N Raz

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Age-related differences in the course of cognitive skill acquisition: the role of regional cortical shrinkage and cognitive resources
    Denise Head
    Department of Psychology, University of Memphis, Tennessee, USA
    Psychol Aging 17:72-84. 2002
  2. doi request reprint Life-span plasticity of the brain and cognition: From questions to evidence and back
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, United States Electronic address
    Neurosci Biobehav Rev 37:2195-200. 2013
  3. pmc Cardiovascular fitness associated with cognitive performance in heart failure patients enrolled in cardiac rehabilitation
    Sarah Garcia
    Department of Psychology, Kent State University, Kent, OH 44242, USA
    BMC Cardiovasc Disord 13:29. 2013
  4. pmc Differential brain shrinkage over 6 months shows limited association with cognitive practice
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI, USA
    Brain Cogn 82:171-80. 2013
  5. pmc Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Biochim Biophys Acta 1822:361-9. 2012
  6. ncbi request reprint Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
  7. ncbi request reprint Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, US
    Neuropsychology 21:149-57. 2007
  8. pmc Trajectories of brain aging in middle-aged and older adults: regional and individual differences
    Naftali Raz
    Institute of Gerontology, Wayne State University, USA
    Neuroimage 51:501-11. 2010
  9. pmc Decline and compensation in aging brain and cognition: promises and constraints. Preface
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychol Rev 19:411-4. 2009
  10. ncbi request reprint Hypertension and the brain: vulnerability of the prefrontal regions and executive functions
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
    Behav Neurosci 117:1169-80. 2003

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Age-related differences in the course of cognitive skill acquisition: the role of regional cortical shrinkage and cognitive resources
    Denise Head
    Department of Psychology, University of Memphis, Tennessee, USA
    Psychol Aging 17:72-84. 2002
    ..When hypertensive participants were excluded, the effect of prefrontal shrinkage on executive aspects of performance was no longer significant, but the effect of working memory remained...
  2. doi request reprint Life-span plasticity of the brain and cognition: From questions to evidence and back
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, United States Electronic address
    Neurosci Biobehav Rev 37:2195-200. 2013
    ..The conference honored Margret M. and Paul B. Baltes, the pioneers of life-span developmental psychology who initiated some of the first studies on experience- and training-related changes in cognition across the life span. ..
  3. pmc Cardiovascular fitness associated with cognitive performance in heart failure patients enrolled in cardiac rehabilitation
    Sarah Garcia
    Department of Psychology, Kent State University, Kent, OH 44242, USA
    BMC Cardiovasc Disord 13:29. 2013
    ....
  4. pmc Differential brain shrinkage over 6 months shows limited association with cognitive practice
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI, USA
    Brain Cogn 82:171-80. 2013
    ..Thus, in healthy adults, differential brain shrinkage can be observed in a narrow time window, vascular risk may aggravate it, and intensive cognitive activity may have a limited effect on it...
  5. pmc Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Biochim Biophys Acta 1822:361-9. 2012
    ..This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease...
  6. ncbi request reprint Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
    ..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment...
  7. ncbi request reprint Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, US
    Neuropsychology 21:149-57. 2007
    ..Thus, poor vascular health contributes to age-related declines in brain and cognition, and some of the age-related declines may be limited to persons with elevated vascular risk...
  8. pmc Trajectories of brain aging in middle-aged and older adults: regional and individual differences
    Naftali Raz
    Institute of Gerontology, Wayne State University, USA
    Neuroimage 51:501-11. 2010
    ..In corpus callosum, shrinkage rate was greater in persons with hypertension, and in the pons, women and carriers of the ApoEepsilon4 allele exhibited declines not noted in the whole sample...
  9. pmc Decline and compensation in aging brain and cognition: promises and constraints. Preface
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychol Rev 19:411-4. 2009
    ..We also need to understand the sources of profound individual variability in aging trajectories, and to learn to tailor interventions to specific individual profiles of decline...
  10. ncbi request reprint Hypertension and the brain: vulnerability of the prefrontal regions and executive functions
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
    Behav Neurosci 117:1169-80. 2003
    ..Among examined cognitive variables, hypertensive patients committed significantly more perseverative errors. Thus, even controlled hypertension may be associated with deficits in brain structure and cognition, warranting further study...
