offers a unique opportunity to study endothelial- and epithelial cell-specific factors that are important for ductal-alveolar morphogenesis, angiogenesis, and progression to malignant phenotype...
  16. pmc Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response
    Alex Lyakhovich
    Breast Cancer Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Mol Cell Biol 23:2463-75. 2003
    ..The data presented in the present study suggest that Rad6-p53-p14ARF complex formation and p53 ubiquitin modification are important damage-induced responses that perhaps determine the fidelity of DNA postreplication repair...
  17. pmc Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum
    Pratima Nangia-Makker
    Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 121:884-94. 2007
    ....
  18. pmc Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance
    Ayman Khdair
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    J Control Release 141:137-44. 2010
    ..These data suggest that nanoparticle-mediated combination chemotherapy and photodynamic therapy using doxorubicin and methylene blue has significant therapeutic potential against drug-resistant tumors...
  19. ncbi request reprint RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response
    Alex Lyakhovich
    Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Oncogene 23:3097-106. 2004
    ....
  20. doi request reprint Surfactant-polymer nanoparticles enhance the effectiveness of anticancer photodynamic therapy
    Ayman Khdair
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    Mol Pharm 5:795-807. 2008
    ..Increased ROS production and favorable alteration in the subcellular distribution contribute to the enhanced PDT efficacy of nanoparticle-encapsulated photosensitizer...
  21. pmc Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer
    Christine J Ye
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 219:288-300. 2009
    ..This study reconciles the difference between evolutionary and molecular mechanisms of cancer and suggests that NCCAs can serve as a biomarker to monitor the probability of cancer progression...
  22. ncbi request reprint Surfactant-polymer nanoparticles overcome P-glycoprotein-mediated drug efflux
    Mahesh D Chavanpatil
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Mol Pharm 4:730-8. 2007
    ..In conclusion, an AOT-alginate nanoparticle system enhanced the cellular delivery and therapeutic efficacy of P-gp substrates in P-gp-overexpressing cells...