Research Topics
| M J RybakSummaryAffiliation: Wayne State University Country: USA Publications
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Publications
The pharmacokinetic and pharmacodynamic properties of vancomycinMichael J Rybak
Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Clin Infect Dis 42:S35-9. 2006..This article reviews the pharmacokinetic and pharmacodynamic data related to vancomycin and discusses such clinical issues as toxicities and serum concentration monitoring...- Correlation of vancomycin and daptomycin susceptibility in Staphylococcus aureus in reference to accessory gene regulator (agr) polymorphism and functionWarren E Rose
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI, USA
J Antimicrob Chemother 59:1190-3. 2007..We investigated the relationship of vancomycin with and without gentamicin or rifampicin, and daptomycin in the development of resistance in agr groups I and II... - Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agentsBrian T Tsuji
Anti Infective Research Laboratory, Department of Pharmacy Practice, Wayne State University, MI 48201, USA
Diagn Microbiol Infect Dis 58:41-7. 2007..Further studies are warranted against a larger number of molecularly defined, geographically diverse CAMRSA to confirm these findings... 
Fluoroquinolone resistance in Streptococcus pneumoniae: area under the concentration-time curve/MIC ratio and resistance development with gatifloxacin, gemifloxacin, levofloxacin, and moxifloxacinKerry L LaPlante
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Department of Pharmacy Practice, School of Medicine, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 51:1315-20. 2007..002) than those of gatifloxacin. The order of resistance development determined from fAUC/MIC breakpoints was levofloxacin>gatifloxacin>moxifloxacin=gemifloxacin, which may be related to structural differences within the class...- Antimicrobial activities of ceragenins against clinical isolates of resistant Staphylococcus aureusJudy N Chin
Anti Infective Research Laboratory, Department of Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 51:1268-73. 2007..However, early synergy at 4 to 8 h was detected against the VRSA Pennsylvania strain (2002) when CSA-13 was tested in combination with gentamicin, while early additivity was demonstrated against all of the other organisms... 
Ceftaroline fosamil for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infectionAnthony M Casapao
Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Anti Infective Research Laboratory, Pharmacy Practice, Detroit, MI 48201, USA
Expert Opin Pharmacother 13:1177-86. 2012..Substantial differences between the cephalosporins exist. Ceftaroline has unique characteristics that may make it useful in specific clinical circumstances, especially against multi-drug-resistant Gram-positive organisms...- Evaluation of ceftaroline activity versus ceftriaxone against clinical isolates of Streptococcus pneumoniae with various susceptibilities to cephalosporins in an in vitro pharmacokinetic/pharmacodynamic modelMolly E Steed
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
Antimicrob Agents Chemother 56:2691-5. 2012..14 log(10) CFU/ml, P ≤ 0.042]). Ceftaroline was the more effective drug and displayed sustained bactericidal activity. Ceftaroline fosamil may provide a therapeutic option to treat ceftriaxone-resistant S. pneumoniae infections... - Pharmacodynamics: relation to antimicrobial resistanceMichael J Rybak
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Am J Infect Control 34:S38-45; discussion S64-73. 2006..But, further work needs to be done before this conclusion can be verified... - Community-associated methicillin-resistant Staphylococcus aureus: a reviewMichael J Rybak
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, and the School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
Pharmacotherapy 25:74-85. 2005..Identifying potential risk factors for CA-MRSA acquisition and fully characterizing the epidemiologic, clinical, and molecular properties of these strains are necessary to provide effective therapeutic guidelines... - Increased bacterial resistance: PROTEKT US--an updateMichael J Rybak
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201 2417, USA
Ann Pharmacother 38:S8-S13. 2004..pneumoniae isolates to beta-lactams and macrolides, as well as the emergence of fluoroquinolone resistance in the US. Importantly, telithromycin was highly active against S. pneumoniae, including resistant isolates... - Characterization of vancomycin-heteroresistant Staphylococcus aureus from the metropolitan area of Detroit, Michigan, over a 22-year period (1986 to 2007)Michael J Rybak
Department of Pharmacy Practice, Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
J Clin Microbiol 46:2950-4. 2008..Our data indicate that the prevalence of hVISA may be increasing. Based on the association of vancomycin treatment failure in patients with hVISA, surveillance of hVISA strains is warranted... - The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram-positive bacteriaM J Rybak
