Roberto Romero

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d
    Joonho Lee
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    PLoS ONE 6:e16806. 2011
  2. pmc Elephant transcriptome provides insights into the evolution of eutherian placentation
    Zhuo Cheng Hou
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH DHHS, Detroit, Michigan, USA
    Genome Biol Evol 4:713-25. 2012
  3. pmc Down-weighting overlapping genes improves gene set analysis
    Adi Laurentiu Tarca
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    BMC Bioinformatics 13:136. 2012
  4. pmc Blood pH and gases in fetuses in preterm labor with and without systemic inflammatory response syndrome
    Roberto Romero
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 25:1160-70. 2012
  5. pmc Hematologic profile of the fetus with systemic inflammatory response syndrome
    Roberto Romero
    Perinatology Research Branch, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI 48201, USA
    J Perinat Med 40:19-32. 2011
  6. pmc Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan 48201, USA
    J Matern Fetal Neonatal Med 25:558-67. 2012
  7. pmc Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 24:1444-55. 2011
  8. pmc OCPAT: an online codon-preserved alignment tool for evolutionary genomic analysis of protein coding sequences
    Guozhen Liu
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine Detroit, MI 48201, USA
    Source Code Biol Med 2:5. 2007
  9. pmc Nuclear factor-kappa B localization and function within intrauterine tissues from term and preterm labor and cultured fetal membranes
    Sonali Vora
    Laboratory of Perinatal Research, Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH, USA
    Reprod Biol Endocrinol 8:8. 2010
  10. pmc Failure of E. coli bacteria to induce preterm delivery in the rat
    Emmet Hirsch
    Department of Obstetrics and Gynecology, NorthShore University Healthsystem, Evanston, IL, USA
    J Negat Results Biomed 8:1. 2009

Collaborators

Detail Information

Publications79

  1. pmc A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d
    Joonho Lee
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    PLoS ONE 6:e16806. 2011
    ..Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth...
  2. pmc Elephant transcriptome provides insights into the evolution of eutherian placentation
    Zhuo Cheng Hou
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH DHHS, Detroit, Michigan, USA
    Genome Biol Evol 4:713-25. 2012
    ....
  3. pmc Down-weighting overlapping genes improves gene set analysis
    Adi Laurentiu Tarca
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    BMC Bioinformatics 13:136. 2012
    ..Most gene set analysis methods treat genes equally, regardless how specific they are to a given gene set...
  4. pmc Blood pH and gases in fetuses in preterm labor with and without systemic inflammatory response syndrome
    Roberto Romero
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 25:1160-70. 2012
    ..those who delivered more than 72 hours after cordocentesis and (ii) patients with fetal inflammatory response syndrome (FIRS) vs. those without this condition...
  5. pmc Hematologic profile of the fetus with systemic inflammatory response syndrome
    Roberto Romero
    Perinatology Research Branch, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI 48201, USA
    J Perinat Med 40:19-32. 2011
    ..The objective of this study was to characterize the hematologic profile of fetuses with FIRS...
  6. pmc Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan 48201, USA
    J Matern Fetal Neonatal Med 25:558-67. 2012
    ....
  7. pmc Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 24:1444-55. 2011
    ....
  8. pmc OCPAT: an online codon-preserved alignment tool for evolutionary genomic analysis of protein coding sequences
    Guozhen Liu
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine Detroit, MI 48201, USA
    Source Code Biol Med 2:5. 2007
    ..Since this feature is not available in most alignment tools, codon reading frames often must be checked manually before evolutionary analyses can commence...
  9. pmc Nuclear factor-kappa B localization and function within intrauterine tissues from term and preterm labor and cultured fetal membranes
    Sonali Vora
    Laboratory of Perinatal Research, Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH, USA
    Reprod Biol Endocrinol 8:8. 2010
    ....
  10. pmc Failure of E. coli bacteria to induce preterm delivery in the rat
    Emmet Hirsch
    Department of Obstetrics and Gynecology, NorthShore University Healthsystem, Evanston, IL, USA
    J Negat Results Biomed 8:1. 2009
    ..We sought to develop a model of bacterially induced preterm delivery in rats to parallel similar models in mice...
