Seetha Shankaran

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Therapeutic hypothermia for neonatal encephalopathy
    Seetha Shankaran
    Neonatal Perinatal Medicine, Children s Hospital of Michigan, 4C19, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA
    Curr Treat Options Neurol 14:608-19. 2012
  2. ncbi Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy
    Seetha Shankaran
    Department of Pediatrics Neonatology, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Arch Dis Child Fetal Neonatal Ed 97:F398-404. 2012
  3. ncbi Hypoxic-ischemic Encephalopathy and Novel Strategies for Neuroprotection
    Seetha Shankaran
    Wayne State University School of Medicine, Division of Neonatal Perinatal Medicine, Children s Hospital of Michigan and Hutzel Women s Hospital, 3901 Beaubien, 4C19, Detroit, MI 48201, USA Electronic address
    Clin Perinatol 39:919-29. 2012
  4. ncbi Childhood outcomes after hypothermia for neonatal encephalopathy
    Seetha Shankaran
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    N Engl J Med 366:2085-92. 2012
  5. ncbi Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Wayne State University School of Medicine, Detroit, MI, USA
    Pediatr Crit Care Med 13:53-9. 2012
  6. ncbi Cumulative index of exposure to hypocarbia and hyperoxia as risk factors for periventricular leukomalacia in low birth weight infants
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatrics 118:1654-9. 2006
  7. ncbi Fetal origin of childhood disease: intrauterine growth restriction in term infants and risk for hypertension at 6 years of age
    Seetha Shankaran
    National Institute of Child Health and Human Development Neonatal Research Network, Bethesda, MD, USA
    Arch Pediatr Adolesc Med 160:977-81. 2006
  8. ncbi Prevention, diagnosis, and treatment of cerebral palsy in near-term and term infants
    Seetha Shankaran
    Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Obstet Gynecol 51:829-39. 2008
  9. ncbi Association between patterns of maternal substance use and infant birth weight, length, and head circumference
    Seetha Shankaran
    Wayne State University, Detroit, Michigan, USA
    Pediatrics 114:e226-34. 2004
  10. ncbi Hypothermia as a treatment for birth asphyxia
    Seetha Shankaran
    Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Clin Obstet Gynecol 50:624-35. 2007

Research Grants

  1. Maternal Lifestyle Study
    Seetha Shankaran; Fiscal Year: 2005
  2. Maternal Lifestyles Study Phase V
    Seetha Shankaran; Fiscal Year: 2007
  3. NICHD Cooperative Multicenter Neonatal Research Network
    Seetha Shankaran; Fiscal Year: 2007

Detail Information

Publications113 found, 100 shown here

  1. ncbi Therapeutic hypothermia for neonatal encephalopathy
    Seetha Shankaran
    Neonatal Perinatal Medicine, Children s Hospital of Michigan, 4C19, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA
    Curr Treat Options Neurol 14:608-19. 2012
    ..All infants should be followed for a minimum of 18 months to evaluate growth parameters and neurodevelopment al outcome...
  2. ncbi Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy
    Seetha Shankaran
    Department of Pediatrics Neonatology, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Arch Dis Child Fetal Neonatal Ed 97:F398-404. 2012
    ..The objective of our study was to examine the relationship between brain injury and outcome following neonatal hypoxic-ischaemic encephalopathy treated with hypothermia...
  3. ncbi Hypoxic-ischemic Encephalopathy and Novel Strategies for Neuroprotection
    Seetha Shankaran
    Wayne State University School of Medicine, Division of Neonatal Perinatal Medicine, Children s Hospital of Michigan and Hutzel Women s Hospital, 3901 Beaubien, 4C19, Detroit, MI 48201, USA Electronic address
    Clin Perinatol 39:919-29. 2012
    ..Facts regarding the clinical application of cooling obtained from the randomized trials and knowledge gaps in hypothermic therapy are presented. The review concludes with the future of hypothermia for neuroprotection...
  4. ncbi Childhood outcomes after hypothermia for neonatal encephalopathy
    Seetha Shankaran
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    N Engl J Med 366:2085-92. 2012
    ..Long-term outcomes are now available...
