Isaac J Powell

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
  2. doi request reprint Minireview: the molecular and genomic basis for prostate cancer health disparities
    Isaac J Powell
    Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Mol Endocrinol 27:879-91. 2013
  3. ncbi request reprint CYP3A4 genetic variant and disease-free survival among white and black men after radical prostatectomy
    Isaac J Powell
    Barbara Ann Karmanos Cancer Institute, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Urol 172:1848-52. 2004
  4. ncbi request reprint Epidemiology and pathophysiology of prostate cancer in African-American men
    Isaac J Powell
    Department of Urology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Urol 177:444-9. 2007
  5. pmc Evidence supports a faster growth rate and/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparity
    Isaac J Powell
    Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA
    J Urol 183:1792-6. 2010
  6. pmc The precise role of ethnicity and family history on aggressive prostate cancer: a review analysis
    Isaac J Powell
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Arch Esp Urol 64:711-9. 2011
  7. ncbi request reprint African American men and hereditary/familial prostate cancer: Intermediate-risk populations for chemoprevention trials
    I J Powell
    Department of Urology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Urology 57:178-81. 2001
  8. ncbi request reprint The effect of race/ethnicity on prostate cancer treatment outcome is conditional: a review of Wayne State University data
    Isaac J Powell
    Department of Urology, Wayne State University, Detroit, Michigan 48201, USA
    J Urol 171:1508-12. 2004
  9. ncbi request reprint Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men
    Dieudonne Bangsi
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Urol Oncol 24:21-7. 2006
  10. ncbi request reprint The impact of CAG repeats in exon 1 of the androgen receptor on disease progression after prostatectomy
    Isaac J Powell
    Barbara Ann Karmanos Cancer Institute and Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Cancer 103:528-37. 2005