Anti Infective Research Laboratory, Wayne State University, Detroit, Michigan 48201, USA
Clin Microbiol Infect 12:24-32. 2006..The favourable clinical profile and low potential for development of resistance combine to make daptomycin a promising alternative to current agents for treatment of Gram-positive bacterial infections... - Pharmacodynamics: relation to antimicrobial resistanceMichael J Rybak
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Am J Med 119:S37-44; discussion S62-70. 2006..But, further work needs to be done before this conclusion can be verified... - Therapeutic options for Gram-positive infectionsM J Rybak
Anti Infective Research Laboratory, Wayne State University and Detroit Receiving Hospital, ML, USA
J Hosp Infect 49:S25-32. 2001..Future agents also being developed to fight multi-resistant Gram-positive infections include oritavancin, daptomycin and the glycylcyclines; however, these are still in the development phase... - Ceftobiprole: first cephalosporin with activity against methicillin-resistant Staphylococcus aureusCeline Vidaillac
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
Pharmacotherapy 29:511-25. 2009.... - Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases PharmacistsMichael J Rybak
Anti Infective Research Laboratory, Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Wayne State University, Detroit Receiving Hospital and University Health Center, Detroit, Michigan 48201, USA
Clin Infect Dis 49:325-7. 2009.... - Therapeutic monitoring of vancomycin in adults summary of consensus recommendations from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases PharmacistsMichael J Rybak
Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
Pharmacotherapy 29:1275-9. 2009..Increasing the dosage to result in higher trough concentrations may increase the potential for toxicity; however additional clinical experience is required to determine the extent... - Clinical isolates of Staphylococcus aureus from 1987 and 1989 demonstrating heterogeneous resistance to vancomycin and teicoplaninMichael J Rybak
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Diagn Microbiol Infect Dis 51:119-25. 2005..To our knowledge, this is the earliest report of S. aureus clinical isolates having reduced vancomycin and teicoplanin susceptibility... - Evaluation of telavancin activity versus daptomycin and vancomycin against daptomycin-nonsusceptible Staphylococcus aureus in an in vitro pharmacokinetic/pharmacodynamic modelMolly E Steed
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
Antimicrob Agents Chemother 56:955-9. 2012..05). Telavancin displayed bactericidal activity in vitro against DNS S. aureus isolates... - Resistance to antimicrobial agents: an updateMichael J Rybak
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Pharmacotherapy 24:203S-15S. 2004..The article also reviews the adverse impact of resistance on outcomes for patients with nosocomial infections. Finally, a brief overview of how the medical community can face its moment of truth is presented... - Efficacy of trovafloxacin against experimental Staphylococcus aureus endocarditisG W Kaatz
Department of Internal Medicine, Department of Veteran s Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 42:254-6. 1998..We conclude that in this model trovafloxacin is as efficacious as vancomycin is and may serve as a viable alternative to vancomycin for use in humans with similar infections... - Pharmacodynamics of RP 59500 (quinupristin-dalfopristin) administered by intermittent versus continuous infusion against Staphylococcus aureus-infected fibrin-platelet clots in an in vitro infection modelM J Rybak
Department of Pharmacy Services, Detroit Receiving Hospital and University Health Center, Wayne State University, Michigan 48201, USA
Antimicrob Agents Chemother 41:1359-63. 1997..RP 59500 efficacy against constitutively erythromycin- and methicillin-resistant S. aureus may be improved by increasing organism exposure to RP 59500 as a function of dosing frequency... - Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and EnteM J Rybak
The Anti Infective Research Laboratory, Department of Pharmacy Services, Detroit Receiving Hospital University Health Center, Wayne State University, Michigan 48201, USA
Antimicrob Agents Chemother 42:721-4. 1998..In time-kill studies, eperezolid and linezolid were bacteriostatic in action. A postantibiotic effect of 0.8+/-0.5 h was demonstrated for both eperezolid and linezolid against S. aureus, S. epidermidis, E. faecalis, and E. faecium... - Efficacy of LY333328 against experimental methicillin-resistant Staphylococcus aureus endocarditisG W Kaatz
Department of Internal Medicine, School of Medicine, Department of Veteran s Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 42:981-3. 1998..We conclude that in this model, LY333328 was microbiologically effective and may be a therapeutic alternative to vancomycin... - Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in viKerry L LaPlante
