Otto Muzik

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat
    Otto Muzik
    Department of Pediatrics, Wayne State University, Detroit, MI 48201, USA
    J Nucl Med 54:523-31. 2013
  2. pmc Assessment of oxidative metabolism in brown fat using PET imaging
    Otto Muzik
    Department of Pediatrics, Wayne State University School of Medicine Detroit, MI, USA
    Front Endocrinol (Lausanne) 3:15. 2012
  3. ncbi request reprint Assessment of diagnostic performance of quantitative flow measurements in normal subjects and patients with angiographically documented coronary artery disease by means of nitrogen-13 ammonia and positron emission tomography
    O Muzik
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor
    J Am Coll Cardiol 31:534-40. 1998
  4. ncbi request reprint Objective method for localization of cortical asymmetries using positron emission tomography to aid surgical resection of epileptic foci
    O Muzik
    Department of Radiology, Children s Hospital of Michigan, Detroit 48201, USA
    Comput Aided Surg 3:74-82. 1998
  5. ncbi request reprint A mathematical model for the analysis of cross-sectional brain glucose metabolism data in children
    O Muzik
    Department of Radiology, Wayne State University, Children s Hospital of Michigan, Detroit, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:589-600. 1999
  6. pmc Application of an objective method for localizing bilateral cortical FDG PET abnormalities to guide the resection of epileptic foci
    Otto Muzik
    Department of Pediatrics and Radiology, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    IEEE Trans Biomed Eng 52:1574-81. 2005
  7. pmc Origin and propagation of epileptic spasms delineated on electrocorticography
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Street, Detroit, MI 48201, U S A
    Epilepsia 46:1086-97. 2005
  8. pmc Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate?
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medcine, Detroit, Michigan, USA
    Epilepsia 50:240-50. 2009
  9. pmc Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
  10. pmc Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 31:738-49. 2011

Research Grants

Collaborators

Detail Information

Publications83

  1. pmc 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat
    Otto Muzik
    Department of Pediatrics, Wayne State University, Detroit, MI 48201, USA
    J Nucl Med 54:523-31. 2013
    ..The objective of this study was to determine to what extent BAT thermogenesis is activated in adults during cold stress and to establish the relationship between BAT oxidative metabolism and (18)F-FDG tracer uptake...
  2. pmc Assessment of oxidative metabolism in brown fat using PET imaging
    Otto Muzik
    Department of Pediatrics, Wayne State University School of Medicine Detroit, MI, USA
    Front Endocrinol (Lausanne) 3:15. 2012
    ....
  3. ncbi request reprint Assessment of diagnostic performance of quantitative flow measurements in normal subjects and patients with angiographically documented coronary artery disease by means of nitrogen-13 ammonia and positron emission tomography
    O Muzik
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor
    J Am Coll Cardiol 31:534-40. 1998
    ....
  4. ncbi request reprint Objective method for localization of cortical asymmetries using positron emission tomography to aid surgical resection of epileptic foci
    O Muzik
    Department of Radiology, Children s Hospital of Michigan, Detroit 48201, USA
    Comput Aided Surg 3:74-82. 1998
    ..90). This objective PET method allows the accurate determination of cortical asymmetries, and it proved to be highly efficient in guiding epilepsy surgery...
  5. ncbi request reprint A mathematical model for the analysis of cross-sectional brain glucose metabolism data in children
    O Muzik
    Department of Radiology, Wayne State University, Children s Hospital of Michigan, Detroit, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:589-600. 1999
    ..Furthermore, this function may provide a useful framework for interpretation of other data sets during development...
  6. pmc Application of an objective method for localizing bilateral cortical FDG PET abnormalities to guide the resection of epileptic foci
    Otto Muzik
    Department of Pediatrics and Radiology, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    IEEE Trans Biomed Eng 52:1574-81. 2005
    ..The accuracy of this approach with respect to invasive subdural electroencephalography (EEG) data was assessed in a group of children with neocortical epilepsy...
  7. pmc Origin and propagation of epileptic spasms delineated on electrocorticography
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Street, Detroit, MI 48201, U S A
    Epilepsia 46:1086-97. 2005
    ....
