David Rosenberg

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits
    D R Rosenberg
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Psychiatry Neurosci 22:29-38. 1997
  2. ncbi Pituitary volume in pediatric obsessive-compulsive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
    Biol Psychiatry 59:252-7. 2006
  3. ncbi Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls
    David R Rosenberg
    Departments of Psychiatry, Wayne State University, Detroit, MI, USA
    J Am Acad Child Adolesc Psychiatry 43:1146-53. 2004
  4. ncbi Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study
    David R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 58:700-4. 2005
  5. ncbi Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging
    D R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    J Child Neurol 16:636-41. 2001
  6. ncbi Brain anatomy and chemistry may predict treatment response in paediatric obsessive--compulsive disorder
    D R Rosenberg
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Neuropsychopharmacol 4:179-90. 2001
  7. ncbi Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine
    D R Rosenberg
    Department of Psychiatry, Wayne State University, Detroit, USA
    J Am Acad Child Adolesc Psychiatry 39:1096-103. 2000
  8. ncbi Paroxetine open-label treatment of pediatric outpatients with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 38:1180-5. 1999
  9. ncbi Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:824-30. 1997
  10. ncbi Oculomotor response inhibition abnormalities in pediatric obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:831-8. 1997

Research Grants

  1. Brain Chemistry and Treatment Responses in Pediatric OCD
    David Rosenberg; Fiscal Year: 2007
  2. Pediatric Obsessive Compulsive Disorder
    David Rosenberg; Fiscal Year: 2007
  3. Brain Chemistry and Treatment Response in Pediatric MDD
    David Rosenberg; Fiscal Year: 2005
  4. 1/3-Brain Chemistry and Genetics in Pediatric OCD
    David R Rosenberg; Fiscal Year: 2010

