Genomes and Genes


A G Schwartz


Affiliation: Wayne State University
Country: USA


  1. Lusk C, Watza D, Dyson G, Craig D, Ratliff V, Wenzlaff A, et al. Profiling the mutational landscape in known driver genes and novel genes in African American non-small cell lung cancer patients. Clin Cancer Res. 2019;: pubmed publisher
    ..These findings suggest that broader mutation profiling including both known and novel driver genes in African Americans with NSCLC will identify additional mutations that may be useful in treatment decision making. ..
  2. Lusk C, Wenzlaff A, Watza D, Sieren J, Robinette N, Walworth G, et al. Quantitative Imaging Markers of Lung Function in a Smoking Population Distinguish COPD Subgroups with Differential Lung Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2019;28:724-730 pubmed publisher
    ..Combining clinical (spirometry) and radiologic (qCT) measures of COPD defines a spectrum of lung disease that predicts lung cancer risk differentially among patient clusters. ..
  3. Liu Y, Lusk C, Cho M, Silverman E, Qiao D, Zhang R, et al. Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer. J Thorac Oncol. 2018;13:1483-1495 pubmed publisher
    ..Our results extend the catalogue of regions associated with LC and highlight the importance of germline rare coding variants in LC susceptibility. ..
  4. request reprint
    Schwartz A, Wenzlaff A, Prysak G, Murphy V, Cote M, Brooks S, et al. Reproductive factors, hormone use, estrogen receptor expression and risk of non small-cell lung cancer in women. J Clin Oncol. 2007;25:5785-92 pubmed
    ..These findings suggest that postmenopausal hormone exposures are associated with reduced risk of ER-alpha- and ER-beta-expressing NSCLC. Understanding tumor characteristics may direct development of targeted treatment for this disease. ..
  5. Schwartz A, Cote M. Epidemiology of Lung Cancer. Adv Exp Med Biol. 2016;893:21-41 pubmed publisher
    ..As lung cancer screening becomes more widespread, a validated model will be needed to better define risk groups to inform screening guidelines. ..
  6. Schwartz A, Lusk C, Wenzlaff A, Watza D, Pandolfi S, Mantha L, et al. Risk of Lung Cancer Associated with COPD Phenotype Based on Quantitative Image Analysis. Cancer Epidemiol Biomarkers Prev. 2016;25:1341-7 pubmed publisher
    ..Cancer Epidemiol Biomarkers Prev; 25(9); 1341-7. ©2016 AACR. ..
  7. Zanetti K, Wang Z, ALDRICH M, Amos C, Blot W, Bowman E, et al. Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer. 2016;98:33-42 pubmed publisher
    ..1 and 5p15.33 respectively, are associated with lung cancer. Additional work is required to map and understand the biological underpinnings of the strong association of these loci with lung cancer risk in African Americans. ..
  8. Musolf A, Simpson C, de Andrade M, Mandal D, Gaba C, Yang P, et al. Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies. Genes (Basel). 2017;8: pubmed publisher
    ..Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease. ..
  9. Beebe Dimmer J, Yee C, Paskett E, Schwartz A, Lane D, Palmer N, et al. Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women's health initiative. BMC Cancer. 2017;17:848 pubmed publisher
    ..Future studies are needed to determine the relative contribution of genes and shared environment to the risk of both cancers. ..

More Information


  1. Schwartz A, Cote M, Wenzlaff A, Land S, Amos C. Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. J Thorac Oncol. 2009;4:1195-201 pubmed publisher