Girija Natarajan

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants
    Girija Natarajan
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Pediatr Cardiol 34:149-54. 2013
  2. pmc Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Pediatr Res 72:414-9. 2012
  3. pmc Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Early Hum Dev 88:509-15. 2012
  4. pmc Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants
    Girija Natarajan
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Res 67:77-82. 2010
  5. ncbi request reprint Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise?
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Pediatrics 119:936-40. 2007
  6. ncbi request reprint Short-term outcomes of patent ductus arteriosus ligation in preterm neonates: reason for concern?
    Girija Natarajan
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 27:431-7. 2010
  7. ncbi request reprint Refractory neonatal candidemia and high-dose micafungin pharmacotherapy
    G Natarajan
    Division of Neonatology, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinatol 29:738-43. 2009
  8. ncbi request reprint Chorioamnionitis and ontogeny of circulating prostaglandin and thromboxane in preterm infants
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, MI 48201, USA
    Am J Perinatol 25:491-7. 2008
  9. ncbi request reprint Apgar scores at 10 min and outcomes at 6-7 years following hypoxic-ischaemic encephalopathy
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Arch Dis Child Fetal Neonatal Ed 98:F473-9. 2013
  10. ncbi request reprint Neurodevelopmental outcome of extremely premature infants exposed to incomplete, no or complete antenatal steroids
    Sanjay Chawla
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI, USA
    J Matern Fetal Neonatal Med 26:1542-7. 2013