Collaborators

Detail Information

Publications46

  1. ncbi Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits
    D R Rosenberg
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Psychiatry Neurosci 22:29-38. 1997
    ..A basic disturbance of neurobehavioral inhibition in OCD may underlie the repetitive behavior that characterizes the illness and be related to abnormalities in orbital prefrontal ventral striatal circuits...
  2. ncbi Pituitary volume in pediatric obsessive-compulsive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
    Biol Psychiatry 59:252-7. 2006
    ..Abnormalities in the limbic-hypothalamic-pituitary-adrenal (LHPA) axis have been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). To our knowledge, however, no prior study has measured pituitary gland volume in OCD...
  3. ncbi Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls
    David R Rosenberg
    Departments of Psychiatry, Wayne State University, Detroit, MI, USA
    J Am Acad Child Adolesc Psychiatry 43:1146-53. 2004
    ....
  4. ncbi Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study
    David R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 58:700-4. 2005
    ..These changes might reflect a change in glutamate, glutamine, or their combination...
  5. ncbi Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging
    D R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    J Child Neurol 16:636-41. 2001
    ..These findings provide new evidence of cytosolic choline abnormalities in the thalamus in pediatric obsessive-compulsive disorder...
  6. ncbi Brain anatomy and chemistry may predict treatment response in paediatric obsessive--compulsive disorder
    D R Rosenberg
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Neuropsychopharmacol 4:179-90. 2001
    ..Developmental neurobiological models for OCD are presented and particular attention is devoted to evaluating neuroimaging studies designed to test these models and how they may help predict treatment response in paediatric OCD...
  7. ncbi Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine
    D R Rosenberg
    Department of Psychiatry, Wayne State University, Detroit, USA
    J Am Acad Child Adolesc Psychiatry 39:1096-103. 2000
    ..To measure in vivo neurochemical changes in the caudate nucleus in pediatric obsessive-compulsive disorder (OCD) before and after treatment...
  8. ncbi Paroxetine open-label treatment of pediatric outpatients with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 38:1180-5. 1999
    ..Paroxetine is a selective serotonin reuptake inhibitor with demonstrated efficacy in treating obsessive-compulsive disorder (OCD) in adults. This study evaluates the safety and effectiveness of paroxetine in pediatric OCD patients...
  9. ncbi Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:824-30. 1997
    ....
  10. ncbi Oculomotor response inhibition abnormalities in pediatric obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:831-8. 1997
    ....
  11. ncbi Corpus callosal morphology in treatment-naive pediatric obsessive compulsive disorder
    D R Rosenberg
    Department of Psychiatry and Behavioral Neuroscience, Wayne State University Medical Center, Detroit, MI, USA
    Prog Neuropsychopharmacol Biol Psychiatry 21:1269-83. 1997
    ..4. These findings support theories of abnormal association cortex development in OCD but also suggest possible abnormalities of other primary cortical regions as well...
  12. ncbi Case study: caudate glutamatergic changes with paroxetine persist after medication discontinuation in pediatric OCD
    J Bolton
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 40:903-6. 2001
    ..These data provide further support for a reversible glutamatergically mediated dysfunction of the caudate nucleus in OCD that may serve as a pathophysiological and treatment response marker...
  13. ncbi Implementing Ask Me 3 to improve African American patient satisfaction and perceptions of physician cultural competency
    Georgia Michalopoulou
    Department of Psychiatry and Behavioral Neurosciences, Division of Child Psychiatry and Psychology, Wayne State University School of Medicine, USA
    J Cult Divers 17:62-7. 2010
    ..Improve African American patient satisfaction and perceptions of physician cultural competency through the implementation of Ask Me 3 pamphlet which encourages patients to ask questions of physicians...
  14. ncbi Physicians' cultural competency as perceived by African American patients
    Georgia Michalopoulou
    Department of Psychiatry and Behavioral Neurosciences, Division of Child Psychiatry and Psychology, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    J Natl Med Assoc 101:893-9. 2009
    ..These results further validate use of the Perceived Cultural Competency scale as a tool to measure patients' perceptions of physicians' cultural competency...
  15. ncbi Neuropsychological study of frontal lobe function in psychotropic-naive children with obsessive-compulsive disorder
    S R Beers
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:777-9. 1999
    ..The authors' goal was to evaluate cognition in children with obsessive-compulsive disorder (OCD) early in their illness...
  16. ncbi Thalamic volumes in patients with first-episode schizophrenia
    A R Gilbert
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:618-24. 2001
