JANICE SCHWARTZ

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Genistein-mediated attenuation of tamoxifen-induced antagonism from estrogen receptor-regulated genes
    J A Schwartz
    Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Biochem Biophys Res Commun 253:38-43. 1998
  2. ncbi Tamoxifen: an emerging preventive
    Jan Schwartz
    Department of Physiology, School of Medicine, 540 E Canfield, Wayne State University, Detroit, MI 48201, USA
    Front Biosci 9:2827-47. 2004
  3. ncbi Estrogen receptor protects p53 from deactivation by human double minute-2
    G Liu
    Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 60:1810-4. 2000
  4. ncbi MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance
    Natasha Atanaskova
    Department of Pathology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, Michigan 48201, USA
    Oncogene 21:4000-8. 2002
  5. ncbi Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-alpha alter its response to estradiol and 4-hydroxytamoxifen
    Janice A Schwartz
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    J Biol Chem 277:13202-9. 2002
  6. ncbi Mutation of Leu-536 in human estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation
    Changqing Zhao
    Department of Physiology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 278:27278-86. 2003

Research Grants

  1. LIGAND STRUCTURE AND ER MEDIATED TRANSACTIVATION
    JANICE SCHWARTZ; Fiscal Year: 2002

Collaborators

  • G Liu
  • KALADHAR REDDY
  • DEBRA SKAFAR
  • Changqing Zhao
  • Natasha Atanaskova
  • Akiko Koide
  • Angela Martinez
  • Judith Abrams
  • Sarah Deighton-Collins
  • Shohei Koide
  • Venkateshwar G Keshamouni
  • Fred Miller
  • Joseph S Krueger

Detail Information

Publications6

  1. ncbi Genistein-mediated attenuation of tamoxifen-induced antagonism from estrogen receptor-regulated genes
    J A Schwartz
    Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Biochem Biophys Res Commun 253:38-43. 1998
    ....
  2. ncbi Tamoxifen: an emerging preventive
    Jan Schwartz
    Department of Physiology, School of Medicine, 540 E Canfield, Wayne State University, Detroit, MI 48201, USA
    Front Biosci 9:2827-47. 2004
    ..The next major effort will be to link these determinants to readily detectable biological changes that could be used to indicate the development of resistance before clinical manifestations develop...
  3. ncbi Estrogen receptor protects p53 from deactivation by human double minute-2
    G Liu
    Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 60:1810-4. 2000
    ..This study also describes a new mechanism of cellular regulation of p53 activity...
  4. ncbi MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance
    Natasha Atanaskova
    Department of Pathology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, Michigan 48201, USA
    Oncogene 21:4000-8. 2002
    ..Taken together, these data suggest that MAPK/ER cross-talk enhances ERalpha-mediated signaling and accelerates E(2)-dependent tumor growth without diminishing sensitivity to the inhibitory effects of anti-estrogens...
  5. ncbi Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-alpha alter its response to estradiol and 4-hydroxytamoxifen
    Janice A Schwartz
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    J Biol Chem 277:13202-9. 2002
    ..These results suggest that the F domain modulates the activity of the estrogen receptor-alpha by multiple mechanisms...
  6. ncbi Mutation of Leu-536 in human estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation
    Changqing Zhao
    Department of Physiology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 278:27278-86. 2003
    ..These results show that Leu-536 is critical in coupling the binding of ligand to the modulation of the conformation and activity of ERalpha...

Research Grants2

  1. LIGAND STRUCTURE AND ER MEDIATED TRANSACTIVATION
    JANICE SCHWARTZ; Fiscal Year: 2002
    ....