Collaborators

Detail Information

Publications35

  1. pmc Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants
    Girija Natarajan
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Pediatr Cardiol 34:149-54. 2013
    ..83-1.17; day 7 OR 0.88, 95 % CI 0.74-1.04) on adjusted analyses. Our results suggest that blood spot TGF-β alone is unlikely to be a reliable biomarker of a clinically significant PDA or its responsiveness to treatment...
  2. pmc Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Pediatr Res 72:414-9. 2012
    ..5 °C for 72 h in term infants (n = 208) with hypoxic-ischemic encephalopathy (HIE) who participated in the Neonatal Research Network (NRN) randomized controlled trial...
  3. pmc Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Early Hum Dev 88:509-15. 2012
    ..We compared neurodevelopmental outcomes of extremely low birth weight (ELBW) infants with and without bronchopulmonary dysplasia (BPD), using the physiologic definition...
  4. pmc Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants
    Girija Natarajan
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Res 67:77-82. 2010
    ..003). The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted...
  5. ncbi request reprint Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise?
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Pediatrics 119:936-40. 2007
    ..We hypothesized that measurement of plasma caffeine concentrations during apnea therapy is not clinically helpful...
  6. ncbi request reprint Short-term outcomes of patent ductus arteriosus ligation in preterm neonates: reason for concern?
    Girija Natarajan
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 27:431-7. 2010
    ..Whether the ductus itself or the "therapeutic" ligation is causally linked to these adverse outcomes remains to be determined...
  7. ncbi request reprint Refractory neonatal candidemia and high-dose micafungin pharmacotherapy
    G Natarajan
    Division of Neonatology, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinatol 29:738-43. 2009
    ..We further evaluate the clinical efficacy of high-dose micafungin pharmacotherapy of refractory candidemia...
  8. ncbi request reprint Chorioamnionitis and ontogeny of circulating prostaglandin and thromboxane in preterm infants
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, MI 48201, USA
    Am J Perinatol 25:491-7. 2008
    ..Further research on their role in the causation of adverse neonatal outcomes is necessary...
  9. ncbi request reprint Apgar scores at 10 min and outcomes at 6-7 years following hypoxic-ischaemic encephalopathy
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Arch Dis Child Fetal Neonatal Ed 98:F473-9. 2013
    ....
  10. ncbi request reprint Neurodevelopmental outcome of extremely premature infants exposed to incomplete, no or complete antenatal steroids
    Sanjay Chawla
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI, USA
    J Matern Fetal Neonatal Med 26:1542-7. 2013
    ..To compare the neurodevelopmental outcomes at 18-22 months' corrected age of extremely premature infants exposed to a complete course, an incomplete course or no dose of antenatal steroids (ANS)...
  11. ncbi request reprint Nitric oxide and prostaglandin response to group B streptococcal infection in the lung
    Girija Natarajan
    Division of Clinical Pharmacology, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Ann Clin Lab Sci 37:170-6. 2007
    ..The interaction between the 2 pathways may play a pathogenic role in GBS lung infections and could be a potential target for pharmacological manipulation...
  12. doi request reprint A right-to-left or bidirectional ductal shunt in preterm neonates: grave implication?
    Roopali Bapat
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 28:709-14. 2011
    ..The independent association between an RL/BD PDA shunt and mortality warrants further investigation. Insights into the etiology of pulmonary hypertension may optimize outcomes in this population...
  13. ncbi request reprint Impact of interhospital transport on the physiologic status of very low-birth-weight infants
    Prem Arora
    Division of Neonatal Perinatal Medicine, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit Medical Center, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, Michigan
    Am J Perinatol 31:237-44. 2014
    ..Better temperature regulation during interhospital transport may decrease the chances of deterioration in physiologic status of VLBW infants. ..
  14. ncbi request reprint Experience with caspofungin in the treatment of persistent fungemia in neonates
    Girija Natarajan
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    J Perinatol 25:770-7. 2005
    ..To review our experience of caspofungin in the treatment of persistent candidemia in the neonatal intensive care unit...
  15. doi request reprint Outcomes of extremely low birth weight infants with varying doses and intervals of antenatal steroid exposure
    Sanjay Chawla
    Department of Neonatology, Wayne State University, Detroit, USA
    J Perinat Med 38:419-23. 2010
    ..To compare outcomes of extremely low birth weight (ELBW) infants exposed to no antenatal steroids (ANS); incomplete ANS and complete course of ANS at varying intervals prior to delivery...
  16. ncbi request reprint Improving admission temperature in extremely low birth weight infants: a hospital-based multi-intervention quality improvement project
    Zeenia Billimoria
    Division of Neonatal Perinatal Medicine, Hutzel Women s Hospital, Wayne State University, Detroit, MI, USA
    J Perinat Med 41:455-60. 2013
    ..To reduce the incidence of hypothermia (admission temperatures <36°C) in extremely low birth weight (ELBW) neonates using a multi-intervention quality improvement (QI) initiative...
  17. ncbi request reprint Enteral feeding of neonates with congenital heart disease
    Girija Natarajan
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Mich, USA gnatara med wayne edu
    Neonatology 98:330-6. 2010
    ..Despite their putative impact on post-operative outcomes, there is paucity of data on enteral feeding practices of neonates with congenital heart disease (CHD)...
  18. ncbi request reprint Trisomy 14 Mosaicism: a case without evidence of neurodevelopmental delay and a review of the literature
    T Allen Merritt
    Department of Pediatrics, Neonatology, Loma Linda University Children s Hospital, Loma Linda, California, USA
    Am J Perinatol 24:563-6. 2007
    ..This child did not demonstrate neurodevelopmental delay, which as been reported universally among children with trisomy 14 mosaicism...
  19. doi request reprint Outcomes of congenital heart disease in late preterm infants: double jeopardy?
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Acta Paediatr 100:1104-7. 2011
    ..To evaluate outcomes of late preterm (34-36 6/7 weeks gestation) infants with congenital heart defects requiring surgical intervention during initial admission (added), in comparison with term (37-42 weeks) controls...