Collaborators

Detail Information

Publications35

  1. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
    ..Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive...
  2. doi request reprint Minireview: the molecular and genomic basis for prostate cancer health disparities
    Isaac J Powell
    Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Mol Endocrinol 27:879-91. 2013
    ..That knowledge will prove useful in developing strategies to predict who will develop advanced PCa among AAM and will provide the rationale to develop effective individualized treatment strategies to overcome disparities...
  3. ncbi request reprint CYP3A4 genetic variant and disease-free survival among white and black men after radical prostatectomy
    Isaac J Powell
    Barbara Ann Karmanos Cancer Institute, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Urol 172:1848-52. 2004
    ..We investigated the impact of this polymorphism on the risk of recurrence after prostatectomy...
  4. ncbi request reprint Epidemiology and pathophysiology of prostate cancer in African-American men
    Isaac J Powell
    Department of Urology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Urol 177:444-9. 2007
    ..The purpose of this review article is to examine specific reports highlighting racial disparity and its possible causes...
  5. pmc Evidence supports a faster growth rate and/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparity
    Isaac J Powell
    Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA
    J Urol 183:1792-6. 2010
    ..We propose that a more rapid prostate cancer growth rate and/or earlier transformation from latent to aggressive prostate cancer in black than in white men contribute to this disparity...
  6. pmc The precise role of ethnicity and family history on aggressive prostate cancer: a review analysis
    Isaac J Powell
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Arch Esp Urol 64:711-9. 2011
    ..Review analysis of prostate cancer among men of sub-Saharan West African descent in comparison to other ethnicities and men with a family history of prostate cancer...
  7. ncbi request reprint African American men and hereditary/familial prostate cancer: Intermediate-risk populations for chemoprevention trials
    I J Powell
    Department of Urology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Urology 57:178-81. 2001
    ..In conclusion, African Americans are an important target population to include in chemoprevention trials that include dietary factors as preventive agents...
  8. ncbi request reprint The effect of race/ethnicity on prostate cancer treatment outcome is conditional: a review of Wayne State University data
    Isaac J Powell
    Department of Urology, Wayne State University, Detroit, Michigan 48201, USA
    J Urol 171:1508-12. 2004
    ..However, there is considerable controversy as to whether race/ethnicity is an independent predictor of survival outcome. We present conditions in which race/ethnicity is and is not an independent predictor of survival outcomes...
  9. ncbi request reprint Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men
    Dieudonne Bangsi
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Urol Oncol 24:21-7. 2006
    ..9 95% confidence interval 1.6-533) were compared with those with the AA genotype. The association between the CYP3A4 genotype and aggressive prostate cancer in African-American men is consistent with findings of other studies...
  10. ncbi request reprint The impact of CAG repeats in exon 1 of the androgen receptor on disease progression after prostatectomy
    Isaac J Powell
    Barbara Ann Karmanos Cancer Institute and Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Cancer 103:528-37. 2005
    ..An earlier series found that, among men at low risk of progressive disease, a small number of CAG repeats predicted a high risk of recurrence, and the impact of CAG repeats varied among men with different risks of progressive disease...
  11. ncbi request reprint Prostate cancer stage shift has eliminated the gap in disease-free survival in black and white American men after radical prostatectomy
    Fernando J Bianco
    Department of Urology, Wayne State University School of Medicine and Prostate Program of Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
    J Urol 168:479-82. 2002
    ..We tested the stage shift effects on disease-free survival in our cohort of patients treated with radical prostatectomy...
  12. ncbi request reprint Ten-year survival after radical prostatectomy: specimen Gleason score is the predictor in organ-confined prostate cancer
    Fernando J Bianco
    Department of Urology, Wayne State University School of Medicine, The Prostate Program, The Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Clin Prostate Cancer 1:242-7. 2003
    ..For patients with pathologically organ-confined tumors, the specimen Gleason score is the only factor predictive of disease-free survival. Of note, Gleason scores of 8-10 are uncommon in these patients...
  13. ncbi request reprint Presence of circulating prostate cancer cells in African American males adversely affects survival
    Fernando J Bianco
    Department of Urology, Wayne State University School of Medicine, Detroit, MI 48201
    Urol Oncol 7:147-52. 2002
    ..This may partially explain the worse prognosis in AAM vs. CAM with clinically localized prostate cancer...
  14. pmc Ten-year follow-up of neoadjuvant therapy with goserelin acetate and flutamide before radical prostatectomy for clinical T3 and T4 prostate cancer: update on Southwest Oncology Group Study 9109
    Ryan K Berglund
    Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 79:633-7. 2012
    ..The optimal management for clinical stage T3 and T4 N0,M0 prostate cancer is uncertain...
  15. ncbi request reprint Radical prostatectomy nomograms in black American men: accuracy and applicability
    Fernando J Bianco
    Department of Urology, Wayne State University, 4160 John R, Suite 1017, Detroit, MI 48201, USA
    J Urol 170:73-6; discussion 76-7. 2003
    ..We tested the accuracy of prognostic nomograms in a population of AAMs with prostate cancer treated with radical prostatectomy...
  16. ncbi request reprint Vitamin D receptor gene polymorphisms and disease free survival after radical prostatectomy
    Heinric Williams
    The Barbara Ann Karmanos Cancer Institute and Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Prostate 61:267-75. 2004
    ..Its hormonal activity is mediated by the vitamin D receptor. We investigated whether germ-line genetic variation in the vitamin D receptor impacts progression of prostate cancer after radical prostatectomy...
  17. ncbi request reprint Disease-free survival difference between African Americans and whites after radical prostatectomy for local prostate cancer: a multivariable analysis
    Isaac J Powell
    Department of Urology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Urology 59:907-12. 2002