  5. ncbi Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Wayne State University School of Medicine, Detroit, MI, USA
    Pediatr Crit Care Med 13:53-9. 2012
    ....
  6. ncbi Cumulative index of exposure to hypocarbia and hyperoxia as risk factors for periventricular leukomalacia in low birth weight infants
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatrics 118:1654-9. 2006
    ..Hypocarbia and hyperoxia are risk factors for periventricular leukomalacia in low birth weight infants. The association of a cumulative index of exposure to hypocarbia and hyperoxia and periventricular leukomalacia has not been evaluated...
  7. ncbi Fetal origin of childhood disease: intrauterine growth restriction in term infants and risk for hypertension at 6 years of age
    Seetha Shankaran
    National Institute of Child Health and Human Development Neonatal Research Network, Bethesda, MD, USA
    Arch Pediatr Adolesc Med 160:977-81. 2006
    ..To examine the association between intrauterine growth restriction (IUGR) status at birth among full-term infants, exposure to substance use during pregnancy, and risk of hypertension at 6 years of age...
  8. ncbi Prevention, diagnosis, and treatment of cerebral palsy in near-term and term infants
    Seetha Shankaran
    Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Obstet Gynecol 51:829-39. 2008
    ..Treatment of CP based on evidenced-based data will be reviewed...
  9. ncbi Association between patterns of maternal substance use and infant birth weight, length, and head circumference
    Seetha Shankaran
    Wayne State University, Detroit, Michigan, USA
    Pediatrics 114:e226-34. 2004
    ..To determine the effects of patterns of drug use during term pregnancy on infant growth parameters at birth...
  10. ncbi Hypothermia as a treatment for birth asphyxia
    Seetha Shankaran
    Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Clin Obstet Gynecol 50:624-35. 2007
    ..The evidence-based trials of hypothermia will be reviewed along with recommendations regarding clinical applications for this therapy and need for long-term follow-up of children receiving this therapy...
  11. ncbi Outcome of extremely-low-birth-weight infants at highest risk: gestational age < or =24 weeks, birth weight < or =750 g, and 1-minute Apgar < or =3
    Seetha Shankaran
    Wayne State University, Detroit, MI, USA
    Am J Obstet Gynecol 191:1084-91. 2004
    ....
  12. ncbi Impact of maternal substance use during pregnancy on childhood outcome
    Seetha Shankaran
    Wayne State University School of Medicine, Detroit, MI, USA
    Semin Fetal Neonatal Med 12:143-50. 2007
    ..Therefore, efforts should be made to prevent and treat behavioral problems as well as to limit the onset of drug use by adolescent children born to women who use drugs during pregnancy...
  13. ncbi Predictive value of an early amplitude integrated electroencephalogram and neurologic examination
    Seetha Shankaran
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Pediatrics 128:e112-20. 2011
    ..To examine the predictive validity of the amplitude integrated electroencephalogram (aEEG) and stage of encephalopathy among infants with hypoxic-ischemic encephalopathy (HIE) eligible for therapeutic whole-body hypothermia...
  14. ncbi Prenatal cocaine exposure and small-for-gestational-age status: effects on growth at 6 years of age
    Seetha Shankaran
    Department of Pediatrics Wayne State University School of Medicine, United States
    Neurotoxicol Teratol 33:575-81. 2011
    ..To evaluate the impact of prenatal cocaine exposure and small-for-gestational-age (SGA) status on childhood growth...
  15. ncbi Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    N Engl J Med 353:1574-84. 2005
    ..Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain...
  16. ncbi Risk for obesity in adolescence starts in early childhood
    S Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    J Perinatol 31:711-6. 2011
    ..The objective of this study was to assess the predictive value of body mass index (BMI) at earlier ages on risk of overweight/obesity at age of 11 years...
  17. ncbi Neonatal encephalopathy: treatment with hypothermia
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Division of Neonatal Perinatal Medicine, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    J Neurotrauma 26:437-43. 2009
    ..Lastly, the status of ongoing neonatal hypothermia trials will be summarized...
  18. ncbi The postnatal management of the asphyxiated term infant
    Seetha Shankaran
    Neonatal Perinatal Medicine, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Clin Perinatol 29:675-92. 2002
    ....
