A G Schwartz

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Genetic variation in glutathione S-transferase omega-1, arsenic methyltransferase and methylene-tetrahydrofolate reductase, arsenic exposure and bladder cancer: a case-control study
    Jennifer L Beebe-Dimmer
    Program of Population Studies and Disparities Research, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA
    Environ Health 11:43. 2012
  2. pmc Genetic epidemiology of cigarette smoke-induced lung disease
    Ann G Schwartz
    Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA
    Proc Am Thorac Soc 9:22-6. 2012
  3. pmc Activating mutation in MET oncogene in familial colorectal cancer
    Deborah W Neklason
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    BMC Cancer 11:424. 2011
  4. ncbi request reprint Familial aggregation of breast cancer with early onset lung cancer
    A G Schwartz
    Epidemiology Section, Karmanos Cancer Institute and Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Genet Epidemiol 17:274-84. 1999
  5. ncbi request reprint The molecular epidemiology of lung cancer
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, and Department of Internal Medicine, Wayne State University School of Medicine, 110 E Warren Avenue, Detroit, MI 48103, USA
    Carcinogenesis 28:507-18. 2007
  6. ncbi request reprint Reproductive factors, hormone use, estrogen receptor expression and risk of non small-cell lung cancer in women
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 E Warren Ave, Detroit, MI 48201, USA
    J Clin Oncol 25:5785-92. 2007
  7. pmc Chronic obstructive lung diseases and risk of non-small cell lung cancer in women
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Thorac Oncol 4:291-9. 2009
  8. pmc Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Thorac Oncol 4:1195-201. 2009
  9. pmc Admixture mapping of lung cancer in 1812 African-Americans
    Ann G Schwartz
    Karmanos Cancer Institute, Detroit, MI 48201, USA
    Carcinogenesis 32:312-7. 2011
  10. ncbi request reprint CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study
    A S Wenzlaff
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Carcinogenesis 26:2207-12. 2005

Detail Information

Publications58

  1. pmc Genetic variation in glutathione S-transferase omega-1, arsenic methyltransferase and methylene-tetrahydrofolate reductase, arsenic exposure and bladder cancer: a case-control study
    Jennifer L Beebe-Dimmer
    Program of Population Studies and Disparities Research, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA
    Environ Health 11:43. 2012
    ..Therefore, we examined the association between genes thought to play a role in the metabolism of arsenic and bladder cancer...
  2. pmc Genetic epidemiology of cigarette smoke-induced lung disease
    Ann G Schwartz
    Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA
    Proc Am Thorac Soc 9:22-6. 2012
    ....
  3. pmc Activating mutation in MET oncogene in familial colorectal cancer
    Deborah W Neklason
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    BMC Cancer 11:424. 2011
    ..Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility...
  4. ncbi request reprint Familial aggregation of breast cancer with early onset lung cancer
    A G Schwartz
    Epidemiology Section, Karmanos Cancer Institute and Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Genet Epidemiol 17:274-84. 1999
    ..Three case families also reported early ovarian cancers (mean age of diagnosis of 35 years). These findings suggest that shared susceptibility genes may act to increase risk of early onset lung and breast cancer in families...
  5. ncbi request reprint The molecular epidemiology of lung cancer
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, and Department of Internal Medicine, Wayne State University School of Medicine, 110 E Warren Avenue, Detroit, MI 48103, USA
    Carcinogenesis 28:507-18. 2007
    ..In the future, studies that focus on complex interactions between multiple genes and environmental exposures within pertinent pathways are needed. New technological advances in genotyping will help move the field forward...
  6. ncbi request reprint Reproductive factors, hormone use, estrogen receptor expression and risk of non small-cell lung cancer in women
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 E Warren Ave, Detroit, MI 48201, USA
    J Clin Oncol 25:5785-92. 2007
    ..We also evaluated whether risk factors were differentially associated with cytoplasmic ER-alpha and/or nuclear ER-beta expression-defined NSCLC in postmenopausal women...