  11. pmc Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
    Lori D Hill
    Department of Obstetrics and Gynecology and Center on Health Disparities, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    BMC Med Genet 12:64. 2011
    ..Furthermore, ERAP2 expression is altered in first trimester placentas of women destined to develop preeclampsia...
  12. pmc Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia
    Neeta Parimi
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    BMC Med Genet 9:60. 2008
    ..However, the optimal analytical approach and study design for evaluating incompatible maternal/offspring genotype combinations is unclear...
  13. pmc Mapping haplotype-haplotype interactions with adaptive LASSO
    Ming Li
    Department of Epidemiology, Michigan State University, East Lansing, Michigan 48824, USA
    BMC Genet 11:79. 2010
    ....
  14. pmc Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:1344-59. 2010
    ....
  15. doi request reprint Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and inflammation
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Perinat Med 36:388-98. 2008
    ..The objective of this study was to determine whether intra-amniotic infection/inflammation (IAI) is associated with changes in the amniotic fluid concentration of sRAGE and esRAGE...
  16. pmc An imbalance between angiogenic and anti-angiogenic factors precedes fetal death in a subset of patients: results of a longitudinal study
    Roberto Romero
    Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 23:1384-99. 2010
    ..The anti-angiogenic factors studied were sVEGFR-1 and soluble endoglin (sEng), and the angiogenic factor, placental growth factor (PlGF)...
  17. pmc Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 202:431.e1-34. 2010
    ..The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery...
  18. pmc Maternal death following cardiopulmonary collapse after delivery: amniotic fluid embolism or septic shock due to intrauterine infection?
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Reprod Immunol 64:113-25. 2010
    ..The amniotic fluid embolism (AFE) syndrome is a catastrophic complication of pregnancy frequently associated with maternal death. The causes and mechanisms of disease responsible for this syndrome remain elusive...
  19. doi request reprint Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Heath and Human Development NIH DHSS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:261-80. 2010
    ....
  20. doi request reprint Evidence of maternal platelet activation, excessive thrombin generation, and high amniotic fluid tissue factor immunoreactivity and functional activity in patients with fetal death
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:672-87. 2009
    ....
  21. pmc Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: evidence of an increased thrombin generation
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:971-82. 2009
    ..The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI) is associated with increased amniotic fluid (AF) thrombin generation in women with preterm and term deliveries...
  22. pmc Allergy-induced preterm labor after the ingestion of shellfish
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:351-9. 2010
    ..The immunological basis for preterm labor induced by an allergic-like reaction (hypersensitivity) is reviewed...
  23. pmc The clinical significance of eosinophils in the amniotic fluid in preterm labor
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:320-9. 2010
    ..The goal of this study was to determine whether women presenting with preterm labor with eosinophils in the amniotic fluid had a different outcome than those without eosinophils as the predominant white blood cell in the amniotic cavity...
  24. pmc A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation
    Chia Ling Nhan-Chang
    Perinatology Research Branch, Intramural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 21:763-75. 2008
    ....
  25. pmc Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: the use of a novel computational method to analyze mass spectrometric profiling
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:367-88. 2008
    ..The purpose of this study was to combine a novel computational method of pattern discovery with mass spectrometric proteomic profiling of amniotic fluid to discover biomarkers of intra-amniotic infection/inflammation (IAI)...
  26. pmc A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
    Roberto Romero
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 203:361.e1-361.e30. 2010
    ..We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM)...
  27. pmc CXCL6 (granulocyte chemotactic protein-2): a novel chemokine involved in the innate immune response of the amniotic cavity
    Pooja Mittal
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Reprod Immunol 60:246-57. 2008
    ..The purpose of this study was to determine if CXCL6 is present in amniotic fluid (AF) and if CXCL6 concentrations in AF change with labor (pre-term and term) or intra-amniotic infection/inflammation (IAI)...
  28. pmc Placental bed disorders in preterm labor, preterm PROM, spontaneous abortion and abruptio placentae
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland and Detroit, Michigan, USA
    Best Pract Res Clin Obstet Gynaecol 25:313-27. 2011
    ..We propose that changes in the population and function of immunocytes at the maternal-fetal interface can be part of the mechanism of disease of obstetrical disorders, and this requires further investigation...