  19. ncbi Prenatal cocaine exposure and BMI and blood pressure at 9 years of age
    Seetha Shankaran
    Wayne State University School of Medicine, Detroit, Michigan, USA
    J Hypertens 28:1166-75. 2010
    ....
  20. ncbi Challenge of conducting trials of neuroprotection in the asphyxiated term infant
    Seetha Shankaran
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Semin Perinatol 27:320-32. 2003
    ..Since clinical trials of brain hypothermia are in progress, many of these issues will be addressed from the perspective of this specific intervention...
  21. ncbi Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatrics 122:e791-8. 2008
    ..Whole-body hypothermia reduced the frequency of death or moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a randomized, controlled multicenter trial...
  22. ncbi Protective factors can mitigate behavior problems after prenatal cocaine and other drug exposures
    Henrietta S Bada
    Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Pediatrics 130:e1479-88. 2012
    ..We determined the role of risk and protective factors on the trajectories of behavior problems associated with high prenatal cocaine exposure (PCE)/polydrug exposure...
  23. ncbi Neonatal neurobehavior predicts medical and behavioral outcome
    Jing Liu
    Department of Pediatrics, Brown Center for the Study of Children at Risk, Warren Alpert Medical School, Brown University, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Pediatrics 125:e90-8. 2010
    ..This study examined the NICU Network Neurobehavioral Scale (NNNS) as a predictor of negative medical and behavioral findings at 1 month to 4.5 years of age...
  24. ncbi Long-term impact of maternal substance use during pregnancy and extrauterine environmental adversity: stress hormone levels of preadolescent children
    Charles R Bauer
    Department of Pediatrics, University of Miami, Miami, Florida 33136, USA
    Pediatr Res 70:213-9. 2011
    ..Anticipating the potential long-term medical, developmental, or behavioral effects of an altered ability to mount a normal protective cortisol stress response is essential in optimizing the outcomes of children with PCE...
  25. ncbi Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy
    Abbot R Laptook
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02906, USA
    Pediatrics 124:1619-26. 2009
    ..The objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy...
  26. ncbi Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation
    Waldemar A Carlo
    Department of Pediatrics, University of Alabama, 9380 Women and Infants Center, 1700 Sixth Ave S, Birmingham, AL 35249, USA
    JAMA 306:2348-58. 2011
    ..However, many infants born before 24 weeks' gestation are provided intensive care...
  27. ncbi Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, and Children s Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA, USA
    Pediatrics 127:817-26. 2011
    ..Guidelines for prevention of group B streptococcal (GBS) infection have successfully reduced early onset (EO) GBS disease. Study results suggest that Escherichia coli is an important EO pathogen...
  28. ncbi Acute neonatal effects of cocaine exposure during pregnancy
    Charles R Bauer
    Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA
    Arch Pediatr Adolesc Med 159:824-34. 2005
    ..Increased infections, particularly sexually transmitted diseases, pose a serious public health challenge. Exposure increased involvement of child protective services and out-of-home placement...
  29. ncbi Outcome trajectories in extremely preterm infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Pediatrics 130:e115-25. 2012
    ..Our objective was to develop serial predictions of outcome by using prognostic factors available over the course of NICU hospitalization...
  30. ncbi Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Arch Pediatr Adolesc Med 162:748-55. 2008
    ..To determine special outpatient services (SOS) use, need, associated factors, and neurodevelopmental and functional outcomes among extremely preterm infants at 18 to 22 months' corrected age...
  31. ncbi Cytokines and neurodevelopmental outcomes in extremely low birth weight infants
    Waldemar A Carlo
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 7335, USA
    J Pediatr 159:919-25.e3. 2011
    ....
  32. ncbi Health-care utilization among mothers and infants following cocaine exposure
    Seetha Shankaran
    Wayne State University, Detroit, MI, USA
    J Perinatol 23:361-7. 2003
    ..The increase in health-care resources for >1500 g cocaine-exposed infants for surveillance and monitoring in the absence of an increase in congenital anomalies should be discouraged...
  33. ncbi Predicting time to hospital discharge for extremely preterm infants
    Susan R Hintz
    Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine and Lucile Packard Children s Hospital, Palo Alto, CA 94304, USA
    Pediatrics 125:e146-54. 2010
    ..Accurate models for predicting time to hospital discharge could aid in resource planning, family counseling, and stimulate quality-improvement initiatives...