  7. pmc Chronic obstructive lung diseases and risk of non-small cell lung cancer in women
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Thorac Oncol 4:291-9. 2009
    ..The link between lung cancer and chronic obstructive lung diseases (COPD) has not been well studied in women even though lung cancer and COPD account for significant and growing morbidity and mortality among women...
  8. pmc Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, MI 48201, USA
    J Thorac Oncol 4:1195-201. 2009
    ..The goal of this study was to determine whether recently identified genetic variation in 3 SNPs (rs1051730, rs931794, rs8034191) on chromosome 15q25.1 contributes to risk of lung cancer in African Americans...
  9. pmc Admixture mapping of lung cancer in 1812 African-Americans
    Ann G Schwartz
    Karmanos Cancer Institute, Detroit, MI 48201, USA
    Carcinogenesis 32:312-7. 2011
    ..33 (P = 0.0009) at rs181696 among ever smokers with NSCLC. These results add to the findings from the GWAS in Caucasian populations and suggest novel regions of interest...
  10. ncbi request reprint CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study
    A S Wenzlaff
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Carcinogenesis 26:2207-12. 2005
    ..Additional studies will be required to further validate these findings among never smokers and to evaluate the effects of this polymorphism among smoking populations as well...
  11. pmc Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study
    M L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, MI, United States
    Lung Cancer 55:255-62. 2007
    ..41 95% Cl 0.19-0.90). These results were not replicated among the African American population, nor were they modified by amount of smoking...
  12. ncbi request reprint Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study
    M L Cote
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Carcinogenesis 26:811-9. 2005
    ..Joint analysis of these genotypes may identify individuals who are at a higher risk of developing early-onset lung cancer with a greater certainty than single gene studies...
  13. ncbi request reprint GSTM1, GSTT1 and GSTP1 polymorphisms, environmental tobacco smoke exposure and risk of lung cancer among never smokers: a population-based study
    A S Wenzlaff
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Carcinogenesis 26:395-401. 2005
    ..56, 95% CI: 1.21-17.21). These findings suggest that in the presence of ETS, the GSTM1 genotype both alone and in combination with the GSTP1 genotype alters the risk of developing lung cancer among never smokers...
  14. pmc Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women
    Alison L Van Dyke
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 18:1829-40. 2009
    ..Pathway analysis results are presented. Inflammatory pathway genotypes may serve to define a high risk group; further exploration of these genes in minority populations is warranted...
  15. ncbi request reprint Conditional median survival of patients with advanced carcinoma: surveillance, epidemiology, and end results data
    I Kato
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer 92:2211-9. 2001
    ..However, there are no published data on the conditional median survival of patients with advanced carcinoma on a population basis...
  16. ncbi request reprint Familial risk of pancreatic cancer
    M Schenk
    Epidemiology Section, Barbara Ann Karmanos Cancer Institute, Wayne State University, 110 E Warren Ave, Detroit, MI 48201, USA
    J Natl Cancer Inst 93:640-4. 2001
    ..We evaluated whether a family history of pancreatic cancer increases the risk of pancreatic cancer in first-degree relatives and whether smoking and younger age at cancer diagnosis further increase this risk...
  17. ncbi request reprint Racial differences in survival after diagnosis with primary malignant brain tumor
    Jill S Barnholtz-Sloan
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer 98:603-9. 2003
    ..The objective of this study was to examine racial differences in survival after diagnosis with primary malignant brain tumor in a population-based sample of patients while adjusting for prognostic variables that differ by race...
  18. pmc Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review
    Michele L Cote
    Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA
    Am J Epidemiol 169:802-14. 2009
    ..Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites...
  19. pmc Results from a prostate cancer admixture mapping study in African-American men
    Cathryn Hufford Bock
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hum Genet 126:637-42. 2009
    ..In conclusion, we confirmed ancestry associations on 8q24, and identified additional ancestry-associated regions potentially harboring prostate cancer susceptibility loci...