  29. pmc Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:389-402. 2008
    ..The purpose of this study was to determine whether patients with preeclampsia and mothers who deliver a SGA neonate have changes in the plasma concentrations of sTie-2...
  30. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
    ....
  31. pmc First-trimester maternal serum PP13 in the risk assessment for preeclampsia
    Roberto Romero
    Department of Health and Human Services, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 199:122.e1-122.e11. 2008
    ..The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia...
  32. pmc What is amniotic fluid 'sludge'?
    R Romero
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland and Detroit, Michigan, USA
    Ultrasound Obstet Gynecol 30:793-8. 2007
  33. pmc The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
    Offer Erez
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:279-87. 2008
    ....
  34. pmc A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 21:732-44. 2008
    ..A decidual hemostatic disorder may link vaginal bleeding, PPROM and placental abruption. This study was conducted to determine the behaviour of maternal TF and its natural inhibitor, the tissue factor pathway inhibitor (TFPI) in PPROM...
  35. doi request reprint The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulation
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:25-40. 2008
    ....
  36. pmc Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor
    Jimmy Espinoza
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 196:326.e1-13. 2007
    ....
  37. pmc Gene expression profiling demonstrates a novel role for foetal fibrocytes and the umbilical vessels in human fetoplacental development
    Jung Sun Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    J Cell Mol Med 12:1317-30. 2008
    ..This study reports fibrocytes in the human umbilical cord and placenta for the first time, and a novel role for both circulating foetal cells and the umbilical vessels in placental development, which is deranged in IUGR...
  38. pmc Amniotic fluid soluble human leukocyte antigen-G in term and preterm parturition, and intra-amniotic infection/inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:1151-66. 2009
    ....
  39. pmc Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy
    Deug Chan Lee
    Perinatology Research Branch, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA
    J Immunol 184:6479-91. 2010
    ..However, AF SP-A and fetal macrophages by themselves do not seem to be exclusive effectors of parturition in humans...
  40. pmc Fetal death: a condition with a dissociation in the concentrations of soluble vascular endothelial growth factor receptor-2 between the maternal and fetal compartments
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:960-72. 2010
    ..The aim of this study was to determine if fetal death was associated with changes in the concentrations of sVEGFR-2 in maternal plasma and amniotic fluid. Study..
  41. pmc Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:34-47. 2010
    ..The aim of this study was to determine the effect of gestational age, parturition (term and preterm) and IAI in the amniotic fluid (AF) concentrations of sTREM-1...
  42. pmc A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:1021-38. 2009
    ..This study was conducted to examine the role of maternal plasma PlGF, sEng, and sVEGFR-1 concentrations in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia...
  43. pmc Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 23:167-78. 2010
    ....
  44. pmc Characterization of the fetal blood transcriptome and proteome in maternal anti-fetal rejection: evidence of a distinct and novel type of human fetal systemic inflammatory response
    Joonho Lee
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, Detroit, MI, USA
    Am J Reprod Immunol 70:265-84. 2013
    ....
  45. pmc Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection
    Mi Jeong Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Lab Invest 89:924-36. 2009
    ..This study emphasizes the importance of assessing the intra-amniotic compartment for diagnosis and treatment of preterm birth...
  46. pmc Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease
    Mi Jeong Kim
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 and Detroit, MI 48201, USA
    J Immunol 182:3919-27. 2009
    ..We propose that VUE be a unique state combining maternal allograft rejection and maternal antifetal graft-vs-host disease mechanisms...
  47. pmc Interleukin-33 in the human placenta
    Vanessa Topping
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 26:327-38. 2013
    ..The purpose of this study was to determine whether IL-33 is expressed in the human placenta and to investigate its expression in the context of acute and chronic chorioamnionitis...
  48. pmc Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranes
    Zeynep Alpay Savasan
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 23:828-41. 2010
    ..The purpose of this study was to determine whether the soluble form of VEGFR-1 and -2 concentrations in amniotic fluid (AF) change with preterm PROM, intra-amniotic infection/inflammation (IAI), or parturition...