  34. ncbi Neurobehavioral assessment predicts motor outcome in preterm infants
    Bonnie E Stephens
    Department of Pediatrics, Alpert Brown Medical School, Providence, RI, USA
    J Pediatr 156:366-71. 2010
    ..To determine whether Neonatal Intensive Care Unit Network Neurobehavior Scales (NNNS) at 44 weeks predict motor outcome at 2 years in preterm infants from the Maternal Lifestyles Study (MLS)...
  35. ncbi Preadolescent behavior problems after prenatal cocaine exposure: Relationship between teacher and caretaker ratings (Maternal Lifestyle Study)
    Henrietta S Bada
    Department of Pediatrics, University of Kentucky, Lexington, KY 40536, USA
    Neurotoxicol Teratol 33:78-87. 2011
    ..However, these behavior problems may not manifest in a structured environment, such as a school setting...
  36. ncbi Infant neurobehavioral dysregulation: behavior problems in children with prenatal substance exposure
    Barry M Lester
    Department of Pediatrics, Brown Center for the Study of Children at Risk, Women and Infants Hospital, Brown University, Providence, Rhode Island 02905, USA
    Pediatrics 124:1355-62. 2009
    ..The objective of this study was to test a developmental model of neurobehavioral dysregulation relating prenatal substance exposure to behavior problems at age 7...
  37. ncbi Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants
    Brenda B Poindexter
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Pediatrics 113:1209-15. 2004
    ..Whether glutamine supplementation would provide a similar benefit to extremely low birth weight (ELBW) infants is not known...
  38. ncbi Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Pediatrics 124:517-26. 2009
    ..Limited information is available on the outcomes of infants managed with SNIPPV...
  39. ncbi Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Early Hum Dev 88:509-15. 2012
    ..We compared neurodevelopmental outcomes of extremely low birth weight (ELBW) infants with and without bronchopulmonary dysplasia (BPD), using the physiologic definition...
  40. ncbi Approach to infants born at 22 to 24 weeks' gestation: relationship to outcomes of more-mature infants
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Pediatrics 129:e1508-16. 2012
    ..We sought to determine if a center's approach to care of premature infants at the youngest gestational ages (22-24 weeks' gestation) is associated with clinical outcomes among infants of older gestational ages (25-27 weeks' gestation)...
  41. ncbi Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infants
    Andi L Shane
    Department of Pediatrics, Emory University School of Medicine, Children s Healthcare of Atlanta, Atlanta, GA 30322, USA
    Pediatrics 129:e914-22. 2012
    ..Data are limited on the impact of methicillin-resistant Staphylococcus aureus (MRSA) on morbidity and mortality among very low birth weight (VLBW) infants with S aureus (SA) bacteremia and/or meningitis (B/M)...
  42. ncbi Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    J Pediatr 160:567-572.e3. 2012
    ..To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia...
  43. ncbi Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy
    William Oh
    Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr 153:375-8. 2008
    ..To assess the association between urinary lactate to creatinine ratio (ULCR) and neurodevelopmental outcome in term infants with hypoxic ischemic encephalopathy and examine the effect of hypothermia on the change in ULCR...
  44. ncbi Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants
    Edward F Bell
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 126:222-31. 2010
    ....
  45. ncbi Importance of stability of early living arrangements on behavior outcomes of children with and without prenatal drug exposure
    Henrietta S Bada
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Dev Behav Pediatr 29:173-82. 2008
    ..We evaluated whether living arrangements of children with or without prenatal drug exposure would be associated with their behavior outcomes and adaptive functioning...
  46. ncbi Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollment
    Wade D Rich
    Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
    Pediatrics 126:e215-21. 2010
    ....
  47. ncbi Low birth weight and preterm births: etiologic fraction attributable to prenatal drug exposure
    Henrietta S Bada
    Department of Pediatrics, College of Medicine and College of Public Health, University of Kentucky, Lexington, KY 40536, USA
    J Perinatol 25:631-7. 2005
    ..20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). CONCLUSION: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine...