    ..Future analysis of individual thalamic nuclei may reveal important, specific relationships between thalamic abnormalities and schizophrenia...
  17. ncbi Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder
    Frank Macmaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Psychiatry Res 181:97-100. 2010
    ..OCD patients had larger right but not left OFC white matter volume than controls. This is fresh evidence implicating white matter in OCD...
  18. ncbi Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness
    Stefan Posse
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, University Health Center 9B, Detroit, MI 48201, USA
    Neuroimage 18:760-8. 2003
    ....
  19. ncbi Cognitive behavior therapy in treatment-naive children and adolescents with obsessive-compulsive disorder: an open trial
    N R Benazon
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Behav Res Ther 40:529-39. 2002
    ..These results must be considered preliminary, given the small sample size and open administration of treatment...
  20. ncbi Distinguishing between major depressive disorder and obsessive-compulsive disorder in children by measuring regional cortical thickness
    Erin Fallucca
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, Michigan, USA
    Arch Gen Psychiatry 68:527-33. 2011
    ..Cortical abnormalities have been noted in previous studies of major depressive disorder (MDD)...
  21. ncbi Magnetic resonance imaging of children without sedation: preparation with simulation
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 36:853-9. 1997
    ....
  22. ncbi Effect of antipsychotics on pituitary gland volume in treatment-naïve first-episode schizophrenia: a pilot study
    Frank P MacMaster
    Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Schizophr Res 92:207-10. 2007
    ..This appeared to be specific to the prolactin-elevating drugs. In controls, pituitary volume did not change significantly (3% decrease). Pituitary volume may be a useful biomarker for treatments that affect neuroendocrine function...
  23. ncbi Developmental biomarkers in schizophrenia and other psychiatric disorders: common origins, different trajectories?
    Matcheri S Keshavan
    Epidemiol Psichiatr Soc 14:188-93. 2005
  24. ncbi Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls
    Yousha Mirza
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:106-11. 2006
    ..Although these results must be considered preliminary, further study of the diagnostic specificity of creatine-phosphocreatine in obsessive-compulsive disorder is indicated...
  25. ncbi Pituitary volume in treatment-naïve pediatric major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children's Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 60:862-6. 2006
    ..CONCLUSIONS: These findings provide new evidence of increased pituitary volume in psychotropic-naïve pediatric patients with MDD that seems to be more prominent in male patients with nonfamilial MDD...
  26. ncbi Striatal volume abnormalities in treatment-naïve patients diagnosed with pediatric major depressive disorder
    Koji Matsuo
    MOOD CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, Texas, USA
    J Child Adolesc Psychopharmacol 18:121-31. 2008
    ..Few studies have examined structural abnormalities of the striatum in pediatric major depressive disorder (MDD) patients. We report striatal volume abnormalities in medication-naïve pediatric MDD compared to healthy comparison subjects...
  27. ncbi Preparing children for MRI
    Frank P MacMaster
    Department of Psychiatry, Children's Hospital of Michigan, Wayne State University School of Medicine, 4201 St. Antoine St, Detroit, MI 48201, USA
    Pediatr Radiol 38:270. 2008
  28. ncbi Pituitary gland volume in adolescent and young adult bipolar and unipolar depression
    Frank P MacMaster
    Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
    Bipolar Disord 10:101-4. 2008
    ..Few studies have examined pituitary gland size in mood disorders, particularly in adolescents. We hypothesized increase in the pituitary gland size in early-onset mood disorders...
  29. ncbi Gray matter differences between pediatric obsessive-compulsive disorder patients and high-risk siblings: a preliminary voxel-based morphometry study
    Andrew R Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Psychiatry 9B, 4201 St Antoine Boulevard, Pittsburgh, PA, United States
    Neurosci Lett 435:45-50. 2008
    ....
  30. ncbi Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 165:1299-307. 2008
    ....
  31. ncbi Prefrontal cortical volume in childhood-onset major depression: preliminary findings
    Carla L Nolan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Arch Gen Psychiatry 59:173-9. 2002
    ..Our findings must be considered preliminary, however, in view of the small sample size...
  32. ncbi Proton magnetic resonance spectroscopic imaging in pediatric major depression
    Tiffany R Farchione
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 52:86-92. 2002
    ..CONCLUSIONS: These results provide new evidence of localized functional neurochemical marker alterations in left DLPFC in pediatric MDD. Our results must be considered preliminary, however, given the small sample size...
  33. ncbi Localized functional neurochemical marker abnormalities in dorsolateral prefrontal cortex in pediatric obsessive-compulsive disorder