  11. ncbi request reprint Differential aging of the brain: patterns, cognitive correlates and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Neurosci Biobehav Rev 30:730-48. 2006
    ..Lastly, we speculate on several proposed mechanisms of differential brain aging, including neurotransmitter systems, stress and corticosteroids, microvascular changes, calcium homeostasis, and demyelination...
  12. pmc Effects of age, genes, and pulse pressure on executive functions in healthy adults
    Naftali Raz
    Institute of Gerontology, Wayne State University, 87 E Ferry St, Detroit, MI 48202, USA
    Neurobiol Aging 32:1124-37. 2011
    ..These findings suggest that in healthy adults, the effects of genetic risk factors significantly modulate the course of cognitive aging...
  13. pmc Brain aging and its modifiers: insights from in vivo neuromorphometry and susceptibility weighted imaging
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
    Ann N Y Acad Sci 1097:84-93. 2007
    ..Future research on brain aging would benefit from combining structural and metabolic techniques in a longitudinal design, as such studies will allow examination of leading-trailing effects of those factors...
  14. pmc Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Cereb Cortex 18:718-26. 2008
    ..VR was independently associated with smaller prefrontal volumes and lower fluid intelligence. Thus, prefrontal and medial-temporal systems may play different roles in age-related differences and changes in cognitive performance...
  15. ncbi request reprint Comment on Greenwood (2007): Which side of plasticity?
    Naftali Raz
    Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 21:676-7; discussion 680-3. 2007
    ..The extrapolation of plasticity phenomena observed in acute lesions to gradual aging process needs to be justified. All in all, this is a positive development in the field that may be ripe for theoretical generalizations...
  16. ncbi request reprint Hormone replacement therapy and age-related brain shrinkage: regional effects
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 E Ferry St Detroit, MI 48202, USA
    Neuroreport 15:2531-4. 2004
    ..Future large scale studies may benefit from applying regional rather than global measures in assessment of brain integrity...
  17. ncbi request reprint Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume
    Naftali Raz
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Neurobiol Aging 25:377-96. 2004
    ....
  18. ncbi request reprint Differential aging of the medial temporal lobe: a study of a five-year change
    N Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neurology 62:433-8. 2004
    ..To test the hypothesis that entorhinal cortex (EC) volume decreases at a slower rate than the hippocampal (HC) volume in healthy adults, and to examine whether the rate of shrinkage increases with age...
  19. pmc Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:105-16. 2009
    ..The findings indicate that age-related cognitive performance is differentially affected by distinct genetic factors and their interactions with vascular health status...
  20. pmc White matter deterioration in 15 months: latent growth curve models in healthy adults
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neurobiol Aging 33:429.e1-5. 2012
    ..Thus, white matter of healthy middle-aged and older adults undergoes significant regional deterioration in a relatively short period, and is negatively affected by vascular risk and lower educational level...
  21. ncbi request reprint Differential age-related changes in the regional metencephalic volumes in humans: a 5-year follow-up
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, Detroit, MI 48202, USA
    Neurosci Lett 349:163-6. 2003
    ..Neither sex differences, nor sex-specific aging trends were found. We conclude that differential age-related shrinkage of the metencephalic structures occurs in healthy adults, but its magnitude differs from cross-sectional estimates...
  22. pmc Only time will tell: cross-sectional studies offer no solution to the age-brain-cognition triangle: comment on Salthouse (2011)
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, USA
    Psychol Bull 137:790-5. 2011
    ..Mediation models of cross-sectional data represent age-related differences in target variables but fail to approximate time-dependent relations; thus, they do not elucidate the dimensions and dynamics of cognitive aging...
  23. ncbi request reprint Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imaging
    N Raz
    Department of Psychology, University of Memphis, Tennessee 38152, USA
    Neuropsychology 12:95-114. 1998
    ..Chronological age adversely influenced all cognitive indices, although its effects on priming were only indirect, mediated by declines in verbal working memory...