  48. ncbi Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants
    Seetha Shankaran
    Wayne State University, Detroit, Michigan, USA
    Pediatrics 110:377-85. 2002
    ....
  49. ncbi Serial pediatric symptom checklist screening in children with prenatal drug exposure
    Toni M Whitaker
    Department of Pediatrics, Boling Center for Developmental Disabilities, University of Tennessee College of Medicine, Memphis, TN 38105, USA
    J Dev Behav Pediatr 32:206-15. 2011
    ..To examine screening results obtained by serial annual behavioral assessment of children with prenatal drug exposure...
  50. ncbi Early nutrition mediates the influence of severity of illness on extremely LBW infants
    Richard A Ehrenkranz
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Pediatr Res 69:522-9. 2011
    ....
  51. ncbi Maternal age, multiple birth, and extremely low birth weight infants
    Betty R Vohr
    Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr 154:498-503.e2. 2009
    ..To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers...
  52. ncbi Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatrics 110:285-91. 2002
    ..Strategies to reduce late-onset sepsis and its medical, social, and economic toll need to be addressed urgently...
  53. ncbi Effects of prenatal cocaine exposure on special education in school-aged children
    Todd P Levine
    Department of Pediatrics, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02905, USA
    Pediatrics 122:e83-91. 2008
    ..The objective of this study was to evaluate the effects of prenatal cocaine exposure on special education at age 7 with adjustment for covariates...
  54. ncbi Impact of prenatal cocaine exposure on child behavior problems through school age
    Henrietta S Bada
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Pediatrics 119:e348-59. 2007
    ..We examined the trajectory of childhood behavior problems after prenatal cocaine exposure...
  55. ncbi Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
    Pediatrics 127:62-70. 2011
    ..We compared neurodevelopmental outcomes at 18 to 22 months' corrected age of infants born with extremely low birth weight at an estimated gestational age of <25 weeks during 2 periods: 1999-2001 (epoch 1) and 2002-2004 (epoch 2)...
  56. ncbi Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy
    Athina Pappas
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Pediatr 158:752-758.e1. 2011
    ..To evaluate the association between early hypocarbia and 18- to 22-month outcome among neonates with hypoxic-ischemic encephalopathy...
  57. ncbi To tap or not to tap: high likelihood of meningitis without sepsis among very low birth weight infants
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatrics 113:1181-6. 2004
    ..Because CSF cultures were performed only half as often as BCs, this discordance in blood and CSF culture results suggests that meningitis may be underdiagnosed among VLBW infants...
  58. ncbi Risk factors for early death among extremely low-birth-weight infants
    Seetha Shankaran
    Wayne State University, Detroit, Michigan, USA
    Am J Obstet Gynecol 186:796-802. 2002
    ..4; 95% CI, 1.3-1.6), and lower birth weight per 50 g (95% CI, 1.2-1.4). CONCLUSION: Early death (<12 hours of age) among extremely low-birth-weight infants may reflect an assessment of non-viability by obstetricians and neonatologists...
  59. ncbi Cytokine profiles of preterm neonates with fungal and bacterial sepsis
    Beena G Sood
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Pediatr Res 72:212-20. 2012
    ..We hypothesized that cytokine profiles in the first 21 d of life in ELBW infants with FS differ from those with bacterial sepsis (BS) or no sepsis (NS)...
  60. ncbi Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants
    Lilia C De Jesus
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    J Pediatr 161:70-4.e1-2. 2012
    ..The study goal was to evaluate maternal and neonatal risk factors associated with post-neonatal intensive care unit (NICU) discharge mortality among extremely low birth weight (ELBW) infants...
  61. ncbi Outcomes following candiduria in extremely low birth weight infants
    James L Wynn
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Clin Infect Dis 54:331-9. 2012
    ..Candidiasis carries a significant risk of death or neurodevelopmental impairment (NDI) in extremely low birth weight infants (ELBW; <1000 g). We sought to determine the impact of candiduria in ELBW preterm infants...
  62. ncbi Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure
    Seetha Shankaran
    Wayne State University, Detroit, MI, USA
    Am J Obstet Gynecol 187:171-7. 2002
    ....