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 52:2156-62. 2008..At present, there are several alternatives that appear promising for treating clindamycin resistance-inducible strains of CA-MRSA... - In vitro activities of daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin against Staphylococci and Enterococci, including vancomycin- intermediate and -resistant strainsM J Rybak
The Anti Infective Research Laboratory, Department of Pharmacy Services, Detroit Receiving Hospital University Health Center, Detroit, MI 48201, USA
Antimicrob Agents Chemother 44:1062-6. 2000..Daptomycin may be a potential alternative drug therapy for multidrug-resistant gram-positive organisms and warrants further investigation... - Synergy between gemifloxacin and trimethoprim/sulfamethoxazole against community-associated methicillin-resistant Staphylococcus aureusSteven N Leonard
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
J Antimicrob Chemother 62:1305-10. 2008..We evaluated whether combining another orally available agent commonly used to treat CA-MRSA with gemifloxacin would enhance gemifloxacin activity against CA-MRSA... - Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureusSteven N Leonard
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 52:2974-6. 2008..Ceftobiprole MIC(50) and MIC(90) values were 1 and 2 microg/ml, respectively, against CA-MRSA and HA-MRSA. In time-kill analysis, ceftobiprole was bactericidal at all concentrations tested... - Clinical glycopeptide-intermediate staphylococci tested against arbekacin, daptomycin, and tigecyclineKerry L LaPlante
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI, USA
Diagn Microbiol Infect Dis 50:125-30. 2004..68 to 2.74 +/- 0.66. Overall, all the antimicrobials tested (with the exception of vancomycin) exhibited significant in vitro activity against GISS. These compounds may offer therapeutic options for the treatment of GISS... - In vitro activities of quinupristin-dalfopristin and cefepime, alone and in combination with various antimicrobials, against multidrug-resistant staphylococci and enterococci in an in vitro pharmacodynamic modelGeorge P Allen
College of Pharmacy and Allied Health Profession, University Health Center, Wayne State University, 4201 St. Antoine Boulevard, Detroit, MI 48201
Antimicrob Agents Chemother 46:2606-12. 2002..Combination regimens including cefepime, Q-D, and/or linezolid warrant further investigation for the treatment of refractive infections due to multidrug-resistant gram-positive pathogens... - Etest synergy testing of clinical isolates of Staphylococcus aureus demonstrating heterogeneous resistance to vancomycinBrian T Tsuji
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Diagn Microbiol Infect Dis 54:73-7. 2006..Agreement between the Etest and time-kill methods for detecting antimicrobial synergy ranged from 66.6% to 71.4%. The Etest method appears promising, and further investigations are warranted... - Teicoplanin pharmacodynamics in reference to the accessory gene regulator (agr) in Staphylococcus aureus using an in vitro pharmacodynamic modelWarren E Rose
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
J Antimicrob Chemother 61:1099-102. 2008..We investigated this relationship in agr groups I-IV using another glycopeptide, teicoplanin, in an in vitro pharmacodynamic model... - Evaluation of accessory gene regulator (agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureusBrian T Tsuji
Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
Antimicrob Agents Chemother 51:1089-91. 2007..The free unbound fraction of the area under the concentration-time curve (fAUC/MIC) required to suppress resistance was fourfold higher (P < 0.001) in agr dysfunctional strains (112 to 169) than that in parent wild-type strains (28)... - Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic modelKerry L LaPlante
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 48:4665-72. 2004..Overall, high-inoculum Staphylococcus aureus had a significant impact on the activities of nafcillin and vancomycin. In contrast, daptomycin was affected minimally and linezolid was not affected by inoculum... - Evaluation of daptomycin pharmacodynamics and resistance at various dosage regimens against Staphylococcus aureus isolates with reduced susceptibilities to daptomycin in an in vitro pharmacodynamic model with simulated endocardial vegetationsWarren E Rose
Department of Pharmacy Practice, Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit Receiving Hospital, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 52:3061-7. 2008.... - Impact of inoculum size and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) on vancomycin activity and emergence of VISA in an in vitro pharmacodynamic modelWarren E Rose
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 53:805-7. 2009..No change in the vancomycin MIC was detected in any isolate at a moderate inoculum amount (10(6) CFU/ml), and bactericidal activity occurred only against the non-hVISA isolate (time to 99% kill, 7.5 h; P = 0.001)... - In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolatesKimberly D Leuthner