  20. pmc Regular adult aspirin use decreases the risk of non-small cell lung cancer among women
    Alison L Van Dyke
    Cancer Biology Program, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, MI 48201, USA
    Cancer Epidemiol Biomarkers Prev 17:148-57. 2008
    ..Few studies have examined the use of aspirin or other NSAIDs on risk of NSCLC in women...
  21. ncbi request reprint Secondary cancers after a lung carcinoid primary: a population-based analysis
    M L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, United States
    Lung Cancer 52:273-9. 2006
    ..The role of genetics and sex hormones in lung carcinoid development, as well as the identification of other risk factors, should be explored...
  22. ncbi request reprint NQO1 T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based study
    C H Bock
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Carcinogenesis 26:381-6. 2005
    ..The observed risk reductions may be attributable to the greatly reduced procarcinogen activating of NAD(P)H:quinone oxidoreductase 1 in individuals with at least one copy of the T allele...
  23. pmc Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study
    Vitaly Balan
    Department of Pathology, Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Cancer Res 68:10045-50. 2008
    ..The data implicate galectin-3 H(64) in breast cancer and explain, in part, the noted racial disparity, thus providing a novel target for diagnosis and treatment...
  24. ncbi request reprint Family history of cancer: is it an accurate indicator of cancer risk in the immigrant population?
    Heather Orom
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer 112:399-406. 2008
    ..Patients' self-reports of family history of cancer influence physician cancer screening recommendations. Little is known about rates of reporting a family history of cancer in the immigrant population...
  25. pmc Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women
    Michele L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Carcinogenesis 30:626-35. 2009
    ..Polymorphisms in the tobacco metabolism, estrogen metabolism and DNA repair pathways will be useful in developing more predictive models of individual risk...
  26. pmc Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies
    Alison L Van Dyke
    Population Studies and Prevention Program, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA
    Cytokine 46:236-44. 2009
    ..Given the racial variability in allele frequencies in inflammatory gene SNPs, studies examining the association between these SNPs and disease should at least incorporate self-reported race in their analyses...
  27. pmc Patterns of care in a population-based sample of soft tissue sarcoma patients in the United States
    Shirish M Gadgeel
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Cancer 115:2744-54. 2009
    ..The authors conducted a detailed analysis of STS patients diagnosed in 2002 and sampled from the Surveillance, Epidemiology, and End Results registries...
  28. ncbi request reprint Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela
    Ikuko Kato
    Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI, 48201, USA
    Cancer Causes Control 17:1183-91. 2006
    ..The aim of the study was to assess the effects of genetic polymorphisms in anti-inflammatory mediators, i.e., IL10, IL4 and IL4R on the prevalence of gastric precancerous lesions and their interactions with other environmental factors...
  29. ncbi request reprint Breast cancer risk estimates for relatives of white and African American women with breast cancer in the Women's Contraceptive and Reproductive Experiences Study
    Michael S Simon
    Division of Hematology and Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI 48201, USA
    J Clin Oncol 24:2498-504. 2006
    ..The purpose of this report is to update breast cancer risk estimates associated with a family history of breast cancer for white and AA women...
  30. ncbi request reprint Racial differences in the familial aggregation of breast cancer and other female cancers
    Michael S Simon
    Division of Haematology and Oncology, Barbara Ann Karmanos Cancer Institute, 4100 John R, 4221 Hudson, Weber Cancer Research Building, Detroit, M1 48201, USA
    Breast Cancer Res Treat 89:227-35. 2005
    ..17 (1.22-3.85). In conclusion, these racially distinct aggregation patterns may reflect different modes of inheritance and/or environmental factors that impact cancer risk...
  31. ncbi request reprint Ethnic differences in survival among women with ovarian carcinoma
    Jill S Barnholtz-Sloan
    Epidemiology Section, Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer 94:1886-93. 2002
    ..The objective of this study was to examine ethnic differences in survival after ovarian carcinoma in a population-based sample of women...