  63. ncbi Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    N Engl J Med 347:240-7. 2002
    ..The change in pathogens over time from predominantly gram-positive to predominantly gram-negative requires confirmation by ongoing surveillance...
  64. ncbi Prenatal cocaine exposure related to cortisol stress reactivity in 11-year-old children
    Barry M Lester
    Department of Pediatrics, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
    J Pediatr 157:288-295.e1. 2010
    ..Determine the association between prenatal cocaine exposure and postnatal environmental adversity on salivary cortisol stress reactivity in school-aged children...
  65. ncbi Inhaled nitric oxide for premature infants with severe respiratory failure
    Krisa P Van Meurs
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    N Engl J Med 353:13-22. 2005
    ..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants...
  66. ncbi Neonatal candidiasis: epidemiology, risk factors, and clinical judgment
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
    Pediatrics 126:e865-73. 2010
    ..We quantified risk factors that predict infection in premature infants at high risk and compared clinical judgment with a prediction model of invasive candidiasis...
  67. ncbi Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Pediatr Res 72:414-9. 2012
    ..5 °C for 72 h in term infants (n = 208) with hypoxic-ischemic encephalopathy (HIE) who participated in the Neonatal Research Network (NRN) randomized controlled trial...
  68. ncbi Survival and morbidity outcomes for very low birth weight infants with Down syndrome
    Nansi S Boghossian
    University of Iowa Health Care, Department of Pediatrics, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Pediatrics 126:1132-40. 2010
    ....
  69. ncbi Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants
    Matthew M Laughon
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7596, USA
    Am J Respir Crit Care Med 183:1715-22. 2011
    ....
  70. ncbi Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months
    Conrad R Cole
    Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 122:e573-82. 2008
    ....
  71. ncbi Stability of neuromotor outcomes at 18 and 30 months of age after extremely low birth weight status
    Myriam Peralta-Carcelen
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatrics 123:e887-95. 2009
    ..Extremely low birth weight (< or =1000 g) children have increased rates of cerebral palsy and other abnormal neurologic findings...
  72. ncbi Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 126:443-56. 2010
    ....
  73. ncbi Intercenter differences in bronchopulmonary dysplasia or death among very low birth weight infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 127:e106-16. 2011
    ....
  74. ncbi Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 123:1132-41. 2009
    ..The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days...
  75. ncbi Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 118:2084-93. 2006
    ..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy...
  76. ncbi T cell cytokines and the risk of blood stream infection in extremely low birth weight infants
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Cytokine 53:249-55. 2011
    ..Altered maturation of regulatory and inflammatory cytokines may increase the risk of serious infection in this population...
  77. ncbi Perinatal systemic inflammatory response syndrome and retinopathy of prematurity
    Beena G Sood
    Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Res 67:394-400. 2010
    ..We conclude that perinatal inflammation may be involved in the pathogenesis of ROP...
  78. ncbi Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants
    Girija Natarajan
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Res 67:77-82. 2010
    ..003). The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted...
  79. ncbi Changes in amplitude-integrated electroencephalography in neonates treated with extracorporeal membrane oxygenation: a pilot study
    Athina Pappas
    Neonatal Perinatal Medicine Department, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Pediatr 148:125-7. 2006
    ..An abnormal aEEG predicted death or moderate to severe intracranial neuropathology with sensitivity = 1.0, specificity = 0.75, positive predictive value = 0.86, and negative predictive value = 1.0...
  80. ncbi Effects of hypoxic-ischemic encephalopathy and whole-body hypothermia on neonatal auditory function: a pilot study
    Ulrike Mietzsch
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Am J Perinatol 25:435-41. 2008
    ..Neonatal audiometric testing is feasible, noninvasive, and capable of enhancing our understanding of the effects of HIE and hypothermia on auditory function...
  81. ncbi Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes
    Abbot Laptook
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley St, Providence, RI 02906, USA
    Pediatrics 122:491-9. 2008
    ....
  82. ncbi Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants
    David Da Costa
    Department of Pediatrics, William Beaumont Hospital, Royal Oak, MI, USA
    Dev Med Child Neurol 51:536-44. 2009
    ..The revised Functional Status questionnaire (FS-II) was designed to assess caregivers' perceptions of the functional status of children with chronic diseases...