Anti Infective Research Laboratory, Department of Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI 48201, USA
Antimicrob Agents Chemother 54:3799-803. 2010..TD-1792 exhibited significant in vitro activity against multidrug-resistant Staphylococcus isolates and represents a promising candidate for the treatment of infections caused by gram-positive organisms... - Pharmacodynamics of cefepime alone and in combination with various antimicrobials against methicillin-resistant Staphylococcus aureus in an in vitro pharmacodynamic infection modelVanthida Huang
Anti-Infective Research Laboratory, Pharmacy Practice-4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 49:302-8. 2005..Overall, the most potent combinations noted were cefepime in combination with low- and high-dose aminoglycosides. Further investigations with combination therapies are warranted... - Influence of protein binding under controlled conditions on the bactericidal activity of daptomycin in an in vitro pharmacodynamic modelRaymond Cha
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
J Antimicrob Chemother 54:259-62. 2004..Further antimicrobial studies that incorporate protein are warranted to assess the influence of protein in the pharmacodynamic evaluation of antimicrobials... - Bactericidal activities of daptomycin, quinupristin-dalfopristin, and linezolid against vancomycin-resistant Staphylococcus aureus in an in vitro pharmacodynamic model with simulated endocardial vegetationsRaymond Cha
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 47:3960-3. 2003..Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA... - Effect of growth phase and pH on the in vitro activity of a new glycopeptide, oritavancin (LY333328), against Staphylococcus aureus and Enterococcus faeciumRenee-Claude Mercier
Anti-Infective Research Laboratory, Department of Pharmacy Services, Detroit Receiving Hospital/University Health Center, Detroit, MI 48201, USA
J Antimicrob Chemother 50:19-24. 2002..aureus and E. faecium. However, oritavancin's activity might be reduced against vancomycin-resistant E. faecium strains in stationary growth phase, as seen in infective endocarditis or when organisms are exposed to an acidic environment... - Emergence of methicillin-resistant Staphylococcus aureus with intermediate glycopeptide resistance: clinical significance and treatment optionsM J Rybak
Wayne State University, Department of Pharmacy Services, Detroit Receiving Hospital and University Health Center, Michigan 48201, USA
Drugs 61:1-7. 2001..Strict infection control practices, routine screening for resistance and controlled use of antibacterial agents, especially vancomycin, are critical steps in preventing the further development of resistance among staphylococci... - Antimicrobial susceptibility and staphylococcal chromosomal cassette mec type in community- and hospital-associated methicillin-resistant Staphylococcus aureusKerry L LaPlante
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Pharmacotherapy 27:3-10. 2007.... - Daptomycin against multiple drug-resistant staphylococcus and enterococcus isolates in an in vitro pharmacodynamic model with simulated endocardial vegetationsRaymond Cha
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Diagn Microbiol Infect Dis 47:539-46. 2003..These results suggest that 6 and 8 mg/kg/day of daptomycin represent potential regimens for further clinical evaluation in drug-resistant Gram-positive endocarditis... - Evaluation of daptomycin treatment of Staphylococcus aureus bacterial endocarditis: an in vitro and in vivo simulation using historical and current dosing strategiesWarren E Rose
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, and Detroit Receiving Hospital, MI 48201, USA
J Antimicrob Chemother 60:334-40. 2007..We attempted to determine if this occurrence was reproducible in vitro and if it could be prevented by various daptomycin dosing strategies... - Short-course gentamicin in combination with daptomycin or vancomycin against Staphylococcus aureus in an in vitro pharmacodynamic model with simulated endocardial vegetationsBrian T Tsuji
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 49:2735-45. 2005..These results suggest that a single high dose of gentamicin in combination with daptomycin or vancomycin may be of utility to maximize synergistic and bactericidal activity and minimize toxicity. Further investigation is warranted... - daptomycin activity against Staphylococcus aureus following vancomycin exposure in an in vitro pharmacodynamic model with simulated endocardial vegetationsWarren E Rose
Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 52:831-6. 2008..Further evaluation of the susceptibility relationship between daptomycin and vancomycin is necessary to understand the factors involved and their clinical significance... - Activities of mutant prevention concentration-targeted moxifloxacin and levofloxacin against Streptococcus pneumoniae in an in vitro pharmacodynamic modelGeorge P Allen