  8. pmc Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate?
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medcine, Detroit, Michigan, USA
    Epilepsia 50:240-50. 2009
    ..To determine the electroclinical significance and histopathological correlates of cortical gamma-aminobutyric acid(A)(GABA(A)) receptor abnormalities detected in and remote from human neocortical epileptic foci...
  9. pmc Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
    ..The purpose of the present study was to evaluate and optimize the performance (lateralization and lobar localization value of epileptic foci) of objective voxel-based analysis of (18)F-FDG PET scans in a pediatric epilepsy population...
  10. pmc Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 31:738-49. 2011
    ..This may be a common link in neurodevelopmental disorders resulting in impairment of the somatosensory system, such as cerebral palsy and autism...
  11. pmc Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure
    Sujatha Kannan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Dev Neurosci 33:231-40. 2011
    ..Molecular imaging of ongoing neuroinflammation in the neonatal period may be helpful as a screening biomarker for detecting patients at risk of developing cerebral palsy due to a perinatal insult...
  12. pmc Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Clin Neurophysiol 115:2718-27. 2004
    ..To quantify the ictal subdural electroencephalogram (EEG) changes using spectral analysis, and to delineate the quantitatively defined ictal onset zones on high-resolution 3D MR images in children with intractable neocortical epilepsy...
  13. doi request reprint PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Wayne State University PET Center, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Nucl Med 51:139-44. 2010
    ..The objective of this study was to derive the biodistribution and in vivo radiation dose estimates of PK in children studied for brain inflammatory conditions and in healthy adults...
  14. pmc Accurate differentiation of recurrent gliomas from radiation injury by kinetic analysis of α-11C-methyl-L-tryptophan PET
    Balint Alkonyi
    PET Center, Children s Hospital of Michigan, Detroit, MI, USA
    J Nucl Med 53:1058-64. 2012
    ..The aim of this study was to evaluate the usefulness of (11)C-AMT PET supplemented by tracer kinetic analysis for distinguishing recurrent gliomas from radiation injury...
  15. ncbi request reprint Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates
    Thomas J Eluvathingal
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    J Child Neurol 21:846-51. 2006
    ..Further investigation of the potential role of the right cerebellum in autism, particularly with regard to the dentatothalamofrontal circuit, is warranted...
  16. ncbi request reprint Longitudinal changes in cortical glucose hypometabolism in children with intractable epilepsy
    Krisztina Benedek
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:26-31. 2006
    ..The findings have implications on how aggressively persistent seizures should be treated in children. (J Child Neurol 2006;21:26-31)...
  17. doi request reprint Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations
    Hiroyuki Wakamoto
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatr Neurol 39:181-8. 2008
    ..When an alpha-[(11)C]methyl-l-tryptophan focus is detected, it likely represents the epileptogenic region to be resected...
  18. pmc Quantification of tryptophan transport and metabolism in lung tumors using PET
    Csaba Juhasz
    PET Center, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    J Nucl Med 50:356-63. 2009
    ..The goal of this study was to evaluate the in vivo kinetics of alpha-(11)C-methyl-l-tryptophan (AMT), a PET tracer for tryptophan metabolism, in human lung tumors...
  19. pmc Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 78:124-30. 2008
    ..In this study we used positron emission tomography (PET) with alpha[11C]methyl-l-tryptophan (AMT) to evaluate serotonergic alterations in subcortical structures following cortical resection in children with intractable epilepsy...
  20. ncbi request reprint Biodistribution, PET, and radiation dosimetry estimates of HSV-tk gene expression imaging agent 1-(2'-Deoxy-2'-18F-Fluoro-beta-D-arabinofuranosyl)-5-iodouracil in normal dogs
    Sridhar Nimmagadda
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201 2013, USA
    J Nucl Med 48:655-60. 2007
    ..This study investigates the biodistribution, metabolism, and DNA uptake of 1-(2'-deoxy-2'-(18)F-fluoro-beta-d-arabinofuranosyl)-5-iodouracil ((18)F-FIAU) in normal dogs...