  83. ncbi Aerosolized PGE1: a selective pulmonary vasodilator in neonatal hypoxemic respiratory failure results of a Phase I/II open label clinical trial
    Beena G Sood
    Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201 USA
    Pediatr Res 56:579-85. 2004
    ..The results of our study indicate that IPGE(1) may be a safe, selective pulmonary vasodilator in neonatal hypoxemic respiratory failure...
  84. ncbi Age of smoking onset as a predictor of smoking cessation during pregnancy
    Xinguang Chen
    Prevention Research Center, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, 4201 St Antoine Street, Detroit, MI 48201, USA
    Am J Health Behav 30:247-58. 2006
    ..To assess age of smoking onset as a predictor of smoking cessation during pregnancy...
  85. ncbi Systemic levels following PGE1 inhalation in neonatal hypoxemic respiratory failure
    Beena G Sood
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Hutzel Women s Hospital and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Acta Paediatr 95:1093-8. 2006
    ..To measure plasma prostaglandin E1 (PGE1) levels in newborns with hypoxemic respiratory failure (NHRF) following inhaled PGE1 (IPGE1), normal term newborns, and newborns with congenital heart disease (CHD) following intravenous PGE1...
  86. ncbi Transient hypermetabolism of the basal ganglia following perinatal hypoxia
    Carlos E A Batista
    Carman and Ann Adams, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 36:330-3. 2007
    ..Thus, positron emission tomography can help predict this form of cerebral palsy in neonates...
  87. ncbi Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development/NIH, 6100 Executive Boulevard, MSC 7510, Bethesda, MD 20892, USA
    J Pediatr 148:170-175. 2006
  88. ncbi Hypothermia for hypoxic ischemic encephalopathy in infants > or =36 weeks
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Early Hum Dev 85:S49-52. 2009
    ..Hypothermia for neonatal HIE is continuing to evolve as a therapy. Studies, gaps in knowledge and opportunities for research are presented herein...
  89. ncbi Changes in the PQRST intervals and heart rate variability associated with rewarming in two newborns undergoing hypothermia therapy
    Robert E Lasky
    Division of Neonatal Perinatal Medicine, Department of Pediatrics and Center for Clinical Research and Evidence Based Medicine, University of Texas Medical School, Houston, TX 77030, USA
    Neonatology 96:93-5. 2009
    ..Little is known about the effects of hypothermia therapy and subsequent rewarming on the PQRST intervals and heart rate variability (HRV) in term newborns with hypoxic-ischemic encephalopathy (HIE)...
  90. ncbi Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure
    N Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Perinatol 28:420-6. 2008
    ..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure...
  91. ncbi The Maternal Lifestyle Study: drug exposure during pregnancy and short-term maternal outcomes
    Charles R Bauer
    Department of Pediatrics, University of Miami School of Medicine, Fla 33101, USA
    Am J Obstet Gynecol 186:487-95. 2002
    ..The Maternal Lifestyle Study (MLS) is a multicenter, prospective, observational study that was initiated to better define the effects of exposure to illicit drugs during pregnancy on the mother, fetus, and infant...
  92. ncbi Role of plasma B-type natriuretic peptide in screening for hemodynamically significant patent ductus arteriosus in preterm neonates
    Sanjeev Sanjeev
    Division of Pediatric Cardiology, Children's Hosptial of Michigan, Detroit, MI 48201, USA
    J Perinatol 25:709-13. 2005
    ..Successful closure is reflected by a corresponding decrease in BNP. At a cutoff of 70 pg/ml, BNP is a useful screening tool for diagnosis and for monitoring efficacy of treatment of hsPDA...
  93. ncbi Attachment status in children prenatally exposed to cocaine and other substances
    Ronald Seifer
    Medical School, Brown University, Providence, RI 02915, USA
    Child Dev 75:850-68. 2004
    ..Attachment status at 18 months was associated with child temperament and caregiver-child interaction; at 36 months, attachment was associated with child temperament, child behavior problems, and caregivers' parenting self-esteem...
  94. ncbi Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents
    Abbot R Laptook
    Brown Medical School, Providence, Rhode Island, USA
    Pediatrics 115:673-80. 2005
    ..This study examined the prevalence of and risk factors for CP and impaired mental development among ELBW infants with a normal HUS...
