I Podgorski

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 7:207-23. 2005
  2. ncbi request reprint Loss of caspase-8 in tumor cells: mechanism to overcome integrin-mediated death?
    Izabela Podgorski
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Interv 6:132-6. 2006
  3. ncbi request reprint Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?
    I Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem Soc Trans 35:701-3. 2007
  4. pmc Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis
    Izabela Podgorski
    Wayne State University School of Medicine, Department of Pharmacology, 540 E Canfield, Detroit, MI 48201, USA
    Am J Pathol 175:1255-69. 2009
  5. pmc Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Rm 6304, Detroit, MI 48201, USA
    Future Med Chem 1:21-34. 2009
  6. pmc Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ
    Christopher Jedeszko
    Department of Pharmacology, Wayne State University, Detroit, Michigan, USA
    Cancer Res 69:9148-55. 2009
  7. ncbi request reprint Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
  8. ncbi request reprint Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006
  9. doi request reprint Macrophage cathepsin K promotes prostate tumor progression in bone
    M K Herroon
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Oncogene 32:1580-93. 2013

Collaborators

Detail Information

Publications9

  1. pmc Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 7:207-23. 2005
    ..Our results suggest that tumor-stromal interactions in the context of the bone microenvironment can modulate the expression of the cysteine protease cathepsin B...
  2. ncbi request reprint Loss of caspase-8 in tumor cells: mechanism to overcome integrin-mediated death?
    Izabela Podgorski
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Interv 6:132-6. 2006
  3. ncbi request reprint Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?
    I Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem Soc Trans 35:701-3. 2007
    ....
  4. pmc Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis
    Izabela Podgorski
    Wayne State University School of Medicine, Department of Pharmacology, 540 E Canfield, Detroit, MI 48201, USA
    Am J Pathol 175:1255-69. 2009
    ..This is the first study implicating bone marrow cathepsin K in regulation of biological activity of SPARC in bone metastasis...
  5. pmc Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Rm 6304, Detroit, MI 48201, USA
    Future Med Chem 1:21-34. 2009
    ....
  6. pmc Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ
    Christopher Jedeszko
    Department of Pharmacology, Wayne State University, Detroit, Michigan, USA
    Cancer Res 69:9148-55. 2009
    ....
  7. ncbi request reprint Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
    ..Using a confocal assay to analyze the contribution of tumor-stromal interactions to proteolysis, we have been able to confirm enhanced degradation of extracellular matrices by all three classes of proteases...
  8. ncbi request reprint Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006
    ..These should be useful clinically as surrogate endpoints for therapies that alter protease activities...
  9. doi request reprint Macrophage cathepsin K promotes prostate tumor progression in bone
    M K Herroon
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Oncogene 32:1580-93. 2013
    ..Together, our data unravel novel roles for CTSK in macrophage-regulated processes, and provide evidence for close interplay between inflammatory, osteolytic and tumor cell-driven events in the bone-tumor microenvironment...