A S Prasad

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Effects of zinc deficiency on Th1 and Th2 cytokine shifts
    A S Prasad
    Wayne State University, University Health Center, Detroit, MI 48201, USA
    J Infect Dis 182:S62-8. 2000
  2. ncbi request reprint Antioxidant effect of zinc in humans
    Ananda S Prasad
    Department of Medicine, Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 37:1182-90. 2004
  3. ncbi request reprint Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, MI, and The University of Michigan, Ann Arbor, MI 48201, USA
    Am J Clin Nutr 85:837-44. 2007
  4. pmc Zinc in human health: effect of zinc on immune cells
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
    Mol Med 14:353-7. 2008
  5. pmc Discovery of human zinc deficiency: its impact on human health and disease
    Ananda S Prasad
    Wayne State University School of Medicine, Department of Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
    Adv Nutr 4:176-90. 2013
  6. ncbi request reprint Zinc: mechanisms of host defense
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nutr 137:1345-9. 2007
  7. ncbi request reprint Clinical, immunological, anti-inflammatory and antioxidant roles of zinc
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Gerontol 43:370-7. 2008
  8. doi request reprint Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate
    Ananda S Prasad
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Infect Dis 197:795-802. 2008
  9. doi request reprint Zinc: role in immunity, oxidative stress and chronic inflammation
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, School of Medicine, Detroit, Michigan, USA
    Curr Opin Clin Nutr Metab Care 12:646-52. 2009
  10. pmc Dietary zinc and prostate cancer in the TRAMP mouse model
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, Detroit, Michigan 48201, USA
    J Med Food 13:70-6. 2010

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Effects of zinc deficiency on Th1 and Th2 cytokine shifts
    A S Prasad
    Wayne State University, University Health Center, Detroit, MI 48201, USA
    J Infect Dis 182:S62-8. 2000
    ..Decreased production of IL-2 in zinc deficiency may be due to decreased activation of NF-kappaB and subsequent decreased gene expression of IL-2 and IL-2 receptors...
  2. ncbi request reprint Antioxidant effect of zinc in humans
    Ananda S Prasad
    Department of Medicine, Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 37:1182-90. 2004
    ..Zinc administration to human subjects with conditions associated with increased oxidative stress should be explored...
  3. ncbi request reprint Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, MI, and The University of Michigan, Ann Arbor, MI 48201, USA
    Am J Clin Nutr 85:837-44. 2007
    ..Zinc deficiency, cell-mediated immune dysfunction, susceptibility to infections, and increased oxidative stress have been observed in elderly subjects (ie, those >55 y old). Zinc is an effective antiinflammatory and antioxidant agent...
  4. pmc Zinc in human health: effect of zinc on immune cells
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
    Mol Med 14:353-7. 2008
    ..We have reported recently that in both young adults and elderly subjects, zinc supplementation decreased oxidative stress markers and generation of inflammatory cytokines...
  5. pmc Discovery of human zinc deficiency: its impact on human health and disease
    Ananda S Prasad
    Wayne State University School of Medicine, Department of Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
    Adv Nutr 4:176-90. 2013
    ..Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent...
  6. ncbi request reprint Zinc: mechanisms of host defense
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nutr 137:1345-9. 2007
    ..We conclude that zinc has an important role in cell-mediated immune functions and also functions as antiinflammatory and antioxidant agent...
  7. ncbi request reprint Clinical, immunological, anti-inflammatory and antioxidant roles of zinc
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Gerontol 43:370-7. 2008
    ..In cell culture studies, we have observed that zinc induces A20 which inhibits NF-kappaB activation resulting in decreased generation of inflammatory cytokines...
  8. doi request reprint Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate
    Ananda S Prasad
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Infect Dis 197:795-802. 2008
    ..Zinc lozenges have been used for treatment of the common cold; however, the results remain controversial...
  9. doi request reprint Zinc: role in immunity, oxidative stress and chronic inflammation
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, School of Medicine, Detroit, Michigan, USA
    Curr Opin Clin Nutr Metab Care 12:646-52. 2009
    ..These efforts were aimed at either supporting immunity by zinc administration or correcting the zinc dependent immune functions in zinc deficient individuals...
  10. pmc Dietary zinc and prostate cancer in the TRAMP mouse model
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, Detroit, Michigan 48201, USA
    J Med Food 13:70-6. 2010
    ..We conclude that optimal prostate zinc concentration has a protective role against cancer...
  11. ncbi request reprint Impact of the discovery of human zinc deficiency on health
    Ananda S Prasad
    Wayne State University School of Medicine, 1122 Elliman Bldg, 421 East Canfield, Detroit, MI 48201, USA
    J Am Coll Nutr 28:257-65. 2009
    ..A controlled clinical trial of zinc supplementation in these disorders in order to document the preventive and therapeutic effects of zinc is warranted...
  12. doi request reprint Zinc in cancer prevention
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Nutr Cancer 61:879-87. 2009
    ..Based on the above, we recommend further studies and propose that zinc should be utilized in the management and chemoprevention of cancer...
  13. doi request reprint Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-κB
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology Oncology, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    Nutrition 27:816-23. 2011
    ....
