Seema Sethi

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Molecular markers of epithelial-to-mesenchymal transition are associated with tumor aggressiveness in breast carcinoma
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Transl Oncol 4:222-6. 2011
  2. pmc Recent updates on the role of microRNAs in prostate cancer
    Oudai Hassan
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Hematol Oncol 5:9. 2012
  3. pmc Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment
    Bin Bao
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 7:e50165. 2012
  4. doi request reprint EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53
    Shelly Seward
    Laboratory of Surgical Oncology and Developmental Therapeutics, Department of Surgery, Wayne State University, Detroit, MI 48201, USA
    Cancer Lett 336:53-60. 2013
  5. doi request reprint Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, 740 HWCRC Bldg, 4100 John R Street, Detroit, MI 48201, USA
    Mol Cancer Ther 11:2193-201. 2012
  6. pmc Clinical advances in molecular biomarkers for cancer diagnosis and therapy
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Sci 14:14771-84. 2013
  7. pmc Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer
    Shuping Yin
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Mol Cancer Ther 12:491-8. 2013
  8. pmc Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer
    Seema Sethi
    Departments of Pathology and Oncology, and division of Statistics, Karmanos Cancer Institute, Wayne State University School of Medicine and Detroit Medical Center Detroit, MI
    Am J Transl Res 5:200-11. 2013
  9. doi request reprint Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101
    Aamer M Qazi
    Laboratory of Surgical Oncology and Developmental Therapeutics, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Surgery 152:704-11; discussion 711-3. 2012

Collaborators

Detail Information

Publications9

  1. pmc Molecular markers of epithelial-to-mesenchymal transition are associated with tumor aggressiveness in breast carcinoma
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Transl Oncol 4:222-6. 2011
    ....
  2. pmc Recent updates on the role of microRNAs in prostate cancer
    Oudai Hassan
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Hematol Oncol 5:9. 2012
    ....
  3. pmc Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment
    Bin Bao
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 7:e50165. 2012
    ..Collectively, these results suggest that the anti-tumor activity of CDF is in part mediated through deregulation of tumor hypoxic pathways, and thus CDF could become a novel, and effective anti-tumor agent for PC therapy...
  4. doi request reprint EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53
    Shelly Seward
    Laboratory of Surgical Oncology and Developmental Therapeutics, Department of Surgery, Wayne State University, Detroit, MI 48201, USA
    Cancer Lett 336:53-60. 2013
    ..Further, silencing of EZH2 resulted in re-expression of p21(waf1/cip1) and down-regulation of mutant p53. Finally, EZH2 knockdown contributed to attenuated EOC growth in SCID mice...
  5. doi request reprint Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, 740 HWCRC Bldg, 4100 John R Street, Detroit, MI 48201, USA
    Mol Cancer Ther 11:2193-201. 2012
    ....
  6. pmc Clinical advances in molecular biomarkers for cancer diagnosis and therapy
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Sci 14:14771-84. 2013
    ..Overall, the novel cancer diagnostic tools have extended their application as prognostic risk factors and can be used as targets for personalized medicine. ..
  7. pmc Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer
    Shuping Yin
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Mol Cancer Ther 12:491-8. 2013
    ..Taken together, our findings suggest that FZD8-mediated Wnt signaling may play a major role in mediating resistance to chemotherapy, making it a potential target to enhance chemotherapeutic efficacy in patients with TNBCs...
  8. pmc Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer
    Seema Sethi
    Departments of Pathology and Oncology, and division of Statistics, Karmanos Cancer Institute, Wayne State University School of Medicine and Detroit Medical Center Detroit, MI
    Am J Transl Res 5:200-11. 2013
    ....
  9. doi request reprint Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101
    Aamer M Qazi
    Laboratory of Surgical Oncology and Developmental Therapeutics, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Surgery 152:704-11; discussion 711-3. 2012
    ..To investigate the possibility of inhibiting the progression of pancreatic ductal adenocarcinoma (PDAC) by facilitating the expression of E-cadherin through the enforced expression of microRNA-101 (miR-101)...