Research Topics
Genomes and GenesSpecies | N RazSummaryAffiliation: Wayne State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Age-related differences in the course of cognitive skill acquisition: the role of regional cortical shrinkage and cognitive resourcesDenise Head
Department of Psychology, University of Memphis, Tennessee, USA
Psychol Aging 17:72-84. 2002..When hypertensive participants were excluded, the effect of prefrontal shrinkage on executive aspects of performance was no longer significant, but the effect of working memory remained...
Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variantsNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Biochim Biophys Acta 1822:361-9. 2012..This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease...- Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertensionNaftali Raz
Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
Neuropsychology 23:105-16. 2009..The findings indicate that age-related cognitive performance is differentially affected by distinct genetic factors and their interactions with vascular health status... - Hormone replacement therapy and age-related brain shrinkage: regional effectsNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, 87 E Ferry St Detroit, MI 48202, USA
Neuroreport 15:2531-4. 2004..Future large scale studies may benefit from applying regional rather than global measures in assessment of brain integrity... - Regional brain changes in aging healthy adults: general trends, individual differences and modifiersNaftali Raz
Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
Cereb Cortex 15:1676-89. 2005..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment... - Differential aging of the brain: patterns, cognitive correlates and modifiersNaftali Raz
Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
Neurosci Biobehav Rev 30:730-48. 2006..Lastly, we speculate on several proposed mechanisms of differential brain aging, including neurotransmitter systems, stress and corticosteroids, microvascular changes, calcium homeostasis, and demyelination... - Vascular health and longitudinal changes in brain and cognition in middle-aged and older adultsNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, US
Neuropsychology 21:149-57. 2007..Thus, poor vascular health contributes to age-related declines in brain and cognition, and some of the age-related declines may be limited to persons with elevated vascular risk... - Brain aging and its modifiers: insights from in vivo neuromorphometry and susceptibility weighted imagingNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
Ann N Y Acad Sci 1097:84-93. 2007..Future research on brain aging would benefit from combining structural and metabolic techniques in a longitudinal design, as such studies will allow examination of leading-trailing effects of those factors... - Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factorsNaftali Raz
Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
Cereb Cortex 18:718-26. 2008..VR was independently associated with smaller prefrontal volumes and lower fluid intelligence. Thus, prefrontal and medial-temporal systems may play different roles in age-related differences and changes in cognitive performance... - Comment on Greenwood (2007): Which side of plasticity?Naftali Raz
Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Neuropsychology 21:676-7; discussion 680-3. 2007..The extrapolation of plasticity phenomena observed in acute lesions to gradual aging process needs to be justified. All in all, this is a positive development in the field that may be ripe for theoretical generalizations... - Effects of age, genes, and pulse pressure on executive functions in healthy adultsNaftali Raz
Institute of Gerontology, Wayne State University, 87 E Ferry St, Detroit, MI 48202, USA
Neurobiol Aging 32:1124-37. 2011..These findings suggest that in healthy adults, the effects of genetic risk factors significantly modulate the course of cognitive aging... - Trajectories of brain aging in middle-aged and older adults: regional and individual differencesNaftali Raz
Institute of Gerontology, Wayne State University, USA
Neuroimage 51:501-11. 2010..In corpus callosum, shrinkage rate was greater in persons with hypertension, and in the pons, women and carriers of the ApoEepsilon4 allele exhibited declines not noted in the whole sample... - White matter deterioration in 15 months: latent growth curve models in healthy adultsNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Neurobiol Aging 33:429.e1-5. 2012..Thus, white matter of healthy middle-aged and older adults undergoes significant regional deterioration in a relatively short period, and is negatively affected by vascular risk and lower educational level... - Only time will tell: cross-sectional studies offer no solution to the age-brain-cognition triangle: comment on Salthouse (2011)Naftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, USA
Psychol Bull 137:790-5. 2011..Mediation models of cross-sectional data represent age-related differences in target variables but fail to approximate time-dependent relations; thus, they do not elucidate the dimensions and dynamics of cognitive aging... - Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volumeNaftali Raz
Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Neurobiol Aging 25:377-96. 2004.... - Differential aging of the medial temporal lobe: a study of a five-year changeN Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Neurology 62:433-8. 2004..To test the hypothesis that entorhinal cortex (EC) volume decreases at a slower rate than the hippocampal (HC) volume in healthy adults, and to examine whether the rate of shrinkage increases with age... - Hypertension and the brain: vulnerability of the prefrontal regions and executive functionsNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