  14. ncbi request reprint Correction of interleukin-2 gene expression by in vitro zinc addition to mononuclear cells from zinc-deficient human subjects: a specific test for zinc deficiency in humans
    Ananda S Prasad
    Department of Medicine, Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    Transl Res 148:325-33. 2006
    ....
  15. ncbi request reprint Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation
    Ananda S Prasad
    Department of Medicine, Division of Hematology Oncology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, University Health Center 5 C, 4201 St Antoine, Detroit, MI 48201, USA
    J Lab Clin Med 140:272-89. 2002
    ..We also document that the binding of NF-kappaB to DNA was adversely affected, thereby decreasing the gene expression of IL-2 and IL-2 Ralpha in zinc-deficient HUT-78 cells...
  16. doi request reprint Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients
    Bin Bao
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Transl Res 152:67-80. 2008
    ..Zinc supplementation also increased relative levels of IL-2 and IL-2Ralpha mRNAs in phytohemagglutinin-p-stimulated MNCs. These results suggest that zinc supplementation may be beneficial to SCD patients...
  17. ncbi request reprint Zinc modulates mRNA levels of cytokines
    Bin Bao
    Internal Medicine Department, Wayne State University Medical School, Detroit, MI 48201, USA
    Am J Physiol Endocrinol Metab 285:E1095-102. 2003
    ..Our study shows that the effect of zinc on gene expression and production of cytokines is cell lineage specific...
  18. pmc Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent
    Bin Bao
    Department of Internal Medicine, Wayne State University, Detroit, MI, USA
    Am J Clin Nutr 91:1634-41. 2010
    ..Zinc is an essential micronutrient that can function as an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properties...
  19. ncbi request reprint Zinc activates NF-kappaB in HUT-78 cells
    A S Prasad
    Department of Medicine, Division of Hematology-Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Lab Clin Med 138:250-6. 2001
    ..We also demonstrate that the binding of recombinant NF-kappaB (p50)(2) to DNA in HUT-78 cells was zinc specific. We conclude that zinc plays an important role in the activation of NF-kappaB in HUT-78 cells...
  20. ncbi request reprint Zinc up-regulates NF-kappaB activation via phosphorylation of IkappaB in HUT-78 (Th0) cells
    Bin Bao
    Department of Internal Medicine, Wayne State University School of Medicine, 2221 Elliman Building, 421 E Canfield, Detroit, MI, USA
    FEBS Lett 581:4507-11. 2007
    ..However, dominant negative IkappaB gene expression decreased these parameters in zinc-sufficient cells, suggesting that zinc increased NF-kappaB activation via IkappaB pathway...
  21. ncbi request reprint Zinc in cancer prevention
    Ananda S Prasad
    Department of Medicine Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine Detroit, MI 48201, USA
    Cancer Metastasis Rev 21:291-5. 2002
    ..Preclinical and clinical studies need to investigate modulation of genetic and epigenetic pathways of carcinogenesis by zinc...
  22. ncbi request reprint Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell line
    Frances W J Beck
    Department of Internal Medicine, Division of Hematology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Nutrition 22:1045-56. 2006
    ....
  23. pmc Serum thymulin in human zinc deficiency
    A S Prasad
    Department of Medicine, Harper Grace Hospital, Detroit, Michigan
    J Clin Invest 82:1202-10. 1988
    ..Inasmuch as thymulin is known to induce intra- and extrathymic T cell differentiation, our studies provide a possible mechanism for the role of zinc on T cell functions...
  24. ncbi request reprint Differential expression of hZnT-4 in human prostate tissues
    Frances W J Beck
    Department of Internal Medicine, Division of Hematology Oncology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Prostate 58:374-81. 2004
    ..It is not known whether loss of zinc, necessary to restrain aggressive growth, results from loss of a single specific or multiple zinc transporters...
  25. ncbi request reprint Zinc deficiency: its characterization and treatment
    Ananda S Prasad
    Wayne State University School of Medicine, University Health Center 5C, 4201 St Antoine, Detroit, MI 48201, USA
    Met Ions Biol Syst 41:103-37. 2004
  26. ncbi request reprint A new mutation in exon 3 of the SCL39A4 gene in a Tunisian family with severe acrodermatitis enteropathica
    Sheila P Meftah
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Nutrition 22:1067-70. 2006
    ..7 kb. We describe a novel mutation in a Tunisian family in which a chain termination codon in exon 3 yielded a truncated ZIP4 zinc transporter protein...
  27. ncbi request reprint Zinc deficiency in Mexican American children: influence of zinc and other micronutrients on T cells, cytokines, and antiinflammatory plasma proteins
    Harold H Sandstead
    Division of Human Nutrition, Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1109, USA
    Am J Clin Nutr 88:1067-73. 2008
    ..The Third National Health and Nutrition Examination Survey suggested some Mexican American children are at risk of zinc deficiency...
  28. pmc Zinc deficiency
    Ananda S Prasad
    BMJ 326:409-10. 2003
  29. ncbi request reprint Zinc deficiency in patients with sickle cell disease
    Ananda S Prasad
    Am J Clin Nutr 75:181-2. 2002