  21. ncbi request reprint Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET)
    Kenji Kagawa
    Department of Pediatrics, Pediatric Neurology PET Center, Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    J Child Neurol 20:429-38. 2005
    ..AMT PET can provide independent complementary information regarding the localization of epileptogenic regions in tuberous sclerosis complex and enhance the confidence of patient selection for successful epilepsy surgery...
  22. pmc Quantitative brain surface mapping of an electrophysiologic/metabolic mismatch in human neocortical epilepsy
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 87:77-87. 2009
    ..The clinical utility of FDG PET in guiding subdural electrode placement in neocortical epilepsy could be greatly enhanced by extending grid coverage to at least 2 cm beyond hypometabolic cortex, when feasible...
  23. pmc Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity
    Csaba Juhasz
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Clin Nucl Med 37:838-42. 2012
    ..We evaluated if kinetic parameters (K-complex, VD') of AMT, measured by PET, can predict the proliferative activity of glioma, and if these AMT parameters are altered in the remote cortex...
  24. ncbi request reprint Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    Epilepsia 45:124-30. 2004
    ..This study analyzed whether increased cortical AMT uptake can detect nonresected epileptic foci in patients with previously failed neocortical resection...
  25. ncbi request reprint Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism
    Sreenivasa R Chandana
    Department of Pharmacology, Wayne State University School of Medicine, 3901 Beaubian Blvd, Detroit, MI 48201, USA
    Int J Dev Neurosci 23:171-82. 2005
    ..Global as well as focal abnormally asymmetric development in the serotonergic system could lead to miswiring of the neural circuits specifying hemispheric specialization...
  26. pmc Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors
    Balint Alkonyi
    PET Center, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    J Neurooncol 107:365-72. 2012
    ..Increased AMT uptake can extend to extratumoral cortex, and presence of such cortical regions may increase the likelihood of recurrent seizures following surgical excision of DNTs...
  27. ncbi request reprint Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome
    Michael Behen
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mov Disord 22:2256-62. 2007
    ..This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS...
  28. ncbi request reprint Imaging DNA synthesis in vivo with 18F-FMAU and PET
    Haihao Sun
    Department of Medicine, Wayne State University, Detroit, Michigan, USA
    J Nucl Med 46:292-6. 2005
    ..We imaged DNA synthesis in vivo with PET and (18)F-1-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)thymine (FMAU), which is phosphorylated by thymidine kinases and incorporated into DNA...
  29. ncbi request reprint Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy
    Tomomi Kimiwada
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 47:167-75. 2006
    ....
  30. ncbi request reprint Biodistribution and radiation dosimetry estimates of 1-(2'-deoxy-2'-(18)F-Fluoro-1-beta-D-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs
    Sridhar Nimmagadda
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201 2013, USA
    J Nucl Med 46:1916-22. 2005
    ..This study reports on the biodistribution and radiation estimates of 1-(2'-deoxy-2'-(18)F-fluoro-1-beta-d-arabinofuranosyl)-5-bromouracil ((18)F-FBAU), a potential tracer for imaging DNA synthesis...
  31. pmc Differential kinetics of α-[¹¹C]methyl-L-tryptophan on PET in low-grade brain tumors
    Csaba Juhasz
    PET Center, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    J Neurooncol 102:409-15. 2011
    ..Kinetic analysis of AMT uptake shows significantly higher tumor/cortex tryptophan metabolic ratios in astrocytomas and oligoastrocytomas in comparison with oligodendrogliomas and DNETs...
  32. pmc Analysis and reproducibility of 3'-Deoxy-3'-[18F]fluorothymidine positron emission tomography imaging in patients with non-small cell lung cancer
    Anthony F Shields
    Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201 2013, USA
    Clin Cancer Res 14:4463-8. 2008
    ..This study assessed the methods to measure FLT retention in patients with non-small cell lung cancer (NSCLC) to measure the reproducibility of this approach...
  33. pmc Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors
    Carlos E A Batista
    Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, USA
    Mol Imaging Biol 11:460-6. 2009
    ..In the present study, we investigated whether increased tryptophan metabolism in brain tumors measured by PET is related to expression of IDO in resected brain tumor specimens...
