- Live-cell imaging of tumor proteolysis: impact of cellular and non-cellular microenvironmentJennifer M Rothberg
Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Biochim Biophys Acta 1824:123-32. 2012..Here we will discuss the background that led to our present studies as well as the techniques and models that we employ. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome...
- 3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironmentKamiar Moin
Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, USA
Methods Enzymol 506:175-94. 2012..Of course, all assays have limitations; however, we suggest that the techniques discussed here will, with attention to their limitations, be useful as a screen for drugs to target the invasive phenotype of tumors...