Research Topics
Species | Marie P PiechockiSummaryAffiliation: Wayne State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Quantitative measurement of anti-ErbB-2 antibody by flow cytometry and ELISAMarie P Piechocki
Karmanos Cancer Institute, School of Medicine, Wayne State University, 429B Prentis Building, 110 E. Warren Avenue, Detroit, MI 48201, USA
J Immunol Methods 259:33-42. 2002..Therefore, excellent concordance in antibody concentration was obtained with different assays using linear regression and properly diluted samples. This concordance was verified with multiple serum samples...
Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trialHåkan Norell
Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
J Transl Med 8:53. 2010..Here we report the first administration of a Her2-plasmid DNA (pDNA) vaccine in humans...- Iressa induces cytostasis and augments Fas-mediated apoptosis in acinic cell adenocarcinoma overexpressing HER2/neuMarie P Piechocki
Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Center, Detroit, MI 48201, USA
Int J Cancer 119:441-54. 2006..These data showing that Iressa induces cytostasis and primes the extrinsic (Fas) and intrinsic (mitochondrial and endoplasmic reticulum) apoptotic pathways should lead to the development of novel therapeutic targets and strategies... - Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neuMarie P Piechocki
Department of Otolaryngology Head and Neck Surgery, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
Cancer Res 67:6825-43. 2007..This model will be useful in understanding the differences between intrinsic drug sensitivity and acquired resistance in the context of therapeutic strategies that target oncogene addicted diseases... - Gefitinib prevents cancer progression in mice expressing the activated rat HER2/neuMarie P Piechocki
Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Center, Detroit, MI 48201, USA
Int J Cancer 122:1722-9. 2008..These studies demonstrate the critical role of HER2 signal transduction in the onset and progression of HER2/neu-dependent breast cancer and suggest a role for specific inhibitors to prevent the outgrowth of early hyperplastic disease... - A stable explant culture of HER2/neu invasive carcinoma supported by alpha-Smooth Muscle Actin expressing stromal cells to evaluate therapeutic agentsMarie P Piechocki
Department of Breast Cancer Immunotherapy, Wayne State University and Karmanos Cancer Center, Detroit, MI, USA
BMC Cancer 8:119. 2008..This co-culture, Mammary Adenocarcinoma Model (MAM-1) maintains a 1:1 ratio of HER2/neu positive tumor cells to alpha-SMA-reactive stromal cells and renews this configuration for over 20 passages in vitro... 
Effect of docetaxel on the surgical tumor microenvironment of head and neck cancer in murine modelsGeorge H Yoo
Department of Otolaryngology Head and Neck Surgery, Wayne State University, 5E University Health Center, 4201 St Antoine, Detroit, MI 48201, USA
Arch Otolaryngol Head Neck Surg 134:735-42. 2008..To identify the antitumor activity and wound-healing effect of docetaxel delivered in the surgical tumor microenvironment of head and neck squamous cell carcinoma (HNSCC)...- Docetaxel associated pathways in cisplatin resistant head and neck squamous cell carcinoma: a pilot studyGeorge H Yoo
Department of Otolaryngology-Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Laryngoscope 115:1938-46. 2005..Furthermore, these differentially expressed genes and proteins can be exploited as useful surrogate endpoint biomarkers in future clinical trials using docetaxel... - BMS-275183-induced gene expression patterns in head and neck carcinomaGeorge H Yoo
Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
Am J Otolaryngol 28:309-15. 2007..However, limited BMS-275183 studies have been performed in head and neck squamous cell carcinoma (HNSCC) cell lines. The purpose of this study is to identify the biological activity of BMS-275183 on HNSCC... - Docetaxel induced gene expression patterns in head and neck squamous cell carcinoma using cDNA microarray and PowerBlotGeorge H Yoo
Department of Otolaryngology-Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Clin Cancer Res 8:3910-21. 2002.... - Combining human and rat sequences in her-2 DNA vaccines blunts immune tolerance and drives antitumor immunityJennifer B Jacob
Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
Cancer Res 70:119-28. 2010..Our findings show that a strategy of combining heterologous antigen with self-antigens could produce a potent DNA vaccine that may be applicable to other tumor-associated antigens... - Enhancement of Ad-p53 therapy with docetaxel in head and neck cancerGeorge H Yoo
Department of Otolaryngology-Head and Neck Surgery, Wayne State University, Detroit, Michigan 48201, USA
Laryngoscope 114:1871-9. 2004..These results support a clinical combination of docetaxel with p53 gene therapy in patients with head and neck cancer... - An in vivo evaluation of docetaxel delivered intratumorally in head and neck squamous cell carcinomaGeorge H Yoo
Department of Otolaryngology-Head and Neck Surgery, Division of Hematology/Oncology, Wayne State University, Detroit, MI 48201, USA
Arch Otolaryngol Head Neck Surg 131:418-29. 2005..It is calculated that IT therapy in men will increase peak concentrations of docetaxel in tumors by 1000-fold over the conventional IV dose used clinically. These preclinical results support further testing of IT docetaxel in HNSCC... - Anticancer activity of docetaxel in murine salivary gland carcinomaMarie P Piechocki
Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Clin Cancer Res 8:870-7. 2002..The purpose of this study was to evaluate the biological mechanisms of docetaxel (TXT) on salivary gland carcinoma... - Intratumoral DNA electroporation induces anti-tumor immunity and tumor regressionOlga Radkevich-Brown
Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Cancer Immunol Immunother 59:409-17. 2010..Intratumoral expression of immune-modulating molecules may be most suitable in the neoadjuvant setting to enhance the therapeutic efficacy and provide long-term protection... - Human ErbB-2 (Her-2) transgenic mice: a model system for testing Her-2 based vaccinesMarie P Piechocki
Karmanos Cancer Institute, Department of Otolaryngology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
J Immunol 171:5787-94. 2003..The breakable tolerance of Her-2 Tg mice resembles that in human and these mice are particularly suited for testing human ErbB-2 based vaccines... - In vivo characteristics of HPV-immortalized and carcinogen transformed oral keratinocytesGeorge H Yoo
Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Laryngoscope 112:1672-9. 2002..To characterize in vivo features of HPV-immortalized and carcinogen transformed oral keratinocytes... - DNA vaccination controls Her-2+ tumors that are refractory to targeted therapiesPaula J Whittington
Department of Immunology and Microbiology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
Cancer Res 68:7502-11. 2008..These results warrant Her-2 vaccination whether tumor cells are sensitive or resistant to Her-2-targeted drugs or antibody therapy... - Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimumPratima Nangia-Makker
Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI 48201, USA
Int J Cancer 121:884-94. 2007.... - Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNAMarie P Piechocki
Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Int J Cancer 131:2562-72. 2012..These findings support DR5 as a promising vaccine target for controlling TNBC and other DR5-positive cancers... - Role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte appendagesStuart Ratner
Breast Cancer Research Program and Stem Cell Transplantation Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
J Leukoc Biol 73:830-40. 2003..The results suggest that one role of Cdc42 in lymphocyte motility is to preserve polarity by concentrating lamellipodial disassembly signals in the uropod...