Jennifer M Rothberg

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Live-cell imaging of tumor proteolysis: impact of cellular and non-cellular microenvironment
    Jennifer M Rothberg
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Biochim Biophys Acta 1824:123-32. 2012
  2. pmc 3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment
    Kamiar Moin
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Methods Enzymol 506:175-94. 2012
  3. pmc Acid-mediated tumor proteolysis: contribution of cysteine cathepsins
    Jennifer M Rothberg
    Cancer Biology Program, Wayne State University, Detroit, MI Department of Pharmacology, Wayne State University, Detroit, MI
    Neoplasia 15:1125-37. 2013

Collaborators

Detail Information

Publications3

  1. pmc Live-cell imaging of tumor proteolysis: impact of cellular and non-cellular microenvironment
    Jennifer M Rothberg
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Biochim Biophys Acta 1824:123-32. 2012
    ..Here we will discuss the background that led to our present studies as well as the techniques and models that we employ. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome...
  2. pmc 3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment
    Kamiar Moin
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Methods Enzymol 506:175-94. 2012
    ..Of course, all assays have limitations; however, we suggest that the techniques discussed here will, with attention to their limitations, be useful as a screen for drugs to target the invasive phenotype of tumors...
  3. pmc Acid-mediated tumor proteolysis: contribution of cysteine cathepsins
    Jennifer M Rothberg
    Cancer Biology Program, Wayne State University, Detroit, MI Department of Pharmacology, Wayne State University, Detroit, MI
    Neoplasia 15:1125-37. 2013
    ..Our results are consistent with the acid-mediated invasion hypothesis and with a role for cathepsin B in promoting degradation of a basement membrane protein substrate, i.e., type IV collagen, in an acidic peritumoral environment. ..