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 47:2606-14. 2003..However, this strategy did not prevent the selection of secondary mutants in strains with preexisting mutations. Further study of the MPC concept to evaluate these relationships is warranted... - Linezolid and vancomycin, alone and in combination with rifampin, compared with moxifloxacin against a multidrug-resistant and a vancomycin-tolerant Streptococcus pneumoniae strain in an in vitro pharmacodynamic modelRaymond Cha
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit Receiving Hospital, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 47:1984-7. 2003..Linezolid, moxifloxacin, and linezolid plus rifampin exhibited 99.9% killing against both isolates. These alternatives should be considered for further evaluation against vancomycin-tolerant S. pneumoniae... - Daptomycin dose-effect relationship against resistant gram-positive organismsRaymond Cha
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 47:1598-603. 2003..Doses ranging between 3 and 7 mg/kg produced significant bactericidal activity (ED(80)) against these multidrug-resistant S. aureus and E. faecium isolates... - In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosaCeline Vidaillac
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 53:2360-6. 2009..This represents a promising therapeutic option, and further studies are warranted to elucidate the clinical value of ceftaroline combinations against resistant gram-negative pathogens... - Evaluation of the Etest GRD for the detection of Staphylococcus aureus with reduced susceptibility to glycopeptidesSteven N Leonard
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
J Antimicrob Chemother 63:489-92. 2009..The objective of this study was to compare a new method for detection of hVISA, the Etest GRD, to PAP-AUC and to macro Etest... - Characteristics of patients with healthcare-associated infection due to SCCmec type IV methicillin-resistant Staphylococcus aureusSusan L Davis
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences and the School of Medicine, Wayne State University, Detroit, MI 48201, USA
Infect Control Hosp Epidemiol 27:1025-31. 2006..Further research is warranted to determine the impact of SCCmec type IV strains in hospital settings... - In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococciVanthida Huang
Anti-Infective Research Laboratory, Department of Pharmacy Practice-4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
Antimicrob Agents Chemother 48:2719-23. 2004..05); CB-181963 > linezolid (P = 0.003); and CB-181963 = quinupristin-dalfopristin = vancomycin. CB-181963 may provide an alternative treatment for multidrug-resistant staphylococci... - In vitro activities of mutant prevention concentration-targeted concentrations of fluoroquinolones against Staphylococcus aureus in a pharmacodynamic modelGeorge P Allen
Anti-Infective Research Laboratory, Eugene Appelbaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Int J Antimicrob Agents 24:150-60. 2004..aureus than ciprofloxacin and levofloxacin. The mutant selection window premise appeared valid for MRSA only. Additional studies are necessary to define the applicability of the MPC... - In vitro evaluation of ceftaroline alone and in combination with tobramycin against hospital-acquired meticillin-resistant Staphylococcus aureus (HA-MRSA) isolatesCeline Vidaillac
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Int J Antimicrob Agents 35:527-30. 2010..Finally, at sub-MIC levels, ceftaroline plus tobramycin displayed significantly greater activity than vancomycin plus tobramycin against MRSA (P < 0.01)... - In vitro activity of ceftaroline against methicillin-resistant Staphylococcus aureus and heterogeneous vancomycin-intermediate S. aureus in a hollow fiber modelCeline Vidaillac
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 53:4712-7. 2009..Although further in vitro and in vivo investigations are warranted, ceftaroline appears to be a promising alternative for the treatment of MRSA infections... - Design, synthesis, and structure-activity relationships of benzophenone-based tetraamides as novel antibacterial agentsSunil K Vooturi
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy, Wayne State University, Detroit, MI 48201, USA
J Med Chem 52:5020-31. 2009..Our studies suggest that caution should be taken in assigning the mechanism of action for DNA binding antibiotics... - Influence of platelets and platelet microbicidal protein susceptibility on the fate of Staphylococcus aureus in an in vitro model of infective endocarditisR C Mercier
The Anti Infective Research Laboratory, Detroit Receiving Hospital University Health Center and College of Pharmacy, Detroit, Michigan 48201, USA
Infect Immun 68:4699-705. 2000..aureus. These findings underscore the likelihood that platelets play an important antimicrobial host defense role in preventing and/or limiting endovascular infections due to tPMP(s) pathogens... - Activities of newer fluoroquinolones against ciprofloxacin-resistant Streptococcus pneumoniaeE A Coyle