  32. ncbi request reprint Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex
    Ann G Schwartz
    Population Studies and Prevention Program, and Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 11:7280-7. 2005
    ..Archival lung tissue was evaluated for the presence of nuclear estrogen receptor (ER)-alpha and ER-beta and the relationship between ER status, subject characteristics, and survival...
  33. ncbi request reprint Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997
    Jill S Barnholtz-Sloan
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Neurosurg 99:458-66. 2003
    ....
  34. ncbi request reprint Risk of lung cancer among white and black relatives of individuals with early-onset lung cancer
    Michele L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, Detroit, Mich, USA
    JAMA 293:3036-42. 2005
    ..Family studies of early-onset lung cancer patients offer a unique opportunity to evaluate lifetime risk of lung cancer in relatives...
  35. pmc Risk of other cancers in individuals with a family history of pancreas cancer
    Michele L Cote
    Barbara Ann Karmanos Cancer Institute, Population Studies and Prevention, 110 E Warren Avenue, Detroit, MI 48201, USA
    J Gastrointest Cancer 38:119-26. 2007
    ..We evaluate whether a family history of pancreas cancer is a risk factor for ten specified cancers in first-degree relatives: bladder, breast, colon, head and neck, lung, lymphoma, melanoma, ovary, pancreas, and prostate...
  36. ncbi request reprint Microsatellite alterations in african americans with head and neck cancer
    George H Yoo
    Department of Otolaryngology Head and Neck Surgery, Wayne State University, Detroit, MI, USA
    Laryngoscope 114:1619-24. 2004
    ..To determine the genetic differences between African Americans (AA) and Non-African Americans (NAA) with head and neck squamous cell carcinoma (HNSCC)...
  37. pmc Familial lung cancer: genetic susceptibility and relationship to chronic obstructive pulmonary disease
    Ann G Schwartz
    Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Am J Respir Crit Care Med 173:16-22. 2006
    ..As familial risk of lung disease is better defined, referral into screening programs and prevention trials can be better targeted to reach families with both a history of lung cancer and COPD...
  38. ncbi request reprint Lung cancer risk in relatives of early-onset lung cancer cases
    Michele L Cote
    Karmanos Cancer Institute, Detroit, MI 48103, USA
    Chest 125:89S-90S. 2004
  39. ncbi request reprint Genetic predisposition to lung cancer
    Ann G Schwartz
    Karmanos Cancer Institute, Detroit, MI 48103, USA schwarta med wayne edu
    Chest 125:86S-9S. 2004
  40. pmc COX-2/EGFR expression and survival among women with adenocarcinoma of the lung
    Alison L Van Dyke
    Cancer Biology Program, Karmanos Cancer Institute, WayneState University School of Medicine, Detroit, MI 48201, USA
    Carcinogenesis 29:1781-7. 2008
    ..In conclusion, COX-2 and EGFR expression, but not combined COX-2+/EGFR+ expression, independently predict survival of women with adenocarcinoma of the lung...
  41. ncbi request reprint Ovarian cancer: changes in patterns at diagnosis and relative survival over the last three decades
    Jill S Barnholtz-Sloan
    Division of Hematology Oncology, Department of Internal Medicine, Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Am J Obstet Gynecol 189:1120-7. 2003
    ..The purpose of this study was to examine patterns of diagnosis and relative survival in women who had a diagnosis of primary invasive epithelial ovarian cancer (EOC) from 1973 to 1997, with follow-up through the end of 1999...
  42. ncbi request reprint Host-bacterial interaction in the development of gastric precancerous lesions in a high risk population for gastric cancer in Venezuela
    Ikuko Kato
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Int J Cancer 119:1666-71. 2006
    ..The present study provides important evidence suggesting host-bacterial interactions in the development of gastric precancerous lesions...