  34. ncbi request reprint Tumor imaging using 1-(2'-deoxy-2'-18F-fluoro-beta-D-arabinofuranosyl)thymine and PET
    Omid S Tehrani
    Karmanos Cancer Institute, Wayne State University, 4100 John R Street, Detroit, MI 48201, USA
    J Nucl Med 48:1436-41. 2007
    ..The concept of tumor retention ratio (TRR) is introduced and validated...
  35. pmc Intrauterine endotoxin administration leads to white matter diffusivity changes in newborn rabbits
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1179-89. 2009
    ..Diffusion tensor imaging may be a clinically useful tool for detecting neuroinflammation induced by maternal infection in neonatal white matter...
  36. doi request reprint Coclustering for cross-subject fiber tract analysis through diffusion tensor imaging
    Cui Lin
    Department of Computer Science, Wayne State University, Detroit, MI 48202, USA
    IEEE Trans Inf Technol Biomed 14:514-25. 2010
    ....
  37. pmc Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy?
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Epilepsia 45:1091-9. 2004
    ..To study the relation between the spike frequency during intraoperative electrocorticography (ECoG) under general anesthesia with isoflurane and that during extraoperative ECoG monitoring in children with intractable neocortical epilepsy...
  38. ncbi request reprint Quantitative analysis of gray- and white-matter volumes and glucose metabolism in Sturge-Weber syndrome
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 18:119-26. 2003
    ..Extensive gray- and white-matter volume loss and hypometabolism ipsilateral to the angioma likely contribute to the frequently observed progressive cognitive dysfunction in these patients, regardless of the extent of the angioma...
  39. pmc Tryptophan PET in pretreatment delineation of newly-diagnosed gliomas: MRI and histopathologic correlates
    David O Kamson
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI, USA
    J Neurooncol 112:121-32. 2013
    ..While tryptophan uptake is low in peritumoral vasogenic edema, AMT-PET can detect tumor-infiltrated brain outside T2-lesions. Thus, AMT-PET may assist pretreatment delineation of tumor infiltration, particularly in high-grade gliomas...
  40. pmc Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
    ..We studied the distribution and expression of translocator protein in the human brain using (11)C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes...
  41. ncbi request reprint Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study
    Joon Soo Lee
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, Michigan 48201, USA
    Muscle Nerve 26:506-12. 2002
    ....
  42. ncbi request reprint PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2
    Fangyu Peng
    Department of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Nucl Med 47:1649-52. 2006
    ..Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET)...
  43. pmc Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis
    Masaaki Nishida
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Hum Brain Mapp 29:1255-64. 2008
    ....
  44. ncbi request reprint Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer
    Haihao Sun
    Karmanos Cancer Institute, Departments of Medicine, Radiology and Pediatrics, Wayne State University, 4100 John R Street, 4 HWCRC, Detroit, MI, 48201 2013, USA
    Eur J Nucl Med Mol Imaging 32:15-22. 2005
    ..This first-in-human study of [18F]FMAU was conducted as a pilot in patients to determine its biodistribution and suitability for imaging DNA synthesis in tumors using positron emission tomography (PET)...
  45. pmc Positron emission tomography imaging of neuroinflammation
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1190-9. 2009
    ....
  46. pmc Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies
    Csaba Juhasz
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Nucl Med Biol 39:926-32. 2012
    ..In this study, we combined quantitative positron emission tomography (PET) with tumor immunohistochemistry to analyze tryptophan transport and metabolism in breast cancer...
  47. doi request reprint Imaging copper metabolism imbalance in Atp7b (-/-) knockout mouse model of Wilson's disease with PET-CT and orally administered 64CuCl2
    Fangyu Peng
    Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Hines Blvd, Dallas, TX 75390 8542, USA
    Mol Imaging Biol 14:600-7. 2012
    ....
  48. pmc Increased L-[1-11 C] leucine uptake in the leptomeningeal angioma of sturge-weber syndrome: a PET study
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    J Neuroimaging 22:177-83. 2012
    ..We used L-[1-(11) C]leucine (LEU) positron emission tomography (PET) to measure amino acid uptake in children with Sturge-Weber syndrome (SWS), and to relate amino acid uptake measures with glucose metabolism...
