K M Wahidur Rahman

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
    Mol Cancer Ther 5:2747-56. 2006
  2. pmc 3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cells
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 8:e54657. 2013
  3. ncbi request reprint The therapeutic value of natural agents to treat miRNA targeted breast cancer in African-American and Caucasian-American women
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 13:1917-25. 2012
  4. ncbi request reprint Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 11:652-66. 2010
  5. doi request reprint 3,3'-Diindolylmethane enhances taxotere-induced apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Res 69:4468-75. 2009
  6. ncbi request reprint Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 HWCRC, 4100 John R, Detroit, MI 48201, USA
    Mol Cancer Ther 6:2757-65. 2007
  7. ncbi request reprint Effect of types and amount of dietary fat during the initiation phase of hepatocarcinogenesis
    K M Rahman
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Nutr Cancer 39:220-5. 2001
  8. ncbi request reprint Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells
    Km Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:4952-60. 2006
  9. ncbi request reprint Chemopreventive effects of melatonin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats
    K M Wahidur Rahman
    First Department of Pathology, Gifu University School of Medicine, Gifu City 500 8705, Japan
    Nutr Cancer 47:148-55. 2003
  10. ncbi request reprint Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer
    Zhiwei Wang
    Departments of Pathology and Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
    Cancer Res 66:7653-60. 2006

Detail Information

Publications21

  1. ncbi request reprint Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
    Mol Cancer Ther 5:2747-56. 2006
    ..These results also suggest that I3C could be a promising agent for the prevention and/or treatment of breast cancer bone metastasis in the future...
  2. pmc 3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cells
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 8:e54657. 2013
    ....
  3. ncbi request reprint The therapeutic value of natural agents to treat miRNA targeted breast cancer in African-American and Caucasian-American women
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 13:1917-25. 2012
    ..In this review, we will discuss the potential role of naturally occurring agents as potent antitumor agents thought to function by targeting miRs as contributing factors to the disparity in breast cancer between AA and CA women...
  4. ncbi request reprint Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 11:652-66. 2010
    ....
  5. doi request reprint 3,3'-Diindolylmethane enhances taxotere-induced apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Res 69:4468-75. 2009
    ..From these results, we conclude that inactivation of survivin by DIM enhanced the therapeutic efficacy of Taxotere in prostate cancer in general, which could be useful for the treatment of HRPC and metastatic prostate cancer...
  6. ncbi request reprint Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 HWCRC, 4100 John R, Detroit, MI 48201, USA
    Mol Cancer Ther 6:2757-65. 2007
    ..The data obtained from our studies could be a novel breakthrough in cancer therapeutics by using nontoxic agents, such as B-DIM, in combination with other conventional therapeutic agents, such as Taxotere...
  7. ncbi request reprint Effect of types and amount of dietary fat during the initiation phase of hepatocarcinogenesis
    K M Rahman
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Nutr Cancer 39:220-5. 2001
    ..Additionally, the enhancing effect of a corn oil diet in hepatocarcinogenesis is mainly present during the initiation phase of carcinogenesis compared with a lard diet...
  8. ncbi request reprint Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells
    Km Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:4952-60. 2006
    ..These results suggest that targeting survivin by 3,3'-diindolylmethane could be a new and novel approach for the prevention and/or treatment of breast cancer...
  9. ncbi request reprint Chemopreventive effects of melatonin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats
    K M Wahidur Rahman
    First Department of Pathology, Gifu University School of Medicine, Gifu City 500 8705, Japan
    Nutr Cancer 47:148-55. 2003
    ..These results suggest that melatonin has an antitumor-promoting ability in DEN-initiated and PB-promoted hepatocarcinogenesis in rats...
  10. ncbi request reprint Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer
    Zhiwei Wang
    Departments of Pathology and Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
    Cancer Res 66:7653-60. 2006
    ..We conclude that ERRP could be an effective agent for inhibiting tumor growth and invasion for the treatment of pancreatic cancer...
  11. pmc 3,3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 129:1781-91. 2011
    ..We conclude that inactivation of FoxM1 and its target genes by DIM could enhance the therapeutic efficacy of Taxotere in breast cancer, which could be a useful strategy for the prevention and/or treatment of breast cancer...
  12. ncbi request reprint Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Nutr Cancer 45:101-12. 2003
    ..From these results, we conclude that I3C selectively induces apoptosis in breast cancer cells, but not in nontumorigenic breast epithelial cells, suggesting the potential therapeutic benefit of I3C against breast cancer...
  13. ncbi request reprint Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:2778-84. 2006
    ....
  14. ncbi request reprint Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Nutr Cancer 48:84-94. 2004
    ..These results also suggest that I3C may be a potential chemopreventive agent by virtue of its selective apoptosis-inducing ability in premalignant and malignant breast epithelial cells...
  15. doi request reprint Induction of growth arrest and apoptosis in human breast cancer cells by 3,3-diindolylmethane is associated with induction and nuclear localization of p27kip
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Cancer Ther 7:341-9. 2008
    ..These effects appear to be independent of Her-2, Akt, or estrogen receptor status and should support further study for its chemoprevention potential in breast cancer...
  16. ncbi request reprint Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Nutr 133:2434S-2439S. 2003
    ....
  17. ncbi request reprint Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Shigeyuki Sugie
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 117:524-30. 2005
    ..These results suggest that dietary DITC could be a preventive agent against BBN-induced bladder carcinogenesis in mice when fed during the initiation phase...
  18. ncbi request reprint Novel targets for detection of cancer and their modulation by chemopreventive natural compounds
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Front Biosci (Elite Ed) 4:410-25. 2012
    ..We believe that this review will stimulate further research for elucidating and appreciating the value of these wonderful gifts from nature...
  19. ncbi request reprint Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells
    Km Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Res 65:364-71. 2005
    ....
  20. ncbi request reprint Steroid hormone mimics: molecular mechanisms of cell growth and apoptosis in normal and malignant mammary epithelial cells
    K M Wahidur Rahman
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 E Canfield Avenue, Detroit, MI 48201, USA
    J Steroid Biochem Mol Biol 80:191-201. 2002
    ....
  21. ncbi request reprint Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
    Mol Cancer Res 5:171-81. 2007
    ..The activation status of the X-chromosome may influence the expression levels of X-linked oncogenes or tumor suppressor genes...