  49. pmc Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers
    Bing Wang
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States
    Int J Pharm 395:298-308. 2010
    ..coli membrane and the G(3.5)-PAMAM-COOH acts as a polyanion, chelating the divalent ions in outer cell membrane of E. coli. This is the first study which shows that G(4)-PAMAM-OH dendrimer acts as an antibacterial agent...
  50. ncbi request reprint Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young Investigator Award
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 190:1541-7; discussion 1547-50. 2004
    ..The purpose of this study was to determine whether preeclampsia is associated with a change in the plasma concentration of sVEGFR-1, and, if so, whether such a change is correlated with the severity of the disease...
  51. pmc Macrophage migration inhibitory factor in patients with preterm parturition and microbial invasion of the amniotic cavity
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 18:405-16. 2005
    ..The objective of this study was to determine whether there is a change in the amniotic fluid concentration of MIF in intra-amniotic infection and human parturition...
  52. pmc Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammation
    Edi Vaisbuch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:905-16. 2009
    ..The aim of this study was to determine whether the amniotic fluid (AF) concentrations of fragment Bb change with gestational age, spontaneous labor (term and preterm) and in the presence of intra-amniotic infection/inflammation (IAI)...
  53. pmc The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: an unexpected observation
    Ichchha Madan
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland and Detroit, MI 48201, USA
    J Perinat Med 38:275-9. 2010
    ..The aim of this study was to determine the frequency and clinical significance of IAI in women with placenta previa and vaginal bleeding in the absence of preterm labor...
  54. ncbi request reprint The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:529-47. 2008
    ..The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI)...
  55. pmc Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Obstet Gynecol 199:651.e1-7. 2008
    ..This study was undertaken to determine whether maternal intrauterine endotoxin administration leads to neurobehavioral deficits in newborn rabbits...
  56. pmc Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammation
    Percy Pacora
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:503-11. 2009
    ....
  57. pmc A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI 48201, USA
    Am J Obstet Gynecol 202:550.e1-10. 2010
    ..The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia...
  58. pmc Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:623-35. 2009
    ..Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate...
  59. doi request reprint MicroRNA expression profiling of the human uterine cervix after term labor and delivery
    Sonia S Hassan
    Department of Obstetrics and Gynecology, Wayne State University Hutzel Hospital, Detroit, MI, USA
    Am J Obstet Gynecol 202:80.e1-8. 2010
    ..MicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional regulation of target genes. The objective of this study was to determine the miRNA expression profile of the human uterine cervix after spontaneous term labor (TL)...
  60. pmc Differential expression of microRNAs with progression of gestation and inflammation in the human chorioamniotic membranes
    Daniel Montenegro
    Perinatology Research Branch, National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 197:289.e1-6. 2007
    ..The aim of this study was to identify differential expression of microRNAs (miRNAs) in chorioamniotic membranes with advancing gestation, labor, and inflammation...
  61. pmc Leukocytes of pregnant women with small-for-gestational age neonates have a different phenotypic and metabolic activity from those of women with preeclampsia
    Giovanna Ogge
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:476-87. 2010
    ..The aim of this study was to determine phenotypic and metabolic changes in granulocytes and monocytes of women who develop preeclampsia and those who deliver an SGA neonate, compared to normal pregnant women...
  62. doi request reprint The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process
    Sonia S Hassan
    Department of Obstetrics and Gynecology, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 22:1183-93. 2009
    ..The aim of this study was to identify changes in the cervical transcriptome in the human uterine cervix as a function of ripening before the onset of labor...
  63. pmc Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance
    Nandor Gabor Than
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, and Department of Health and Human Services, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 105:15819-24. 2008
    ....
  64. pmc The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth
    Chong Jai Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Mod Pathol 23:1000-11. 2010
    ..Its association with villitis of unknown etiology and the chemokine profile in amniotic fluid suggests an immunological origin, akin to transplantation rejection and graft-versus-host disease in the chorioamniotic membranes...
  65. pmc A sonographic short cervix as the only clinical manifestation of intra-amniotic infection
    Sonia Hassan
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Wayne State University, Hutzel Women s Hospital, 3990 John R, 7 Brush North, MFM Mail Drawer 163, Detroit, MI 48201, USA
    J Perinat Med 34:13-9. 2006
    ..This study was conducted to determine the rate of MIAC and intra-amniotic inflammation in patients with a cervical length < 25 mm in the mid-trimester...