  49. pmc Evaluating reverse speech as a control task with language-related gamma activity on electrocorticography
    Erik C Brown
    MD PhD Program, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 60:2335-45. 2012
    ..Superior temporal lobe engagement may indicate increased attention to reverse speech. Reverse speech does not appear to be a suitable task for the control of non-language auditory functions on ECoG...
  50. ncbi request reprint Metabolic changes of subcortical structures in intractable focal epilepsy
    Krisztina Benedek
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 45:1100-5. 2004
    ..In the present study, we analyzed alterations of glucose metabolism in subcortical nuclei and hippocampus by using FDG-PET in young patients with intractable epilepsy...
  51. ncbi request reprint In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    J Cereb Blood Flow Metab 26:345-57. 2006
    ..AMT PET might be a useful molecular imaging method to guide therapeutic approaches aimed at controlling tumor cell proliferation by acting on tryptophan metabolism...
  52. pmc Short-latency median-nerve somatosensory-evoked potentials and induced gamma-oscillations in humans
    Miho Fukuda
    Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, MI, 48201, USA
    Brain 131:1793-805. 2008
    ....
  53. ncbi request reprint Non-rigid surface registration using spherical thin-plate splines
    Guangyu Zou
    Department of Computer Science, Wayne State University, USA
    Med Image Comput Comput Assist Interv 10:367-74. 2007
    ..We have applied our method in the identification of cortical abnormalities in PET imaging of patients with neurological disorders and accurate results are obtained...
  54. ncbi request reprint Autism with facial port-wine stain: a new syndrome?
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Neurol 37:192-9. 2007
    ..Unilateral facial port-wine stain and autism with no intracranial angioma on conventional imaging may represent a rare clinical entity distinct from both infantile autism and previously described variants of Sturge-Weber syndrome...
  55. ncbi request reprint White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Arch Neurol 64:1169-74. 2007
    ..To assess the role of gray and white matter volume loss vs seizures in cognitive impairment of children with Sturge-Weber syndrome with unilateral involvement...
  56. pmc In vivo animation of auditory-language-induced gamma-oscillations in children with intractable focal epilepsy
    Erik C Brown
    MD PhD Program, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 41:1120-31. 2008
    ..Further studies are warranted to determine whether recording of language-induced gamma-oscillations can supplement language mapping using neurostimulation in presurgical evaluation of children with focal epilepsy...
  57. ncbi request reprint Cocluster analysis of thalamo-cortical fibre tracts extracted from diffusion tensor MRI
    Cui Lin
    Department of Computer Science, Wayne State University, 5143 Cass Avenue, Detroit, MI, 48202, USA
    Int J Data Min Bioinform 2:342-61. 2008
    ..We develop the first coclustering algorithm, Genetic Coclustering Algorithm (GCA), to solve the coclustering problem. We apply GCA to segment the thalamus into thalamic nuclei and visualise main thalamo-cortical fibre tracts...
  58. ncbi request reprint Computerized detection of lung tumors in PET/CT images
    Iyad Jafar
    Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2320-3. 2006
    ..The remaining set of tumor candidates are ranked according to their likelihood of being actual tumors. We show the preliminary results of a retrospective evaluation of clinical PET/CT images...
  59. ncbi request reprint Imaging the pharmacokinetics of [F-18]FAU in patients with tumors: PET studies
    Haihao Sun
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201 2013, USA
    Cancer Chemother Pharmacol 57:343-8. 2006
    ..This first-in-human study of [F-18]FAU was conducted in cancer patients to determine its suitability for imaging and also to understand its pharmacokinetics as a potential antineoplastic agent...
  60. pmc Differentiation of glioblastomas from metastatic brain tumors by tryptophan uptake and kinetic analysis: a positron emission tomographic study with magnetic resonance imaging comparison
    David O Kamson
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Mol Imaging 12:327-37. 2013
    ..This approach may be particularly useful in patients with a newly diagnosed solitary ring-enhancing mass...
  61. doi request reprint Differentiation of septic and aseptic loosening by PET with both 11C-PK11195 and 18F-FDG in rat models
    Weiping Ren
    Department of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USA
    Nucl Med Commun 33:747-56. 2012
    ..This study aims to determine the value of PET with C-isoquinoline carboxamide (C-PK11195) and F-fluorodeoxyglucose (F-FDG) in assisting the differentiation of aseptic loosening (AL) from septic loosening (SL) in rat models...