Behav Neurosci 117:1169-80. 2003..Among examined cognitive variables, hypertensive patients committed significantly more perseverative errors. Thus, even controlled hypertension may be associated with deficits in brain structure and cognition, warranting further study... - Decline and compensation in aging brain and cognition: promises and constraints. PrefaceNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Neuropsychol Rev 19:411-4. 2009..We also need to understand the sources of profound individual variability in aging trajectories, and to learn to tailor interventions to specific individual profiles of decline... - Differential age-related changes in the regional metencephalic volumes in humans: a 5-year follow-upNaftali Raz
Institute of Gerontology, Wayne State University, Detroit, Detroit, MI 48202, USA
Neurosci Lett 349:163-6. 2003..Neither sex differences, nor sex-specific aging trends were found. We conclude that differential age-related shrinkage of the metencephalic structures occurs in healthy adults, but its magnitude differs from cross-sectional estimates... - Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imagingN Raz
Department of Psychology, University of Memphis, Tennessee 38152, USA
Neuropsychology 12:95-114. 1998..Chronological age adversely influenced all cognitive indices, although its effects on priming were only indirect, mediated by declines in verbal working memory... - Regional grey matter shrinks in hypertensive individuals despite successful lowering of blood pressureJ R Jennings
Department of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Hum Hypertens 26:295-305. 2012..These novel results suggest that essential hypertension is associated with regional grey matter shrinkage, and successful reduction of BP may not completely counter that trend... - Age and sex differences in the cerebellum and the ventral pons: a prospective MR study of healthy adultsN Raz
Department of Psychology, The University of Memphis, Memphis, TN 38152-3230, USA
AJNR Am J Neuroradiol 22:1161-7. 2001..The cerebellum and the pons are larger in men than in women and the difference is especially pronounced in the cerebellar hemispheres and the anterior vermis... - Neuroanatomical and cognitive correlates of adult age differences in acquisition of a perceptual-motor skillN Raz
Department of Psychology, The University of Memphis, Memphis, Tennessee 38152 6400, USA
Microsc Res Tech 51:85-93. 2000..During initial stages of skill acquisition, reduced volume of the putamen is also predictive of poorer performance... - Age, sex and regional brain volumes predict perceptual-motor skill acquisitionKristen M Kennedy
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Cortex 41:560-9. 2005..Thus, mirror-drawing represents a task that, despite its visual-spatial nature, favors women, and may exhibit sexually dimorphic brain substrates... - Aging, vascular risk, and cognition: blood glucose, pulse pressure, and cognitive performance in healthy adultsCheryl L Dahle
Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
Psychol Aging 24:154-62. 2009.... - Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI studyFaith M Gunning-Dixon
Department of Psychology, Kaufman Building, Hillside Division of Long Island Jewish Medical Center, 75 59 263rd St, Glen Oaks, NY 11040, USA
Neuropsychologia 41:1929-41. 2003..The volumes of the fusiform gyrus (FG) and the temporal white matter hyperintensities (TWMH) were unrelated to cognitive performance... - Age-related deficits in generation and manipulation of mental images: II. The role of dorsolateral prefrontal cortexN Raz
Department of Psychology, University of Memphis, Tennessee 38152 6400, USA
Psychol Aging 14:436-44. 1999..The volume of cortical regions associated with modality-specific visual information processing did not show a consistent relationship with specific mental imagery processes... - Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learningKristen M Kennedy
Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
Neuropsychology 23:475-91. 2009..The results indicate that age-related differences in perceptual priming and skill learning have dissociable cognitive and neural correlates... - Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigationAwantika Deshmukh
Institute of Gerontology, Wayne State University, Detroit, MI 48202, United States
Biol Psychol 80:240-5. 2009..These findings indicate that hypertension combined with a genetic vascular risk factor may significantly increase risk for cognitive impairment... - Neuroanatomical and cognitive mediators of age-related differences in episodic memoryDenise Head
Department of Psychology, Division of Biology and Biomedical Sciences, Washington University in St Louis, MO 63130, USA
Neuropsychology 22:491-507. 2008..No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging... - Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adultsKaren M Rodrigue
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
J Neurosci 24:956-63. 2004..Thus, in a healthy and educated population, even mild age-related shrinkage of the EC may be a sensitive predictor of memory decline... - Extrahippocampal contributions to age differences in human spatial navigationScott D Moffat