  66. pmc Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure
    Sujatha Kannan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Dev Neurosci 33:231-40. 2011
    ..Molecular imaging of ongoing neuroinflammation in the neonatal period may be helpful as a screening biomarker for detecting patients at risk of developing cerebral palsy due to a perinatal insult...
  67. pmc Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteome
    Giovanna Ogge
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    J Pathol 223:553-65. 2011
    ....
  68. pmc Preeclampsia and pregnancies with small-for-gestational age neonates have different profiles of complement split products
    Eleazar Soto
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 23:646-57. 2010
    ..The objective of this study was to determine whether preeclampsia and small-for-gestational age (SGA) are associated with changes in the maternal plasma concentrations of anaphylatoxins C3a, C4a and C5a...
  69. pmc Dysregulation of maternal serum adiponectin in preterm labor
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, HutzelWomen s Hospital, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:887-904. 2009
    ..The aim of this study was to determine whether spontaneous preterm labor (PTL) with intact membranes and intra-amniotic infection/inflammation (IAI) is associated with changes in maternal serum circulating adiponectin multimers...
  70. doi request reprint Maternal anti-protein Z antibodies in pregnancies complicated by pre-eclampsia, SGA and fetal death
    Offer Erez
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:662-71. 2009
    ..The objective of this study was to determine the maternal plasma concentration of APZ-AB in women with a normal pregnancy, and patients with PE, an SGA neonate or a FD...
  71. ncbi request reprint Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia?
    Yeon Mee Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 193:921-7. 2005
    ..This study was conducted to determine whether changes in TLR-4 and TLR-2 expressions can be detected in the trophoblasts at the placental bed of women with and without preeclampsia...
  72. pmc Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome
    Sun Kwon Kim
    Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:543-52. 2009
    ..The aim of this study was to determine whether fetal and maternal granulocytes and monocytes have the phenotypic and metabolic characteristics of activation in cases with FIRS...
  73. pmc Unexplained fetal death has a biological signature of maternal anti-fetal rejection: chronic chorioamnionitis and alloimmune anti-human leucocyte antigen antibodies
    Joonho Lee
    Perinatology Research Branch, NICHD NIH DHHS, USA
    Histopathology 59:928-38. 2011
    ..The aim of this study was to assess whether there is evidence of cellular and antibody-mediated rejection in fetal death...
  74. pmc Serum and plasma determination of angiogenic and anti-angiogenic factors yield different results: the need for standardization in clinical practice
    Giovanna Ogge
    Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan, USA
    J Matern Fetal Neonatal Med 23:820-7. 2010
    ..The purpose of this study was to determine if there are differences in the concentrations of these analytes between plasma and serum in normal pregnancy and in preeclampsia...
  75. pmc Unexplained fetal death is associated with increased concentrations of anti-angiogenic factors in amniotic fluid
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 23:794-805. 2010
    ..These observations indicate that an excess of anti-angiogenic factors in the amniotic cavity is associated with unexplained fetal death especially in preterm gestations...
  76. pmc Twin-to-twin transfusion syndrome: an antiangiogenic state?
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 198:382.e1-8. 2008
    ..This study was conducted to determine maternal plasma concentrations of placental growth factor (PlGF), soluble VEGFR-1, and soluble endoglin (s-Eng) in monochorionic-diamniotic pregnancies with and without TTTS...
  77. pmc Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
    J Perinat Med 36:485-96. 2008
    ....
  78. pmc Region-specific gene expression profiling: novel evidence for biological heterogeneity of the human amnion
    Yu Mi Han
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Reprod 79:954-61. 2008
    ..The novel observations herein strongly suggest that the seemingly homogeneous amnion is biologically heterogeneous and compartmentalized, with implications for the physiology of pregnancy and parturition...
  79. pmc Could alterations in maternal plasma visfatin concentration participate in the phenotype definition of preeclampsia and SGA?
    Shali Mazaki-Tovi
    Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, and Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 23:857-68. 2010
    ..Visfatin is a novel adipocytokine with metabolic and immunomodulating properties. The objective of this study was to determine whether preeclampsia and SGA are associated with alterations in maternal circulating visfatin concentrations...