Seema Sethi

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Molecular markers of epithelial-to-mesenchymal transition are associated with tumor aggressiveness in breast carcinoma
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Transl Oncol 4:222-6. 2011
  2. pmc Recent updates on the role of microRNAs in prostate cancer
    Oudai Hassan
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Hematol Oncol 5:9. 2012
  3. pmc Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment
    Bin Bao
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 7:e50165. 2012
  4. doi EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53
    Shelly Seward
    Laboratory of Surgical Oncology and Developmental Therapeutics, Department of Surgery, Wayne State University, Detroit, MI 48201, USA
    Cancer Lett 336:53-60. 2013
  5. doi Clinical implication of microRNAs in molecular pathology
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street, Detroit, MI 48201, USA
    Clin Lab Med 33:773-86. 2013
  6. pmc Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan
    Prostate 75:161-74. 2015
  7. pmc Clinical advances in molecular biomarkers for cancer diagnosis and therapy
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Sci 14:14771-84. 2013
  8. pmc miR-20b is up-regulated in brain metastases from primary breast cancers
    Aamir Ahmad
    Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA
    Oncotarget 6:12188-95. 2015
  9. pmc Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer
    Shuping Yin
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Mol Cancer Ther 12:491-8. 2013
  10. pmc Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, 740 HWCRC Bldg, 4100 John R Street, Detroit, MI 48201, USA
    Mol Cancer Ther 11:2193-201. 2012

Collaborators

Detail Information

Publications14

  1. pmc Molecular markers of epithelial-to-mesenchymal transition are associated with tumor aggressiveness in breast carcinoma
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Transl Oncol 4:222-6. 2011
    ....
  2. pmc Recent updates on the role of microRNAs in prostate cancer
    Oudai Hassan
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Hematol Oncol 5:9. 2012
    ....
  3. pmc Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment
    Bin Bao
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 7:e50165. 2012
    ..Collectively, these results suggest that the anti-tumor activity of CDF is in part mediated through deregulation of tumor hypoxic pathways, and thus CDF could become a novel, and effective anti-tumor agent for PC therapy...
  4. doi EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53
    Shelly Seward
    Laboratory of Surgical Oncology and Developmental Therapeutics, Department of Surgery, Wayne State University, Detroit, MI 48201, USA
    Cancer Lett 336:53-60. 2013
    ..Further, silencing of EZH2 resulted in re-expression of p21(waf1/cip1) and down-regulation of mutant p53. Finally, EZH2 knockdown contributed to attenuated EOC growth in SCID mice...
  5. doi Clinical implication of microRNAs in molecular pathology
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street, Detroit, MI 48201, USA
    Clin Lab Med 33:773-86. 2013
    ....
  6. pmc Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan
    Prostate 75:161-74. 2015
    ..The mechanism(s) by which androgen receptor (AR) splice variants contribute to castration-resistant prostate cancer (CRPC) is still lacking...
  7. pmc Clinical advances in molecular biomarkers for cancer diagnosis and therapy
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Sci 14:14771-84. 2013
    ..Overall, the novel cancer diagnostic tools have extended their application as prognostic risk factors and can be used as targets for personalized medicine. ..
  8. pmc miR-20b is up-regulated in brain metastases from primary breast cancers
    Aamir Ahmad
    Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA
    Oncotarget 6:12188-95. 2015
    ..Together, our findings suggest a novel role of miR-20b in breast cancer brain metastasis that warrants further investigation for its potential to be developed as prognostic and/or therapeutic target. ..
  9. pmc Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer
    Shuping Yin
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Mol Cancer Ther 12:491-8. 2013
    ..Taken together, our findings suggest that FZD8-mediated Wnt signaling may play a major role in mediating resistance to chemotherapy, making it a potential target to enhance chemotherapeutic efficacy in patients with TNBCs...
  10. pmc Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, 740 HWCRC Bldg, 4100 John R Street, Detroit, MI 48201, USA
    Mol Cancer Ther 11:2193-201. 2012
    ....
  11. pmc Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1
    Sharon K Michelhaugh
    Department of Neurosurgery, Wayne State University, 4160 John R Street, Suite 930, Detroit, MI, 48201, USA
    J Transl Med 13:227. 2015
    ..There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic approaches...
  12. pmc Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer
    Seema Sethi
    Departments of Pathology and Oncology, and division of Statistics, Karmanos Cancer Institute, Wayne State University School of Medicine and Detroit Medical Center Detroit, MI
    Am J Transl Res 5:200-11. 2013
    ....
  13. pmc Racial disparities in Human Papillomavirus (HPV) associated head and neck cancer
    Jose Jiron
    Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Otolaryngol 35:147-53. 2014
    ..We aimed to elucidate whether racial disparities in HPV prevalence and overall survival were due to confounding from smoking or alcohol use...
  14. doi Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101
    Aamer M Qazi
    Laboratory of Surgical Oncology and Developmental Therapeutics, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Surgery 152:704-11; discussion 711-3. 2012
    ..To investigate the possibility of inhibiting the progression of pancreatic ductal adenocarcinoma (PDAC) by facilitating the expression of E-cadherin through the enforced expression of microRNA-101 (miR-101)...