A K Rishi

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
  2. pmc CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells
    Shazia Jamal
    John D Dingell VA Medical Center, Wayne State University, Detroit, Michigan, United States of America Department of Oncology, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 9:e89146. 2014
  3. pmc CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth
    Abdelkader E Ashour
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    PLoS ONE 8:e66733. 2013
  4. pmc Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA
    Liyue Zhang
    Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA
    J Mol Signal 5:12. 2010
  5. pmc A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1
    Yan Jiang
    Karmanos Cancer Institute, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA
    J Mol Signal 5:7. 2010
  6. pmc Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437
    A K Rishi
    Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Nucleic Acids Res 27:3111-9. 1999
  7. ncbi request reprint S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid
    Y Zhang
    John D Dingell VA Medical Center, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer Res 60:2025-32. 2000
  8. ncbi request reprint Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis
    J A Fontana
    Department of Medicine, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Int J Cancer 86:474-9. 2000
  9. ncbi request reprint Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR
    Y Yu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 280:C1083-9. 2001
  10. ncbi request reprint Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway
    Lulu Farhana
    John D Dingell VA Medical Center and Karmanos Cancer Institute, and Department Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 62:3842-9. 2002

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
    ..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents...
  2. pmc CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells
    Shazia Jamal
    John D Dingell VA Medical Center, Wayne State University, Detroit, Michigan, United States of America Department of Oncology, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 9:e89146. 2014
    ....
  3. pmc CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth
    Abdelkader E Ashour
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    PLoS ONE 8:e66733. 2013
    ..Together our data support anti-MB properties of CFM-4, and provide a proof-of-concept basis for further development of CFMs as potential anti-cancer agents for MBs. ..
  4. pmc Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA
    Liyue Zhang
    Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA
    J Mol Signal 5:12. 2010
    ..We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their mRNA stability...
  5. pmc A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1
    Yan Jiang
    Karmanos Cancer Institute, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA
    J Mol Signal 5:7. 2010
    ..CARP-1/CCAR1, a perinuclear phospho-protein, regulates signaling by adriamycin, steroids, or growth factors. However, intracellular events that regulate CARP-1-dependent cell growth are not fully understood...
  6. pmc Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437
    A K Rishi
    Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Nucleic Acids Res 27:3111-9. 1999
    ....
  7. ncbi request reprint S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid
    Y Zhang
    John D Dingell VA Medical Center, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer Res 60:2025-32. 2000
    ..We hypothesize that this enhanced E2F-1 transcriptional activity results in S-phase arrest and subsequent apoptosis that has been observed in other systems...
  8. ncbi request reprint Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis
    J A Fontana
    Department of Medicine, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Int J Cancer 86:474-9. 2000
    ..Our results suggest that apoptosis induction by AHPN (CD437) may occur through interaction with another protein and is independent of the RAR/RXR-signaling pathways...
  9. ncbi request reprint Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR
    Y Yu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 280:C1083-9. 2001
    ..We conclude that the ERRP cDNA may represent a new member of the EGFR gene family and that ERRP plays a role in regulating cell proliferation by modulating the function of EGFR...
  10. ncbi request reprint Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway
    Lulu Farhana
    John D Dingell VA Medical Center and Karmanos Cancer Institute, and Department Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 62:3842-9. 2002
    ..Thus, CD437 modulates the expression of E2F-1 and cyclin B through the simultaneous stimulation and inhibition of the cyclin B and E2F-1 E3 ligases, respectively...
  11. ncbi request reprint Classical and novel retinoids: their targets in cancer therapy
    J A Fontana
    John D Dingell VA Medical Center and the Department of Medicine and Karmanos Cancer Institute, Wayne State University Detroit, MI 48201, USA
    Leukemia 16:463-72. 2002
    ..Both 4-HPR and CD437/AHPN display significant potential as therapeutic agents in the treatment of a number of premalignant and malignant conditions...
  12. ncbi request reprint Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo
    Liyue Zhang
    Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    Mol Cancer Ther 6:1661-72. 2007
    ..We conclude that CARP-1 is a suppressor of human breast cancer growth, and its expression is diminished in tumors, in part, by methylation-dependent silencing...
  13. ncbi request reprint Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog
    Yuxiang Zhang
    Department of Medicine, Karmanos Cancer Institute, Wayne State University, and the John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Blood 100:2917-25. 2002
    ..These results suggest that CD437 and MM002 analogs may have a potential role in the treatment of B-CLL and ALL...
  14. ncbi request reprint Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog
    Yuxiang Zhang
    John D Dingell VA Medical Center, and Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Blood 102:3743-52. 2003
    ..3-log kill in the leukemic blasts. While 3-Cl-AHPC does not activate retinoic nuclear receptors, it is a potent inducer of apoptosis in AML cells and may represent a novel therapy in the treatment of this disease...
  15. pmc ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cells
    Jyoti Nautiyal
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Mol Cancer Ther 9:1503-14. 2010
    ..The latter could be attributed to induction of apoptosis. We conclude that combining dasatinib and EBIP could be an effective therapeutic strategy for breast cancer by targeting EGFRs and Src signaling...
