I Podgorski

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 7:207-23. 2005
  2. ncbi Loss of caspase-8 in tumor cells: mechanism to overcome integrin-mediated death?
    Izabela Podgorski
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Interv 6:132-6. 2006
  3. ncbi Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?
    I Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem Soc Trans 35:701-3. 2007
  4. ncbi Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis
    Izabela Podgorski
    Wayne State University School of Medicine, Department of Pharmacology, 540 E Canfield, Detroit, MI 48201, USA
    Am J Pathol 175:1255-69. 2009
  5. ncbi Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Rm 6304, Detroit, MI 48201, USA
    Future Med Chem 1:21-34. 2009
  6. ncbi Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ
    Christopher Jedeszko
    Department of Pharmacology, Wayne State University, Detroit, Michigan, USA
    Cancer Res 69:9148-55. 2009
  7. ncbi Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
  8. ncbi Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006

Detail Information

Publications8

  1. ncbi Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 7:207-23. 2005
    ..Our results suggest that tumor-stromal interactions in the context of the bone microenvironment can modulate the expression of the cysteine protease cathepsin B...
  2. ncbi Loss of caspase-8 in tumor cells: mechanism to overcome integrin-mediated death?
    Izabela Podgorski
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Interv 6:132-6. 2006
  3. ncbi Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?
    I Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem Soc Trans 35:701-3. 2007
    ....
  4. ncbi Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis
    Izabela Podgorski
    Wayne State University School of Medicine, Department of Pharmacology, 540 E Canfield, Detroit, MI 48201, USA
    Am J Pathol 175:1255-69. 2009
    ..This is the first study implicating bone marrow cathepsin K in regulation of biological activity of SPARC in bone metastasis...
  5. ncbi Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?
    Izabela Podgorski
    Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Rm 6304, Detroit, MI 48201, USA
    Future Med Chem 1:21-34. 2009
    ....
  6. ncbi Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ
    Christopher Jedeszko
    Department of Pharmacology, Wayne State University, Detroit, Michigan, USA
    Cancer Res 69:9148-55. 2009
    ....
  7. ncbi Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
    ..Using a confocal assay to analyze the contribution of tumor-stromal interactions to proteolysis, we have been able to confirm enhanced degradation of extracellular matrices by all three classes of proteases...
  8. ncbi Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006
    ..These should be useful clinically as surrogate endpoints for therapies that alter protease activities...