  62. pmc Positron emission tomography of copper metabolism in the Atp7b-/- knock-out mouse model of Wilson's disease
    Fangyu Peng
    Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8542, USA
    Mol Imaging Biol 14:70-8. 2012
    ..This study aims to determine feasibility and utility of copper-64(II) chloride (⁶⁴CuCl₂) as a tracer for positron emission tomography (PET) of copper metabolism imbalance in human Wilson's disease (WD)...
  63. ncbi request reprint Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study
    Thomas J Eluvathingal
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatrics 117:2093-100. 2006
    ..The present study used diffusion tensor imaging tractography to examine the integrity of white matter tracts that connect these brain regions...
  64. ncbi request reprint A simplified analysis of [18F]3'-deoxy-3'-fluorothymidine metabolism and retention
    Anthony F Shields
    Karmanos Cancer Institute, 4100 John R Street, 4 HWCRC, Detroit, MI 48201 2013, USA
    Eur J Nucl Med Mol Imaging 32:1269-75. 2005
    ..To quantitatively assess images, the blood activities of FLT and its glucuronidated metabolite were measured and its kinetics analyzed. This study sought to limit the number of blood samples needed to measure FLT retention...
  65. ncbi request reprint Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    J Nucl Med 48:946-54. 2007
    ....
  66. doi request reprint Multimodality neuroimaging in Tourette syndrome: alpha-[11C] methyl-L-tryptophan positron emission tomography and diffusion tensor imaging studies
    Anita S D Saporta
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    J Child Neurol 25:336-42. 2010
    ....
  67. ncbi request reprint Quantitative interictal subdural EEG analyses in children with neocortical epilepsy
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Epilepsia 44:425-34. 2003
    ....
  68. ncbi request reprint Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635
    Dilip K Maiti
    Department of Pediatrics, School of Medicine, PET Center, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Appl Radiat Isot 62:721-7. 2005
    ..0 Ci/micromol, EOS, n=2) when ca. 37.0 GBq (ca. 1.0 Ci) of starting [(11)C]CO(2) was used. Unlabeled mass of [(11)C]DWAY was found to be 0.15-0.24 microg/mL and the precursor was present in less than 50 ng/mL in final production solution...
  69. pmc Multimodality data integration in epilepsy
    Otto Muzik
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA
    Int J Biomed Imaging 2007:13963. 2007
    ..Moreover, our software environment holds promise to be useful in many other neurological disorders, where integration of multimodality data is crucial for a better understanding of the underlying disease mechanisms...
  70. doi request reprint Positron emission tomography of human hepatocellular carcinoma xenografts in mice using copper (II)-64 chloride as a tracer with copper (II)-64 chloride
    Haiyuan Zhang
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Acad Radiol 18:1561-8. 2011
    ..The aim of this study was to assess copper metabolism of human hepatocellular carcinoma (HCC) with positron emission tomographic (PET) imaging using copper (II)-64 chloride ((64)CuCl(2)) as a tracer...
  71. doi request reprint Early dose response to yttrium-90 microsphere treatment of metastatic liver cancer by a patient-specific method using single photon emission computed tomography and positron emission tomography
    Janice M Campbell
    Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI Department of Radiation Oncology, Wayne State University, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 74:313-20. 2009
    ..To evaluate a patient-specific single photon emission computed tomography (SPECT)-based method of dose calculation for treatment planning of yttrium-90 ((90)Y) microsphere selective internal radiotherapy (SIRT)...
  72. ncbi request reprint Use of 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography to monitor therapeutic response by rhabdomyosarcoma in children: report of a retrospective case study
    Fangyu Peng
    The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Nucl Med 31:394-7. 2006
    ..The purpose of this study was to study the use of 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography (F-18 FDG PET) for monitoring therapeutic response by rhabdomyosarcoma (RMSA) in children...
  73. ncbi request reprint Quantification of protein synthesis in the human brain using L-[1-11C]-leucine PET: incorporation of factors for large neutral amino acids in plasma and for amino acids recycled from tissue
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Nucl Med 47:1787-95. 2006
    ....