The Anti-Infective Research Laboratory and Department of Pharmacy Services, Detroit Receiving Hospital and University Health Center, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 45:1654-9. 2001..7 and C(max)/MIC ratios of < or =3.1. It is evident that the newer fluoroquinolones tested possess improved activity against S. pneumoniae, including strains for which ciprofloxacin MICs were elevated... - Impact of Enterococcus faecalis on the bactericidal activities of arbekacin, daptomycin, linezolid, and tigecycline against methicillin-resistant Staphylococcus aureus in a mixed-pathogen pharmacodynamic modelKerry L LaPlante
Anti-Infective Research Laboratory, Pharmacy Practice-4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 50:1298-303. 2006..aureus. This contribution was enhanced or improved compared to the activity of each antimicrobial alone. Further research is warranted to determine the impact of polymicrobial infections on antimicrobial activity... - Telavancin: an antimicrobial with a multifunctional mechanism of action for the treatment of serious gram-positive infectionsSteven N Leonard
Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Pharmacotherapy 28:458-68. 2008..Telavancin appears to be a promising agent for the treatment of serious infections caused by gram-positive pathogens, including drug-resistant pathogens. Further clinical experience will clarify its role in therapy... - Comparative activity of the new lipoglycopeptide telavancin in the presence and absence of serum against 50 glycopeptide non-susceptible staphylococci and three vancomycin-resistant Staphylococcus aureusKimberly D Leuthner
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, and Detroit Receiving Hospital, MI 48201, USA
J Antimicrob Chemother 58:338-43. 2006..Similar to daptomycin, telavancin activity was diminished in the presence of serum but bactericidal activity was maintained. Further investigation with telavancin against GISS, hGISS and VRSA is warranted... - Evaluation of vancomycin and daptomycin against methicillin-resistant Staphylococcus aureus and heterogeneously vancomycin-intermediate S. aureus in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetationsSteven N Leonard
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, and Detroit Receiving Hospital, Detroit, MI 48201, USA
J Antimicrob Chemother 63:155-60. 2009..The objective of this study was to evaluate vancomycin and daptomycin against vancomycin-susceptible MRSA and hVISA in a pharmacokinetic/pharmacodynamic (PK/PD) model with simulated endocardial vegetations... - Ceftaroline: a new cephalosporin with activity against resistant gram-positive pathogensMolly E Steed
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Pharmacotherapy 30:375-89. 2010.... - Evaluation of dalbavancin, tigecycline, minocycline, tetracycline, teicoplanin and vancomycin against community-associated and multidrug-resistant hospital-associated meticillin-resistant Staphylococcus aureusVanthida Huang
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Int J Antimicrob Agents 35:25-9. 2010..006), and with MDR HA-MRSA demonstrated DAL=VAN=TEC>TIG=MIN>TET (P>0.05). DAL demonstrated potent activity against clinical strains of CA-MRSA and MDR HA-MRSA, including tetracycline-resistant S. aureus... - Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serumBrian T Tsuji
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Diagn Microbiol Infect Dis 60:441-4. 2008..The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone... - Daptomycin versus vancomycin for complicated skin and skin structure infections: clinical and economic outcomesSusan L Davis
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
Pharmacotherapy 27:1611-8. 2007..To assess the effect of daptomycin compared with vancomycin on the clinical and economic outcomes in patients with complicated skin and skin structure infections... - Evaluation of daptomycin activity against Staphylococcus aureus in an in vitro pharmacodynamic model under normal and simulated impaired renal functionVanthida Huang
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
J Antimicrob Chemother 57:116-21. 2006..Fractional doses of daptomycin at 30 h t(1/2) were inferior to daptomycin regimens of 4, 6 and 8 mg/kg administered every 48 h (P = 0.03)... - Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremiaThomas P Lodise
Anti-Infective Research Laboratory, Detroit Receiving Hospital and University Health Center, Detroit, MI, USA
Clin Infect Dis 36:1418-23. 2003..2 days versus 14.3 days; P=.05). These findings support the notion that delay of therapy has deleterious effects on clinical outcomes, and efforts should be made to ensure that appropriate therapy is initiated promptly... - Epidemiology, resistance, and outcomes of Acinetobacter baumannii bacteremia treated with imipenem-cilastatin or ampicillin-sulbactamT K Jellison