  43. ncbi request reprint Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer
    Ikuko Kato
    Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, Michigan 48201, USA
    Dig Dis Sci 52:254-61. 2007
    ..These results suggest that genetic polymorphisms in HP LPS signaling may be implicated in the development of intermediate stages of gastric premalignant lesions...
  44. pmc Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 100:1326-30. 2008
    ..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...
  45. ncbi request reprint Occupation, pesticide exposure and risk of multiple myeloma
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892, United States
    Scand J Work Environ Health 30:215-22. 2004
    ..This population-based case-control study examined the relationship between occupation, living or working on a farm, pesticide exposure, and the risk of multiple myeloma...
  46. ncbi request reprint Racial differences in cancer risk among relatives of patients with early onset lung cancer
    Jessica L Naff
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Chest 131:1289-94. 2007
    ..This study evaluates whether first-degree relatives of patients with early onset lung cancer are at increased risk for cancer at sites other than lung...
  47. ncbi request reprint Why do Black Americans have a higher risk of pancreatic cancer than White Americans?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Epidemiology 14:45-54. 2003
    ..For several decades, the incidence of pancreatic cancer has been 50% to 90% higher among blacks than among whites in the United States. The purpose of this study was to identify risk factors that may contribute to this racial disparity...
  48. ncbi request reprint Existing data on breast cancer in African-American women: what we know and what we need to know
    Christina A Clarke
    Northern California Cancer Center, Union City, California 94587, USA
    Cancer 97:211-21. 2003
    ..Thus, it is important to consider the accuracy of these resources in describing the impact of breast cancer in AA populations...
  49. ncbi request reprint Lung cancer: family history matters
    Ann G Schwartz
    Chest 130:936-7. 2006
  50. ncbi request reprint Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers
    Kevin K Divine
    Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Int J Cancer 114:400-5. 2005
    ..Adenocarcinomas may develop through 2 distinct processes: multiple gene inactivations through promoter hypermethylation and activation of the K-ras gene...
  51. ncbi request reprint Examining population stratification via individual ancestry estimates versus self-reported race
    Jill S Barnholtz-Sloan
    Cancer Prevention and Control Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Cancer Epidemiol Biomarkers Prev 14:1545-51. 2005
    ..This study suggests that significant population substructure differences exist that self-reported race alone does not capture and that individual ancestry may be confounded with disease status and/or a candidate gene risk genotype...
  52. ncbi request reprint Evaluation of African-American and white racial classification in a surveillance, epidemiology, and end results cancer registry
    Divya A Patel
    Department of Obstetrics and Gynecology, University of Michigan, L4000 Women s Hospital, Ann Arbor, MI 48109, USA
    Ethn Dis 15:713-9. 2005
    ....
  53. pmc Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1
    Min Wang
    School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
    Cancer Res 67:93-9. 2007
    ..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25...
  54. pmc Linkage analysis of chromosome 4 in families with familial pancreatic cancer
    Alison P Klein
    The Sol Goldman Pancreatic Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 6:320-3. 2007
    ....
  55. ncbi request reprint Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression
    Leah C Pulling
    Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108 L C P, K K D, D M K, S A B
    Cancer Res 63:4842-8. 2003
    ..This study also suggests that K-ras activation is independent of MGMT methylation...
  56. pmc Endometrial cancer: socioeconomic status and racial/ethnic differences in stage at diagnosis, treatment, and survival
    Terri Madison
    School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Am J Public Health 94:2104-11. 2004
    ..We evaluated the association between socioeconomic status and racial/ ethnic differences in endometrial cancer stage at diagnosis, treatment, and survival...
  57. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
    ..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...
  58. ncbi request reprint Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cancer Prev 17:178-83. 2008
    ..60, 95% CI=1.01-2.54, and OR=0.66, 95% CI=0.43-0.99). We conclude that genetic variability in the genes we studied does not play a major role in the early stages of gastric carcinogenesis...