  74. doi request reprint Congruence of happy and sad emotion in music and faces modifies cortical audiovisual activation
    Jeong Won Jeong
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuroimage 54:2973-82. 2011
    ..We hypothesized that neural mechanisms involved in listening to music may differ when presented together with visual stimuli that conveyed the same emotion as the music when compared to visual stimuli with incongruent emotional content...
  75. ncbi request reprint Synthesis of Poly[APMA]-DOTA-64Cu conjugates for interventional radionuclide therapy of prostate cancer: assessment of intratumoral retention by micro-positron emission tomography
    Jianchao Yuan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Mol Imaging 6:10-7. 2007
    ..The data suggest that the poly[APMA]-DOTA-(64)Cu conjugates might be useful for interventional radionuclide therapy of locally recurrent prostate cancer in humans...
  76. doi request reprint A diffusion tensor imaging study of the cerebellar pathways in children with autism spectrum disorder
    Lalitha Sivaswamy
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 25:1223-31. 2010
    ..This study reiterates the underconnectivity between the cerebellum and neocortex, using diffusion tensor imaging...
  77. ncbi request reprint Alpha[11C] methyl-L-typtophan positron emission tomography in patients with alternating hemiplegia of childhood
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA
    J Child Neurol 17:253-60. 2002
    ..Furthermore, the attack number may have an effect on neurodevelopmental delay, thus supporting the notion that alternating hemiplegia of childhood may be a progressive disorder...
  78. ncbi request reprint Self-reported physical activity and myocardial flow reserve in postmenopausal women at risk for cardiovascular disease
    Claire S Duvernoy
    Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA
    J Womens Health (Larchmt) 15:45-50. 2006
    ..Regular exercise protects against coronary heart disease (CHD) events and improves vascular reactivity. Exercise effects on myocardial flow reserve (MFR) are not well studied...
  79. ncbi request reprint Mouse extrahepatic hepatoma detected on MicroPET using copper (II)-64 chloride uptake mediated by endogenous mouse copper transporter 1
    Fangyu Peng
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Mol Imaging Biol 7:325-9. 2005
    ..This study was conducted to assess the positron-emitting copper (II)-64 chloride ((64)CuCl(2)) as a probe for imaging mouse extrahepatic hepatoma expressing mouse copper transporter 1 (mCtr1) with positron emission tomography (PET)...
  80. ncbi request reprint Imaging [18F]FAU [1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) uracil] in dogs
    Haihao Sun
    Karmanos Cancer Institute, Department of Medicine, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA
    Nucl Med Biol 30:25-30. 2003
    ..The results showed that [(18)F]FAU evenly distributed to most of organs. In sharp contrast to our prior experience with thymidine and its analogs, marrow had less retention of [(18)F]FAU than the non-proliferating tissues...
  81. ncbi request reprint Hypotheses from functional neuroimaging studies
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Int Rev Neurobiol 49:37-55. 2002
    ....
  82. doi request reprint Coronary diameter and vasodilator function in children following arterial switch operation for complete transposition of the great arteries
    Daniel R Turner
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Am J Cardiol 106:421-5. 2010
    ..15, p = 0.36). In conclusion, coronary growth and function appear to be normal in most children after neonatal ASO. Children with anatomic LAD abnormalities may be at increased risk of impaired MFR...
  83. ncbi request reprint Assessment of myocardial perfusion by dynamic N-13 ammonia PET imaging: comparison of 2 tracer kinetic models
    Aliasghar Khorsand
    Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Nucl Cardiol 12:410-7. 2005
    ..We compared 2 commonly used models with 2 compartments (2C) and 3 compartments (3C) for quantification of MBF and coronary flow reserve (CFR)...

Research Grants4

  1. Software tools for pediatric neuroimaging
    Otto Muzik; Fiscal Year: 2004
    ..If successful, this determination will impact upon a large number of children with uncontrolled epilepsy as well as other neurological disorders. ..
  2. ONTOGENY OF GABAA RECEPTOR COMPLEX MEASURED WITH PET
    Otto Muzik; Fiscal Year: 2002
    ..abstract_text> ..