Department of Pharmacy Services, Detroit Receiving Hospital, Wayne State University, Michigan 48201, USA
Pharmacotherapy 21:142-8. 2001..004). CONCLUSION: Ampicillin-sulbactam is at least as effective as imipenem-cilastatin based on clinical response at days 2, 7, and end of treatment and is a cost-effective alternative for treatment of A. baumannii infections... - Linezolid, levofloxacin, and vancomycin against vancomycin-tolerant and fluoroquinolone-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic modelRaymond Cha
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Pharmacotherapy 23:1531-7. 2003..Further investigation of treatment alternatives for infections due to vancomycin-tolerant S. pneumoniae are needed... - Pulsatile delivery of amoxicillin against Streptococcus pneumoniaeRaymond Cha
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences and School of Medicine, Wayne State University, Detroit, MI 48201, USA
J Antimicrob Chemother 54:1067-71. 2004..CONCLUSION: Pulsatile dosing, which involves administration of the total daily dose over the first 6 h of the day, may represent a unique and alternative strategy for dosing beta-lactam antimicrobials... - Antimicrobial stewardshipMichael J Rybak
Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Pharmacotherapy 27:131S-135S. 2007..Successful programs have reduced not only institutional resistance rates, but also morbidity, mortality, and cost... - Pharmacodynamics of cefepime in patients with Gram-negative infectionsVincent H Tam
The Anti-Infective Research Laboratory, Department of Pharmacy Services, Detroit Receiving Hospital and University Health Center, Wayne State University, MI, USA
J Antimicrob Chemother 50:425-8. 2002..3 x MIC. Our results support in vitro data that suggest bactericidal activity of beta-lactams is optimized at concentrations approximately 4 x MIC. These results should be validated by large prospective clinical trials... - Activity of telavancin against Staphylococcus aureus strains with various vancomycin susceptibilities in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetationsSteven N Leonard
Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 53:2928-33. 2009..Combination therapy, particularly with gentamicin, may improve bacterial killing against certain strains... - Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicityM J Rybak
The Anti Infective Research Laboratory, Department of Pharmacy Services, Detroit Receiving Hospital and University Health Center, College of Pharmacy and Allied Health Professions, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 43:1549-55. 1999..These data suggest that once-daily administration of aminoglycosides has a predictably lower probability of causing nephrotoxicity than twice-daily administration... - Characterizing vancomycin-resistant Enterococcus strains with various mechanisms of daptomycin resistance developed in an in vitro pharmacokinetic/pharmacodynamic modelMolly E Steed
Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 55:4748-54. 2011..Further characterization of DAP-resistant VRE is warranted... - Pharmacokinetics of single-dose daptomycin in patients with suspected or confirmed neurological infectionsRavina Kullar
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 55:3505-9. 2011..5%. Additional pharmacokinetic studies evaluating multiple and/or higher dosages of daptomycin are necessary in human subjects to better characterize the CSF penetration of daptomycin in neurosurgical patients... - Evaluation of ceftaroline activity versus daptomycin (DAP) against DAP-nonsusceptible methicillin-resistant Staphylococcus aureus strains in an in vitro pharmacokinetic/pharmacodynamic modelMolly Steed
Anti Infective Research Laboratory, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
Antimicrob Agents Chemother 55:3522-6. 2011..Isolates with increased MIC values for daptomycin (all 4 strains) but not for ceftaroline were recovered. Ceftaroline was effective against the 4 isolates tested and may provide a clinical option for the treatment of DNS MRSA infections... - Impact of dose de-escalation and escalation on daptomycin's pharmacodynamics against clinical methicillin-resistant Staphylococcus aureus isolates in an in vitro modelCeline Vidaillac
Anti Infective Research Laboratory, Pharmacy Practice 4148, Eugene Applebaum College of Pharmacy and Health Sciences, School of Medicine, Wayne State University, and Detroit Receiving Hospital, 259 Mack Ave, Detroit, MI 48201, USA
Antimicrob Agents Chemother 55:2160-5. 2011..Different therapeutic scenarios including isolates with higher MICs and prolonged drug exposures are warranted to better understand the outcomes of escalation and de-escalation strategies... - Antimicrobial susceptibility of Streptococcus pneumoniae, Streptococcus pyogenes and Haemophilus influenzae collected from patients across the USA, in 2001-2002, as part of the PROTEKT US studySteven D Brown
Clinical Microbiology Institute, 9725 SW Commerce Circle, Suite A1, Wilsonville, OR 97070, USA
