Suganthini Krishnan Natesan

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Levamisole-induced leukocytoclastic vasculitis and neutropenia in a patient with cocaine use: an extensive case with necrosis of skin, soft tissue, and cartilage
    Natasha Purai Arora
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit Medical Center, 4201 Saint Antoine Street, Detroit, 48201 MI, USA
    Addict Sci Clin Pract 7:19. 2012
  2. doi request reprint In vitro-in vivo correlation of voriconazole resistance due to G448S mutation (cyp51A gene) in Aspergillus fumigatus
    S Krishnan Natesan
    John D Dingell VA Medical Center, Detroit, MI, USA
    Diagn Microbiol Infect Dis 74:272-7. 2012
  3. doi request reprint In vitro efficacy of the combination of voriconazole and anidulafungin against voriconazole-resistant cyp51A mutants of Aspergillus fumigatus
    Suganthini Krishnan-Natesan
    Wayne State University, Detroit, MI, USA
    Diagn Microbiol Infect Dis 73:135-7. 2012
  4. doi request reprint Efficacy of anidulafungin, caspofungin and fluconazole in the early phase of infection in a neutropenic murine invasive candidiasis model
    Suganthini Krishnan-Natesan
    Division of Infectious Diseases, Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Antimicrob Agents 36:33-6. 2010
  5. doi request reprint Terbinafine: a pharmacological and clinical review
    S Krishnan-Natesan
    Wayne State University John D Dingell VA Medical Center, Medicine Infectious Diseases, 3990 John R, 5 Hudson, Detroit, MI 48201, USA
    Expert Opin Pharmacother 10:2723-33. 2009
  6. doi request reprint A comparison of the fungicidal activity of amphotericin B and posaconazole against Zygomycetes in vitro
    Suganthini Krishnan-Natesan
    Department of Medicine, Division of Infectious Diseases, Wayne State University, John D Dingell VA Medical Center, Detroit, MI, USA
    Diagn Microbiol Infect Dis 63:361-4. 2009
  7. doi request reprint Aspergillus flavus: an emerging non-fumigatus Aspergillus species of significance
    Suganthini Krishnan
    Division of Infectious Diseases, Wayne State University, John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Mycoses 52:206-22. 2009
  8. doi request reprint Successful treatment of primary cutaneous Aspergillus ustus infection with surgical debridement and a combination of voriconazole and terbinafine
    Suganthini Krishnan-Natesan
    Wayne State University, Detroit, MI 48202, USA
    Diagn Microbiol Infect Dis 62:443-6. 2008
  9. doi request reprint Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus
    Suganthini Krishnan-Natesan
    Division of Infectious Diseases, Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Antimicrob Agents 32:519-24. 2008
  10. ncbi request reprint Current and future therapeutic options in the management of invasive aspergillosis
    Suganthini Krishnan-Natesan
    Department of Internal Medicine, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA
    Drugs 68:265-82. 2008

Collaborators

Detail Information

Publications11

  1. pmc Levamisole-induced leukocytoclastic vasculitis and neutropenia in a patient with cocaine use: an extensive case with necrosis of skin, soft tissue, and cartilage
    Natasha Purai Arora
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit Medical Center, 4201 Saint Antoine Street, Detroit, 48201 MI, USA
    Addict Sci Clin Pract 7:19. 2012
    ..Two months later, she had a recurrence related to cocaine use. To the best of our knowledge, this is only the second reported case of levamisole-induced vasculitis that required above-knee amputation...
  2. doi request reprint In vitro-in vivo correlation of voriconazole resistance due to G448S mutation (cyp51A gene) in Aspergillus fumigatus
    S Krishnan Natesan
    John D Dingell VA Medical Center, Detroit, MI, USA
    Diagn Microbiol Infect Dis 74:272-7. 2012
    ..fumigatus. Our study demonstrated that azole resistance is based on specific site of cyp51A mutation and that in vitro VRC-R correlates with in vivo resistance...
  3. doi request reprint In vitro efficacy of the combination of voriconazole and anidulafungin against voriconazole-resistant cyp51A mutants of Aspergillus fumigatus
    Suganthini Krishnan-Natesan
    Wayne State University, Detroit, MI, USA
    Diagn Microbiol Infect Dis 73:135-7. 2012
    ..5) not only against VCZ-susceptible isolates, but also against 8 of 10 VCZ-R, G448S mutants of A. fumigatus. The combination demonstrated synergy against the VCZ-R clinical isolate as well...
  4. doi request reprint Efficacy of anidulafungin, caspofungin and fluconazole in the early phase of infection in a neutropenic murine invasive candidiasis model
    Suganthini Krishnan-Natesan
    Division of Infectious Diseases, Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Antimicrob Agents 36:33-6. 2010
    ..Thus, echinocandins have excellent antifungal activity in the early phase of disseminated Candida albicans infection and may contribute to an improved outcome in critically ill immunocompromised/neutropenic patients...
  5. doi request reprint Terbinafine: a pharmacological and clinical review
    S Krishnan-Natesan
    Wayne State University John D Dingell VA Medical Center, Medicine Infectious Diseases, 3990 John R, 5 Hudson, Detroit, MI 48201, USA
    Expert Opin Pharmacother 10:2723-33. 2009
    ....
  6. doi request reprint A comparison of the fungicidal activity of amphotericin B and posaconazole against Zygomycetes in vitro
    Suganthini Krishnan-Natesan
    Department of Medicine, Division of Infectious Diseases, Wayne State University, John D Dingell VA Medical Center, Detroit, MI, USA
    Diagn Microbiol Infect Dis 63:361-4. 2009
    ....
  7. doi request reprint Aspergillus flavus: an emerging non-fumigatus Aspergillus species of significance
    Suganthini Krishnan
    Division of Infectious Diseases, Wayne State University, John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Mycoses 52:206-22. 2009
    ..flavus in the literature. This article reviews the microbiology, toxigenicity and epidemiology of A. flavus as well as describes the clinical characteristics, diagnosis and management of infections caused by this organism...
  8. doi request reprint Successful treatment of primary cutaneous Aspergillus ustus infection with surgical debridement and a combination of voriconazole and terbinafine
    Suganthini Krishnan-Natesan
    Wayne State University, Detroit, MI 48202, USA
    Diagn Microbiol Infect Dis 62:443-6. 2008
    ..Combination of VRC with TBF showed synergistic activity (FICI = 0.5). Therefore, combination of VRC and TBF with surgical debridement, when appropriate, may be a viable treatment option for refractory A. ustus infections...
  9. doi request reprint Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus
    Suganthini Krishnan-Natesan
    Division of Infectious Diseases, Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Antimicrob Agents 32:519-24. 2008
    ..flavus isolates can be readily isolated in the laboratory under selection pressure. Multiple mechanisms, including drug target modification, may be responsible for the in vitro resistance of A. flavus to VCZ...
  10. ncbi request reprint Current and future therapeutic options in the management of invasive aspergillosis
    Suganthini Krishnan-Natesan
    Department of Internal Medicine, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA
    Drugs 68:265-82. 2008
    ..The promise of newer classes of drugs, immune-modulating therapies and vaccines are exciting future additions to the arsenal against invasive aspergillosis...
  11. ncbi request reprint Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitro
    Suganthini Krishnan Natesan
    Department of Internal Medicine Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Diagn Microbiol Infect Dis 60:369-73. 2008
    ..9% killing of A. fumigatus conidia, whereas either drug alone showed poor activity at subinhibitory concentrations. FST potentiated the antifungal activity of CFG but displayed no specific interaction with voriconazole or amphotericin B...