  16. pmc Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines
    Ying Wang
    John D Dingell VA Medical Center, Karmanos Cancer Institute, Wayne State University, VAMC, 4646 John R, Detroit, MI, 48201, USA
    Cancer Chemother Pharmacol 66:455-66. 2010
    ..Although proteasome inhibitor Velcade (Bortezomib) has been under clinical investigation for a number of cancers, limited preclinical studies with this agent have thus far been conducted in HBC and MPM malignancies...
  17. ncbi request reprint Pressure stimulates breast cancer cell adhesion independently of cell cycle and apoptosis regulatory protein (CARP)-1 regulation of focal adhesion kinase
    Christina Downey
    Department of Surgery, John D Dingell VA Medical Center, Wayne State University, 4646 John R Street, Detroit, MI 48201 1932, USA
    Am J Surg 192:631-5. 2006
    ..We hypothesized that pressure stimulates breast cancer adhesion and that CARP-1, which influences cancer biology, inhibits FAK, and modulates pressure effects...
  18. ncbi request reprint Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells
    Hu Xu
    John D Dingell Veterans Affairs Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
    Mol Cancer Ther 4:435-42. 2005
    ..Our results suggest that ERRP is an effective pan-erbB inhibitor and, thus, may be a potential therapeutic agent for a wide variety of epithelial cancers expressing different levels and subclasses of EGFRs...
  19. ncbi request reprint Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor
    Arun K Rishi
    Veterans Affairs Medical Center, Wayne State Umiversity, Detroit, Michigan 48201, USA
    J Biol Chem 281:13188-98. 2006
    ..Together, data demonstrate that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9...
  20. ncbi request reprint Folic acid reduces nuclear translocation of beta-catenin in rectal mucosal crypts of patients with colorectal adenomas
    Richard Jaszewski
    Division of Gastroenterology, and Department of Internal Medicine, Veterans Affairs Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Lett 206:27-33. 2004
    ..05) and cellular expression of pGSK3beta (P < 0.01) when compared to placebo. Folic acid may exert its chemopreventive effect, at least in part, through inhibition of nuclear translocation of beta-catenin...
  21. ncbi request reprint Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells
    Kiran K Nagothu
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 287:G541-6. 2004
    ..This could partly be responsible for FA-mediated inhibition of growth-related processes in colorectal neoplasia...
  22. ncbi request reprint EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo
    Edi Levi
    Veterans Affairs Medical Center, Pathology and Laboratory Medicine Service, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Anticancer Res 24:2885-91. 2004
    ..However, the mechanisms by which ERRP exerts its anti-tumor properties are poorly understood The current investigation was undertaken to delineate the inhibitory mechanisms that are triggered by ERRP...
  23. ncbi request reprint Epidermal growth factor receptor-related peptide inhibits growth of PC-3 prostate cancer cells
    Dorota J Marciniak
    Departments of Internal Medicine and Pathology, John D Dingell Veterans Affairs Medical Center, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mol Cancer Ther 3:1615-21. 2004
    ..In summary, our data show that ERRP inhibits the growth of prostate cancer cells by attenuating EGFR signaling processes. ERRP could potentially be an effective therapeutic agent for prostate cancer...
  24. pmc Schlafen 3, a novel gene, regulates colonic mucosal growth during aging
    Bhaumik B Patel
    Veterans Administration Medical Center, Department of Medicine, Karmanos Cancer Institue, Wayne State University, 4646 John R St, Detroit, MI 48201, USA
    Am J Physiol Gastrointest Liver Physiol 296:G955-62. 2009
    ..Schlafen 3, a novel negative regulator of growth, which is markedly downregulated in the colonic mucosa of the aged, may play a role in regulating colonic mucosal growth during aging...
  25. pmc TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements
    Mary F Walsh
    Department of Surgery, Wayne State University, Detroit 48201 1932, USA
    Biochim Biophys Acta 1789:88-98. 2009
    ..TGF-beta regulation of FAK transcription reflects a complex interplay between positive and negative non-Smad signals and SBE's, the last independent of p53 or AML1a...
  26. ncbi request reprint Cell growth inhibition by okadaic acid involves gut-enriched Kruppel-like factor mediated enhanced expression of c-Myc
    Liyue Zhang
    John D Dingell V A Medical Center and Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 67:10198-206. 2007
    ..Thus, OA-dependent attenuation of HBC growth is accomplished, in part, by zinc finger transcription factor GKLF-mediated enhanced transcription of c-myc...
  27. ncbi request reprint Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells
    Sudha Reddy
    Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Michigan 48201, USA
    Nutr Cancer 55:185-94. 2006
    ..The superior effects of the combinatorial treatment could partly be attributed to inhibition of constitutive activation of EGFRs and IGF-1R signaling pathways...
  28. ncbi request reprint Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
    ..As a result, the position of RARgamma helix H12 in forming the coactivator-binding site was impacted in a manner consistent with the experimental effect of each analogue on RARgamma transcriptional activation...