J Antimicrob Chemother 54:i7-15. 2004.... - Evaluation of endocarditis caused by methicillin-susceptible Staphylococcus aureus developing nonsusceptibility to daptomycinGeorge Sakoulas
Department of Medicine, Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595, USA
J Clin Microbiol 46:220-4. 2008..Early surgical intervention or combination therapy or both might have prevented the loss of daptomycin susceptibility... - DaptomycinKerry L Tedesco
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Pharmacotherapy 24:41-57. 2004..Further clinical experience with this compound will help define its role in the treatment of resistant gram-positive organisms... - Susceptibility studies of piperazinyl-cross-linked fluoroquinolone dimers against test strains of Gram-positive and Gram-negative bacteriaRobert J Kerns
Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242 1112, USA
Diagn Microbiol Infect Dis 54:305-10. 2006..aureus previously observed for individual cross-linked dimers was not observed with test strains of the various organisms used here... - Daptomycin - a novel antibiotic against Gram-positive pathogensKerry L LaPlante
University of Rhode Island, Department of Pharmacy Practice, Kingston, RI 02881, USA
Expert Opin Pharmacother 5:2321-31. 2004..There is a continuing need for the development of new antibiotics with Gram-positive activity, to combat multi-drug-resistant Gram-positive infections... - Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureusRobert J Kerns
Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City 52242, USA
Bioorg Med Chem Lett 13:1745-9. 2003.... - Clinical rationale for treatment of endocarditis caused by methicillin-susceptible Staphylococcus aureus developing nonsusceptibility to daptomycinZukile Gqada
J Clin Microbiol 46:2471; author reply 2471-2. 2008 - Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureusThomas P Lodise
Albany College of Pharmacy, Albany, NY 12208 3492, USA
Antimicrob Agents Chemother 51:3731-3. 2007.... - Effect of linezolid versus vancomycin on length of hospital stay in patients with complicated skin and soft tissue infections caused by known or suspected methicillin-resistant staphylococci: results from a randomized clinical trialJim Zhiming Li
Pharmacia Corporation, Kalamazoo, Michigan 49001, USA
Surg Infect (Larchmt) 4:57-70. 2003..CONCLUSION: Results from this randomized trial show that linezolid can significantly reduce LOS for patients with complicated skin and soft tissue infections from suspected or confirmed methicillin-resistant staphylococci... - Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureusRobert J Kerns
Division of Medicinal and Natural Products Chemistry, The University of Iowa, 52242, Iowa City, IA, USA
Bioorg Med Chem Lett 13:2109-12. 2003.... - Case study and panel discussionDennis G Maki
Section of Infectious Diseases, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
Pharmacotherapy 27:136S-143S. 2007 - Clinical outcomes for patients with bacteremia caused by vancomycin-resistant enterococcus in a level 1 trauma centerThomas P Lodise
Anti-Infective Research Laboratory, Detroit Receiving Hospital, Wayne State University, Detroit, MI, 48201, USA
Clin Infect Dis 34:922-9. 2002..7plus minus1.88 vs. 15.9 +/- 1.7, P=.006). These observations indicate that vancomycin resistance in EB independently affects outcomes... - Virulence characteristics of community-associated Staphylococcus aureus and in vitro activities of moxifloxacin alone and in combination against community-associated and healthcare-associated meticillin-resistant and -susceptible S. aureusEllie J C Goldstein
R M Alden Research Laboratory, Santa Monica, CA 90404, USA
J Med Microbiol 57:452-6. 2008..The FICI values for doxycycline were 3-6 for 32/34 strains, indicating antagonism, suggesting that it should not be used in combination with moxifloxacin... - Assessment of differences in antimicrobial effect determined with two in vitro pharmacodynamic models: impact of surface area to volume ratioRoger L White
Anti Infective Research Laboratories, College of Pharmacy, Medical University of South Carolina, Charleston 29425, USA
Pharmacotherapy 23:603-8. 2003..To measure the influence of different surface area:volume ratios (SA:Vs) on antibiotic penetration and subsequent antibacterial effect... - Epidemiology, treatment, and outcomes of nosocomial bacteremic Staphylococcus aureus pneumoniaC Andrew DeRyke
Center for Anti-Infective Research and Development, Hartford Hospital, CT, USA
Chest 128:1414-22. 2005..These findings suggest that newer agents with enhanced clinical activity in NBSAP are needed and that these should be evaluated in a real-world setting, where outcomes of the most ill patients can be assessed... - Pulsatile delivery of clarithromycin alone or in combination with amoxicillin against Streptococcus pneumoniaeKimberly D Leuthner
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
Antimicrob Agents Chemother 50:813-6. 2006..Pulse dosing of antimicrobials warrants further investigation...