  95. ncbi Gestational cocaine exposure and intrauterine growth: maternal lifestyle study
    Henrietta S Bada
    The University of Kentucky, Lexington, Kentucky 40536, USA
    Obstet Gynecol 100:916-24. 2002
    ..To estimate the effects of cocaine exposure on intrauterine growth and to investigate at what point in gestation growth deviation would be manifested...
  96. ncbi The maternal lifestyle study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants
    Barry M Lester
    Brown Medical School, Infant Development Center, Women and Infant s Hospital and Bradley Hospital, Providence, Rhode Island 02905 2499, USA
    Pediatrics 110:1182-92. 2002
    ..This was a prospective longitudinal multisite study of the effects of prenatal cocaine and/or opiate exposure on neurodevelopmental outcome in term and preterm infants at 1 month of age...
  97. ncbi The Maternal Lifestyle Study (MLS): effects of prenatal cocaine and/or opiate exposure on auditory brain response at one month
    Barry M Lester
    Brown Medical School, the Infant Development Center, Women and Infant's Hospital, and Bradley Hospital, Providence, Rhode Island 02905-2499, USA
    J Pediatr 142:279-85. 2003
    ..CONCLUSIONS: Prenatal cocaine and/or opiate exposure affects neural transmission. Detection of these effects requires a large sample with control for gestational age, other drugs, and level of cocaine use...
  98. ncbi Summary statistics of neonatal intensive care unit network neurobehavioral scale scores from the maternal lifestyle study: a quasinormative sample
    Barry M Lester
    Brown Medical School, Infant Development Center, Women and Infants Hospital and Bradley Hospital, Providence, Rhode Island 02903, USA
    Pediatrics 113:668-75. 2004
    ..These tables can be used as quasinorms for comparison with other infants of this age...
  99. ncbi The maternal lifestyle study: cognitive, motor, and behavioral outcomes of cocaine-exposed and opiate-exposed infants through three years of age
    Daniel S Messinger
    Department of Psychology, University of Miami, Coral Gables, Florida, USA
    Pediatrics 113:1677-85. 2004
    ..To evaluate the direct effects of prenatal cocaine exposure and prenatal opiate exposure on infant mental, motor, and behavioral outcomes longitudinally between 1 and 3 years old...
  100. ncbi Interactions between maternal characteristics and neonatal behavior in the prediction of parenting stress and perception of infant temperament
    Stephen J Sheinkopf
    Brown Medical School, Bradley Hospital, 1011 Veterans Memorial Parkway, East Providence, Rhode Island 02915, USA
    J Pediatr Psychol 31:27-40. 2006
    ..Prenatal cocaine exposure is a marker of developmental risk. Social environmental risk factors may include maternal stress and maternal perceptions of difficult infant temperament...
  101. ncbi Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants
    William Oh
    Women and Infants Hospital of Rhode Island Brown University, Providence, Rhode Island 02905, USA
    Pediatrics 112:773-9. 2003
    ..To assess the association between peak total serum bilirubin (PSB) levels during the first 2 weeks of life and neurodevelopmental outcomes of extremely low birth weight (ELBW) infants at 18 to 22 months' postmenstrual age...

Research Grants6

  1. Maternal Lifestyle Study
    Seetha Shankaran; Fiscal Year: 2005
    ..I n the current grant period, the Principal Investigator at the Wayne State University site, Dr. Seetha Shankaran, served as PI for the Antenatal Phenobarbital to Prevent IVH Study and is currently PI of the Induced ..
  2. Maternal Lifestyles Study Phase V
    Seetha Shankaran; Fiscal Year: 2007
    ..A thorough understanding of the consequences of prenatal cocaine exposure and associated maternal lifestyle is necessary to the development of treatment and public policy initiatives. ..
  3. NICHD Cooperative Multicenter Neonatal Research Network
    Seetha Shankaran; Fiscal Year: 2007
    ..The Wayne State site PI, Dr. Seetha Shankaran, is the only PI in the Neonatal Research Network who has served as Lead Investigator in 2 Randomized ..