  20. ncbi request reprint Patterns of drug utilization in a neonatal intensive care unit
    Indulekha Warrier
    Division of Pediatric Clinical Pharmacology, 3N47, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI 48201, USA
    J Clin Pharmacol 46:449-55. 2006
    ..Caucasians, males, gestational age<28 weeks, and birthweight<1000 g were the risk factors for higher drug exposure. Future research/education must emphasize these therapeutic areas with priority assigned to low-birthweight infants...
  21. ncbi request reprint Single-center experience of outcomes of tracheostomy in children with congenital heart disease
    Geetha Challapudi
    Division of Cardiology, Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Mich, USA
    Congenit Heart Dis 8:556-60. 2013
    ..Data on outcomes of children with CHD and tracheostomy are scarce. Our objectives were to describe indications for tracheostomy and outcomes, including readmission data in this population...
  22. ncbi request reprint Outcomes of tracheostomy in the neonatal intensive care unit: is there an optimal time?
    Sharayu Rane
    Department of Pediatrics, Division of Neonatal Perinatal Medicine
    J Matern Fetal Neonatal Med 27:1257-61. 2014
    ..Conclusions: Of infants who underwent tracheostomy during the initial hospitalization after birth, 21% died. On adjusted analysis, tracheostomy timing was not independently associated with outcomes. ..
  23. doi request reprint Pneumatoceles in infants in the neonatal intensive care unit: clinical characteristics and outcomes
    Prem Arora
    Division of Neonatal Perinatal Medicine, The Carman and Ann Adams Department of Paediatrics, Wayne State University School of Medicine, Detroit Medical Center, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, MI 48201, USA
    Am J Perinatol 30:689-94. 2013
    ..To describe the clinical characteristics and outcomes of neonatal intensive care unit patients with a radiographic diagnosis of pneumatocele...
  24. doi request reprint Association between anemia and packed cell transfusion and outcomes of ventricular septal defect and atrioventricular canal repair in children
    Zeeshan Khan
    Division of Pediatric Cardiology, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Blvd, Detroit, MI, 48201, USA
    Pediatr Cardiol 35:471-8. 2014
    ..PRBC transfusions in the initial 5 postoperative days, but not anemia, are independently associated with adverse postoperative outcomes. Further studies to evaluate conservative transfusion strategies in this population are needed...
  25. doi request reprint Impact of small-for-gestational age (SGA) status on gentamicin pharmacokinetics in neonates
    Mirjana Lulic-Botica
    Department of Pharmacy, Hutzel Women s Hospital, Detroit, MI, USA Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA
    J Clin Pharmacol 54:39-45. 2014
    ..The prolonged half-life of gentamicin may need to be considered in dosing regimens for preterm SGA infants in the initial week of life. ..
  26. doi request reprint Parental perception of functional status following tracheostomy in infancy: a single center study
    Sharayu Rane
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    J Pediatr 163:860-6. 2013
    ..To examine the functional outcomes of children who underwent a tracheostomy in the initial hospitalization after birth and to determine their correlates...
  27. pmc Real-time polymerase chain reaction for the rapid detection of group B streptococcal colonization in neonates
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan, Detroit, Michigan, USA
    Pediatrics 118:14-22. 2006
    ..In this cohort, who undergo at least a 48-hour observation, a rapid method of detection of GBS colonization would allow targeted evaluation and treatment, as well as prevent delayed discharge...
  28. doi request reprint Fluctuations of anti-Xa concentrations during maintenance enoxaparin therapy for neonatal thrombosis
    Mirjana Lulic-Botica
    Department of Pharmacy, Hutzel Women s Hospital, Detroit, MI, USA
    Acta Paediatr 101:e147-50. 2012
    ..To evaluate fluctuations in anti-Xa concentrations in infants treated with enoxaparin for thrombosis and describe clinical outcomes...
  29. ncbi request reprint Clinical and neuroimaging findings in neonatal herpes simplex virus infection
    Monika Bajaj
    Carman and Ann Department of Pediatrics, Wayne State University, Detroit, MI Electronic address
    J Pediatr 165:404-407.e1. 2014
    ..Neurodevelopmental sequelae were correlated with MRI abnormalities. Our findings demonstrate that MRI, including diffusion-weighted imaging, is a valuable prognostic adjunct in neonatal herpes simplex virus disease. ..
  30. ncbi request reprint Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia
    Girija Natarajan
    Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, Detroit, Michigan
    Am J Perinatol 31:223-30. 2014
    ..01). Conclusions Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population. ..
  31. doi request reprint Role of spontaneous breathing trial in predicting successful extubation in premature infants
    Sanjay Chawla
    Division of Neonatal Perinatal Medicine, Hutzel Women s Hospital, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Pulmonol 48:443-8. 2013
    ..Identifying objective criteria for predicting successful extubation may reduce the incidence of failed extubation and the duration of mechanical ventilation...
  32. ncbi request reprint Hypoplastic left heart syndrome, restrictive patent foramen ovale, and pulmonary valve stenosis: an unusual combination
    Sanjeev Aggarwal
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Pediatr Cardiol 33:357-9. 2012
    ..In preparation for heart transplantation, bilateral pulmonary artery banding was performed to protect the pulmonary vasculature...
  33. ncbi request reprint The right ventricular systolic to diastolic duration ratio: a simple prognostic marker in congenital diaphragmatic hernia?
    Sanjeev Aggarwal
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Acta Paediatr 100:1315-8. 2011
    ..i) To compare the ratio of right ventricular systolic to diastolic duration (SD/DD) in infants with congenital diaphragmatic hernia (CDH) and normal controls and (ii) to examine its association, if any, with outcomes in CDH...
  34. ncbi request reprint A novel mutation associated with congenital hyperinsulinism
    Girija Natarajan
    Division of Neonatology, Wayne State University and Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 24:401-4. 2007
    ..Our case highlights the need for genetic evaluation in this condition. The unraveling of new mutations with unique phenotypic features may have diagnostic and prognostic utility...
  35. ncbi request reprint Persistent pulmonary hypertension of the newborn: pathogenesis, etiology, and management
    Enrique M Ostrea
    Wayne State University, Detroit, Michigan, USA
    Paediatr Drugs 8:179-88. 2006
    ..Inhaled nitric oxide has been one of the latest measures to successfully treat PPHN and significantly reduce the need for extracorporeal membrane oxygenation...