  24. pmc Regional grey matter shrinks in hypertensive individuals despite successful lowering of blood pressure
    J R Jennings
    Department of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Hum Hypertens 26:295-305. 2012
    ..These novel results suggest that essential hypertension is associated with regional grey matter shrinkage, and successful reduction of BP may not completely counter that trend...
  25. ncbi request reprint Age and sex differences in the cerebellum and the ventral pons: a prospective MR study of healthy adults
    N Raz
    Department of Psychology, The University of Memphis, Memphis, TN 38152-3230, USA
    AJNR Am J Neuroradiol 22:1161-7. 2001
    ..The cerebellum and the pons are larger in men than in women and the difference is especially pronounced in the cerebellar hemispheres and the anterior vermis...
  26. ncbi request reprint Neuroanatomical and cognitive correlates of adult age differences in acquisition of a perceptual-motor skill
    N Raz
    Department of Psychology, The University of Memphis, Memphis, Tennessee 38152 6400, USA
    Microsc Res Tech 51:85-93. 2000
    ..During initial stages of skill acquisition, reduced volume of the putamen is also predictive of poorer performance...
  27. pmc Aging, vascular risk, and cognition: blood glucose, pulse pressure, and cognitive performance in healthy adults
    Cheryl L Dahle
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Psychol Aging 24:154-62. 2009
    ....
  28. ncbi request reprint Age, sex and regional brain volumes predict perceptual-motor skill acquisition
    Kristen M Kennedy
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Cortex 41:560-9. 2005
    ..Thus, mirror-drawing represents a task that, despite its visual-spatial nature, favors women, and may exhibit sexually dimorphic brain substrates...
  29. ncbi request reprint Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study
    Faith M Gunning-Dixon
    Department of Psychology, Kaufman Building, Hillside Division of Long Island Jewish Medical Center, 75 59 263rd St, Glen Oaks, NY 11040, USA
    Neuropsychologia 41:1929-41. 2003
    ..The volumes of the fusiform gyrus (FG) and the temporal white matter hyperintensities (TWMH) were unrelated to cognitive performance...
  30. ncbi request reprint Age-related deficits in generation and manipulation of mental images: II. The role of dorsolateral prefrontal cortex
    N Raz
    Department of Psychology, University of Memphis, Tennessee 38152 6400, USA
    Psychol Aging 14:436-44. 1999
    ..The volume of cortical regions associated with modality-specific visual information processing did not show a consistent relationship with specific mental imagery processes...
  31. pmc Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:475-91. 2009
    ..The results indicate that age-related differences in perceptual priming and skill learning have dissociable cognitive and neural correlates...
  32. pmc Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation
    Awantika Deshmukh
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, United States
    Biol Psychol 80:240-5. 2009
    ..These findings indicate that hypertension combined with a genetic vascular risk factor may significantly increase risk for cognitive impairment...
  33. pmc Neuroanatomical and cognitive mediators of age-related differences in episodic memory
    Denise Head
    Department of Psychology, Division of Biology and Biomedical Sciences, Washington University in St Louis, MO 63130, USA
    Neuropsychology 22:491-507. 2008
    ..No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging...
  34. pmc Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI, USA
    Neuropsychologia 47:916-27. 2009
    ..The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause...
  35. ncbi request reprint Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults
    Karen M Rodrigue
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
    J Neurosci 24:956-63. 2004
    ..Thus, in a healthy and educated population, even mild age-related shrinkage of the EC may be a sensitive predictor of memory decline...
  36. ncbi request reprint Extrahippocampal contributions to age differences in human spatial navigation
    Scott D Moffat
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Cereb Cortex 17:1274-82. 2007
    ..We conclude that human navigation requires both hippocampal and extrahippocampal brain systems and draws on executive resources for successful performance...
  37. pmc Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test
    Denise Head
    Department of Psychology, Washington University, St Louis, USA
    Neuropsychologia 47:1200-3. 2009
    ..We conclude that age-related increase in perseveration is indeed differentially dependent on the integrity of prefrontal cortex and on declines in selected cognitive processes dependent on this region...
  38. ncbi request reprint Differential aging of the human striatum: longitudinal evidence
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit MI, USA
    AJNR Am J Neuroradiol 24:1849-56. 2003
    ....