    ..In an attempt to address this controversy of localized prostate cancer, we report on a multivariable analysis of survival data of a large number of AAM and WM who underwent radical prostatectomy...
  18. pmc Results from a prostate cancer admixture mapping study in African-American men
    Cathryn Hufford Bock
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hum Genet 126:637-42. 2009
    ..In conclusion, we confirmed ancestry associations on 8q24, and identified additional ancestry-associated regions potentially harboring prostate cancer susceptibility loci...
  19. doi request reprint The effect of race/ethnicity on the accuracy of the 2001 Partin Tables for predicting pathologic stage of localized prostate cancer
    Elisabeth I Heath
    Barbara Ann Karmanos Cancer Institute, Department of Hematology and Oncology, Wayne State University, 4100 John R, 4 HWCRC, Detroit, MI 48201, USA
    Urology 71:151-5. 2008
    ..To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States...
  20. pmc Interplay of race, socioeconomic status, and treatment on survival of patients with prostate cancer
    Kendra Schwartz
    Department of Family Medicine and Public Health Sciences, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Urology 74:1296-302. 2009
    ....
  21. ncbi request reprint Prostate specific antigen progression after radical prostatectomy in African-American men versus white men
    Mousumi Banerjee
    Center for Healthcare Effectiveness Research, Wayne State University, 121 Shiffman Library, 4325 Brush Avenue, Detroit, MI 48201, USA
    Cancer 94:2577-83. 2002
    ..Racial differences in the pattern of rising PSA would warrant different intervention strategies for reducing the disproportionality in survival outcomes between the two racial groups...
  22. doi request reprint Genes associated with prostate cancer are differentially expressed in African American and European American men
    Isaac J Powell
    Barbara Ann Karmanos Cancer Institute, Wayne State University Department of Oncology, Detroit, MI, USA
    Cancer Epidemiol Biomarkers Prev 22:891-7. 2013
    ..Limited early evidence indicates that underlying causes for disparities may be observed in tumor-specific gene expression programs...
  23. doi request reprint Epidemiology, pathology, and genetics of prostate cancer among African Americans compared with other ethnicities
    Heinric Williams
    Department of Urology, Wayne State University, Detroit, MI, USA
    Methods Mol Biol 472:439-53. 2009
    ..In conclusion, there are multiple factors that impact prostate cancer outcome and that may be responsible for ethnic disparity. These factors are discussed in this chapter...
  24. ncbi request reprint A similar pattern of chromosomal alterations in prostate cancers from African-Americans and Caucasian Americans
    M L Cher
    Department of Urology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 4:1273-8. 1998
    ..These data support the notion that sporadic prostate cancers from AAMs and CAMs develop by similar chromosomal mechanisms. Biological differences, if present, do not occur on the chromosomal level...
  25. ncbi request reprint Neoadjuvant therapy before radical prostatectomy for clinical T3/T4 carcinoma of the prostate: 5-year followup, Phase II Southwest Oncology Group Study 9109
    Isaac J Powell
    Wayne State University Medical Center, Detroit, Michigan, USA
    J Urol 168:2016-9. 2002
    ....
  26. ncbi request reprint Biochemical recurrence after radical prostatectomy in black and white American men with a positive or negative family history of prostate cancer
    V Narain
    Department of Pathology and Urology, Harper University Hospital, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Urol 165:474-7. 2001
    ..CONCLUSIONS: Biochemical recurrence was not significantly worse in patients with a family history of prostate cancer than in those with nonfamilial disease in either race...
  27. ncbi request reprint Validation of a food frequency questionnaire measurement of selected nutrients using biological markers in African-American men
    M D Holmes
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Eur J Clin Nutr 61:1328-36. 2007
    ..To validate selected nutrients assessed by the food frequency questionnaire (FFQ) used in the Harvard cohort studies in an African-American group...
  28. pmc African-American heredity prostate cancer study: a model for genetic research
    I J Powell
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    J Natl Med Assoc 93:25S-28S. 2001
    ..Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases...
  29. pmc African-American heredity prostate cancer study: a model for genetic research
    I J Powell
    Dept of Urology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    J Natl Med Assoc 93:120-3. 2001
    ..Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases...
  30. ncbi request reprint Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma
    G Altinok
    Department of Pathology, Harper University Hospital and Wayne State University, and Karmanos Cancer Institute, Detroit, MI, USA
    Prostate Cancer Prostatic Dis 9:77-82. 2006
    ..This preliminary study suggests that decreased QM expression may be associated with early development of prostate cancer, but later a high level of QM may facilitate progression of the tumors to a more aggressive phenotype...
  31. ncbi request reprint A decision aid for teaching limitations of prostate cancer screening
    Sally P Weinrich
    School of Nursing, Medical College of Georgia, Augusta, USA
    J Natl Black Nurses Assoc 19:1-11. 2008
    ....
  32. ncbi request reprint African-American race is a predictor of prostate cancer detection: incorporation into a pre-biopsy nomogram
    Brent V Yanke
    State University of New York Downstate Medical Center, New York, NY, USA
    BJU Int 98:783-7. 2006
    ....
  33. pmc A randomized trial comparing web-based decision aids on prostate cancer knowledge for African-American men
    Gary L Ellison
    Department of Family and Community Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    J Natl Med Assoc 100:1139-45. 2008
    ..Few decision aids are tailored for African-American men. We sought to determine if web-based decision aids increased knowledge of prostate cancer screening among African men...
  34. doi request reprint Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases
    Christiane M Robbins
    Translational Genomics Research Institute, Division of Integrated Cancer Genomics, Phoenix, Arizona 85004, USA
    Prostate 68:1790-7. 2008
    ..The RNASEL and HPC2/ELAC2 genes have been implicated in hereditary prostate cancer. Further assessment of the role of these genes in sporadic prostate cancer in African American men (AAM) is warranted...
  35. ncbi request reprint Knowledge of hereditary prostate cancer among high-risk African American men
    Sally Weinrich
    School of Nursing, Medical College of Georgia, Augusta, USA
    Oncol Nurs Forum 34:854-60. 2007
    ..To measure knowledge of hereditary prostate cancer in a group of high-risk African American men...