    Aileen Russell
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Adolesc Psychopharmacol 13:S31-8. 2003
    ..Increased left DLPFC NAA may represent neuronal hypertrophy or hyperplasia, glial hypoplasia, and/or abnormal pruning of neural brain elements in DLPFC...
  34. ncbi Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study
    Ethan A Smith
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 54:1399-405. 2003
    ..Although these results must be considered preliminary, further study of the diagnostic specificity of Cho as a relevant biomarker in OCD is clearly warranted...
  35. ncbi Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression
    Shauna MacMillan
    Department of Psychiatry, 9B, Wayne State University School of Medicine, 4201 St. Antoine Boulevard, Detroit, MI 48201, USA
    J Child Adolesc Psychopharmacol 13:65-73. 2003
    ..These results underscore the importance of assessment for comorbidity in the study of MDD...
  36. ncbi Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression
    Yousha Mirza
    Department of Psychiatry, Wayne State University, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 43:341-8. 2004
    ..Altered anterior cingulate Glx neurotransmission may be involved in the pathogenesis of MDD...
  37. ncbi Reduced superior temporal gyrus volume in young offspring of patients with schizophrenia
    Rajaprabhakaran Rajarethinam
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Psychiatry 161:1121-4. 2004
    ..Nonpsychotic children with greater genetic risk for schizophrenia exhibit language deficits. The authors studied the superior temporal gyrus in nonpsychotic children at risk for schizophrenia...
  38. ncbi Amygdala and hippocampal volumes in familial early onset major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 63:385-90. 2008
    ..To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD)...
  39. ncbi Development of the corpus callosum in childhood, adolescence and early adulthood
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Life Sci 70:1909-22. 2002
    ..CC maturational changes appeared synchronous across sub-regions suggesting parallel maturation of diverse brain regions during childhood and adolescence...
  40. ncbi Hypoplasia of the corpus callosum and obsessive-compulsive symptoms
    Tiffany R Farchione
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 17:535-7. 2002
    ..This is a report of two cases of obsessive-compulsive disorder associated with hypoplasia of the corpus callosum. These data provide further support for corpus callosum-mediated dysfunction in obsessive-compulsive disorder...
  41. ncbi Childhood anxiety disorders and developmental issues in anxiety
    Paul Arnold
    Department of Psychiatry, Centre for Addiction and Mental Health and the University of Toronto, Toronto, ON, Canada
    Curr Psychiatry Rep 5:252-65. 2003
    ..This article will review significant diagnostic and developmental issues, and highlight recent studies in psychosocial and pharmacologic therapies of pediatric anxiety disorders...
  42. ncbi Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hilside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:1049-56. 2004
    ..The authors investigated structural abnormalities in brain regions comprising cortical-striatal-thalamic-cortical loops in pediatric patients with obsessive-compulsive disorder (OCD)...
  43. ncbi Neurochemical analyses in pediatric obsessive-compulsive disorder in patients treated with cognitive-behavioral therapy
    Nili R Benazon
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA
    J Am Acad Child Adolesc Psychiatry 42:1279-85. 2003
    ..To investigate neurochemical changes in the caudate nucleus of pediatric obsessive-compulsive disorder (OCD) patients before and after cognitive-behavioral therapy (CBT), and to examine corresponding changes in symptom severity...
  44. ncbi Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study
    Paul D Arnold
    Child Psychiatry Program, Neurogenetics Section, 1st Floor, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Psychopharmacology (Berl) 174:530-8. 2004
    ....
  45. ncbi Development and sexual dimorphism of the pituitary gland
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Life Sci 80:940-4. 2007
    ....
  46. ncbi Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:826-32. 2004
    ..These preliminary findings suggest that abnormal asymmetry of the amygdala may play a role in the pathogenesis of OCD and that paroxetine treatment may be associated with a reduction in amygdala volume...

Research Grants17

  1. Brain Chemistry and Treatment Responses in Pediatric OCD
    David Rosenberg; Fiscal Year: 2007
    ..abstract_text> ..
  2. Pediatric Obsessive Compulsive Disorder
    David Rosenberg; Fiscal Year: 2007
    ....
  3. Brain Chemistry and Treatment Response in Pediatric MDD
    David Rosenberg; Fiscal Year: 2005
    ..An understanding of the neurochemical disturbances in MDD may be important for the development of new treatment approaches. ..
  4. 1/3-Brain Chemistry and Genetics in Pediatric OCD
    David R Rosenberg; Fiscal Year: 2010
    ..By combining brain imaging and genetics, as we do in this proposal, we can better understand the biology of pediatric OCD and, in turn, develop more effective treatments for this severe form of childhood psychopathology. ..