  39. pmc Life span adult faces: norms for age, familiarity, memorability, mood, and picture quality
    Kristen M Kennedy
    Department of Psychology and Institute of Gerontology, Wayne State University, Detroit, Michigan 48202, USA
    Exp Aging Res 35:268-75. 2009
    ..Because the pictures did not differ in any of the measured attributes, the authors provide three balanced sets of face stimuli to researchers desiring normed face stimuli free from age confounds...
  40. ncbi request reprint Age-related differences in acquisition of perceptual-motor skills: working memory as a mediator
    Kristen M Kennedy
    Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:165-83. 2008
    ..The third model provided the best fit to the data, indicating age differences in simple perceptual-motor skill are partially mediated by more complex abilities...
  41. pmc Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry
    Kristen M Kennedy
    Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI, USA
    Neurobiol Aging 30:1657-76. 2009
    ..It may be beneficial to use VBM as a first-pass strategy, followed by manual measurement of anatomically defined regions...
  42. ncbi request reprint Memory impairment in multiple sclerosis: a quantitative review
    A E Thornton
    Department of Psychology, University of Memphis, USA
    Neuropsychology 11:357-66. 1997
    ..The findings suggest a more global pattern of memory deficits in MS than has been previously believed, with deficits clearly associated with neurological disability and disease course...
  43. ncbi request reprint Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults
    Karen M Rodrigue
    Institute of Gerontology, Wayne State University, 226 Knapp Building, 87 E Ferry St, Detroit MI 48202, USA
    J Gerontol B Psychol Sci Soc Sci 60:P174-81. 2005
    ..Moreover, those who maintained a processing speed comparable with that of the younger participants evidenced no age-related performance decrements on the mirror-drawing task...
  44. ncbi request reprint Fragmented pictures revisited: long-term changes in repetition priming, relation to skill learning, and the role of cognitive resources
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Gerontology 53:148-58. 2007
    ..The common assumption, based on cross-sectional studies, is that these processes are only mildly (if at all) affected by age...
  45. ncbi request reprint Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy
    Kirk I Erickson
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 61801, USA
    Neurobiol Aging 26:1205-13. 2005
    ..HRT should be considered a possible mediator of age-related neural decline in both grey and white matter tissues...
  46. ncbi request reprint Aerobic fitness reduces brain tissue loss in aging humans
    Stanley J Colcombe
    Beckman Institute, University of Illinois, Urbana 61801, USA
    J Gerontol A Biol Sci Med Sci 58:176-80. 2003
    ..We examined the relationship between aerobic fitness and in vivo brain tissue density in an older adult population, using voxel-based morphometric techniques...
  47. ncbi request reprint Memory in multiple sclerosis: contextual encoding deficits
    Allen E Thornton
    Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada
    J Int Neuropsychol Soc 8:395-409. 2002
    ..Specifically, problems with binding of contextual information at encoding impair effective retrieval of memories. Nonetheless, access to these memories can be gained through preexisting associations organized in the semantic network...
  48. pmc Multiple shifts in the representation of a motor sequence during the acquisition of skilled performance
    Maria Korman
    Department of Neurobiology, Brain Research, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 100:12492-7. 2003
    ..Altogether, our results indicate multiple time-dependent shifts in the representation of motor experience during the acquisition of skilled performance...

Research Grants14

  1. Neural Correlates and Modifiers of Cognitive Aging
    Naftali Raz; Fiscal Year: 2007
    ..We expect these modeling techniques will allow testing hypotheses about relations between regional brain changes and specific cognitive skills in healthy aging adults. ..
  2. Hemodynamic predictors of brain and cognitive aging
    Naftali Raz; Fiscal Year: 2005
    ....
  3. NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORY
    Naftali Raz; Fiscal Year: 2003
    ....
  4. NEURAL CORRELATES OF AGE-RELATED DIFFERENCES IN MEMORY
    Naftali Raz; Fiscal Year: 1993
    ..Are the deficits in procedural (skill) memory, frequently observed in older adults, related to age-dependent atrophy of the basal ganglia and the cerebellum?..