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Cereb Cortex 17:1274-82. 2007..We conclude that human navigation requires both hippocampal and extrahippocampal brain systems and draws on executive resources for successful performance... - Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speedKristen M Kennedy
Institute of Gerontology, Wayne State University, Detroit, MI, USA
Neuropsychologia 47:916-27. 2009..The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause... - Differential aging of the human striatum: longitudinal evidenceNaftali Raz
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit MI, USA
AJNR Am J Neuroradiol 24:1849-56. 2003..Moreover, the magnitude of observed longitudinal change was greater than predicted from cross-sectional studies... - Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetryKristen M Kennedy
Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI, USA
Neurobiol Aging 30:1657-76. 2009..It may be beneficial to use VBM as a first-pass strategy, followed by manual measurement of anatomically defined regions... - Life span adult faces: norms for age, familiarity, memorability, mood, and picture qualityKristen M Kennedy
Department of Psychology and Institute of Gerontology, Wayne State University, Detroit, Michigan 48202, USA
Exp Aging Res 35:268-75. 2009..Because the pictures did not differ in any of the measured attributes, the authors provide three balanced sets of face stimuli to researchers desiring normed face stimuli free from age confounds... - Age-related differences in acquisition of perceptual-motor skills: working memory as a mediatorKristen M Kennedy
Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:165-83. 2008..The third model provided the best fit to the data, indicating age differences in simple perceptual-motor skill are partially mediated by more complex abilities... - Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting TestDenise Head
Department of Psychology, Washington University, St Louis, USA
Neuropsychologia 47:1200-3. 2009..We conclude that age-related increase in perseveration is indeed differentially dependent on the integrity of prefrontal cortex and on declines in selected cognitive processes dependent on this region... - Memory impairment in multiple sclerosis: a quantitative reviewA E Thornton
Department of Psychology, University of Memphis, USA
Neuropsychology 11:357-66. 1997..The findings suggest a more global pattern of memory deficits in MS than has been previously believed, with deficits clearly associated with neurological disability and disease course... - Aging and longitudinal change in perceptual-motor skill acquisition in healthy adultsKaren M Rodrigue
Institute of Gerontology, Wayne State University, 226 Knapp Building, 87 E. Ferry St, Detroit MI 48202, USA
J Gerontol B Psychol Sci Soc Sci 60:P174-81. 2005..Moreover, those who maintained a processing speed comparable with that of the younger participants evidenced no age-related performance decrements on the mirror-drawing task... - Fragmented pictures revisited: long-term changes in repetition priming, relation to skill learning, and the role of cognitive resourcesKristen M Kennedy
Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
Gerontology 53:148-58. 2007..The common assumption, based on cross-sectional studies, is that these processes are only mildly (if at all) affected by age... - Aerobic fitness reduces brain tissue loss in aging humansStanley J Colcombe
Beckman Institute, University of Illinois, Urbana 61801, USA
J Gerontol A Biol Sci Med Sci 58:176-80. 2003..CONCLUSIONS: These findings extend the scope of beneficial effects of aerobic exercise beyond cardiovascular health, and they suggest a strong solid biological basis for the benefits of exercise on the brain health of older adults... - Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapyKirk I Erickson
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 61801, USA
Neurobiol Aging 26:1205-13. 2005..HRT should be considered a possible mediator of age-related neural decline in both grey and white matter tissues... - Memory in multiple sclerosis: contextual encoding deficitsAllen E Thornton
Department of Psychology, Simon Fraser University, Burnaby, British Columbia, Canada
J Int Neuropsychol Soc 8:395-409. 2002..Specifically, problems with binding of contextual information at encoding impair effective retrieval of memories. Nonetheless, access to these memories can be gained through preexisting associations organized in the semantic network... - Multiple shifts in the representation of a motor sequence during the acquisition of skilled performanceMaria Korman
Department of Neurobiology, Brain Research, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 100:12492-7. 2003..Altogether, our results indicate multiple time-dependent shifts in the representation of motor experience during the acquisition of skilled performance...
Research Grants
- Neural Correlates and Modifiers of Cognitive AgingNaftali Raz; Fiscal Year: 2007..We expect these modeling techniques will allow testing hypotheses about relations between regional brain changes and specific cognitive skills in healthy aging adults. ..
- Hemodynamic predictors of brain and cognitive agingNaftali Raz; Fiscal Year: 2005....
- NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORYNaftali Raz; Fiscal Year: 2003....
- NEURAL CORRELATES OF AGE-RELATED DIFFERENCES IN MEMORYNaftali Raz; Fiscal Year: 1993..Are the deficits in procedural (skill) memory, frequently observed in older adults, related to age-dependent atrophy of the basal ganglia and the cerebellum?..